• Clinical and Experimental Pediatrics
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• 제51권12호
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• pp.1290-1294
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• 2008

Seizures are a frequent symptom in metabolic disorders, although metabolic disorders are rarely found to be the cause of epilepsy. A precise diagnosis might not only influence treatment, but it might also call for counseling of the family, even if there are no direct therapeutic consequences. We review the main characteristics of epilepsy in metabolic disorders with regard to energy metabolism, toxic effects, neurotransmitters, and vitamins.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.20-21
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• 2001

Free radicals and oxidative stress playa crucial role in the pathophysiology of a broad spectrum of cardiovascular diseases including congestive heart failure, valvular heart disease, cardiomyopathy, hypertrophy, atherosclerosis and ischemic heart disease. We have demonstrated that IH 636 proanthocyanidin extract (GSPE) provides excellent protection against free radicals in both in vitro and in vivo models, and exhibits significantly better efficacy as compared to vitamins C, E and $\beta$-carotene.(omitted)

• Journal of Nutrition and Health
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• 제43권3호
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• pp.233-245
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• 2010

The purpose of this study was to investigate the effects of dietary habits and nutrient intakes on skin condition of female university students. The subjects were 95 female university students in Daegu. This study examined anthropometric measurements, dietary intake, food intake habits and skin condition (moisture, elasticity, sebum (U-zone, T-zone), pores, evenness and melanin pigmentation. The subjects in this study had an average age of 21.4, an average height and weight of 161.2 cm and 52.9 kg, respectively, and the average body mass index (BMI) was 20.3 $kg/m^2$. The means of skin elasticity, pores, evenness, and melanin pigmentation were within the normal range of women in their 20s and the skin moisture state was slightly lower than the normal range, which showed a dry tendency. The sebum in the U-zone and the T-zone was lower than the standard values, which showed less secretion in both areas. The subjects with high nut intake showed a better skin pore state (p < 0.05). Those with a high intake of instant foods showed a sig-nificantly low skin moisture and a significantly higher sebum rate (p < 0.05). The group with high skin elasticity and the group with less melanin pigmentation showed a significantly low animal protein intake (p < 0.05). The group with high skin elasticity also showed a significantly higher vitamin A and niacin intakes as well (p < 0.05). The group with high skin evenness showed a significantly lower animal lipid intake and a significantly higher vitamin E intake (p < 0.05). In addition, those with high skin elasticity and evenness as well as low melanin pigmentation showed a tendency of high intake of antioxidant vitamins, such as vitamin A, carotene, vitamin C or vitamin E. In summary, a moderate intake of plant-based products and also the antioxidant vitamins within such products seems to have a beneficial effect on maintaining a healthy and good skin condition.

• 한국식품영양과학회지
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• 제33권1호
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• pp.72-77
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• 2004

당뇨병 상태에서 항산화영양소인 carotenoids의 공급이 체내 항산화비타민의 함량에 어떠한 영향을 미치는지에 대하여 조사하고자 Sprague-Dawley종 흰쥐를 이용하여 당뇨를 유도하고 비타민 A와 E의 함량 변화를 측정하였다. 당뇨를 유도하기 전에는 체중증가량에 있어서 별다른 차이를 나타내지 않았으나 당뇨가 유도된 후에는 체중증가량이 감소되었으나 $\beta$-carotene의 섭취에 의한 영향은 나타나지 않았다. 식이섭취량은 당뇨쥐에서 대조군에 비해 별다른 차이를 나타내지 않았으나 식이효율은 대조군에 비해 당뇨군에서 유의적으로 감소되었다. 당뇨 유도로 흰쥐의 혈당치는 대조군에 비하여 2배 이상 증가하였으나 당뇨군 사이에서 $\beta$-carotene의 급여에 의한 혈당강하 효과는 관찰되지 않았다. 혈장의 retinol 함량은 당뇨군에서 유의적으로 감소하였으나 $\beta$-carotene의 급여에 의한 영향은 관찰되지 않았다. 당뇨군에서 retinol함량이 유의적으로 감소되었고 혈장의 $\alpha$-to-copherol의 함량은 혈장 지질 함량을 이용하여 보정하였을 때 당뇨군에서 현저한 감소를 보였으나 $\beta$-carotene의 급여에 의한 영향은 나타나지 않았다. 간조직 중의 retinol과 retinyl palmitate 함량은 당뇨 유발군에서 유의적인 감소를 보였으며, $\beta$-carotene 급여에 의해 증가하는 경향을 나타내었다. 그러나 $\alpha$-tocopherol 함량은 당뇨 유도와 $\beta$-carotene급여에 의해 영향을 받지 않았다. 이상의 결과를 통해 볼 때 당뇨병 환자의 혈관계 합병증을 예방하기 위해 한국인의 식생활에서 $\beta$-carotene 섭취를 효과적으로 할 수 있는 실제적인 식사관리 방안을 강구한다면 당뇨병환자의 혈관계 합병증을 완화시킬 수 있으리라고 여겨진다.

• 미생물학회지
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• 제51권1호
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• pp.61-67
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• 2015

최근 우리나라는 서구화된 식생활과 생활양식의 변화로 다양한 대사성 질환과 만성 질환이 나타나고 있다. 이러한 질환들은 지속적으로 약물을 복용해야 한다. 또한 많은 사람들이 건강한 삶을 유지하기 위해 건강기능식품과 각종 비타민, 영양제를 복용한다. 하지만 복용하는 약물들이 장내 세균에는 어떠한 영향을 주는 지에 대한 연구는 많이 이뤄지지 않고 있다. 이에 본 연구에서는 흔하게 사용되며 장기간 복용하는 약이 항균활성시험으로 위장 관련 박테리아에 영향을 미치는 지를 조사하였다. 그 결과 비타민 및 미네랄, 중추신경계에 작용하는 약들이 장내 세균과 유산균에 대해 항균력을 나타냈으며, 그 중 중추신경계에 작용하는 약 중 항현훈제의 dexibuprofen는 장내 유익균 인 Lactobacillus casei과 Lactobacillus rhamnosus와 장내 유해균 인 Staphylococcus aureus에 대해 항균력이 높게 작용하였다. 또한 심혈관계, 조혈기계에 작용하는 약 중 항이뇨제 의 fenofibric acid는 장내 유익균인 Lactobacillus casei에 대해 항균력이 나타났다. 비타민 및 미네랄은 대부분의 장내 균에서 항균력을 보이지만, 특히 Vitamin B-Complex/with C와 vitamin C가 유익균인 Bifidobacterium infantis과 장내 유해균 인 Escherichia coli, Enterobacter aerogenes, Shigella flexneri, Salmonella Typhimurium, Staphylococcus aureus에서 높게 나타났다. 따라서 본 연구결과 장내 유해균과 유익균에 다양하게 복용되는 약들이 대체적으로 항균활성을 보이는 것으로 판단된다.

• 대한지역사회영양학회지
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• 제23권4호
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• pp.341-351
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• 2018

Objectives: Use of dietary supplements containing vitamins and minerals is growing in Korean adults, especially in pregnant and lactating women. Vitamin and mineral supplements are available in different composition and in a wide range of contents. The purposes of the study were to examine nutrient composition and content of vitamin and mineral supplements for pregnant and lactating women and assess their appropriateness as dietary supplements. Methods: Information on the name, manufacturer, nutrient composition, and usage of vitamin and mineral supplements for pregnant and lactating women were obtained from the homepage of the Food Safety Information Portal managed by the Ministry of Food and Drug Safety, and Korean Index of Medical Specialties. A total of 264 products were identified. Results: Among 264 products, 26.1% were single nutrient products, and 73.9% were multinutrient products. The most commonly included nutrient was iron (70.1%), folic acid (66.3%), vitamin $B_{12}$ (45.8%), vitamin C (38.6%), and vitamin $B_6$ (38.6%). Although more than 50% of products contained nutrients less than 150% of Recommended Nutrient Intakes or Adequate Intakes for daily use, some products contained inappropriately high amounts of nutrients. When a maximum daily dose of supplements was taken as described on the label, iron in 73 products (39.5%), folic acid in 14 products (8.0%) were likely to be consumed in amounts greater than Tolerable Upper Intake Levels. Most products were assessed as inappropriate for pregnant women due to the possibility of excessive intake of vitamins or minerals when compared with Dietary Reference Intakes. Conclusions: Pregnant and lactating women need to carefully select dietary supplements containing adequate amounts of vitamins and minerals. Nutritionists should provide guidelines regarding selection of appropriate vitamin and mineral supplements for pregnant and lactating women.

• 한국식생활문화학회지
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• 제15권3호
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• pp.163-174
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• 2000

This research was designed to develop a computer program and evaluate the nutritional balances especially the balance of fatty acids, amino acids and antioxidant vitamins for convenience foods. The Korean convenience food, Kimbab purchased from markets was evaluated by using the self-developed computer program. Contents of calories, protein and calcium were lower$(1/3^{\circ}{\neq}1/2)$ than the recommended levels of Korean adult woman, and the carbohydrate/ protein/ fat(CPF) energy ratio was 70: 13: 17. The mean P/ M/ S ratio was 2.2/ 1.4/ 1 and that of ${\omega}6/\;{\omega}3$ fatty acids was 17.9/ 1, which was higher than the desirable ratio of $4{\sim}8/\;1$. Average essential amino acid balance of market-Kimbab samples was within the desirable range even though the absolute amount of protein was lower than the recommended level. Contents of antioxidant vitamins (A, C &E) were lower than recommended levels. Two kinds of nutritionally adjusted Kimbab menu were established by self-developed computer program. Some of major changes was adding food ingredients such as tuna fish and perilla leaf cooked with sesame oil and soybean oil to increase ${\omega}3$ series fatty acids. Some fruits and milk were also added to the menu. The adjusted CPF ratios was 63: 15: 22 and the new values for P/ M/ S and ${\omega}6/\;{\omega}3$ fatty acids ratios were 1.0/ 1.2/ 1/0 and 6.1/ 1 respectively. In sensory evaluation of two kinds of adjusted Kimbab, the taste and overall estimation scores were higher than unadjusted Kimbab. The computer program developed in this study might be used as a tool for the evaluation of nutritional balance of other convenience foods and menu planning.

• 대한지역사회영양학회지
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• 제3권3호
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• pp.349-357
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• 1998

This study was done to investigate the effect of adolescent smoking on dietary intakes and nutritional status of serum lipids and antioxidant vitamins. Subjects were 82 somkers whose average pack-year was 0.73, and 85 nonsmokers of male technical high school students in Seoul. Anthropometric measurement was performed and % body fat was also analyzed by Bioelectrical Impedance Fatness Analyzer(GIF-891). Dietary intakes and habits were examined through questionnaires and nutrient intakes were analyzed by Computer Aided Nutritional (CAN) analysis programs. Serum TG and total cholesterol levels were measured by Spotchem sp-4410 and serum HDL-cholesterol levels were measured by test kit. serum vitamin C level was measured by 2,4-dinitrophenylhydrazine method and serum levels of vitamin A and vitamin E were measured by HPLC. All data were statistically analyzed by SAS PC package program. There was a significant difference in body fat percentage and systolic blood pressure while other anthropometric measurements were not different between smokers and monsmokers. Caloric intakes(2335㎉) in adolescent smokers tended to be higher than that of nonsmokers (2,175㎉) but the difference was not statistically significant. Intakes of protein(76.67g) and niacin(16.49㎎) in adolescent male smokers were significantly higher(P<0.05) than those of nonsmokers although other nutrient intakes were not significantly different. Analysis of serum lipids showed that serum HDL-cholesterol level of smokers was significantly different. Analysis of serum lipids showed that serum HDL-cholesterol level of smokers was significantly lower(p<0.05) than that of nonsmokers, whereas other lipid levels were not significantly different. Serum vitamin C level was also significantly lower(p<0.05) in adolescent smokers than in nonsmokers. In addition, serum vitamin E level, which was 7.85㎎/1 in smokers, was lower than that of 9.20㎎/1 in nonsmokers(p<0.05) while serum vitamin A level was not significantly different between the two groups. These results indicate that cigarette smoking in adolescence decreases serum levels of HDL-cholesterol, vitamin C and vitamin E even thoughth their smoking history is very short. (Korean J Community Nutrition 3(3) : 349∼357, 1998)

• 생명과학회지
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• 제33권7호
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• pp.574-585
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• 2023

노인들에서 근감소증은 의료-간호비용 증가의 주요 원인 중 하나가 되고 있다. 한국에서는 근감소증 예방 대책이 일반적으로 특정 질병이 없는 노인들을 대상으로 하지만, 요양원-요양병원에서 집단 거주하는 노인들의 근감소증 대책도 필요하다. 근감소증은 운동량 감소, 단백질 및 영양분(미네랄, 비타민 포함) 섭취 감소, 테스토스테론 및 성장호르몬 변화, 염증 등의 원인으로 발생한다. 분자 생물학적인 정확한 병태생리 기전의 이해가 요구된다. 근감소증은 골다공증, 낙상으로 인한 골절, 치매, 당뇨병, 심혈관 질환 등의 증상을 연결될 수 있다. 비타민 B 패밀리(B1-3, B5-7, B9 및 B12) 결핍을 근감소증 유발의 연구 대상으로 선택한 이유는 다음과 같다. 이는 비타민 B가 에너지 및 단백질 대사에 직접 관여하여 정상적인 신경 기능 유지에 필수적이다. 비타민 B 결핍은 신경-근육 질환, 신경성 질환으로 나타날 수 있으며, 노인성 근감소증과 병행하는 경우가 많다. 노인들은 적정치 이하의 비타민 B 패밀리 섭취, 흡수 장애 및 무식증 문제 등을 겪을 가능성이 높다. 초고령화 사회에서 elderly가 자립적으로 일상생활을 할 수 있는 'health lifetime'을 유지하는 것은 개인의 행복추구와 사회경제적 부담을 줄일수 있는 최고의 목표이다. 본 연구는 근감소증과 관련하여 노인들의 근육량 감소 및 근육 기능 저하를 조절하는 수용성 비타민 B 패밀리의 최신 정보를 제공한다. 또한, 비타민 B 패밀리를 통한 마이오카인에 의한 근감소증의 조절 가능성도 소개한다.

• 한국축산식품학회지
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• 제31권2호
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• pp.191-199
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• 2011

The objective of this study was to develop a method to simultaneously quantify vitamins A and E in infant formula. To determine the vitamin A and E content, vitamin A and four different vitamin E isomers (${\alpha}$-, ${\beta}$-, ${\gamma}$-, and ${\delta}$-tocopherol) were separated by high performance liquid chromatography with a photodiode array detector using a Develosil RPAQUEOUS RP-$C_{30}$ column ($4.6{\times}250$ mm, 5 ${\mu}M$). The vitamin A and E contents in the certified reference material determined using this method were within the certified range of standard values. The limits of detection (LODs) and limits of quantitation (LOQs) for vitamin A were 0.02 and 0.06 ${\mu}g/L$, respectively. LODs and LOQs for the vitamin E isomers ranged from 0.20 to 0.55 and from 0.67 to 1.81 ${\mu}g/L$, respectively. Linear analyses indicated that the square of the correlation coefficient for the vitamin A and E isomers was 0.9997-0.9999. The recovery of vitamins ranged from 96.69 to 97.79%. The results demonstrate that this novel method could be used to reliably analyze vitamin A and E content in infant formula.