The Effects of Yunpyesan on Cell Proloferation, Apoptosis and Cell Cycle Progression of Human Lung Cancer A549 Cells |
Kang Yun-Keong
(Internal Medicine of Respiratory System, College of Oriental Medicine, Dongeui University)
Park Dong Il (Internal Medicine of Respiratory System, College of Oriental Medicine, Dongeui University) Lee Jun Hyuk (Department of Anatomy, College of Oriental Medicine, Dongeui University) Choi Yung Hyun (Department of Biochemistry, College of Oriental Medicine, Dongeui University) |
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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage.
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Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c.
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Apoptosis and the cell cycle.
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Premature p34cdc2 activation required for apoptosis.
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Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
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The Pezcoller lecture: cancer cell cycles revisited.
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The retinoblastoma protein and cell cycle control.
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D-type cyclin-dependent kinase activity in mammalian cells.
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Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
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Cyclin-dependent regulation of G1 in mammalian fibroblasts.
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Mammalian G1 cyclins.
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Cyclin A is required for the onset of DNA replication in mammalian fibroblasts.
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A link between cyclin A expression and adhesion- dependent cell cycle progression.
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Role for cyclin A in the dependence of mitosis on completion of DNA replication.
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The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.
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Cdk inhibitors: on the threshold of checkpoints and development.
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Principles of CDK regulation.
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Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
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WAF1, a potential mediator of p53 tumor suppression.
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p21 is a universal inhibitor of cyclin kinases.
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Multiple pathways to apoptosis.
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Apoptosis. The role of the endonuclease.
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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.
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Apoptosis by death factor.
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Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.
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Research technics for the cell cycle study
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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.
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p53- independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells.
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Regulation of cyclin D1 by calpain protease.
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Specific proteolytic cleavage of poly(ADP- ribose) polymerase: an early marker of chemotherapy- induced apoptosis.
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Cleavage of poly ADP-ribose polymerase by a proteinase with properties like ICE.
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Yama/CPP32 , a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
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Cell adhesion molecules in the development and progression of malignant melanoma.
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E-cadherin- catenin cell-cell adhesion complex and human cancer.
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The role of the E-cadherin/catenin complex in gastrointestinal cancer.
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Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells.
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Apoptosis-associated cleavage of β-catenin in human colon cancer and rat hepatoma cells.
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Apoptosis- induced cleavage of β-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential.
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Bcl-2 functions in an antioxidant pathway to prevent apoptosis.
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Fas/APO-1 (CD95)-mediated apoptosis is activated by interferon-gamma and interferon- in interleukin-6 (IL-6)-dependent and IL-6-independent multiple myeloma cell lines.
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CD 95-independent mechanisms of IL-2 deprivation-induced apoptosis in activated human lymphocytes.
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Cyclic AMP induces inhibition of cyclin A expression and growth arrest in human hepatoma cells.
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Control of the cell cycle and apoptosis.
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Genistein- induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.
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Cyclin A is required for the onset of DNA replication in mammalian fibroblasts.
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Temporal and spatial control of cyclin B1 destruction in metaphase.
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Tumor suppressors and oncogenes in cellular senescence.
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Functions of the MDM2 oncoprotein.
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mdm2: a bridge over the two tumour suppressors, p53 and Rb.
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MDM2 oncogene as a novel target for human cancer therapy.
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Regulation and function of the p53-related proteins: same family, different rules.
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Genetic analysis of the BRCA1 region in a large breast/ovarian family: refinement of the minimal region containing BRCA1.
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BRCA1 is a cell cycle-regulated nuclear phosphoprotein.
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Down-regulation of BRCA1 and BRCA2 in human ovarian cancer cells exposed to adriamycin and ultraviolet radiation.
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The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter.
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The retinoblastoma gene: a prototypic and multifunctional tumor suppressor.
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BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site.
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Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-damaging agents.
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The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter.
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Cloning of the guinea pig 5-lipoxygenase gene and nucleotide sequence of its promoter.
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Induction of low density lipoprotein receptor and a transcription factor SP-1 by tumor necrosis factor in human microvascular endothelial cells.
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The c-Jun N-terminal kinase pathway and apoptotic signaling.
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WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
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The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration.
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DNA bending and the curious case of Fos/Jun.
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Bcl-2 family proteins.
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Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?
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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.
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The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-<TEX>$\beta$</TEX>.
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Functional importance of an Sp1- and an NF<TEX>$\kappa$</TEX>B-related nuclear protein in a keratinocyte-specific promoter of rabbit K3 keratin gene.
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Polymorphism at the Sp 1 binding site in the collagen type I alpha 1 gene does not predict bone mineral density in postmenopausal women in sweden.
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Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1.
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