• 한국산학기술학회논문지
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• 제18권1호
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• pp.310-315
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• 2017

대규모 건설공사 현장에서는 발파공사에 대한 표준발파패턴과 시험발파패턴의 발파진동추정식의 상이에 따른 설계변경의 반영 문제로 시공사, 건설사업관리자, 발주처간의 갈등요인을 해소하기 위한 체계적인 자료의 수집 및 분석 과정을 통하여 효율적인 대책수립이 필요한 실정이다. 발파진동에 의한 인접 구조물에 미치는 영향을 여러 각도로 평가하려는 연구들은 계속 되어 왔으나, 노천발파를 수행하면서 현장계측의 진동파형을 분석하여 인접 건축물의 안전성을 확보하고 현장여건에 적합한 발파공법을 연구한 사례는 미미한 실정이다. 따라서 현장여건에 적합하고 경제적이며 효율적인 발파작업을 수행할 수 있도록 시험발파를 통하여 발파패턴 선정의 개선방안을 제시하는 것이 필요하다. 본 연구에서는 실제 도로확장공사 현장에서 시험발파를 통한 표준발파공법 및 진동규제기준별로 적용되는 이격 거리를 기준으로 노천 발파작업을 수행하여 발파진동 값을 계측하고 이를 통한 발파공법별 진동예측식을 회귀분석 전산프로그램을 이용하여 신뢰수준 95%의 K, n, R등을 산출하였다. 시험발파 대상지역의 발파허용진동기준을 0.3cm/sec로 설정하고 노천발파지침의 발파진동추정식과 시험발파의 발파진동추정식에 따른 이격 거리별 장약량과 발파공법을 비교분석한 결과 사업비가 증가하는 요인을 도출할 수 있었다. 또한, 노천발파 작업 중 인접 구조물에 대한 계측 및 분석을 수행하고 노천발파지점과 가장 인접한 구조물을 선정하여 발파진동 계측 및 평가를 시행하여 노천발파공사를 완료하는 과정에서 나타난 노천발파 설계 시공 지침에서의 시험발파 절차 및 해석방법에 대한 문제점을 분석하여 개선방안을 제시하였다.

• 동의신경정신과학회지
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• 제15권2호
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• pp.53-70
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• 2004

Objective : This study was designed to assess the protective effects of Bambusae caulis and St. John's Wort on the animal model of depression, induced by chronic mild stress(CMS) Method : Male Wistar rats were used for this experiment. The subjects were divided into 4 groups ( 1. CMS-drugs: Bambusae caulis administered during CMS treatment, 2. CMS-drugs: St. John's Wort administered during CMS treatment, 3. CMS-vehicle: Water administered during CMS treatment, 4. normal control group without CMS treatment ). After 3 weeks of CMS treatment, they were executed open field test and weight, sucrose intake were measured. Result : 1. CMS Bambusae caulis group showed significant difference of locomotor activities and marginal difference of start latency in comparison with other groups in open field test. 2. There was no change of weights between CMS Bambusae caulis, St. John's Wort groups and CMS control group. 3. CMS St. John's Wort group showed upper level of sucrose intake than CMS Bambusae caulis group and CMS control group. Conclusion : These results suggest that Bambusae caulis may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated locomotor activities in open field test.

• 한국식품저장유통학회지
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• 제19권5호
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• pp.767-773
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• 2012

괴각 추출물의 항불안 효능을 탐색하기 위하여 elevated plus-maze, horizontal wire test 및 open field test와 같은 동물행동실험을 통하여 비교한 결과 다음과 같은 결론을 얻었다. Elevated plus-maze를 이용한 본 연구에서 괴각 추출물의 100 mg/kg, 200 mg/kg 및 400 mg/kg 투여군에서 대조군에 비하여 open arm에서 머무른 시간의 백분율이 증가하였고, open arm으로의 출입 백분율 또한 증가하였다. Elevated plus-maze를 이용한 길항실험에서는 benzodiazepine 수용체의 antagonist인 flumazenil에 의해 괴각 추출물 400 mg/kg의 항불안 효능이 차단되는 것이 관찰되었다. Locomotor activity 측정에서도 괴각 추출물의 모든 용량에서 총 이동거리의 변화가 없었으며, 또한 horizontal wire test에서도 대조군과 괴각 추출물 투여군 사이에 차이를 나타내지 않았다. 결론적으로, 본 연구의 결과에서 괴각의 메탄올 추출물이 elevated plus-maze test, horizontal wire test 및 open field test를 통하여 locomotor activity 및 근육이완이나 진정 등의 부작용이 없으면서 우수한 항불안 작용을 가지는 천연물이라고 생각되어지며 이러한 작용이 특히 GABA 신경계와 관련이 있음을 시사하고 있다. 향후 괴각의 항불안 작용의 평가를 위하여 다양한 실험모델의 개발이 필요할 것으로 생각되며 또한 이러한 작용에 대한 기전 연구가 포괄적이고 다각적으로 진행되어져야 할 필요성이 있다고 사료된다.

• Architectural research
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• 제8권2호
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• pp.11-16
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• 2006

The purpose of this study is to scrutinize the effect of office layouts and ambient office sounds on the performance of office workers involved with a proof-reading test (simple task). Twenty subjects, who were professional researchers and computer programmers, were from three different office layouts: 1) Nine subjects from a combined office type with open meeting places and closed individual offices; 2) five from an open office with rectangular individual workstations, and 3) six from an open office with triangular individual workstations. Architects and consultants working in the field of office have reported from interviews and their own observations that occupants' satisfaction differs as their office layouts vary although the sizes are the same. This finding leads to the hypothesis of this experiment. Proof-reading test results were obtained from three different office layouts (combined office type, rectangular and triangular individual workstations in open offices) under two different sound conditions (quiet background sound and ambient sound of their own workplace) for 10 minutes. The test analysis shows the mean test score of subjects from the triangular individual workstations in open offices is significantly different from the mean test scores of subjects from the combined office type and the rectangular individual workstations in open offices.

• Biomolecules & Therapeutics
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• 제16권3호
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• pp.261-269
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• 2008

This experiment was performed to investigate the anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen (CFAZ), by using the experimental paradigms of anxiety, and compared with those of a known anxiolytic, diazepam. CFAZ (8.0 mg/kg, p.o.) increased the percentage of time spent on the open arms and the number of open arms entries in the elevated plus-maze test, increased the number of head dips in the hole-board test, and increased the percentage of center zone ambulatory time in the open-field box. However, CFAZ has no effect on the locomotor activity, while diazepam (2.0 mg/kg, p.o.) significantly reduced locomotor activity. CFAZ did not influence the grip force in the grip strength meter test, either. From the molecular experiments, CFAZ increased chloride influx in cultured cerebellar granule cells. In addition, $GABA_A$ receptors $\gamma$-subunit were over-expressed by CFAZ in cultured cerebellar granule cells. It is concluded that CFAZ may have anxiolytic-like effects, and these effects may be mediated by $GABA_A$ receptors.

• Journal of Advanced Marine Engineering and Technology
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• 제32권6호
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• pp.989-996
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• 2008

Recently, a few types of fish-cage in open sea are researched. This fish-cage has to operate monitoring system for keeping an optimum living condition for fish. The most efficient monitoring system is WVMS(Wireless Vision Monitoring System) for fish-cage in open sea. WVMS should be able to transmit video signal and communicate with each controller. So. it needs to be based on WLAN(Wireless LAN) which has characteristic of higher transfer-rate, In this paper, we propose a structure of WVMS using WLAN equipments for maritime environment and prove its effectiveness. We present the propagation loss model of WVMS's communication channel. measured by field test, and discuss its validity compared with the predictive value based on the Friss propagation model and Plane earth reflection model. We present the number of frames that is received from WLAN modem connecting with underwater-camera in field test spots. As a result, we confirmed that proposed WVMS is suitable for maritime environment and it is possible to be applied to fish-cage in open sea on 'seogwipo'.

• 한국초전도ㆍ저온공학회논문지
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• 제3권2호
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• pp.32-38
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• 2001

A 30[kVA] superconducting generator (SCG) is built and tested at Korea Electrotechnology Research Institute (KERI) in Korea. This superconducting generator has an air-gap winding instead of the typical steel teeth structure. The rotor has 4 field coils of race-track type with NbTi superconducting wired. The rotor is composed of two dampers and a liquid helium composed of two dampers and a liquid helium container in which the field poles reside. The space between the outermost damper and the container is vacuum insulated. A ferrofluid seal is used between the stationary part connected to the couping and the rotor. A helium transfer coupling(HTC) has 3 passages of the recovered heilum gas and a gas flow control system. The open circuit test and sustained short circuit test are preformed to obtain the open circuit characteristics (OCC) and short circuit characteristics (SCC) Also. the test results usder the light load (up to 3.6[kW]) are given. The structure, manufacturing and basis test of the 30[kVA]SCG are discussed.

• 생명과학회지
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• 제25권2호
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• pp.151-157
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• 2015

Zebrafish는 약리학 연구에 널리 사용되는 실험 동물 중 하나이다. Oxytetracycline은 넓은 항균 범위를 가지는 항생제로써 단백질 합성을 억제하여 정균 작용을 가진 항생제이다. 본 연구의 목적은 OTC에 노출이 되었을 때 zebrafish에게서 나타나는 행동변화와 내분비계의 변화를 관찰하였다. OTC (50, 100 or 200 mg/l)에 노출된 zebrafish의 행동변화를 확인하기 위해 novel tank test와 open field test를 진행하였다. 또한 내분비계의 변화를 확인하기 위하여 whole-body cortisol의 수치를 cortisol kit를 이용하여 측정하였다. Novel tank test 결과 상층부에서 머문 시간과 부동 시간에서 OTC를 약욕하였을 때 통계적으로 유의성이 있는 증가현상이 확인되었다. 반면에, 총 이동거리, 과행동 시간, 유영 속도 그리고 상하 변위에서 OTC를 약욕하였을 때 통계적으로 유의성 있는 감소 현상이 확인되었다. Open field test 결과 부동시간에서 OTC를 약욕 하였을 때 통계적으로 유의성 있는 증가 현상이 확인 되었다. 그러나 OTC를 약욕 하였을 때 총 이동거리, 움직인 시간, 유영 속도에서 통계적으로 유의성이 있는 감소 현상이 확인 되었다. Whole-body cortisol에서는 zebrafish에게 약욕을 하였을 때 증가하는 경향이 관찰되었다. 이러한 결과를 통하여 OTC가 zebrafish에게 화학적 스트레스로 작용한 것으로 사료된다.

• 동의신경정신과학회지
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• 제14권1호
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• pp.1-16
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• 2003

Objective : This study was designed to assess the protective effects of Hwangryeonhaedoktang on the animal model of depression, induced by chronic mild stress(CMS). Method : Male Sprague-Dawley rats were used for this experiment. The subjects were divided into 3 groups ( 1. CMS-drug: Hwangryeonhaedoktang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment, they were executed forced swimming test(FST), open field test and c-Fos in paraventricular nucleus(PVN) were measured. Result : 1. In FST, immobility behavior decreased significantly in CMS-drug group. 2. There was no difference in the open field test between 3 groups 3. c-Fos expressed cell bodies in PVN were significantly less in CMS-drug than in CMS-vehicle group. Conclusion : These results suggest that Hwangryeonhaedoktang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus.

• Biomolecules & Therapeutics
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• 제26권5호
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• pp.432-438
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• 2018

Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This study investigates whether treatment with the Evodia rutaecarpa aqueous extract (ERAE) from berries and its major molecular component, evodiamine, can reduce the adverse caffeine-induced sleep-related and excitation effects. We combined measurements from the pentobarbital-induced sleep test, the open field test, and the locomotor activity test in mice that had been dosed with caffeine. We found that ERAE and evodiamine administration reduced the degree of caffeine-induced sleep disruption during the sleep test. Additionally, we found that evodiamine significantly inhibits caffeine-induced excitation during the open field test, as well as decreasing hyperlocomotion in the locomotor activity test. Additional in vitro experiments showed that caffeine administration decreased the expression of ${\gamma}$-aminobutyric acid $(GABA)_A$ receptor subunits in the mouse hypothalamus. However, evodiamine treatment significantly reversed this expression reduction. Taken together, our results demonstrate that ERAE and its major compound, evodiamine, provide an excellent candidate for the treatment or prevention of caffeine-induced sleep disturbances and excitatory states, and that the mechanism of these beneficial effects acts, at least in part, through the $GABA_A$-ergic system.