• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5A
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• pp.823-832
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• 2006

To ensure the serviceability requirements of PSC composite girder bridges, it is essential to predict the stresses and deformations of the structure under service load conditions. Stresses and deformations vary continuously with time due to the effects of creep and shrinkage of concrete and relaxation of prestressing steel. The importance of these time-dependent effects is much more pronounced in precast prestressed concrete structures built in stages than in those constructed in one operation. In this paper, time-dependent analyses for PSC composite bridges using 30m standard girders have been conducted considering with the variation of the times of introducing initial prestressing forces and casting concrete. A computer program has been developed for the time-dependent analysis of simple or continuous PSC composite girders and parametric studies are conducted. Based on the numerical results, it is investigated the long-term behaviors of PSC composite girder bridges and discussed the limitations of the current codes for the prestress loss.

• Geomechanics and Engineering
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• v.21 no.5
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• pp.489-501
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• 2020

This paper conducts a complicated coupled effective stress analysis of X-section-in-place concrete (XCC) pile installation and consolidation processes using the dual-stage Eulerian-Lagrangian (DSEL) technique incorporating the modified Cam-clay model. The numerical model is verified by centrifuge data and field test results. The main objective of this study is to investigate the shape effect of XCC pile cross-section on radial total stress, excess pore pressure and time-dependent strength. The discrepancies of the penetration mechanism and set-up effects on pile shaft resistance between the XCC pile and circular pile are discussed. Particular attention is placed on the time-dependent strength around the XCC pile shaft. The results show that soil strength improved more significantly close to the flat side compared with the concave side. Additionally, the computed ultimate shaft resistance of XCC pile incorporating set-up effects is 1.45 times that of the circular pile. The present findings are likely helpful in facilitating the incorporation of set-up effects into XCC pile design practices.

• Journal of Families and Better Life
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• v.32 no.1
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• pp.1-12
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• 2014

The purpose of this study was to examine: (1) whether the level of parental monitoring changes during adolescence; (2) if it changes, what is the pattern of the change; and (3) whether the effects of adolescents' attachment to their parents on parental monitoring are dependent on time. Six waves of data from the Korea Youth Panel Study (KYPS) were used to address the research questions. The participants of the KYPS were 3,449 (1,725 boys and 1,724 girls) adolescents who participated in the study once a year for 6 years (from the 2nd grade in middle school until their high school graduation). Latent growth modeling (LGM) was used to analyze the data. The findings are as follows: the level of parental monitoring significantly increased over the six waves of the study, and the adolescents' attachment to their parents was a time-dependent predictor of parental monitoring. The results indicate that the quality of adolescents' attachment to their parents is an important factor that makes a difference in the level of parental monitoring by, possibly, affecting the level of adolescents' disclosure to their parents.

• Geomechanics and Engineering
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• v.18 no.3
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• pp.299-313
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• 2019

This research investigated the nonlinear compressibility, permeability, the yielding due to structural degradation and their effects on consolidation behavior of structured soft soils. Based on oedometer and hydraulic conductivity test results of natural and reconstituted soft clays, linear log (1+e) ~ $log\;{\sigma}^{\prime}$ and log (1+e) ~ $log\;k_v$ relationships were developed to capture the variations in compressibility and permeability, and the yield stress ratio (YSR) was introduced to characterize the soil structure of natural soft clay. Semi-analytical solutions for one-dimensional consolidation of soft clay under time-dependent loading incorporating the effects of soil nonlinearity and soil structure were proposed. The semi-analytical solutions were verified against field measurements of a well-documented test embankment and they can give better accuracy in prediction of excess pore pressure compared to the predictions using the existing analytical solutions. Additionally, parametric studies were conducted to analyze the effects of YSR, compression index (${\lambda}_r$ and ${\lambda}_c$), and permeability index (${\eta}_k$) on the consolidation behavior of structured soft clays. The magnitude of the difference between degree of consolidation based on excess pore pressure ($U_p$) and that based on strain ($U_s$) depends on YSR. The parameter ${\lambda}_c/{\eta}_k$ plays a significant role in predicting consolidation behavior.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.214.1-214.1
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• 2003

Metabonomic analysis using Liquid Chromatography-Mass Spectrometry (LC-MS) was employed to test the feasibility to predict chemical-induced toxicity. Time-dependent metabolic variations were evaluated in rats treated with the model hepatotoxin, ${\alpha}$- naphthylisothiocyanate (ANIT). Urine samples of ANIT treated group and control group were collected up to 7 days postdose. Urine samples were analyzed by gradient HPLC combined with electrospray mass spectrometry. The chromatographic results were data-reduced and analyzed using principal component analysis to show the time dependent biochemical variations induced by ANIT toxicity. (omitted)

• Journal of Korean Society of Industrial and Systems Engineering
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• v.36 no.4
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• pp.130-137
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• 2013

In this paper, we consider a two-agent scheduling with sequence-dependent exponential learning effects consideration, where two agents A and B have to share a single machine for processing their jobs. The objective function for agent A is to minimize the total completion time of jobs for agent A subject to a given upper bound on the objective function of agent B, representing the makespan of jobs for agent B. By assuming that the learning ratios for all jobs are the same, we suggest an enumeration-based backward allocation scheduling for finding an optimal solution and exemplify it by using a small numerical example. This problem has various applications in production systems as well as in operations management.

• Magazine of the Korea Concrete Institute
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• v.5 no.2
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• pp.181-188
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• 1993

In this study, a numerical method for the material nonlinear analysis of reinforced concrete shell structures including the time dependent effects due to creep and shrinkage is developed. Degenerate shell elements with the layered approach are used. The perfect or strain hardening plasticity model in compression and the linearly elastic model in tension until cracking for concrete are employed. The reinforcing bars are considered as a steel layer of equivalent thickness. Each :steel layer has an uniaxial behaviour resisting only the axial force in the bar direction. A bilinear idealization is adopted to model elasto-plastic stress-strain relationships. For the nonlinear anaysis, incremental load method combined with unbalanced load iterations for each load increment is used. To include time dependent effects of concrete, time domain is divided into several time steps which may have different length. Some numerical examples are presented to study the validity and applicability of the present method. The results are compared with experimental and numerical results obtained by other investigator.

• Proceedings of the Korea Concrete Institute Conference
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• 2005.11a
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• pp.319-322
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• 2005

When a concrete structure is subjected to load, its response is both immediate and time dependent. Under sustained load, the deformation of a structure gradually increases with time and eventually may be many time greater than its instantanneous value. The gradual development of strain with time is caused by creep and shrinkage. On this study, to estimate of stress variations on time effects in partially prestressed concrete composite girder bridges, computer program applied Age-adjusted Effective Modulus Method(AEMM) in used.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.3
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• pp.169-180
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• 2015

Recently, scheduling problems with position-dependent processing times have received considerable attention in the literature, where the processing times of jobs are dependent on the processing sequences. However, they did not consider cases in which each processed job has different learning or aging ratios. This means that the actual processing time for a job can be determined not only by the processing sequence, but also by the learning/aging ratio, which can reflect the degree of processing difficulties in subsequent jobs. Motivated by these remarks, in this paper, we consider a two-agent single-machine scheduling problem with linear job-dependent position-based learning effects, where two agents compete to use a common single machine and each job has a different learning ratio. Specifically, we take into account two different objective functions for two agents: one agent minimizes the total weighted completion time, and the other restricts the makespan to less than an upper bound. After formally defining the problem by developing a mixed integer non-linear programming formulation, we devise a branch-and-bound (B&B) algorithm to give optimal solutions by developing four dominance properties based on a pairwise interchange comparison and four properties regarding the feasibility of a considered sequence. We suggest a lower bound to speed up the search procedure in the B&B algorithm by fathoming any non-prominent nodes. As this problem is at least NP-hard, we suggest efficient genetic algorithms using different methods to generate the initial population and two crossover operations. Computational results show that the proposed algorithms are efficient to obtain near-optimal solutions.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.745-755
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• 2002

To examine the effects of Yunpyesan on the cell proliferation of A549 human lung carcinoma cell line, we performed various experiments such as dose-dependent effect of Yunpyesan on cell proliferation and viability, morphological changes, quantification of apoptotic cell death and alterations of apoptosis/cell cycle-regulatory gene products. Yunpyesan declined cell viability and proliferation in both a dose- and a time-dependent manner. The anti-proliferative effect by Yunpyesan treatment in A459 cells was associated with morphological changes such as membrane shrinking and cell rounding up. Yunpyesan Induced apoptotic cell death in a time-dependent manner, which was associated with degradation of poly-(ADP-ribose) polymerase (PARP), an apoptotic target protein, without alterations of the balance between Bcl-2 and Bax expressions. DNA flow cytometric histograms showed that population of G1 phase of the cell cycle was increased by Yunpyesan treatment in a dose-dependent manner. Western blot analysis revealed that cyclin D1 and A were reduced by Yunpyesan treatment, whereas cyclin dependent kinase (Cdk) inhibitor p27 was markedly increased in a time-dependent fashion. The level of tumor suppressor p53 proteins was also increased by Yunpyesan treatment and its increase might be linked to increase of Cdk inhibitor p27. In addition, Mdm2, negative regulator of p53, was down-regulated by Yunpyesan treatment. Since the expression of retinoblastome protein (pRB), a key regulator of G1/S progression, was reduced by Yunpyesan treatment, we supposed that phosphorylation of pRB might be also blocked. The present results indicated that Yunpyesan-induced inhibition of lung cancer cell proliferation is associated with the induction of apoptosis and the blockage of G1/S progression.