• Biomolecules & Therapeutics
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• v.26 no.3
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• pp.313-321
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• 2018

Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive. To address this issue, we focused on the expression of cellular prion protein ($PrP^C$) in 5-FU-resistant CRC cells. In 5-FU-resistant CRC cells, $PrP^C$ expression is significantly increased, compared with that in normal CRC cells. In the presence of 5-FU, $PrP^C$ increased CRC cell survival and proliferation by maintaining the activation of the PI3K-Akt signaling pathway and the expression of cell cycle-associated proteins, including cyclin E, CDK2, cyclin D1, and CDK4. In addition, $PrP^C$ inhibited the activation of the stress-associated proteins p38, JNK, and p53. Moreover, after treatment of 5-FU-resistant CRC cells with 5-FU, silencing of $PrP^C$ triggered apoptosis via the activation of caspase-3. These results indicate that $PrP^C$ plays a key role in CRC drug resistance. The novel strategy of combining chemotherapy with $PrP^C$ targeting may yield efficacious treatments of colorectal cancer.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.10
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• pp.25-30
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• 2009

We have developed recycling technology of ethylen carbonate to use in photoresist stripping and cleaning process, which will be core processing technology for high performance and low price semiconductor and LCD fabrication. Using this technology, it is possible for semiconductor wafer and LCD planer to process more rapid and chip, and productivity will be improved.

• 한국정보디스플레이학회:학술대회논문집
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• 2000.01a
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• pp.33-34
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• 2000

The effect of $Y^{3+}$ addition to $SrTiO_3:Pr^{3+}$ on the photoluminescence and cathodoluminescence was studied. We discovered that light emitting levels of $Pr^{3+}$ vary by addition of $Y^{3+}$. In $(Sr_{1-x}Y_x)TiO_3:Pr^{3+}$, both the green and red emission are discovered while the red emission prevails in $Sr(Ti_{1-x}Y_x)O_3:Pr^{3+}$ . $Sr(Ti_{1-x}Y_x)O_3:Pr^{3+}$ shows enhancement of red emission by two kinds of enhancement process.

• Journal of Oral Medicine and Pain
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• v.34 no.2
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• pp.153-167
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• 2009

The present study was performed to observe the effect of phytoncide on oral normal microflora and the inhibitory effect of the surviving resident oral bacteria on Pr. intermedia. In this study, saliva from each of 20 healthy subjects was treated with 1% phytoncide from Japanese Hinoki (Chamaecyparis obtusa Sieb. et Zucc.). Surviving salivary bacteria were isolated on blood agar plates and identified by 16S rDNA sequencing. In order to select inhibitory isolates against Pr. intermedia, the isolates from the phytoncide-treated saliva were cultured with Pr. intermedia. The results were as follows: 1. Among the 200 surviving resident oral bacterium, 148(74.0%) bacterium inhibit the growth of Pr. intermedia on blood agar plates. 2. The 200 surviving resident oral bacterium were 109 Streptococcus salivarius(54.5%), 25 Streptococcus sanguinis(12.5%), 15 Streptococcus mitis(7.5%). 3. Among the 148 bacteria which inhibit Pr. intermedia, Streptococcus salivarius was 85.3%(93/109), Streptococcus sanguinis was 64.0%.(16/25), Streptococcus mitis was 54.3%(8/15), Streptococcus parasanguinis was 66.7%(6/9), and Streptococcus Alactolyticus was 100%(8/8). Taken together, among the surviving resident oral bacterium, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus mitis were mainly observed to inhibit Pr. intermedia. and they may exert an additional inhibitory activity against the periodontopathic bacterium. Therefore, phytoncide can be used for preventing and ceasing the progress of periodontal disease and halitosis, and thus is expect to promote oral health.

• Journal of Digital Convergence
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• v.13 no.4
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• pp.1-7
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• 2015

Policy Customer Relationship Management(PCRM) is a customer relationship management of public institution. Most of public servants at the 37 government ministries, however, has used PCRM as a simple tool for email service and online survey. This study shows government officials should understand the fact that PCRM is not a tool but a management system for general public; and utilize PCRM in each and every government PR practices. When using the PCRM indispensable to be shared with the PR of public sector, PCRM PR will be activated. The study also furnish various strategies and tactics for government PCRM PR.

• Journal of the Korean Institute of Landscape Architecture
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• v.33 no.5 s.112
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• pp.83-93
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• 2005

Research was initiated to investigate turf performance under USGA soil system. USGA system 45 centimeters deep was built with rootzone layer, intermediate layer, and drainage layer. Six turfgrass entries were comprised of 3 blends and 3 mixtures from cool-season grasses (CSG). Turfgrass color and quality ratings were best in spring and fall, especially early May to early July and late August to early November. Kentucky bluegrass (KB) consistently produced the greatest performance, while perennial ryegrass (PR) the poorest. Intermediate turf performance between KB and PR was observed with tall fescue (TF). Among CSG mixtures it increased with KB but decreased with PR. There were considerable variations in summer turf Performance. No summer drought injury was found in KB and TF. However, PR showed poor performance through summer as compared with others. Among mixtures, it decreased with PR. It was suggested that PR mix in less than $20\%$ in the mixtures to have an acceptable quality in summer. Cultural intensity also affected it. With lowering mowing height, KB of rhizomatous-type in growth habit kept good quality, while PR and TF with bunch-type in growth habit poor quality. Mowing quality was greatly different among CSG. KB produced clean-cut surface, but PR unclean one. If had an intermediate mowing quality between KB and PR. A great difference in green color retention was observed among CSG. The longest CSG was PR that kept green for 339 days, while the shortest one TF for 267 days. KB continued to keep green for 290 days. The mixtures kept green in color for 292 to 315 days, depending on turfgrass mixing intensity. The greater the PR in content, the longer the green color duration. These results demonstrate that KB was the best and PR the worst among CSG grown in USGA system under a domestic climate, in regards of turf quality, color, mowing quality, summer turf performance and green color duration. KB and TF are most adequate for high-maintenance and low-maintenance area, respectively. In case of mixtures for high-quality turf, it was desirable to use KB-based mixture with PR of below $20\%$ in seeding rate.

• The Plant Pathology Journal
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• v.31 no.2
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• pp.195-201
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• 2015

Plant growth promoting rhizobacteria (PGPR) are known to confer disease resistance to plants. Bacillus sp. JS demonstrated antifungal activities against five fungal pathogens in in vitro assays. To verify whether the volatiles of Bacillus sp. JS confer disease resistance, tobacco leaves pre-treated with the volatiles were damaged by the fungal pathogen, Rhizoctonia solani and oomycete Phytophthora nicotianae. Pre-treated tobacco leaves had smaller lesion than the control plant leaves. In pathogenesis-related (PR) gene expression analysis, volatiles of Bacillus sp. JS caused the up-regulation of PR-2 encoding ${\beta}$-1,3-glucanase and acidic PR-3 encoding chitinase. Expression of acidic PR-4 encoding chitinase and acidic PR-9 encoding peroxidase increased gradually after exposure of the volatiles to Bacillus sp. JS. Basic PR-14 encoding lipid transfer protein was also increased. However, PR-1 genes, as markers of salicylic acid (SA) induced resistance, were not expressed. These results suggested that the volatiles of Bacillus sp. JS confer disease resistance against fungal and oomycete pathogens through PR genes expression.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.9
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• pp.1297-1302
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• 2003

To determine whether the feeding of different species of hay affects the dry-matter intake and the serum cortisol level of sheep, 6 non-pregnant, non-lactating ewes were offered alfalfa (Medicago sativa) hay (Al), oats (Avena sativa) hay (Ot) and perennial ryegrass (Lolium perenne) hay (Pr) under 6 kinds of treatment including 1) change from Al to Ot, 2) Al to Pr, 3) Ot to Al, 4) Ot to Pr, 5) Pr to Al, and 6) Pr to Ot. The experimental design was a 6${\times}$6 Latin square with a 14 day period of which 9 days were a preliminary period and 5 days as a digestion trial period. The change in hay feeding was done abruptly on the first day of each period without an adaptation period. The blood from the jugular vein was collected on the first, third and the last day of each period through a sterile catheter for the analysis of cortisol. The dry-matter intake was recorded daily throughout the period. The mean daily intake of dry matter (DM, g/kg live weight) was significantly different among the 3 species of hay (Al>Ot>Pr; p<0.05). The digestibility of DM for Al and Ot was the same, but that for Pr was significantly lower than Al and Ot (p<0.05). The mean serum cortisol levels were significantly different among the hays (p<0.05). The level for Pr was the highest and that for Al was the lowest. The abrupt change of hay feeding of 6 treatments produced a significant change in the serum cortisol levels. The DM intake was inversely related to the change of the cortisol level. It is suggested that the animal' intake response to different species of hay may be partly motivated by the psychological feelings toward the hay offered.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.1283-1284
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• 2007

The barium strontium calcium titanate((Ba,Sr,Ca)$TiO_3$) powders prepared by the sol-gel method and $MnCO_3$ as acceptor were mixed oxide method. The microstructure was investigated with variation of $Pr_{2}O_{3}$ amount. The BSCT powder and $Pr_{2}O_{3}$ were mixed with organic vehicle(Ferro. B75001). BSCT thick films were fabricated by the screen-printing method on alumina substrates. The bottom electrode was Pt and upper electrode was Ag, respectively. All BSCT thick films were sintered at $1420^{\circ}C$, for 2h. The result of the differential thermal analysis(DTA), exothermic peak at around $654^{\circ}C$ due to the formation of the polycrystalline perovskite phase. In the X-ray diffraction(XRD) patterns, all BSCT thick films showed the typical perovskite polycrystalline structure and no pyrochlore phase was dbserved. The microstructure investigated by scanning electron microscope(SEM). Pore and grain size of BSCT thick films were decreased with increasing amount of $Pr_{2}O_{3}$ dopant. And the average grain size and thickness of BSCT thick films doped with 0.1 mol% $Pr_{2}O_{3}$ was $3.09{\mu}m$, $60{\mu}m$, respectively. The relative dielectric constant decreased and dielectric loss decreased with increasing amount of $Pr_{2}O_{3}$ dopant, the values of the BSCT thick films no doped with $Pr_{2}O_{3}$ were 7443 and 4 % at 1 kHz, respectively.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.30 no.11
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• pp.745-750
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• 2017

Terahertz time-domain spectroscopy has been used to study the optical properties of $Pr^{3+}-doped$ selenide glasses. The complex refractive indexes of $Pr^{3+}-selenide$ glasses were measured in a frequency range from 0.3 to 1.5 THz. The real and imaginary refractive indexes increased with increasing frequency and $Pr^{3+}$ ion concentration. The obtained result indicated that the phonon modes of the $Pr^{3+}-doped$ selenide glasses shift to lower frequencies with the concentration of $Pr^{3+}$ ions. The theory of far-infrared absorption in amorphous materials was used to analyze the results. The measured data showed that the disorder-induced terahertz absorption increased with increasing $Pr^{3+}$ ion concentration.