• Title/Summary/Keyword: stepwise process

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Enhancement of Immune Activity of the Extracts from Codonopsis lanceolata by Stepwise Steaming Process and High Pressure Process (증숙 및 초고압 증숙 공정을 통한 더덕의 면역활성 증진)

  • Kim, Nam Young;Chung, Jae Youn;Lee, Hyeon Yong
    • Korean Journal of Medicinal Crop Science
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    • v.22 no.2
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    • pp.134-139
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    • 2014
  • This study was to investigate the improvement of immune activities of the extracts from Codonopsis lanceolata by stepwise steaming process and high pressure process. The phenol contents was $8.742{\mu}g/mg$ which was higher than that from conventional extraction using 70% ethyl alcohol at $80^{\circ}C$ for 24 hours. All of extracts at a concentration of $1.0mg/m{\ell}$ showed relatively low cytotoxicity on human normal kidney cell (HEK293) in range of 16 19%. The immune B and T cell growth was improved by extracts using the steamed and high pressure precess of C. lanceolata up to $180{\times}10^4cells/m{\ell}$ and $96{\times}10^4cells/m{\ell}$, respectively. The extract prepared also greatly increased the secretion of both IL-6 and TNF-${\alpha}$ from the stepwise steamed and high pressure process. This results can conclude that stepwise steamed and high pressure process effectively released active biomaterials which could important role in enhancing immune activity in the body.

Stepwise Ni-silicide Process for Parasitic Resistance Reduction for Silicon/metal Contact Junction

  • Choi, Hoon;Cho, Il-Whan;Hong, Sang-Jeen
    • Transactions on Electrical and Electronic Materials
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    • v.9 no.4
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    • pp.137-142
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    • 2008
  • The parasitic resistance is studied to silicon/metal contact junction for improving device performance and to lower contact/serial resistance silicide in natural sequence. In this paper constructs the stepwise Ni silicide process for parasitic resistance reduction for silicon/metal contact junction. We have investigated multi-step Ni silicide on SiGe substrate with stepwise annealing method as an alternative to compose more thermally reliable Ni silicide layer. Stepwise annealing for silicide formation is exposed to heating environment with $5^{\circ}C/sec$ for 10 seconds and a dwelling for both 10 and 30 seconds, and ramping-up and the dwelling was repeated until the final annealing temperature of $700\;^{\circ}C$ is achieved. Finally a direct comparison for single step and stepwise annealing process is obtained for 20 nm nickel silicide through stepwise annealing is $5.64\;{\Omega}/square$ at $600\;^{\circ}C$, and it is 42 % lower than that of as nickel sputtered. The proposed stepwise annealing for Ni silicidation can provide the least amount of NiSi at the interface of nickel silicide and silicon, and it provides lower resistance, higher thermal-stability, and superior morphology than other thermal treatment.

Buckling of axial compressed cylindrical shells with stepwise variable thickness

  • Fan, H.G.;Chen, Z.P.;Feng, W.Z.;Zhou, F.;Shen, X.L.;Cao, G.W.
    • Structural Engineering and Mechanics
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    • v.54 no.1
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    • pp.87-103
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    • 2015
  • This paper focuses on an analytical research on the critical buckling load of cylindrical shells with stepwise variable wall thickness under axial compression. An arctan function is established to describe the thickness variation along the axial direction of this kind of cylindrical shells accurately. By using the methods of separation of variables, small parameter perturbation and Fourier series expansion, analytical formulas of the critical buckling load of cylindrical shells with arbitrary axisymmetric thickness variation under axial compression are derived. The analysis is based on the thin shell theory. Analytic results show that the critical buckling load of the uniform shell with constant thickness obtained from this paper is identical with the classical solution. Two important cases of thickness variation pattern are also investigated with these analytical formulas and the results coincide well with those obtained from other authors. The cylindrical shells with stepwise variable wall thickness, which are widely used in actual engineering, are studied by this method and the analytical formulas of critical buckling load under axial compression are obtained. Furthermore, an example is presented to illustrate the effects of each strake's length and thickness on the critical buckling load.

Temperature Uniformity Control of Wafer During Vacuum Soldering Process (진공 솔더링 공정 중 웨이퍼 온도균일화 제어)

  • Kang, Min Sig;Jee, Won Ho;Yoon, Wo Hyun
    • Journal of the Semiconductor & Display Technology
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    • v.11 no.2
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    • pp.63-69
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    • 2012
  • As decreasing size of chips, the need of wafer level packaging is increased in semi-conductor and display industries. Temperature uniformity is a crucial factor in vacuum soldering process to guarantee quality of bonding between chips and wafer. In this paper, a stepwise iterative algorithm has been suggested to obtain output profile of each heat source. Since this algorithm is based on open-loop stepwise iterative experimental technique, it is easier to implement and cost effective than real time feedback controls. Along with some experiments, it was shown that the suggested algorithm can remarkably improve temperature uniformity of wafer during whole heating process compared with the ordinary manual trial-and error method.

Enhancement of Cosmeceutical Activity from Codonopsis lanceolata Extracts by Stepwise Steaming Process (증숙 및 초고압 증숙 공정을 통한 더덕의 향장활성 증진)

  • Kim, Ji Seon;Choi, Woo Seok;Chung, Jae Youn;Chung, Hee Chul;Lee, Hyeon Yong
    • Korean Journal of Medicinal Crop Science
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    • v.21 no.3
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    • pp.204-212
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    • 2013
  • In general, stepwise hot steaming process is known to be effective in improving its biological activities; however, not much employed in processing Codonopsis lanceolata due to its hardness. The complex processed C. lanceolata showed highest free radical scavenging acitivity as 45.21%. Total phenol and flavonoid content were of complex processed C. lanceolata higher than conventional extract and alone steaming process. It was showed the lower melanogenesis rate on melanin production test by B16F10 cells as 27.46%. High inhibitory of tyrosinase was also measured as 28.61% by adding steamed Codonopsis lanceolata extracts by high pressure extraction of 1.0 $mg/m{\ell}$. And anti-wrinkle activity were 39.08%. In comparing phenolic acids profiles in the extract, in general higher amounts of polyphenol were obtained possibly by easy release of active components during thermal processing, which results in better antioxidant activities than that of general extract. This findings can also be supported by result that the extract by steaming process showed better activities than the general extraction extract.

Domain Wall Motions in a Near-Morphotropic PZT during a Stepwise Poling Observed by Piezoresponse Force Microscopy

  • Kim, Kwanlae
    • Korean Journal of Materials Research
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    • v.27 no.9
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    • pp.484-488
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    • 2017
  • In the present study, domain evolution processes of a near-morphotropic PZT ceramic during poling was studied using vertical piezoresponse force microscopy (PFM). To perform macroscopic poling in bulk polycrystalline PZT, poling was carried out in a stepwise fashion, and PFM scan was performed after unloading the electric field. To identify the crystallographic orientation and planes for the observed non-$180^{\circ}$ domain walls in the PFM images, compatibility theory and electron backscatter diffraction (EBSD) were used in conjunction with PFM. Accurate registration between PFM and the EBSD image quality map was carried out by mapping several grains on the sample surface. A herringbone-like domain pattern consisting of two sets of lamellae was observed; this structure evolved into a single set of lamellae during the stepwise poling process. The mechanism underlying the observed domain evolution process was interpreted as showing that the growth of lamellae is determined by the potential energy associated with polarization and an externally applied electric field.

Optimal Parameter Design for a Cryogenic Submerged Arc Welding(SAW) Process by Utilizing Stepwise Experimental Design and Multi-dimensional Design Space Analysis (단계적 실험 설계와 다차원 디자인 스페이스 분석 기술을 통한 초저온 SAW 공정의 최적 용접 파라미터 설계)

  • Lee, Hyun Jeong;Kim, Young Cheon;Shin, Sangmun
    • Journal of Korean Society for Quality Management
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    • v.48 no.1
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    • pp.51-68
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    • 2020
  • Purpose: The primary objective of this research is to develop the optimal operating conditions as well as their associated design spaces for a Cryogenic Submerged Arc Welding(SAW) process by improving its quality and productivity simultaneously. Methods: In order to investigate functional relationships among quality characteristics and their associated control factors of an SAW process, a stepwise design of experiment(DoE) method is proposed in this paper. Based on the DoE results, not only a multi-dimensional design space but also a safe operating space and normal acceptable range(NAR) by integrating statistical confidence intervals were demonstrated. In addition, the optimal operating conditions within the proposed NAR can be obtained by a robust optimal design method. Results: This study provides a customized stepwise DoE method (i.e., a sequential set of DoE such as a factorial design and a central composite design) for Cryogenic SAW process and its statistical analysis results. DoE results can then provide both the main and interaction effects of input control factors and the functional relationships between the input factors and their associated output responses. Maximizing both the product quality with high impact strength and the productivity with minimum processing times simultaneously in a case study, we proposed a design space which can provide both acceptable productivity and quality levels and NARs of input control factors. In order to confirm the optimal factor settings and the proposed NARs, validation experiments were performed. Conclusion: This research may provide significant contributions and applications to many SAW problems by preparing a standardization of the functional relationship between the input factors and their associated output response. Moreover, the proposed design space based on DoE and NAR methods can simultaneously consider a number of quality characteristics including tradeoff between productivity and quality levels.

Improved sintering process of counter electrode for dye-sensitized solar cells

  • Lee, Su Young;Kim, Sang Ho
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2012.05a
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    • pp.227-228
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    • 2012
  • In interfaces between carbon black or Pt and FTO glass in dye-sensitized solar cell counter electrodes, a marginal resistant channel for electrons, we tried to improve the connection by modifying the sintering process. A stepwise sintering process for carbon black and Pt counter electrodes was applied and its effect on power conversion efficiency was studied. Power conversion efficiencies of built-in DSSC made by a one-step sintering process with carbon black and Pt counter electrodes were about 5.01% and 5.02%, respectively. Cells made with the stepwise sintering process were 5.96% and 6.21%, respectively, indicating an 20% improvement. Fill factor (FF) increased, and it was them main reason for the power conversion efficiency improvement. Step wise sintering increased the adhesion of the interface and reduced the film thickness and surface roughness. As a result, the resistivity of the counter electrode and EIS impedance of DSSCs decreased.

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A Prediction Method Combining Clustering Method and Stepwise Regression (군집분석 기법과 단계별 회귀모델을 결합한 예측 방법)

  • Chong Il-gyo;Jun Chi-Hyuck
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2002.05a
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    • pp.949-952
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    • 2002
  • A regression model is used in predicting the response variable given predictor variables However, in case of large number of predictor variables, a regression model has some problems such as multicollinearity, interpretation of the functional relationship between the response and predictors and prediction accuracy. A clustering method and stepwise regression could be used to reduce the amount of data by grouping predictors having similar properties and by selecting the subset of predictors. respectively. This paper proposes a prediction method combining clustering method and stepwise regression. The proposed method fits a global model and local models and predicts responses given new observations by using both models. The paper also compares the performance of proposed method with stepwise regression via a real data of ample obtained in a steel process.

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Experimental Study on Application of Multi-Stepwise TPSM (다단계 온도프리스트레싱 공법의 현장적용을 위한 실험적 연구)

  • Ahn, Jin-Hee;Kim, Jun-Hwan;Kim, Sang-Hyo;Lee, Sang-Woo
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.12 no.1
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    • pp.91-100
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    • 2008
  • Multi-stepwise Thermal Prestressing Method(TPSM) is a newly proposed prestressing method, which is combined the external prestressing method and the external bonding method. Multi-stepwise thermal prestressing force is induced by cooling process of cover-plate in the multi-stepwise temperature distribution after the cover-plate being bolted to the girder. In this study, the heating capacity test of the developed heating system for applying the multi-stepwise TPSM effectively and multi-stepwise TPSM inducing test of H-beam is performed. Also, a field test of the rhamen type temporary bridge is carried out to evaluate the effect and application of the multi-stepwise TPSM. Truck load was loaded and compared with the structure analysis results.