MOLECULAR MECHANISMS OF CARDIOPROTECTION BY A NOVEL GRAPE SEED PROANTHOCYANIDIN EXTRACT

  • Bagchi, Debasis (Creighton University School of Pharmacy & Allied Health Professions) ;
  • Preuss, Harry G. (Creighton University School of Pharmacy & Allied Health Profession) ;
  • Das, Dipak K. (Creighton University School of Pharmacy & Allied Health Professions)
  • Published : 2001.10.01

Abstract

Free radicals and oxidative stress playa crucial role in the pathophysiology of a broad spectrum of cardiovascular diseases including congestive heart failure, valvular heart disease, cardiomyopathy, hypertrophy, atherosclerosis and ischemic heart disease. We have demonstrated that IH 636 proanthocyanidin extract (GSPE) provides excellent protection against free radicals in both in vitro and in vivo models, and exhibits significantly better efficacy as compared to vitamins C, E and $\beta$-carotene.(omitted)

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