• Journal of applied mathematics & informatics
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• v.31 no.3_4
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• pp.443-456
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• 2013

In this paper we consider a model with demographics for sexually transmitted diseases (STDs) spread on scale-free networks. We derive the epidemic threshold, which is depend on the birth rate, the natural death rate and other parameters. The absence of a threshold in infinite scale-free network is proved. For a hard cut off scale-free network, we also analyze the stability of disease-free equilibrium and the persistence of STDs infection. Two immunization schemes, proportional scheme and targeted vaccination, are studied and compared. We find that targeted strategy is more effective on scale-free networks.

• The Journal of the Korean life insurance medical association
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• v.31 no.1
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• pp.34-36
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• 2012

Lung cancer such as small cell lung cancer(SCLC) and non small cell lung cancer(NSCLC) have high mortality rate, so, we insurance doctors have little interest in their risk. But nowadays there's a lot of development in targeted therapy of NSCLC. Screening by CT scanning and early resection strategy also shows better prognosis. It is helpful for underwriters and insurance doctors to review the current development of targeted therapy of NSCLC and estimation of extra-risk of early lung cancer. The preferred treatment option for patients whose tumors contain EGFR-activating mutations are one of the EGFR-directed tyrosine kinase inhibitors, such as gefitinib or erlotinib. In patients with NSCLC whose tumors harboured an ALK rearrangement, there was 61% objective response rate to crizotinib in the phase 1 study. The median survival progression-free survival was 10 months. Mortality analysis of early lung cancer who were detected by CT screening, MR of 105% and EDR of 1‰ were calculated.

• Mass Spectrometry Letters
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• v.7 no.3
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• pp.74-78
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• 2016

Targeted glycoproteomics is an effective way to discover disease-associated glycoproteins in proteomics and serial affinity chromatography (SAC) using lectin and glycan-targeting antibodies shows glycan diversity on the captured glycoproteins. This study suggests a way to determine glycan heterogeneity and structural analysis on the post-translationally modified proteins through serial affinity column set (SACS) using four Lycopersicon esculentum lectin (LEL) columns. The great advantage of this method is that it differentiates between glycoproteins on the basis of their binding affinity. Through this study, some proteins were identified to have glycoforms with different affinity on a single glycoprotein. It will be particularly useful in determining biomarkers in which the disease-specific feature is a unique glycan, or a group of glycans.

• Journal of Microbiology and Biotechnology
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• v.18 no.7
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• pp.1342-1351
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• 2008

The feasibility of the use of Flp-mediated cassette exchange in the development of a CHO cell line, which produces erythropoietin (EPO) stably and largely, was investigated. A stable, high enhanced green fluorescence protein (EGFP)-producing clone was screened by extensive flow cytometric analysis. An EPO expression unit was targeted into the premarked locus of the stable parental clone by Flp-mediated cassette exchange and a correctly targeted clone (FC28T7) was obtained. The EPO production of FC28T7 was proven to be stable in long-term culture. Furthermore, the Flp-mediated cassette exchange did not alter the stable parental clone's characteristics concerning transgene expression level and stability. Taken together, the data obtained here indicated that the establishment of CHO cell lines stably producing a desired protein is achievable using Flp-mediated cassette exchange.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2727-2728
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• 2016

• Korean Journal of Oriental Medicine
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• v.14 no.2
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• pp.81-86
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• 2008

Objective: This study was aimed to review the recent trends of complementary medicine research in ICCMR 2008. Methods: Analyzed data include all researches of both oral and poster presentations in ICCMR. We classified presented researches according to their treatment method, nations, and targeted diseases. Results: In total, 338 researches were presented. In terms of methods, 68 basic researches, 98 clinical trials, 55 commentaries, 46 reviews, 71 trend analysis papers were classified. Herbal medicine was the most common treatment for research in ICCMR. And in terms of nation. Australia's announcement was the most in ICCMR. Lastly, cancer was the most focused theme in the conference. Conclusion: In the recent CAM research, cancer, depression and stress are the most targeted diseases since they are difficult to cure in modern medicine and since patients have high hopes to overcome their state by CAM. This review will help Korean doctors or scientists to systematically understand traditional medicine and to develop their researches.

• Journal of Korea Society of Digital Industry and Information Management
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• v.6 no.4
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• pp.117-130
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• 2010

Paper is on defense for so-called internet crisis, the attack of DDoS (Distributed Denial of Service) which was targeted to the central government ministries, financial sector, and portal sites of chief counties including Korea on June 7th, 2009 as its start. By conducting attack with various DDoS attacking methods in the lab environment and dividing networks targeted by the attack by layers, this paper records and analyzes the chief information for attack, destination information of packets, defense policy setting, and the flow of packet attack with the subjects of the networks separated. This study suggests CFC system using multiple firewalls applying defense policy corresponding to the target layer for ultimate attack and tests it according to the result of analyzing the attack packet information and its amount, log analysis, access recording port, and MAC and IT information, etc. by layers. This article is meaningful in that it analyzes the attack by layers, establishes firewall policy for protecting each layer, and secures accurate mechanism for detect and defense.

• Journal of Biomedical Engineering Research
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• v.41 no.5
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• pp.179-184
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• 2020

Purpose: The purpose of this study was to evaluate the effect according to the NEX, VENC, targeted cardiac phases on the velocity measurement of 4D phase-contrast MRI. Materials and Methods: The abdominal aortic phantom was made to experiment. The working fluid was mixed with water and glycerin to mimic the density and viscosity of human blood. The inlet velocity was Reynolds number 2000. The experimental conditions were NEX 1 and 4, VENC 102 cm/s and 200 cm/s, and 10 and 15 targeted cardiac phases, respectively. The average flow rate, average velocity, maximum velocity, and cross-section area were measured. Results: As a result of the case-by-case comparison, the error rate was less than 5%. There was no significant difference (p > 0.05). Conclusion: It is expected that this result will be useful for acquiring blood flow information in clinical practice.

• The Korean Journal of Health Service Management
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• v.7 no.4
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• pp.81-92
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• 2013

This research was conducted to analyze the perception of the dental hygienists who work in ordinary dental clinics regading patient safety culture and to analyze the related elements. As for the research subjects and methods, 233 dental hygienists who work at the dental clinics located in Daegu, Gyeongbuk and Jeonnam were targeted from February 6, 2012 to March 5, 2012 to administer survey by utilizing patient safety culture recognition tool. Collected data was subjected to the SPSS 18.0 program to calculate average and standard deviation, and to carry out t-test, ANOVA and multiple regression analysis. Dental hygienists' level of perception towards patient safety culture was mid level, and it was demonstrated that there is a correlation with age, work experience at department, title and type of department that affect level of perception towards patient safety culture. In conclusion, Since this research targeted only a limited number of dental hygienists, it is necessary to be cautious about over-interpreting the results. Above anything, it is necessary to carry out repetitive research by targeting medical professionals of diverse jobs.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.3
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• pp.61-67
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• 2020

The fourth industrial revolution encourages manufacturing industry to pursue a new paradigm shift to meet customers' diverse demands by managing the production process efficiently. However, it is not easy to manage efficiently a variety of tasks of all the processes including materials management, production management, process control, sales management, and inventory management. Especially, to set up an efficient production schedule and maintain appropriate inventory is crucial for tailored response to customers' needs. This paper deals with the optimized inventory policy in a steel company that produces granule products under supply contracts of three targeted on-time delivery rates. For efficient inventory management, products are classified into three groups A, B and C, and three differentiated production cycles and safety factors are assumed for the targeted on-time delivery rates of the groups. To derive the optimized inventory policy, we experimented eight cases of combined safety stock and data analysis methods in terms of key performance metrics such as mean inventory level and sold-out rate. Through simulation experiments based on real data we find that the proposed optimized inventory policy reduces inventory level by about 9%, and increases surplus production capacity rate, which is usually used for the production of products in Group C, from 43.4% to 46.3%, compared with the existing inventory policy.