• Journal of the Korean Applied Science and Technology
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• v.35 no.1
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• pp.235-246
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• 2018

Paeony has pharmacological activities such as anti-inflammatory, anti-allergic, anti-bacterial, central inhibitory, gastric secretion inhibition, and antispasmodic activities. In addition, its antioxidant activity and whitening effect being reported, thus it is being explored as raw materials for cosmetics. We compared the changes in the contents of paeoniflorin and paeonol in Peony extracts, depending on the changes of extracting solvents, temperature and time. The HPLC method was set up for simultaneous analysis, the system suitabilities were confirmed by using the calibration curves and the QC samples for each assay batch. Paeonol was detected only in roots, and paeoniflorin was higher in leaf and flower than root. Higher concentrations of both ingredients were extracted when the root was used after grinding to a suitable size, and when 30% 1,3-butylene glycol was used as the extraction solvent. Also the concentrations tended to increase at higher temperature and longer time, but the increase was gradual at over $75^{\circ}C$ and 4 hours. The ratio of root, leaf and flower was determined to be 2+2+1g/0.5kg of batch, reaching the contents criteria of paeoniflorin and paeonol. Finally, we selected as the best extraction condition when the raw materials are mixed with 2+2+1g/0.5kg and extracted with 30% 1,3-butylene glycol as an extraction solvent at $75^{\circ}C$ for 4 hours, considering both the concentrations of two components and the cost of raw materials and manufacturing process, The extraction units were scaled up to 10 kg under this condition.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.28 no.2
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• pp.1-8
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• 2010

"Dokseoyeoga Do"(An Enjoyable Pleasure with Reading) is a work included in a collection book of both poems and works called as "Gyunggyo Myungseung Cheop"(Collections of Beautiful Scenary in the Suburb of Seoul) with a promise that a great painter Gyumjae Jung-Sun(謙齋 鄭敾) and his lifelong friend, Sacheon Lee Byung-Yeon(李秉淵) should hopefully exchange their poems and painted works. So far, general perspective of art history toward this work is either self-portrait of Gyumjae himself or genre painting of the aristocrat. The purpose of this study is to interpret in-depth meanings implied in this work with various considerations of plant elements appeared in this work. As a result of this study, We could draw newer and additional meanings beyond the existing perspectives of art history research categories, and the details can be summarized as following below. First of all, we could approach a new interpretation implying that Gyumjae and Sacheon hopefully wished their well-being, friendship, and reunion. Second, as a means of expressing this meaning, plant elements like old juniper(Juniperus chinensis L.), orchid(Orchidaceae), and peony(Paeonia lactiflora var. hortensis) were used. Third, each plant element can be literally seen as an icon implying message that Gyumjae desired to give to Sacheon. To be more detailed, experience and greenness of old juniper imply well-being of two people, and orchid implies fragrant friendship, and peony implies the feeling that Gyumjae hopefully desired to make a reunion with a parted friend. The significance of this study is that throughout old paintings, we could observe substantial examples of recognizing the meanings of plant elements in a category of traditional landscaping and utilizing them. Moreover, adding various point-of-views of many professional categories like Korean Landscaping history in the traditional painting research, we could also recognize the potentials for making rich interpretation toward implicated meanings of old paintings.

• Korean Journal of Medicinal Crop Science
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• v.8 no.1
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• pp.58-63
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• 2000

Changes of yield and paeoniflorin content according to chemical control and harvest time were investigated. Peonies were harvested after four years from planting. Disease and pest control method was applied normally in first year. From second year to forth year we set two blocks and controlled them differently. In one, peonies were withered early under non-control condition. In the other which was controlled by spraying chemicals four time a year, top part withering was delayed. Harvest was taken four times top part withering was delayed. Harvest was taken four times: Jul. 25, Aug. 25, Sep. 25, and Oct. 25. In non-chemical, at harvest of Jul. 25, paeoniflorin content was highest and dry root weight was 1,126kg/10a which was little less than 1,177kg/10a of Aug. 25. In chemical control, dry root yield of Oct. 25. showed an increase of 33% over that of Jul. But paeoniflorin content in root at Oct. was lower than at Jul. or Aug. For high qualities and harvest yields of peony root, chemical control is necessary to maintain top part to late in Oct.

• Korean Journal of Medicinal Crop Science
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• v.5 no.3
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• pp.206-210
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• 1997

The pathogenic fungi associated with blight of leaf and stem in peony were leaf spot (Alternaria sp.), powdery mildew (Erysiphe aquilegiae) and rust (Cronartium flaccidum). The infection of leaf spot and powdery mildew begins from late April to midMay and rust was infected in early June. Blight time of aerial part in peony started from late May and the ratio of blight on leaf and stem was more than 50% in late Aug. Yields of root by the incidence time of blight of leaf and stem were 69.1% in late June, 65.4% in late July and $87.6{\sim}92.7$% in August and September. The number of root of more than 10mm in root diameter blighted in late June and July was much lower than in August, but the paeoniflorin content in the former was much higher than the latter.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.32 no.4
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• pp.73-84
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• 2014

This research has conducted historical data analysis and on-site investigation on Chungam Pavilion and Seokchun Valley in Bonghwa. Based on the results, the original planting form was identified, and the vegetation management were drawn up. The results of this study can be summarized as follows. First of all, The Book of Seokchun states that there used to be forest trees such as pine tree, saw-leaf zelkova and maple tree, and flowering trees such as peony, royal azalea, rose, chrysanthemum, and lotus, planted around Chungamjeong. Around Seokchunjeongsa, there used to be boxwood, bamboo, maple, peach, gooseberry and peony planted in the area. Through this discovery it can be realized that the vicinity of Chungam Pavilion and Seokchunjeongsa provided not only the grand aesthetics of four clear seasons, but also planting landscapes with various symbolistic significance and meanings. The description of the planting situation in the historical records offers a useful reference for future vegetation management in Chungam Pavilion, Seokchunjeongsa and surrounding valleys. Furthermore, it holds critical value in the identification of planting pattern in late Chosun dynasty. Second, the planting landscape in and around Chungam Pavilion and Seokchunjeongsa will have to be maintained as described in the historical records The Book of Seokchun. Also, the once famous colony of pine trees in the area is gradually reducing in its scale, which calls for active management measures such as elimination of broadleaf trees.

• Weed & Turfgrass Science
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• v.6 no.3
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• pp.165-178
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• 2017

This study was carried out to investigate the characteristics of weeds occurring in paeony field in June and July, 2015 in Uiseong, Cheongsong of Kyungbuk province, and Hwasun, Jangheung, Gangjin of Jeonnam province. In total paeony field, there were 35 families and 105 species, including 30 species of Asteraceae, nine species of Poaceae, eight species of Polygonaceae, and each five species of Fabaceae and Convolvulaceae, By life style, there were 49 species of annuals, 27 species of winter annuals and 24 species of perennials. In Kyeongbuk province, 30 families and 75 species were found including 20 species of Asteraceae, seven species of Poaceae, six species of Polygonaceae, each four species of Brassicaceae, Fabaceae and Convolvulaceae, three species of Euphorbiaceae. By life style, there were 35 species of annuals, 21 species of winter annuals and 19 species of perennials. In Jeonnam province, 34 families and 88 species were found including 23 species of Asteraceae, seven species of Poaceae, eight species of Polygonaceae, six species of Fabaceae and four species of Scrophulariaceae. By life style, there were 43 species of annuals, 15 species of winter annuals and 25 species of perennials. Therefore, there are various occurrences of annual, annual, and perennial weeds in peony fields, and weed control system should be set up accordingly.

• Journal of Korean Medical classics
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• v.23 no.2
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• pp.33-62
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• 2010

"The Golden Mirror of Medicine(醫宗金鑑)" was compiled by the medical officers of the Cheong(淸) government headed by Ogyeom(吳謙: 1736-1795) in 1742, and was adopted as a textbook by the Institute of Imperial Physicians(太醫院) in 1749. This book provides a good summary of academic contents and clinical experiences from before the Cheong(淸) dynasty, and serves as a convenient and practical guide book. "The Notes of Treatise on Cold-Induced Diseases(傷寒論注)" is one part of "The Golden Mirror of Medicine(醫宗金鑑)", and this is placed at the beginning of the book, indicating its importance. The chapter on taeeum-disease[太陰病篇], which is the third part of "The Notes of the Treatise on Cold-Induced Diseases(傷寒論注)", has not yet been translated into Korean. Therefore, in this study, the characteristics of Ogyeom's(吳謙) notes are inspected through a comparative study of the chapter of taeeum-disease[太陰病篇] based on translation and the notes of famous scholars. The texts first provide an outline of taeeum-disease[太陰病], which is followed by diarrhea, vomiting and therapeutic methods of syndrome involving both the exterior and interior[表裏兼證], as well as abdominal distension and pain. The prognoses are then explained in succession. The eight texts that have been shown in the chapter of taeeum-disease[太陰病篇] of original text were relocated and the seven texts that existed in the chapters of taeyang(太陽), yangmyeong(陽明) and gwol-eum(厥陰) were moved to this chapter. Furthermore, Ogyeom(吳謙) moved the cold-dysphagia[寒格] text from a chapter of gwol-eum-disease[厥陰病] to a chapter of taeeum-disease[太陰病] and explained vomiting due to pathogenic cold. The origins of taeeum-disease[太陰病] are purported to occur through the yang-channel[陽經] to the eum-channel[陰經], and taeeum-disease[太陰病] was reported to include both interior-deficiency-cold-syndrome[裏虛寒證] and interior-excess-heat-syndrome[裏實熱證]. In the case of diarrhea-more-severe-symptoms[自利益甚], he thought it induced by faultpurgation[誤下], and in indication for decoction of cinnamon with peony[桂枝加芍藥湯] and decoction of cinnamon with rhubarb[桂枝加大黃湯], he thought it included the exterior syndrome of taeyang-disease[太陽表證], and rhubarb was used in purgation of taeeum-excess[太陰實].

• Korean Journal of Medicinal Crop Science
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• v.6 no.3
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• pp.193-197
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• 1998

This experiment was carried out to determine the proper time for flower bud removing to improve growth, yield and paeoniflorin content of root in peony(Paeonia lactiflora Pallas). The flower buds removement caused short stem length by $7{\sim}9cm$ compared with control, but number of stem and stem diameter were similar to that of control. The number of root, fresh root weight and paeoniflorin content in peony increased when their flower buds were removed at earlier stages. The root dry weight was highest of 1.647kg/10a, and increased by 27% compared with control when their flower buds were removed at early stage (bud diameter was less than 10mm). The root dry weight increased by 13% and 10%, respectively. when their flower buds were removed prior to flowering and at flowering stage. Paeoniflorin content in leaf was higher than that in stem, and was higher at early stage. Leaf and stem showed higher paeonif1orin content when their flower buds were removed.

• Preventive Nutrition and Food Science
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• v.8 no.4
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• pp.356-364
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• 2003

A methanol extract from seeds of Paeonia lactiflora (Paeoniaceae, peony) was found to possess different antiproliferative activities against four different human cancer cell lines: Hela, MCF-7, HepG2 and HT-29. Furthermore, five different methanol (20, 40, 60, 80 and 100 % MeOH) fractions obtained by fractionation of the methanol extract of the seeds on a Diaion HP-20 column exhibited differential antiproliferative effects against the above four cancer cell lines. Among five fractions, the 60 % MeOH fraction showed relatively lower antiproliferative activity on MCF-7 estrogen-sensitive breast cancer cell than the other cancer cell lines. Systematic separation of 60% the MeOH fraction by silica gel and Sephadex LH-20 columns led to the isolation of four known stilbenes, trans-resveratrol (1), trans-(+)- $\varepsilon$ -viniferin (2), gnetin H (3) and suffruticosol B (4). The four stilbenes (1∼4) exerted differential biphasic effects on cell proliferation of MCF-7 cells in a similar manner as genistein, a soybean isoflavone used as a positive reference, in the concentration range from 1.0 to 200 $\mu$M. Three stilbenes (1 ∼ 3) weakly stimulated the proliferation of MCF -7 cells at doses below 10 JIM. However, strong antiproliferative effects on MCF-7 cell were exerted by extract 1 at a dose of 200 JIM, and by 2 and 3 at doses above 25 $\mu$M. In contrast, 4 inhibited the proliferation of MCF-7 cell at a dose below 25 $\mu$M, but stimulated cell proliferation at concentrations of 50 and 100 $\mu$M. All four stilbenes (1∼4) stimulated the proliferation of ROS 17/2.8 osteoblast-like cells in the range of 10$^{-10}$ ∼10$^{-1}$ $\mu$M. Compound 1 exhibited especially potent proliferative activity, although its activity was weaker than that of genistein. Additionally, three resveratrol oligomers (2∼4) also exhibited concentration-dependently moderate proliferative activity, but less than that of 1. These results suggest that resveratrol, and its dimer and trimers from the seeds of Paeonia lactiflora may act as a phytoestrogen, but in a somewhat different manner from that of genistein.

• Korean Journal of Plant Resources
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• v.36 no.5
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• pp.446-454
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• 2023

This study aimed to assess the potential use of Paeonia lactiflora Pall. seed cake (PSC). The extraction yield of the PSC extract ranged from 22% to 45%, depending on the extraction solvent used. The PSC extract showed significantly higher levels of total polyphenols and flavonoids contents, and radical scavenging compared to the P. lactiflora seed oil (PSO) extract. The antibacterial activity of the PSC extract was superior to that of the positive control and remained effective for up to 48 hours. Furthermore, when the PSC extract was applied, it significantly reduced the inflammatory response induced by LPS, demonstrating the anti-inflammatory activity of PSC. This study confirmed the effective bioactivity not only in PSO, but also in the PSC extract, highlighting the potential of PSC as a bio-health ingredient.