• JSTS:Journal of Semiconductor Technology and Science
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• v.13 no.6
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• pp.647-654
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• 2013

The design and analysis of analog circuit application on CMOS technology are a challenge in deep sub-micrometer process. This paper is a study on the performance value of Double Gate (DG) Metal Oxide Semiconductor Field Effect Transistor (MOSFET) with Gate Stack and the channel engineering Single Halo (SH), Double Halo (DH). Four different structures have been analysed keeping channel length constant. The short channel parameters and different sub-threshold analog figures of merit (FOMs) are analysed. This work extensively provides the device structures which may be applicable for high speed switching and low power consumption application.

• ETRI Journal
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• v.45 no.3
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• pp.379-393
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• 2023

Underwater communication (UWC) is widely used in coastal surveillance and early warning systems. Precise channel estimation is vital for efficient and reliable UWC. The sparse direct-adaptive filtering algorithms have become popular in UWC. Herein, we present an improved adaptive convex-combination method for the identification of sparse structures using a reweighted normalized leastmean-square (RNLMS) algorithm. Moreover, to make RNLMS algorithm independent of the reweighted l₁-norm parameter, a modified sparsity-aware adaptive zero-attracting RNLMS (AZA-RNLMS) algorithm is introduced to ensure accurate modeling. In addition, we present a quantitative analysis of this algorithm to evaluate the convergence speed and accuracy. Furthermore, we derive an excess mean-square-error expression that proves that the AZA-RNLMS algorithm performs better for the harsh underwater channel. The measured data from the experimental channel of SPACE08 is used for simulation, and results are presented to verify the performance of the proposed algorithm. The simulation results confirm that the proposed algorithm for underwater channel estimation performs better than the earlier schemes.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.45-45
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• 2003

We isolated a novel ankyrin-repeat containing protein, rSIAP (rSlo Interacting Ankyrin-repeat Protein), as an interacting protein to the cytosolic domain of the alpha-subunit of rat large-conductance Ca$\^$2+/-activated K$\^$+/ channel (rSlo) by yeast two-hybrid screening. Affinity pull-down assay showed the direct and specific interaction between rSIAP and rSlo domain. The channel-binding proteins can be classified into several categories according to their functional effects on the channel proteins, i.e. signaling adaptors, scaffolding net, molecular tuners, molecular chaperones, etc. To obtain initial clues on its functional roles, we investigated the cellular localization of rSIAP using immunofluorescent staining. The results showed the possible co-localization of rSlo and rSIAP protein near the plasma membrane, when co-expressed in CHO cells. We then investigated the functional effects of rSIAP on the rSlo channel using electrophysiological means. The co-expression of rSIAP accelerated the activation of rSlo channel. These effects were initiated at the micromolar [Ca$\^$2+/]$\_$i/ and gradually increased as [Ca$\^$2+/]$\_$i/ raised. Interestingly, rSIAP decreased the inactivation kinetics of rSlo channel at micromolar [Ca$\^$2+/]$\_$i/, while the rate was accelerated at sub-micromolar [Ca$\^$2+/]$\_$i/. These results suggest that rSIAP may modulate the activity of native BK$\_$Ca/ channel by altering its gating kinetics depending on [Ca$\^$2+/]$\_$i/. To localize critical regions involved in protein-protein interaction between rSlo and rSIAP, a series of sub-domain constructs were generated. We are currently investigating sub-domain interaction using both of yeast two-hybrid method and in vitro binding assay.

• 한국해양학회지
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• v.12 no.1
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• pp.7-12
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• 1977

Vertical mixing in the ocean affects the formation of water masses as well as the vertical distribution of nutrients and dissolved substances. this study is to investigate the effect of stability on the intensity of vertical transfer in the case of shallow and straitfied channel. It is found that the relation of the stability and vertical turbulent diffusion is given by K$\sub$z/ = -${\beta}$-(c+${\beta}$) / ${\alpha}$(E-1/${\alpha}$) where K$\sub$z/ and E denotes the vertical turbulent diffusion coefficient and stability, respectively. The empirical coefficients ${\alpha}$, ${\beta}$ and c depend on the magnitude of vertical components and stability, i.e., through thermocline intensity. The study indicates that the diffusivity of the surface mixed layer is (K$\sub$z/)=300∼1,200$\textrm{cm}^2$/sec, the thermocline layer is (K$\sub$z/)= 50∼200$\textrm{cm}^2$/sec and the cold layer is (K$\sub$z/)=200∼600$\textrm{cm}^2$/sec based on near- minimum least-squares error estimates from the regression analysis. An important result of our study comes out that the model is in accordance with the general trends of the effect of stability on the vertical turbulent diffusion coefficients in the case of shallow and strongly stratified channel.

• Journal of IKEEE
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• v.23 no.1
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• pp.29-34
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• 2019

We investigated on-off voltage ${\Delta}V_{on-off}$ of sub-10 nm JLCSG (Junctionless Cylindrical Surrounding Gate) MOSFET. The gate voltage was defined as ON voltage for the subthreshold current of $10^{-7}A$ and OFF voltage for the subthreshold current of $10^{-12}A$, and the difference between ON and OFF voltage was obtained. Since the tunneling current was not negligible at 10 nm or less, we observe the change of ${\Delta}V_{on-off}$ depending on the presence or absence of the tunneling current. For this purpose, the potential distribution in the channel was calculated using the Poisson equation and the tunneling current was calculated using the WKB approximation. As a result, it was found that ${\Delta}V_{on-off}$ was increased due to the tunneling current in JLCSG MOSFETs below 10 nm. Especially, it increased rapidly with channel lengths less than 8 nm and increased with increasing channel radius and oxide thickness.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.5
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• pp.481-491
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• 2023

The β subunits of high voltage-gated calcium channels (HGCCs) are essential for optimal channel functions such as channel gating, activation-inactivation kinetics, and trafficking to the membrane. In this study, we report for the first time the potent blood pressure-reducing effects of peptide fragments derived from the β subunits in anesthetized and non-anesthetized rats. Intravenous administration of 16-mer peptide fragments derived from the interacting regions of the β1 [cacb1(344-359)], β2 [cacb2(392-407)], β3 [cacb3(292-307)], and β4 [cacb4(333-348)] subunits with the main α-subunit of HGCC decreased arterial blood pressure in a dose-dependent manner for 5-8 min in anesthetized rats. In contrast, the peptides had no effect on the peak amplitudes of voltage-activated Ca²⁺ current upon their intracellular application into the acutely isolated trigeminal ganglion neurons. Further, a single mutated peptide of cacb1(344-359)-cacb1(344-359)_K357R-showed consistent and potent effects and was crippled by a two-amino acid-truncation at the N-terminal or C-terminal end. By conjugating palmitic acid with the second amino acid (lysine) of cacb1(344-359)_K357R (named K2-palm), we extended the blood pressure reduction to several hours without losing potency. This prolonged effect on the arterial blood pressure was also observed in non-anesthetized rats. On the other hand, the intrathecal administration of acetylated and amidated cacb1(344-359)_K357R peptide did not change acute nociceptive responses induced by the intradermal formalin injection in the plantar surface of rat hindpaw. Overall, these findings will be useful for developing antihypertensives.

• Clinical and Experimental Reproductive Medicine
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• v.46 no.4
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• pp.189-196
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• 2019

Objective: We aimed to evaluate the effects of different oxygen conditions (20% [high O₂], 5% [low O₂] and 5% decreased to 2% [dynamic O₂]) on mouse pre- and peri-implantation development using a novel double-channel gas supply (DCGS) incubator (CNC Biotech Inc.) to alter the oxygen concentration during in vitro culture. Methods: The high-O₂ and low-O₂ groups were cultured from the one-cell to the blastocyst stage under 20% and 5% oxygen concentrations, respectively. In the dynamic-O₂ group, mouse embryos were cultured from the one-cell to the morula stage under 5% O₂ for 3 days, followed by culture under 2% O₂ to the blastocyst stage. To evaluate peri-implantation development, the blastocysts from the three groups were individually transferred to a fibronectin-coated dish and cultured to the outgrowth stage in droplets. Results: The blastocyst formation rate was significantly higher in the low-O₂ and dynamic-O₂ groups than in the high-O₂ group. The total cell number was significantly higher in the dynamic-O₂ group than in the low-O₂ and high-O₂ groups. Additionally, the apoptotic index was significantly lower in the low-O₂ and dynamic-O₂ groups than in the high-O₂ group. The trophoblast outgrowth rate and spread area were significantly higher in the low-O₂ and dynamic-O₂ groups than in the high-O₂ group. Conclusion: Our results showed that a dynamic oxygen concentration (decreasing from 5% to 2%) had beneficial effects on mouse pre- and peri-implantation development. Optimized, dynamic changing of oxygen concentrations using the novel DCGS incubator could improve the developmental competence of in vitro cultured embryos in a human in vitro fertilization and embryo transfer program.

• Journal of the Korea Institute of Military Science and Technology
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• v.24 no.6
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• pp.655-663
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• 2021

In this paper, DFT-Based channel estimation with channel response mirroring is proposed and analyzed. In General, pilot symbols for channel estimation in MIMO(Multi-Input Multi-Output) OFDM(Orthogonal Frequency-Division Multiplexing) Systems have a diamond shape in the time-frequency plane. An interpolation technique to estimate the channel response of sub-carriers between reference symbols is needed. Various interpolation techniques such as linear interpolation, low-pass filtering interpolation, cubic interpolation and DFT interpolation are employed to estimate the non-pilot sub-carriers. In this paper, we investigate the conventional DFT-based channel estimation for noise reduction and channel response interpolation. The conventional method has performance degradation by distortion called "edge effect" or "border effect". In order to mitigate the distortion, we propose an improved DFT-based channel estimation with channel response mirroring. This technique can efficiently mitigate the distortion caused by the DFT of channel response discontinuity. Simulation results show that the proposed method has better performance than the conventional DFT-based channel estimation in terms of MSE.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.7
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• pp.1-6
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• 2004

For MOSFET devices with nanometer range gate length, accurate extraction of effective gate length is highly important because transistor characteristics become very sensitive to effective channel length. In this paper, we propose a new approach to extract the effective channel length of nanometer range MOSFET by Capacitance Voltage(C-V) method. The effective channel length is extracted using gate to source/drain capacitance( $C_{gsd}$). It is shown that 1/$\beta$ method, Terada method and other C-V method are inadequate to extract the accurate effective channel length. Therefore, the proposed method is highly effective for extraction of effective channel length of 100nm CMOSFETs.s.

• International Journal of Computer Science & Network Security
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• v.23 no.5
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• pp.172-178
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• 2023

In this paper, performance of autoencoder based OFDM communication systems is compared with IEEE 802.11a Wireless Lan System (Wi-Fi). The proposed autoencoder based OFDM system is composed of the following steps. First, one sub-carrier's transmitter - channel - receiver system is created by autoencoder. Then learning process of the one sub-carrier autoencoder generates constellation map. Secondly, using the plural sub-carrier autoencoder systems, parallel bundle is configured with inserting IFFT and FFT before and after the channel to configure OFDM system. Finally, the receiver part of the OFDM communication system was updated by re-learning process for adapting channel condition such as multipath channel. For performance comparison, IEEE802.11a and the proposed autoencoder based OFDM system are compared. For channel estimation, Wi-Fi uses initial long preamble to measure channel condition. but Autoencoder needs re-learning process to create an equalizer which compensate a distortion caused by the transmission channel. Therefore, this autoencoder based system has basic advantage to the Wi-Fi system. For the comparison of the system, additive random noise and 2-wave and 4-wave multipaths are assumed in the transmission path with no inter-symbol interference. A simulation was performed to compare the conventional type and the autoencoder. As a result of the simulation, the autoencoder properly generated automatic constellations with QPSK, 16QAM, and 64QAM. In the previous simulation, the received data was relearned, thus the performance was poor, but the performance improved by making the initial value of reception a random number. A function equivalent to an equalizer for multipath channels has been realized in OFDM systems. As a future task, there is not include error correction at this time, we plan to make further improvements by incorporating error correction in the future.