• Journal of Pharmaceutical Investigation
• /
• 제15권3호
• /
• pp.151-159
• /
• 1985

For the determination of aliphatic carbamates, the quantitative analysis of carisoprodol was investigated by gab chromatography (GC) and spectrophotometry. All the methods studied were found to be very quantitative. The minimum experimental amounts of GC method, spectrophotometric method I and II were approximately $10^{-9},\;10^{-5}$ and $10^{-8}$ mole, respectively. The obtained results showed that GC method I was much more sensitive and rapid than spectrophotometric method II.

• 분석과학
• /
• 제26권1호
• /
• pp.80-85
• /
• 2013

본 연구는 유해화학물질관리법에 지정되어 있는 사고대비물질에 대한 실험실적 분석방법을 정립하기 위한 것으로, GC/MS 분석이 가능한 25종 사고대비물질을 대상으로 정량분석을 수행하였다. GC/MS 정량분석결과 69종 사고대비물질 중 산화프로필렌(propylene oxide) 등 21개 물질에 대한 결정계수($r^2$)는 0.998 이상을 보였고, 포스겐(phosgene)의 결정계수는 0.994, 노말-부틸아민(n-butyl amine) 외 1종은 0.987, 에틸렌디아민(ethylene diamine)은 0.958의 결정계수를 보였다. 동일한 GC/MS 분석 조건으로 표준물질을 분석한 결과 총 25종에 대한 검량선이 작성되었다. 현재 사고대비물질에 대한 분석 연구가 필요한 상황에서, 본 연구결과는 화학사고 사후 환경 영향 조사를 위한 정량분석에 도움이 될 것으로 판단된다.

• 대한화학회지
• /
• 제43권1호
• /
• pp.30-35
• /
• 1999

어패류 속의 마이크로시스틴은 다른 단백질과 서로 결합하여 존재하기 때문에 이를 정확하게 정량 분석하기는 매우 어렵다. 따라서 본 연구에서는 마이크로시스틴의 가장 특징적인 Adda부분을 화학적으로 잘라내면 2-methyl-3-methoxy-4-phenylbutyric acid(MMPB)라는 물질이 생성된다. 이 물질을 에스테르화시켜서 GC로 분석하는 방법을 이용하여 어패류 속의 마이크로시스틴을 정확하게 정량분석할 수 있었다.

• 생약학회지
• /
• 제31권4호
• /
• pp.416-420
• /
• 2000

Ursolic acid was isolated from Prunellae Herba (Prunella vulgaris var. lilacina) and identified by direct comparison with an authentic sample. A method of analysis for the evaluation of ursolic acid was developed based on extraction of ground plant material, followed by quantitative determination using capillary gas chromatography of the TMS derivative. Quantitative analysis by GC after derivatisation under mild silylating conditions showed 0.31% ursolic acid in 20 samples collected throughout regions of Korea while no ursolic acid was detected in the samples of the whole plant of Thesium chinense, a substitute for Prunellae Herba in southern regions of Korean peninsula.

• 한국대기환경학회:학술대회논문집
• /
• 한국대기환경학회 1999년도 춘계학술대회 논문집
• /
• pp.298-299
• /
• 1999

• 생약학회지
• /
• 제51권3호
• /
• pp.207-216
• /
• 2020

The analysis method for qualitative analysis of the screening method that can be performed prior to the quantitative analysis of individual pesticide was reviewed in order to meet the safety standards that are being strengthened in the field of pesticide residue testing of herbal medicines. Among the residual pesticides presented in the Korean Pharmacopoeia, 56 pesticides, excluding 15 pesticides that need to be individually analyzed, were selected for analysis using QuEChERS preprocessing and GC-MS/MS, which are used in the existing agricultural products field. For each pesticide, the detection limit level of 0.001-0.005 mg/kg and the quantitative limit level of 0.002-0.017 mg/kg were confirmed. In the recovery test in which the standard was treated at a concentration of 0.02 mg/kg, it was confirmed that the proportion of pesticides satisfying the recovery of 70-120% was 85.7-96.4% for each herbal medicine, so it was confirmed that it was a level that could be reviewed by the screening method.

• Natural Product Sciences
• /
• 제26권1호
• /
• pp.97-107
• /
• 2020

Isolation of oils from leaves of Juniperus phoenicea and Juniperus oxycedrus was obtained by steam distillation extraction method. The compositions of essential oils (EOs) were studied by means of GC-MS and GC-FID, using the internal standard method and relative response factors. Around ninety eight compounds were determined in total, representing 98.25 g/100 g of EO of J. phoenicea and 98.48 g/100 g of EO of J. oxycedrus, respectively. The volatile leaf oils were dominated by the terpenic hydrocarbon fractions (79.87 g/100 g) and (61.27 g/100 g) characterized by high contents of α-pinene (64.6 g/100 g) and (54.0 g/100 g) in J. phoenicea and J. oxycedrus, respectively, as the main component. Also, the enantiomeric distribution of α-pinene, sabinene, camphene, δ-3-carene, β-pinene, limonene, linalool, terpinen-4-ol, bornyl acetate, and borneol in both oils is presented for the first time.

• 한국산업보건학회지
• /
• 제26권3호
• /
• pp.301-306
• /
• 2016

Objectives: Direct-reading instrument(Photoionization detectors, PID) and quantitative analysis using active type air sampling (Gas chromatography-flame ionization detector, GC-FID) were tested to evaluate their ability to detect volatile organic compounds(VOCs) in a semiconductor manufacturing plant. Methods: The organic compounds used were acetone and ethanol which are normally used as cleaning solutions in the semiconductor manufacturing. The evaluation was based on the preparation of test solutions of known acetone and ethanol concentration in a chamber($600{\times}600{\times}1150mm$). Samples were prepared that would be equivalent to 5~100 ppm for acetone and 10~ 200 ppm ethanol. GC-FID and PID were evaluated simultaneously. Quantitative analysis was performed after sampling and the direct-reading instrument was checked using real-time data logging. Results: Positive correlations between PID and GC-FID were found for acetone and ethanol at 0.04~2.4% for acetone(TLV: 500 ppm) and 0.1~8.3% for ethanol(TLV: 1000 ppm). When the sampling time was 15 min, concentration of test solution was the most similar between measurement methods. However, the longer the sampling time, the less similar the results. PID and GC-FID had similar exposure patterns. Conclusions: The results indicate that PID and GC-FID have similar exposure pattern and positive correlation for detection of acetone and ethanol. Therefore, PID can be used for exposure monitoring for VOCs in the semiconductor manufacturing industry. This study has significance in that it validates measuring occupational exposure using a portable device.

• 한국대기환경학회:학술대회논문집
• /
• 한국대기환경학회 2000년도 춘계학술대회 논문집
• /
• pp.313-314
• /
• 2000

최근들어 유해한 작업환경의 대기나 공장의 배기 가스, 또는 주변 주거 지역의 대기에서 검출되는 인체 유해 물질들에 많은 관심이 모아지고 있다. 이들 물질 중 휘발성 유기오염물(VOC)은 대기 중에 매우 낮은 농도로 존재하기 때문에 이의 측정은 매우 중요시되고 있다. 휘발성 유기화합물(VOC)의 분석 방법에는 GC-MS 또는 GC-FID에서 정확하게 측정하기 위하여 저온 농축법을 이용한 분석방법이 있으며 이들 두 가지 방법은 각각의 저온 농축시스템은 조절이 어렵고 작동하기가 복잡하다. (중략)

• 한국대기환경학회:학술대회논문집
• /
• 한국대기환경학회 2000년도 춘계학술대회 논문집
• /
• pp.315-316
• /
• 2000

유해한 작업 환경지역, 공장밀집 지역 또는 주변 주거 지역의 대기에서 발생하는 악취성분 및 휘발성유기화합물은 환경규제 물질로 분류되고 국내적으로도 이들의 검출 및 정확한 정량적 분석을 위한 연구가 활발하게 진행되고 있다. 일반적으로 이들 성분들은 대기중에 미량으로 존재하기 때문에 흡착관 및 canister등에 의한 시료의 포집을 행하고 이들 분석시료를 실험실에서 저온농축과정을 거쳐 GC/FID 혹은 GC/MS등을 사용하여 정량분석을 실시한다. (중략)