• Title/Summary/Keyword: stress reduce

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The Roles of Dietary Polyphenols in Brain Neuromodulation (뇌 신경조절에서의 식이 폴리페놀 화합물의 역할)

  • Lee, Hyeyoung;Lee, Heeseob
    • Journal of Life Science
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    • v.28 no.11
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    • pp.1386-1395
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    • 2018
  • Over recent years, it has become evident that the central nervous system bidirectionally interacts with the gastrointestinal tract along the gut-brain axis. A series of preclinical studies indicate that the gut microbiota can modulate central nervous system function through a multitude of physiological functions. Polyphenols are ubiquitous plant chemicals included in foods such as fruits, vegetables, tea, coffee and wine, and their consumption is directly responsible for beneficial health effects due to antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, anticancer, vasodilating, and prebiotic-like effects. There is increasing evidence that dietary polyphenol can contribute to beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury as well as in cognitive functions. In this paper, we overview the neuroprotective role of dietary polyphenols especially focusing on the neuroinflammation and neurovascular function by interaction with the gut microbiome. Polyphenol metabolites could directly act as neurotransmitters crossing the blood-brain barrier and modulating the cerebrovascular system or indirectly modulating gut microbiota. In addition, evidence suggests that dietary polyphenols are effective in preventing and managing neurological disorders, such as age-related cognitive decline and neurodegeneration, through a multitude of physiological functions. Dietary polyphenols are increasingly envisaged as a potential nutraceuticals in the prevention and treatment of neurological disorders, because they possess the ability to reduce neuroinflammation, to improve memory and cognitive function and to modulate the gut microbiota.

Current smoking rate and related factors of people with disability (장애유무에 따른 현재흡연율과 관련요인)

  • Yeob, Kyoung Eun;Kim, So Young;Park, Jong Eun;Lee, Byeong Hyeon;Park, Jong-Hyock
    • Korean Public Health Research
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    • v.44 no.4
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    • pp.51-65
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    • 2018
  • Objective : Smoking can increase the risk of secondary conditions for people with disabilities, which can in turn counteract primary disorders and exacerbate existing disorders. More active interventions for smoking cessation are necessary for people with disabilities because the physical condition of people with disabilities is more vulnerable, and risk factors such as smoking, drinking, obesity, and stress can have a decisive influence on people with disabilities compared to non-disabled people. Methods : In this study, the subjects who participated in National Health and Nutrition Survey of 2013 were those aged over 19 and smoker. The final 299 people with disability and 4,260 people without disability were analyzed. Results : Current smoking rate was 21.5% of non-disabled people and 21.4% of disabled people respectively. Factors influencing the current smoking rate of the disabled people were analyzed by type of household, economic status, home ownership, drinking, binge drinking, activity limit. Conclusions : In order to reduce socioeconomic inequalities of smoking and to actively intervene with the disabled, there need a new approach strategy focusing on people with disabilities.

Preparation and Electrochemical Characterization of Si/C/CNF Anode Material for Lithium ion Battery Using Rotary Kiln Reactor (회전킬른반응기를 이용한 리튬이온전지용 Si/C/CNF 음극활물질의 제조 및 전기화학적 특성 조사)

  • Jeon, Do-Man;Na, Byung-Ki;Rhee, Young-Woo
    • Korean Chemical Engineering Research
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    • v.56 no.6
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    • pp.901-908
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    • 2018
  • Graphite is used as a sample anode active material. However, since the maximum theoretical capacity is limited to $372mA\;h\;g^{-1}$, a new anode active material is required for the development of a high capacity lithium ion battery. The maximum theoretical capacity of Si is $4200mA\;h\;g^{-1}$, which is higher than that of graphite. However, it is not suitable for direct application to the anode active material because it has a volume expansion of 400%. In order to minimize the decrease of the discharge capacity due to the volume expansion, the Si was pulverized by the dry method to reduce the mechanical stress and the volume change of the reaction phase, and the change of the volume was suppressed by coating the carbon layers to the particle size controlled Si particles. And carbon fiber is grown like a thread on the particle surface to control secondary volume expansion and improve electrical conductivity. The physical and chemical properties of the materials were measured by XRD, SEM and TEM, and their electrochemical properties were evaluated. In this study, we have investigated the synthesis method that can be used as anode active material by improving cycle characteristics of Si.

Development of High Capacity Lithium Ion Battery Anode Material by Controlling Si Particle Size with Dry Milling Process (건식 분쇄 공정으로 Si 입도 제어를 통한 고용량 리튬이온전지 음극 소재의 개발)

  • Jeon, Do-Man;Na, Byung-Ki;Rhee, Young-Woo
    • Clean Technology
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    • v.24 no.4
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    • pp.332-338
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    • 2018
  • Currently graphite is used as an anode active material for lithium ion battery. However, since the maximum theoretical capacity of graphite is limited to $372mA\;h\;g^{-1}$, a new anode active material is required for the development of next generation high capacity and high energy density lithium ion battery. The maximum theoretical capacity of Si is $4200mA\;h\;g^{-1}$, which is about 10 times higher than the maximum theoretical capacity of graphite. However, since the volume expansion rate is almost 400%, the irreversible capacity increases as the cycle progresses and the discharge capacity relative to the charge is remarkably reduced. In order to solve these problems, it is possible to control the particle size of the Si anode active material to reduce the mechanical stress and the volume change of the reaction phase, thereby improving the cycle characteristics. Therefore, in order to minimize the decrease of the charge / discharge capacity according to the volume expansion rate of the Si particles, the improvement of the cycle characteristics was carried out by pulverizing Si by a dry method with excellent processing time and cost. In this paper, Si is controlled to nano size using vibrating mill and the physicochemical and electrochemical characteristics of the material are measured according to experimental variables.

A Practical Method for Predicting Initial Maintenance Time To Repair (MTTR) Using Maintenance Complexity in Equipment Design (장비 설계 시 정비복잡도를 활용한 현실적인 초기 정비시간 및 정비도(MTTR) 예측방법)

  • Shin, Sang-Hee;Lee, Hak-Jae;Hwang, Seong-Guk;Kim, Moo-Young;Kwon, Ki-Sang
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.9
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    • pp.247-254
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    • 2019
  • Recently, in designing military equipment, considerable attention has been paid to maintaining operations, including reliability, maintenance, and maintenance time of equipment, from the early stages of development. Therefore, both users and developers stress the importance of design considering the maintenance time. This study evaluated the specific methodologies for predicting the realistic maintenance time, such as the access complexity of equipment, other than the standard maintenance time provided by the conventional method mil-hdbk-470a at the beginning of the design, and applied the time conversion factor using a measure of the maintenance complexity. In addition, the actual maintenance time reflecting the actual maintenance time of the developed equipment and the time-conversion factor applied was compared/verified to confirm the reliability of the data. In a study to set a target for repair and the repair of equipment design in the future, it is expected that the maintenance time of equipment that fails to measure the maintenance time for the initial actual equipment will be reflected as a more realistic time. Moreover, activities, such as research and design reflection activities, will be performed to reduce the maintenance time, operational maintenance cost, etc.

A mixture of blackberry leaf and fruit extracts decreases fat deposition in HepG2 cells, modifying the gut microbiome

  • Wu, Xuangao;Jin, Bo Ram;Yang, Hye Jeong;Kim, Min Jung;Park, Sunmin
    • Journal of Applied Biological Chemistry
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    • v.62 no.3
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    • pp.229-237
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    • 2019
  • More effective treatments are needed for non-alcoholic fatty liver disease (NAFLD). We hypothesized that water extracts of blackberry fruits (BF) and leaves (BL) and their combinations (BFL) reduce fat deposition in HepG2 cells and modulate shor-tchain fatty acids (SCFA) and fecal bacteria in vitro. HepG2 cells were treated with BF, BL, BFL1:2, and BFL1:3 for 1 h, and 0.5 mM palmitate was added to the cells. Moreover, low ($30{\mu}g/mL$) and high doses ($90{\mu}g/mL$) of BL and BF were applied to fecal bacteria in vitro, and SCFA was measured by GC. BL, BF, BFL1:2, and BFL1:3 reduced triglyceride deposition in the cells in a dose-dependent manner, and BFL1:2 and BFL1:3 had a stronger effect than BF. The content of malondialdehyde, an index of oxidative stress, was also reduced in BL, BF, and BFL1:2 with increasing superoxide dismutase and glutathione peroxidase activities. The mRNA expression of acetyl CoA carboxylase, fatty acid synthase, and sterol regulatory element-binding protein-1c was reduced in BL, BF, BFL1:2, and BFL1:3 compared to the control, and BFL1:2 had the strongest effect. By contrast, the carnitine palmitolytransferase-1expression, a regulator of fatty acid oxidation, increased mostly in BFL1:2 and BFL1:3. Tumor necrosis factor-${\alpha}$ and interleukin-$1{\beta}$ expression was reduced in BL compared to that in BF and BFL1:2 in HepG2 cells. Interestingly, BL increased propionate production, and BF increased butyrate and propionate production and increased total SCFA content in fecal incubation. BF increased the contents of Bifidobacteriales and Lactobacillales and decreased those of Clostridiales, whereas BL elevated the contents of Bacteroidales and decreased those of Enterobacteriales. In conclusion, BFL1:2 and BFL1:3 may be potential therapeutic candidates for NAFLD.

An Experimental Study on Ground Reinforcement Effect of Concrete and Expansion Mat for Prevention of Buried Pipe Damage (지중매설관 손상 방지를 위한 콘크리트매트와 팽창매트의 지반보강효과에 관한 실험적 연구)

  • Park, Jeong-Jun;Shin, Heesoo;Yuu, Jungjo;Hong, Gigwon
    • Journal of the Korean Geosynthetics Society
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    • v.18 no.1
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    • pp.91-101
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    • 2019
  • Recently, small-scale excavation like ground cavity restoration and buried pipe replacement works are being carried out in urban area, in order to improve living convenience. This paper describes experiment results on the ground reinforcement method that can reduce the buried pipe damage, when the differential settlement occurred due to poor compaction of ground below the buried pipe. Plate load tests were conducted to evaluate a reinforcement effect of ground using concrete mat and expansion mat in the ground below the buried pipe. The results showed that the stress reduction ratio by concrete mat and expansion mat according to the surcharge load was about 46%~48% and 39%~42%, respectively. Therefore, the differential settlement of the buried pipe and the ground deformation below the buried pipes were reduced by the reinforcement effect of the concrete mat and expansion mat. This means that it is possible to prevent a buried pipe damage due to underground cavity and ground subsidence, if concrete mat and expansion mat are reinforced in the ground below the buried pipe or on the ground between the buried pipes.

Sasa quelpaertensis Nakai ethyl acetate fraction protects the liver against chronic alcohol-induced liver injury and fat accumulation in mice (만성 알코올 유발 마우스 간손상 및 지방 축적에 대한 제주조릿대잎 에틸 아세테이트 분획물의 간 보호 효과)

  • Kim, Areum;Lee, Youngju;Herath, Kalahe Hewage Iresha Nadeeka Madushani;Kim, Hyo Jin;Yang, Jiwon;Kim, Ju-Sung;Jee, Youngheun
    • Korean Journal of Veterinary Research
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    • v.60 no.4
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    • pp.215-223
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    • 2020
  • Sasa (S.) quelpaertensis Nakai (Korean name, Jeju-Joritdae), which has anti-oxidative and anti-inflammatory activities, is a type of bamboo grass distributed widely in Jeju Island, Korea. S. quelpaertensis leaves are used for therapeutic purposes in traditional Korean medicine. This study examined the hepatoprotective effects of the S. quelpaertensis ethyl acetate fraction (SQEA) in a mouse model to mimic alcoholic liver damage. The mice were administered orally with 30% alcohol (5 g/kg) once per day with or without SQEA treatments (100 and 200 mg/kg) for 14 days consecutively. Alcohol consumption increased the serum alcohol content and histopathological changes but reduced the liver weight. Moreover, the livers of the alcohol group exhibited the accumulation of malondialdehyde and cytochrome P450 2E1 (CYP2E1), and lipid droplet coating protein perilipin-2. On the other hand, SQEA dose-dependently attenuated the alcohol-induced serum ethanol content and liver histopathological changes but increased the liver weight. Moreover, SQEA attenuated the level of CYP2E1 and inhibited alcohol-induced lipogenesis in the liver via decreased perilipin-2 expression. These results suggest that SQEA can provide a potent way to reduce the liver damage caused by alcohol consumption.

A Study on the Experience of Nursing Student's Clinical Education in School Practice: Focused on Psychiatric Nursing Practice (간호대학생의 임상실습 교과의 교내실습 경험연구: 정신간호학 실습을 중심으로)

  • Kim, Hyeun-sil;Kim, Eun-mi;Lee, Dong-suk
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.2
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    • pp.169-178
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    • 2021
  • This study is a qualitative study to explore the experiences of nursing students' psychological nursing practice in-school. The subjects of this study were 62 students who were the 3rd grade nursing students at a University in Gangwon-do. The data were collected from August 3rd to August 20th, 2020. For data analysis, Colaizzi's qualitative analysis method was applied. Six categories were derived from data analysis: 1) Lingering affection for clinical practice in field. 2) Achievement through learning 3) Fear of nurse's role in future 4) Burden for many tasks 5) Feeling free of stress from clinical practice in field 6) Importance of cooperation with other departments. The positive aspects of in-school practice education, which from nursing students' evaluation, were immediate feedback, detailed explanations, and indirect experiences. Based on this study result, it is recommended to develop in-school nursing practice education program for gap-reducing with clinical practice. It would be consisted of various contents: simulation, online/non-face-to-face practice, face-to-face practice for indirect experience. In addition, these multi-aspect effort is needed more in psychological nursing practice education to reduce the gap with clinical practice such as therapeutic communication and hallucination interventions.

Regional Variation of EQ-5D Index and Related Factors in Community Health Survey: Major Role of Psychosocial Factors in Korea (지역사회건강조사에서 EQ-5D index의 지역간 변이와 관련 요인: 사회심리적 요인의 중요성)

  • Kim, Eunsu;Nam, Hae-Sung
    • Journal of agricultural medicine and community health
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    • v.45 no.4
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    • pp.183-193
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    • 2020
  • Objectives: As an ecological study, this study was performed to identify the community-level variation of health related quality-of-life (HRQOL), and to explore the factors that explain the variation, using 2017 Korean Community Health Survey (KCHS) data. Methods: Community health indicators of KCHS, which are correlated with the EQ-5D index of Si-gun-gu districts, were selected as independent variables. Multiple linear regression model was used to derive factors that explain regional variations in the EQ-5D index. Results: The EQ-5D index variation in 229 districts nationwide was 1.1 times for extremal quotient (EQ) and 1.0 for coefficient of variance (CV). The Si-gun-gu districts with the EQ-5D index in the lower 25% were more distributed in the province (27.7%) than in the metropolitan area (20.3%). As a result of multiple linear regression analysis, the depressed mood experience rate, perceived stress rate, suicide ideation rate, and physician diagnosed arthritis rate were derived as major factors of the variation. Conclusions: In order to reduce the gap in HRQOL between the districts, the priority of local health policies should be placed on the above factors including psychosocial factors.