• 기술혁신연구
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• 제9권1호
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• pp.167-187
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• 2001

Bioindustry is rapidly changing. Many biologists redefine biotechnlolgy as 'reprogramming the genetic codes of living things to suit cultural and economic needs and desires.'We regarded this change as the 'paradigm shift'in bioindustry. The genome research is reorganizing agricultural and environmental industries as well as a pharmaceutical industry. By analysing patent data granted in the United States from 1997 to 1999, we tried to explore the international patterns and trends of technological innovation in bioindustry, especially in the genome research. As the result, we could find that the United States'monopolistic position in the bioindustry was consolidated by the genome research. Competitive positions in the countries such as Japan and Germany, however, have been aggravated continuously. Korean inventors weren't also active in many biotechnological areas as comparing to developed countries such as US and UK. Especially, the gaps between Korea and developed countries in genome research were greater than any other areas.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2006년도 한국컴퓨터종합학술대회 논문집 Vol.33 No.1 (D)
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• pp.85-87
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• 2006

센서 네트워크에서의 네트워크 리프로그래밍은 무선 통신을 통해 센서 노드에서 수행되는 소프트웨어를 변경하는 것으로서, 이를 사용하면 센서 네트워크를 구성하는 수백 개 혹은 수천 개의 노드들의 소프트웨어를 효과적으로 변경시킬 수 있다. 현재 네트워크 리프로그래밍을 위해 XNP, MNP. MOAP, Deluge, Mate 및 Incremental 기법 등이 제안되어 왔지만 아직 만족할만한 방법은 찾아보기 힘든 실정이다. 본 논문에서는 멀티홉을 지원하는 Deluge에 Incremental 기법을 통합하여 효율적인 리프로그래밍 기법을 구현하였다. 제안된 기법은 TinyOS 1.1.14 버전에 구현되었으며, 이를 통해서 네트워크 리프로그래밍을 위해 요구되는 패킷의 수와 소요시간을 크게 단축시킬 수 있다. 또한 센서 노드에서 패킷 전송에 따른 전력소 모가 가장 큰 점을 고려할 때 본 연구에서 제안하는 방식을 사용하면 센서 노드의 전력소모량도 크게 감소시킬 수 있는 효과를 기대할 수 있다.

• IEIE Transactions on Smart Processing and Computing
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• 제3권5호
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• pp.313-318
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• 2014

Recently, Ethernet-based Diagnostic Over Internet Protocol (DoIP) was applied to automotive systems, and in-vehicle gateways have been introduced to integrate Ethernet with traditional in-vehicle networks, such as the local interconnect network (LIN), controller area network (CAN) and FlexRay. The introduction of in-vehicle gateways and of Ethernet based diagnostic protocols not only decreases the complexity of the networks, but also reduces the update time for ECU software reprogramming while enabling the use of a range of services, including remote diagnostics. In this paper, a diagnostic gateway was implement for an automotive system, and the performance measurements are presented. In addition, a range of applications provided by the diagnostic gateway are proposed.

• Molecules and Cells
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• 제38권9호
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• pp.750-758
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• 2015

Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that fine-tune metabolism in response to DNA damage will enhance our understanding of molecular mechanisms of tumorigenesis and have profound implications for the development of strategies for cancer therapy. Sirtuins have been established as critical regulators in cellular homeostasis and physiology. Here, we review the emerging data revealing a pivotal function of sirtuins in genome maintenance and cell metabolism, and highlight current advances about the phenotypic consequences of defects in these critical regulators in tumorigenesis. While many questions should be addressed about the regulation and context-dependent functions of sirtuins, it appears clear that sirtuins may provide a promising, exciting new avenue for cancer therapy.

• 대한전자공학회논문지
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• 제21권3호
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• pp.19-25
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• 1984

Microprogrammed 디지탈 시스템에서 재프로그램을 위한 가변성을 고려한 제어기억장치의 비트 폭을 최소화시키는 새로운 알고리즘을 제시한다. 본 알고리즘은 비트 폭을 최소화시킴과 동시에 weight가 높은 MOP에 고유영역을 부여함으로써 비트 최소화 과정시에 수반되는 가변성의 손실을 보상할 수 있다. 또 본 알고리즘을 프로그램하여 종래의 연구결과와 비교 검토하여 비트 감소와 가변성이 개선된 것을 중명하였다.

• Journal of Plant Biotechnology
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• 제44권1호
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• pp.19-26
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• 2017

Rapid progress in epigenetic studies has resulted in genome wide information of genetic functions, other than DNA sequence information. However, insufficient understanding and unclear research direction in epigenetics has failed to attract many researchers. Here, we review the sexual reproduction processes that are particularly related to epigenetics in plants. We aim to elucidate the roles of epigenetic information and molecular mechanisms involved in the complex sexual reproduction process of plants, and examine their biological significance.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.3-6
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• 2003

The birth of the clone animals is influencing the frontier of research of animal biotechnology. It has effects on research of animal biotechnology itself by necessitating setting of new research subjects, modifications of the strategy of ongoing research projects, and challenges to schemes formerly considered impossible. In my talk, such topics including mass production of fertile ova and oocyte maturation will be discussed. (1) Oocytes are needed for the production of a clone by nuclear transplantation. Mitochondrial DNA inherited via the oocyte are involved also in the morphogenesis. Therefore, oocytes from the same animal must be used as recipients to produce genuine clones by nuclear transplantation. Experimenting on the assumption that selective oogenesis can be avoided, and apoptosis of oocytes can be prevented, by using ovarian angiogenic factos will be introduced. (2) It is important to clarify the factors of oocytes involving in reprogramming of somatic cells. Such factors are thought to be expressed in oocytes during oogenesis and oocyte maturation. Therefore, molecular mechanisms of oogenesis and oocyte maturation must be clarified extensively. Topics in this field including our recent advances will be discussed. (중략)

• BMB Reports
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• 제51권11호
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• pp.557-562
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• 2018

Reactive oxygen species (ROS) are major sources of cellular oxidative stress. Specifically, cancer cells harbor genetic alterations that promote a continuous and elevated production of ROS. While such oxidative stress conditions could be harmful to normal cells, they facilitate cancer cell growth in multiple ways by causing DNA damage and genomic instability, and ultimately by reprogramming cancer cell metabolism. This review provides up to date findings regarding the roles of ROS generation induced by diverse biological molecules and chemicals in representative women's cancer. Specifically, we describe the cellular signaling pathways that regulate direct or indirect interactions between ROS homeostasis and metabolism within female genital cancer cells.

• Molecules and Cells
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• 제41권4호
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• pp.264-270
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• 2018

Cells cope with diverse intrinsic and extrinsic stimuli in order to make adaptations for survival. The epigenetic landscape plays a crucial role in cellular adaptation, as it integrates the information generated from stimuli. Signaling pathways induced by stimuli communicate with chromatin to change the epigenetic landscape through regulation of epigenetic modifiers. Metabolic dynamics altered by these stimuli also affect the activity of epigenetic modifiers. Here, I review the current understanding of epigenetic regulation via signaling and metabolic pathways. In addition, I will discuss possible ways to achieve specificity of epigenetic modifications through the cooperation of stimuli-induced signal transduction and metabolic reprogramming.

• Journal of Chest Surgery
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• 제51권5호
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• pp.363-366
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• 2018

One of the complications of permanent pacemaker implantation is unintended phrenic nerve stimulation. A 15-year-old boy with a permanent pacemaker presented with chest discomfort due to synchronous chest wall contraction with pacing beats. Even after reprogramming of the pacemaker, diaphragmatic stimulation persisted. Therefore, we performed thoracoscopic phrenic nerve insulation using a Gore-Tex patch to insulate the phrenic nerve from the wire. A minimally invasive approach using a thoracoscope is a feasible option for retractable phrenic nerve stimulation after pacemaker implantation.