• Biomolecules & Therapeutics
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• 제32권5호
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• pp.601-610
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• 2024

Tofacitinib, a Janus kinase (JAK) inhibitor used to treat rheumatoid arthritis, is metabolized through hepatic cytochrome P450 (CYP), specifically CYP3A1/2 and CYP2C11. Prolonged administration of rheumatoid arthritis medications is generally associated with an increased risk of renal toxicity. Loganin (LGN), an iridoid glycoside, has hepatorenal regenerative properties. This study investigates the potential of LGN to mitigate acute kidney injury (AKI) and its effects on the pharmacokinetics of tofacitinib in rats with cisplatin-induced AKI. Both intravenous and oral administration of tofacitinib to AKI rats significantly increased the area under the plasma concentration-time curve from time 0 to infinity (AUC) compared with control (CON) rats, an increase attributed to the decelerated non-renal clearance (CL_NR) and renal clearance (CL_R) of tofacitinib. Administration of LGN to AKI rats, however, protected kidneys from severe impairment, restoring the pharmacokinetic parameters (AUC, CL_NR, and CL_R) of tofacitinib to those observed in untreated CON rats, with partial recovery of kidney function, as evidenced by an increase in creatinine clearance. Possible interactions between drugs and natural components should be considered, especially when co-administering both a drug and a natural extract containing LGN or iridoid glycosides to patients with kidney injury.

• 한국자원식물학회지
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• 제27권6호
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• pp.671-679
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• 2014

Molecular phylogenetic analyses of Korean Elaeagnus L. were conducted using seven species, one variety, one forma and four outgroups to evaluate their relationships and phylogeny. The sequences of internal transcribed spacer regions in nuclear ribosomal DNA were employed to construct phylogenetic relationships using maximum parsimony (MP) and Bayesian analysis. Molecular phylogenetic analysis revealed that Korean Elaeagnus was a polyphyly. E. umbellata var. coreana formed a subclade with E. umbellata. Additionally, the genetic difference between E. submacrophylla and E. macrophylla was very low. Moreover, E. submacrophylla formed a branch from E. macrophylla, indicating that E. submacrophylla can be regarded as a variety. However, several populations of this species were not clustered as a single clade; therefore, further study should be conducted using other molecular markers. Although E. glabra f. oxyphylla was distinct in morphological characters of leaf shape with E. glabra. But E. glabra f. oxyphylla was formed one clade by molecular phylogenetic with E. glabra. Additionally, this study clearly demonstrated that E. pungens occurs in Korea, although it was previously reported near South Korea in Japan and China. According to the results of ITS regions analyses, it showed a resolution and to verify the relationship between interspecies of Korean Elaeagnus.

• 한국정보과학회논문지:정보통신
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• 제29권1호
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• pp.1-14
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• 2002

이동 컴퓨팅 환경에서 멀티미디어 트래픽 제공에 관련된 가장 중요한 이슈는 이동 호스트(클라이언트)에게 지속적인 QoS(Quality of Service)를 보장하는 것이다. 그러나, 핸드-오프를 초래하는 클라이언트의 이동성으로 인해 클라이언트와 네트워크간에 협상된 QoS가 보장되지 못할 수도 있다. 본 논문에서는 이동 컴퓨팅 환경에서 멀티미디어 트래픽에 대해 지속적인 QoS를 지원하기 위한 호 수락 제어 메커니즘을 제안한다. 각 셀은 핸드-오프 호를 위해 이웃 셀로부터 대역폭을 예약한다. 만약, 핸드-오프 호를 위해 필요 이상으로 대역폭이 예약된다면 신규 호의 블록킹 확률이 증가하므로, 핸드-오프 호를 위해 예약할 대역폭의 크기를 정확히 결정하는 것이 중요하다. 본 논문에서는 예약할 대역폭의 정확한 크기를 결정하고, 네트워크 상태에 다라 이 크기를 적응적으로 조정하기 위해 MPP(Mobility Pattern Profile)와 2-계층 셀 구조를 기반으로 한 적응적 대역폭 예약을 제안한다. 또한, MPP를 이용한 다음-셀 예측 기법과 적응적 대역폭 예약을 기반으로 한 호 수락 제어 메커니즘을 제안한다. 본 논문에서 제시된 호 수락 제어 메커니즘의 성능을 평가하기 위해, 신규 호 블록킹률, 핸드-오프 호 종료율, 대역폭 이용률을 측정하였다. 시뮬레이션 결과, 본 논문의 호 수락 제어 메커니즘의 성능이 NR-CAT1, FR-CAT1, AR-CAT1과 같은 기존의 메커니즘들보다 우수함을 알 수 있었다.

• International Journal of Control, Automation, and Systems
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• 제3권2호
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• pp.211-216
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• 2005

In electrical impedance tomography (EIT), various image reconstruction algorithms have been used in order to compute the internal resistivity distribution of the unknown object with its electric potential data at the boundary. Mathematically, the EIT image reconstruction algorithm is a nonlinear ill-posed inverse problem. This paper presents a simulated annealing technique as a statistical reconstruction algorithm for the solution of the static EIT inverse problem. Computer simulations with 32 channels synthetic data show that the spatial resolution of reconstructed images by the proposed scheme is improved as compared to that of the mNR algorithm at the expense of increased computational burden.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.159-164
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• 2004

In electrical impedance tomography (EIT), various image reconstruction algorithms have been used in order to compute the internal resistivity distribution of the unknown object with its electric potential data at the boundary. Mathematically the EIT image reconstruction algorithm is a nonlinear ill-posed inverse problem. This paper presents a simultaneous perturbation method as an image reconstruction algorithm for the solution of the static EIT inverse problem. Computer simulations with the 32 channels synthetic data show that the spatial resolution of reconstructed images by the proposed scheme is improved as compared to that of the mNR algorithm at the expense of increased computational burden.

• 대한전자공학회논문지
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• 제11권6호
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• pp.16-24
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• 1974

본 논문은 종래의 NIC회로의 구성방법을 종합하여 일반화하는 방법으로써 파라미터 제어회로와 전압 또는 전류제어회로에 의한 NIC구성방법을 제시하였다. 그리고 FET에 의해 개방 및 단락안정형 NIC회로를 구성하고 회로해석에 의한 임피던스와 실험치를 비교하여 NIC특성을 확인하고 회로해석이 타당함을 검토 확인하였다. 또한 병렬 LC를 NIC와 직렬로 연결하여 발진상태를 실험으로 확인하고 NR에 의한 발진상태와 비교 검토하였다.

• 대한전기학회논문지:시스템및제어부문D
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• 제52권2호
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• pp.120-127
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• 2003

In electrical impedance tomography(EIT), various image reconstruction algorithms have been used in order to compute the internal resistivity distribution of the unknown object with its electric potential data at the boundary. Mathematically the EIT image reconstruction algorithm is a nonlinear ill-posed inverse problem. This paper presents a simulated annealing technique as a statistical reconstruction algorithm for the solution of the static EIT inverse problem. Computer simulations with the 32 channels synthetic data show that the spatial resolution of reconstructed images by the proposed scheme is improved as compared to that of the mNR algorithm or genetic algorithm at the expense of increased computational burden.

• 한국소음진동공학회논문집
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• 제21권7호
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• pp.650-656
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• 2011

The noise inside a naval vessel is very important in considering the need for hearing protection, improving the working environment and maintaining good communications for crews living on board a naval vessel. The indoor noise of a ship usually is specified by the A-weighted sound pressure level, but other evaluating parameters are required to reflect human senses more effectively. This paper uses additional noise indices related to room acoustics, such as NR(noise rating), NC(noise criterion), RC(room criterion), PSIL(preferred speech interference level) and loudness level to evaluate the noise inside cabins on a naval vessel. Using these psychological noise indices, allowable limit of noise level in cabins is suggested through psycho-acoustic evaluation for the noise in cabins.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2022년도 추계학술대회
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• pp.50-50
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• 2022

비짜루과 둥굴레속(Asparagaceae: Polygonatum)은 전 세계적으로 약 90여 종이 알려져 있으며, 유럽, 북아메리카, 아시아 등 북반구 온대 지역에 집중적으로 분포한다. 국내 둥굴레속 분류군은 총 16분류군이며, 이중 잎이 호생하고, 난형에서 타원형 모양의 엽질성 포를 가지며, 화피통 내부에 털이 없고, 수술대 표면에 돌기가 나있는 분류군들은 용둥굴레열(series. Bracteata)에 속한다. 그러나 이들은 종간 교잡 또는 주요 기관의 형질 변이가 다양하여 중간형질을 보이는 개체군들에 대한 종 식별에 많은 어려움이 있었다. 경남 창원시에서 채집된 목포용둥굴레(P. cryptanthum) 변이 개체집단는 기존의 목포용둥굴레와 달리 식물체 높이와 화경·소화경이 길며, 포 부착위치의 변이 폭이 넓으며, 포가 타원형이고 밖으로 말리는 습성으로 형태적 차이가 나타났다. 따라서 본 연구에서는 명확한 분류학적 실체를 구명하고자 분자생물학적 계통분석(nrDNA ITS + cpDNA matK, trnK-rps16, rps16, rbcL) 연구를 진행중에 있다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.1624-1627
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• 1997

The 6-DOF parallel manipulator is a closed-kindmatic chain robot manipulator that is capable of providing high structural rigidity and positional accuracy. Because of its advantage, the parallel manipulator have been widely used in many engineering applications such as vehicle/flight driving simulators, rogot maniplators, attachment tool of machining centers, etc. However, the kinematic analysis for the implementation of a real-time controller has some problem because of the lack of an efficient lagorithm for solving its highly nonliner forward kinematic equation, which provides the translational and orientational attitudes of the moveable upper platform from the lenght of manipulator linkages. Generally, Newton-Raphson method has been widely sued to solve the forward kinematic problem but the effectiveness of this methodology depend on how to set initial values. This paper proposes a hybrid method using genetic algorithm(GA) and Newton-Raphson method to solve forward kinematics. That is, the initial values of forward kinematics solution are determined by adopting genetic algorithm which can search grobally optimal solutions. Since determining this values, the determined values are used in Newton-Raphson method for real time calcuation.