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http://dx.doi.org/10.7783/KJMCS.2014.22.2.134

Enhancement of Immune Activity of the Extracts from Codonopsis lanceolata by Stepwise Steaming Process and High Pressure Process  

Kim, Nam Young (Department of Medical Biomaterials Engineering, Kangwon National University)
Chung, Jae Youn (Newtree Co., Ltd.)
Lee, Hyeon Yong (Department of Food Science and Engineering, Seowon University)
Publication Information
Korean Journal of Medicinal Crop Science / v.22, no.2, 2014 , pp. 134-139 More about this Journal
Abstract
This study was to investigate the improvement of immune activities of the extracts from Codonopsis lanceolata by stepwise steaming process and high pressure process. The phenol contents was $8.742{\mu}g/mg$ which was higher than that from conventional extraction using 70% ethyl alcohol at $80^{\circ}C$ for 24 hours. All of extracts at a concentration of $1.0mg/m{\ell}$ showed relatively low cytotoxicity on human normal kidney cell (HEK293) in range of 16 19%. The immune B and T cell growth was improved by extracts using the steamed and high pressure precess of C. lanceolata up to $180{\times}10^4cells/m{\ell}$ and $96{\times}10^4cells/m{\ell}$, respectively. The extract prepared also greatly increased the secretion of both IL-6 and TNF-${\alpha}$ from the stepwise steamed and high pressure process. This results can conclude that stepwise steamed and high pressure process effectively released active biomaterials which could important role in enhancing immune activity in the body.
Keywords
Codonopsis lanceolata; Immune Activity; Stepwise Steaming Process; High Pressure Process;
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Times Cited By KSCI : 10  (Citation Analysis)
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1 Parent M, Parent F and Chedid L. (1978). Enhancement of the neonate's nonspecific immunity to klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant. Proceedings of the National Academy of Sciences of the United States of America. 75:3395-3399.   DOI   ScienceOn
2 Hong WS, Lee JS, Ko SY and Choi YS. (2006). A study on the perception of Codonopsis lanceolatae dishes and the development of Codonopsis lanceolatae dishes. The Korean Journal of Food and Cookery Science. 22:181-192.
3 Cho JY, Park JS, Yoo ES, Baik KU, Park MH and Han BH. (1998). Effect of ginsenosides from Panax ginseng on TNF-alpha production and T cell proliferation. Yakhak Hoeji. 42:296-301.   과학기술학회마을
4 Ji WD, Jeong HC, Lee SJ and Chun YG. (1997). Antimicrobial activity and distilled components of garlic and ginger. Journal of the Korean Society of Agricultural Chemistry and Biotechnology. 40:514-518.   과학기술학회마을
5 Choi WS, Kwon HS, No RH, Choi GP and Lee HY. (2013). Enhancement of anti-inflammatory activities of fermented Scutellaria baicalensis extracts using Lactobacillus rhamnosus. Journal of The Society of Cosmetic Scientists of Korea. 39:303-311.   과학기술학회마을   DOI
6 Kim CH, Kwon MC, Han JG, Na CS, Kwak HG, Choi GP, Park UY and Lee HY. (2008). Skin-whitening and UV-protective effects of Angelica gigas Nakai extracts on ultra high pressure extraction process. Korean Journal of Medicinal Crop Science. 16:255-260.   과학기술학회마을
7 Kim JP, Chon IJ, Cho HK, Han IH and Whang WK. (2004). The antioxidant and the antidiabetic effects of ethanol extract from biofuntional foods prescriptions. Korean Journal of Pharmacognition. 35:98-103.   과학기술학회마을
8 Park SJ, Park DS, Lee SB, He X, Ahn JH, Yoon WB and Lee HY. (2010). Enhancement of antioxidant activities of Codonopsis lanceolata and fermented Codonopsis lanceolata by ultra high pressure extraction. Journal of the Korean Society of Food Science and Nutrition. 39:1898-1902.   과학기술학회마을   DOI
9 Park JH, Lee HS, Mun HC, Kim DH, Seong NS, Jung HG, Bang JK and Lee HY. (2004). Effect of ultrasonification process on enhancement of immuno-stimulatory activity of Ephedra sinica Stapf and Rubus coreanus Miq. Korean Society for Biotechnology and Bioengineering. 19:113-117.   과학기술학회마을
10 Kim JS, Choi WS, Chung JY, Chung HC and Lee HY. (2013). Enhancement of cosmeceutical activity from Codonopsis lanceolata extracts by stepwise steaming process. Korean Journal of Medicinal Crop Science. 21:204-212.   과학기술학회마을   DOI   ScienceOn
11 Kim HT, Kim JW, Lim MK, Jin TW, Yeo SG, Jang KH, Oh TH and Lee KW. (2007). Cytotoxic effect of Artemisia capillaris extracts on the cancer cells on in vitro. Journal of Veterinary Clinics. 24:367-371.   과학기술학회마을
12 Kim YS, Lee SJ, Hwang JW, Kim EH, Park PJ and Jeong JH. (2012). Anti-inflammatory effects of extracts from Ligustrum ovalifolium H. leaves on RAW264.7 macrophages. Journal of The Korean Society of Food Science and Nutrition. 41:1205-1210.   과학기술학회마을   DOI
13 Park KU, Wee JJ, Kim JY, Jeong CH, Kang KS, Cho YS and Seo KI. (2005). Anticancer and immuno-activities of edible crude saponin from soybean cake. Journal of the Korean Society of Food Science and Nutrition. 34:1509-1513.   과학기술학회마을   DOI
14 Singleton VL and Rossi JA. (1966). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture. 16:144-158.
15 Osawa T. (1994). Novel natural antioxidants for utilization in food and biological systems. In Uritani I. et al. (eds.). Postharvest biochemistry of plant food-materials in the tropics. Japan Scientific Societies Press. Tokyo, Japan. p.241-251.
16 Merluzzi VJ, Walker MM, Williams N, Susskind B, Hadden JW and Faanes RB. (1982). Immunoenhancing activity of NPT 15392: A potential immune response modifier. International Journal of Immunopharmacology 4:219-24.   DOI   ScienceOn
17 Lim SD, Seong KS, Kim KS and Han DU. (2007). Effects of fermented milk containing herb extract from Acanthopanax divaricatus var. Albeofructus and Codonopsis lanceolata on the immune status of mouse. Korean Journal for Food Science of Animal Resources. 27:95-101.   DOI
18 Ling J, Ha JH, Choi WY, Seo YC, Kim JS, Kim YO, Cha SW, Kim JC and Lee HY. (2011). Enhancement of cosmecceutical activities of Berberis koreana bark by high pressure and ultrasonification extraction processes. Korean Journal of Medicinal Crop Science. 19:54-65.   DOI