• Biodesign
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• 제5권3호
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• pp.122-125
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• 2017

Receptor for advanced glycation end products (RAGE) is one of the single transmembrane domain containing receptors and causes various inflammatory diseases including diabetes and atherosclerosis. RAGE extracellular domain has three consecutive IgG-like domains (V-C₁-C₂ domain) which interact with various soluble ligands including heparan sulfate or HMGB1. Studies have shown that each ligand induces different oligomeric forms of RAGE which results in a ligand-specific signal transduction. The structure of mouse RAGE bound to heparan sulfate has been previously determined but the electron density map of heparan sulfate was too ambiguous that the exact position of heparin sulfate could not be defined. Furthermore, the complex structure of human RAGE and heparin sulfate still remains elusive. Therefore, to determine the structure, human RAGE was overexpressed using bacterial expression system and crystallized using the sitting drop method in the condition of 0.1 M sodium acetate trihydrate pH 4.6, 8 % (w/v) polyethylene glycol 4,000 at 290 K. The crystal diffracted to 3.6 Å resolution and the space group is C121 with unit cell parameters a= 206.04 Å, b= 68.64 Å, c= 98.73 Å, α= 90.00°, β= 90.62°, γ= 90.00°.

• 생명과학회지
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• 제34권1호
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• pp.37-47
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• 2024

Fun14 도메인 함유 단백 1(Fun14 domain-containing protein 1, FUNDC1)은 미토콘드리아 외막에 존재하는 단백질로, 미토콘드리아의 마이토파지(mitophage) 기전 조절에 관여하는 것으로 알려져 있다. 본 연구에서는 해마 뉴런 기원의 HT-22 세포에서 아밀로이드 베타 펩티드(A_β)에 의한 미토콘드리아와 세포 손상 과정에서 FUNDC1의 개재 가능성과 역할을 조사하였다. HT-22 세포에서 A_β를 처리하면 처리 시간에 의존적으로 FUNDC1의 발현 감소가 관찰되었다. 또한 MTT 환원능과 세포 내 ATP 농도, 미토콘드리아 막전압의 감소, 반응성 산소종의 생성과 미토콘드리아 Ca²⁺ 부하의 증가 등 미토콘드리아의 기능적 손상을 나타내는 지표들의 변화와 함께 세포사멸의 증가가 관찰되었다. FUNDC1의 발현을 일시적으로 차단한 세포군에서도 미토콘드리아의 기능적 손상을 나타내는 지표 변화와 세포사멸의 증가가 관찰되었다. 반면에 FUNDC1을 일시적으로 과발현시킨 세포군에서는 A_β 처리에 의한 미토콘드리아 손상과 세포 사멸이 유의하게 억제되었다. 이와 같은 결과들은 A_β에 의한 미토콘드리아와 세포 손상 기전에 FUNDC1이 중요하게 관여할 가능성을 시사한다.

• 대한수학회보
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• 제60권6호
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• pp.1453-1461
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• 2023

Let R be a one-dimensional Noetherian domain with quotient field K and T be the integral closure of R in K. In this note we prove that if the conductor ideal (R :_K T) is a nonzero prime ideal, then every finitely generated reflexive (and hence finitely generated G-projective) R-module is isomorphic to a direct sum of some ideals.

• Korean Journal of Mathematics
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• 제29권4호
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• pp.665-677
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• 2021

The main object of this study is to introduce the spaces $c_0({\hat{F}^q)$ and $c({\hat{F}^q)$ derived by the matrix ${\hat{F}^q$ which is the multiplication of Riesz matrix and Fibonacci matrix. Moreover, we find the 𝛼-, 𝛽-, 𝛾- duals of these spaces and give the characterization of matrix classes (${\Lambda}({\hat{F}^q)$, Ω) and (Ω, ${\Lambda}({\hat{F}^q)$) for 𝚲 ∈ {c₀, c} and Ω ∈ {ℓ₁, c₀, c, ℓ_∞}.

• 대한수학회보
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• 제57권5호
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• pp.1319-1334
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• 2020

In this paper, we study the basic theory of the category of graded w-Noetherian modules over a graded ring R. Some elementary concepts, such as w-envelope of graded modules, graded w-Noetherian rings and so on, are introduced. It is shown that: (1) A graded domain R is graded w-Noetherian if and only if R^g_𝔪 is a graded Noetherian ring for any gr-maximal w-ideal m of R, and there are only finite numbers of gr-maximal w-ideals including a for any nonzero homogeneous element a. (2) Let R be a strongly graded ring. Then R is a graded w-Noetherian ring if and only if R_e is a w-Noetherian ring. (3) Let R be a graded w-Noetherian domain and let a ∈ R be a homogeneous element. Suppose 𝖕 is a minimal graded prime ideal of (a). Then the graded height of the graded prime ideal 𝖕 is at most 1.

• Structural Engineering and Mechanics
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• 제25권4호
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• pp.467-480
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• 2007

Two methods were developed for analyzing problems with two adjacent sub-domains modeled by different kinds of elements in finite element method. Each sub-domain can be defined independently without the consideration of equivalent division with common nodes used for the interface. These two methods employ an individual interface to accomplish the compatibility. The MLSA method uses the moving least square approximation which is the basic formulation for Element Free Galerkin Method to formulate the interface. The displacement field assumed by this method does not pass through nodes on the common boundary. Therefore, nodes can be chosen freely for this method. The results show that the MLSA method has better approximation than traditional methods.

• 대한수학회논문집
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• 제37권2호
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• pp.585-594
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• 2022

In this article we classify four dimensional gradient Ricci solitons (M, g, f) with half harmonic Weyl curvature and at most two distinct Ricci-eigenvalues at each point. Indeed, we showed that, in a neighborhood V of each point in some open dense subset of M, (V, g) is isometric to one of the following: (i) an Einstein manifold. (ii) a domain in the Riemannian product (ℝ², g₀) × (N, ${\tilde{g}}$), where g₀ is the flat metric on ℝ² and (N, ${\tilde{g}}$) is a two dimensional Riemannian manifold of constant curvature λ ≠ 0. (iii) a domain in ℝ × W with the warped product metric $ds^2+h(s)^2{\tilde{g}}$, where ${\tilde{g}}$ is a constant curved metric on a three dimensional manifold W.

• 한국기계가공학회지
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• 제15권6호
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• pp.16-23
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• 2016

This study was carried out to investigate how grade level and experiences when taking courses affect the creativity of engineering students in a Korean college. The sample group consisted of 372 engineering students of which 49.5% were first graders, 15.6% second graders, 22.6% third graders, and 12.4% fourth graders. They conducted self-report measures on a domain-general and domain-specific view of creativity. The engineering creativity test, developed by Kang and Yune (2015), is based on the domain-specific view of creativity and consists of four sub-factors: creative attitude, knowledge research, interest in engineering, and team work ability. The domain-general creativity test consists of three sub-factors. Analysis of the results led to the following conclusions: First, we found significant differences in engineering creativity between students depending on experiences in taking courses and tests; and, second, we discovered significant differences in integrative creativity among students depending on experiences in taking courses and tests, and/or grade level. These conclusions suggest that we should develop and apply appropriate strategies to enhance creativity in engineering education.

• Archives of Metallurgy and Materials
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• 제67권4호
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• pp.1469-1473
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• 2022

Tungsten diselenide (WSe₂) is one of the promising transition metal dichalcogenides (TMDs) for nanoelectronics and optoelectronics. To enhance and tune the electronic performance of TMDs, chemical functionalization via covalent and van der Waals approaches has been suggested. In the present report, the electric and structural transition of WSe₂ oxidized by exposure to O₃ is investigated using scanning tunneling microscopy. It is demonstrated that the exposure of WSe₂/high-ordered pyrolytic graphite sample to O₃ induces the formation of molecular adsorbates on the surface, which enables to increase in the density of states near the valence band edge, resulting from electric structural modification of domain boundaries via exposure of atomic O. According to the work function extracted by Kelvin probe force microscopy, monolayer WSe₂ with the O₃ exposure results in a gradual increase in work function as the exposure to O₃. Therefore, the present report demonstrates the potential pathway for the chemical functionalization of TMDs to enhance the electric performance of TMDs devices.

• 한국학교보건학회지
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• 제32권3호
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• pp.165-174
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• 2019

Purpose: The purpose of this study was to identify the influence of eHealth literacy on health promoting behaviors, thereby providing basic data for the development of interventions for health promoting behaviors among university students. Methods: Data were collected from 242 university students aged 19 and over in a university located in K province in South Korea. Participants responded to structured questionnaires in September 2018. eHealth literacy and health promoting behaviors were measured by eHealth Litaracy (EHL) and a translated version of the Health Promoting Lifestyle Profile (HPLP-II), respectively. The correlation between eHealth literacy and health promoting behaviors were analyzed using Pearson's correlation, and multiple regression analysis was carried out to examine the influence of eHealth literacy on health promoting behaviors. Results: The participants had a moderate level of eHealth literacy with the greatest score recorded in the sub-domain of functional eHealth literacy and the lowest in the sub-domain of critical eHealth literacy. Female students and students who majored in healthcare had higher levels of eHealth literacy than male students and those with non-healthcare majors. The degree of health promoting behaviors was moderate or lower with the highest score being in the sub-domain of interpersonal support and the lowest in the sub-domain of health responsibility. Health promoting behaviors had significant relationships with eHealth literacy, exercise hours, subjective health status, and health concerns. Multiple regression analyses revealed that the participants engaged more in health promoting behaviors when they had greater eHealth literacy (β=.18, p<.001), interest in their own health (β=.33, p<.001), exercise hours (β=.18~.23, p<.001), and subjective health status (β=.17~.18, p=.007~.031). Conclusion: In order to facilitate health promoting behaviors of university students, interventions for health promoting behaviors need to be developed including strategies to improve competencies relevant to critical eHealth literacy and to increase exercise hours.