Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The effects of Bambusae Caulis and St. John's Wort in the chronic mild stress model of depression in rats

우울증(憂鬱症)모델 흰쥐에 대한 죽여(竹茹)와 St. John's Wort의 항우울효과(抗憂鬱效果)에 대한 비교 연구

  • Park, Se-Jin (Dept. of Neuropsychiatry, Kyung-Hee Oriental Medical Center, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Jong-Woo (Dept. of Neuropsychiatry, Kyung-Hee Oriental Medical Center, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Hyun-Taek (Dept. of Psychology, Korea University) ;
  • Chi, Sang-Eun (Dept. of Psychology, Korea University) ;
  • Kim, Wonn-Ryoung (Dept. of Psychology, Korea University) ;
  • Hwang, Ui-Wan (Dept. of Neuropsychiatry, Kyung-Hee Oriental Medical Center, College of Oriental Medicine, Kyung-Hee University)
  • 박세진 (경희대학교 한의과대학부속 경희의료원한방병원 신경정신과) ;
  • 김종우 (경희대학교 한의과대학부속 경희의료원한방병원 신경정신과) ;
  • 김현택 (고려대학교 심리학과) ;
  • 지상은 (고려대학교 심리학과) ;
  • 김운령 (고려대학교 심리학과) ;
  • 황의완 (경희대학교 한의과대학부속 경희의료원한방병원 신경정신과)
  • Published : 2004.11.30
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Abstract

Objective : This study was designed to assess the protective effects of Bambusae caulis and St. John's Wort on the animal model of depression, induced by chronic mild stress(CMS) Method : Male Wistar rats were used for this experiment. The subjects were divided into 4 groups ( 1. CMS-drugs: Bambusae caulis administered during CMS treatment, 2. CMS-drugs: St. John's Wort administered during CMS treatment, 3. CMS-vehicle: Water administered during CMS treatment, 4. normal control group without CMS treatment ). After 3 weeks of CMS treatment, they were executed open field test and weight, sucrose intake were measured. Result : 1. CMS Bambusae caulis group showed significant difference of locomotor activities and marginal difference of start latency in comparison with other groups in open field test. 2. There was no change of weights between CMS Bambusae caulis, St. John's Wort groups and CMS control group. 3. CMS St. John's Wort group showed upper level of sucrose intake than CMS Bambusae caulis group and CMS control group. Conclusion : These results suggest that Bambusae caulis may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated locomotor activities in open field test.

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