Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Sasa quelpaertensis Nakai ethyl acetate fraction protects the liver against chronic alcohol-induced liver injury and fat accumulation in mice

만성 알코올 유발 마우스 간손상 및 지방 축적에 대한 제주조릿대잎 에틸 아세테이트 분획물의 간 보호 효과

  • Kim, Areum (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University) ;
  • Lee, Youngju (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Herath, Kalahe Hewage Iresha Nadeeka Madushani (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University) ;
  • Kim, Hyo Jin (Department of Food Bioengineering, College of Engineering, Jeju National University) ;
  • Yang, Jiwon (Animal Biotechnology, College of Applied Life Sciences, Jeju National University) ;
  • Kim, Ju-Sung (Majors in Plant Resource and Environment, College of Agriculture and Life Sciences, Jeju National University) ;
  • Jee, Youngheun (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University)
  • 김아름 (차세대융복합과학기술협동과정, 제주대학교) ;
  • 이영주 (수의학과, 수의과대학, 제주대학교) ;
  • ;
  • 김효진 (식품생명공학과, 공과대학, 제주대학교) ;
  • 양지원 (동물생명공학전공, 생명자원과학대학, 제주대학교) ;
  • 김주성 (식물자원환경전공, 생명자원과학대학, 제주대학교) ;
  • 지영흔 (차세대융복합과학기술협동과정, 제주대학교)
  • Received : 2019.09.06
  • Accepted : 2020.10.23
  • Published : 2020.12.30
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Abstract

Sasa (S.) quelpaertensis Nakai (Korean name, Jeju-Joritdae), which has anti-oxidative and anti-inflammatory activities, is a type of bamboo grass distributed widely in Jeju Island, Korea. S. quelpaertensis leaves are used for therapeutic purposes in traditional Korean medicine. This study examined the hepatoprotective effects of the S. quelpaertensis ethyl acetate fraction (SQEA) in a mouse model to mimic alcoholic liver damage. The mice were administered orally with 30% alcohol (5 g/kg) once per day with or without SQEA treatments (100 and 200 mg/kg) for 14 days consecutively. Alcohol consumption increased the serum alcohol content and histopathological changes but reduced the liver weight. Moreover, the livers of the alcohol group exhibited the accumulation of malondialdehyde and cytochrome P450 2E1 (CYP2E1), and lipid droplet coating protein perilipin-2. On the other hand, SQEA dose-dependently attenuated the alcohol-induced serum ethanol content and liver histopathological changes but increased the liver weight. Moreover, SQEA attenuated the level of CYP2E1 and inhibited alcohol-induced lipogenesis in the liver via decreased perilipin-2 expression. These results suggest that SQEA can provide a potent way to reduce the liver damage caused by alcohol consumption.

Keywords

References

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