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http://dx.doi.org/10.14405/kjvr.2020.60.4.215

Sasa quelpaertensis Nakai ethyl acetate fraction protects the liver against chronic alcohol-induced liver injury and fat accumulation in mice  

Kim, Areum (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University)
Lee, Youngju (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University)
Herath, Kalahe Hewage Iresha Nadeeka Madushani (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University)
Kim, Hyo Jin (Department of Food Bioengineering, College of Engineering, Jeju National University)
Yang, Jiwon (Animal Biotechnology, College of Applied Life Sciences, Jeju National University)
Kim, Ju-Sung (Majors in Plant Resource and Environment, College of Agriculture and Life Sciences, Jeju National University)
Jee, Youngheun (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University)
Publication Information
Korean Journal of Veterinary Research / v.60, no.4, 2020 , pp. 215-223 More about this Journal
Abstract
Sasa (S.) quelpaertensis Nakai (Korean name, Jeju-Joritdae), which has anti-oxidative and anti-inflammatory activities, is a type of bamboo grass distributed widely in Jeju Island, Korea. S. quelpaertensis leaves are used for therapeutic purposes in traditional Korean medicine. This study examined the hepatoprotective effects of the S. quelpaertensis ethyl acetate fraction (SQEA) in a mouse model to mimic alcoholic liver damage. The mice were administered orally with 30% alcohol (5 g/kg) once per day with or without SQEA treatments (100 and 200 mg/kg) for 14 days consecutively. Alcohol consumption increased the serum alcohol content and histopathological changes but reduced the liver weight. Moreover, the livers of the alcohol group exhibited the accumulation of malondialdehyde and cytochrome P450 2E1 (CYP2E1), and lipid droplet coating protein perilipin-2. On the other hand, SQEA dose-dependently attenuated the alcohol-induced serum ethanol content and liver histopathological changes but increased the liver weight. Moreover, SQEA attenuated the level of CYP2E1 and inhibited alcohol-induced lipogenesis in the liver via decreased perilipin-2 expression. These results suggest that SQEA can provide a potent way to reduce the liver damage caused by alcohol consumption.
Keywords
Sasa quelpaertensis Nakai; chronic alcohol-induced liver damage; hepatoprotective effect; oxidative stress; lipid peroxidation;
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