• 한국응용과학기술학회지
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• 제31권3호
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• pp.367-374
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• 2014

In this study, skin permeation enhancement was confirmed by designing it to have a structure and composition similarity to the intercellular lipids that improve miscibility with skin by cross-linked lipids poloxamer. The cross-linked lipids poloxamer was synthesized and analyzed by 1H NMR that structure dose had conjugated pluronic with ceramide3. Active component is released by modification of liquid crystal structure because PPO part, large-scale molecule block of pluronic, has hydrophobic nature at skin temperature of $35^{\circ}C$. Conjugated pluronic with ceramide3 was synthesized using Pluronic F127 and p-NPC (4-nitrophenyl chloroformate) at room temperature yielded 89%. Pluronic(Ceramide 3-conjugated Pluronic) was synthesized by reaction of p-NP-Pluronic with Ceramide3 and DMAP. The yield was 51%. This cross-linked lipids poloxamer was blended and dissolved at isotropic state with skin surface lipids, phospholipid, ceramide, cholesterol and anhydrous additive solvent. Next step was preceded by ${\alpha}$-Transition at low temperature for making the structure of Meso-Phase Lamella, and non-hydrous skin analogue liquid crystal using thermo-sensitivity smart sensor, lamellar liquid crystal structure through aging time. For confirmation of conjugation thermo-sensitivity smart sensor and non-hydrous skin analogue liquid crystal, structural observation and stability test were performed using XRD(Xray Diffraction), DSC(Differential Scanning Calorimetry), PM (Polarized Microscope) And C-SEM (Cryo-Scanning Electron Microscope). Thermo-sensitivity observation by Franz cell revealed that synthesized smart sensor shown skin permeation effect over 75% than normal liquid crystal. Furthermore, normal non-hydrous skin analogue liquid crystal that not applied smart sensor shown similar results below $35^{\circ}C$ of skin temperature, but its effects has increased more than 30% above $35^{\circ}C$.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.192-202
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• 2003

The wrinkles correspond to the most obvious expression of skin ageing and are manifested by changes on the organization and dermal structure. In the extracellular matrix, decreased quantities of collagens and glycosaminoglycans as well as a deterioration of the fibrillary network is noted, result in a reduction of dermal thickness. In addition, the activity of the collagenases increases in contrast to the synthesis of collagen fibers. Nor are cells spared during the aging process. We thus studied and compared the contractile capacity as well as the synthesis capacity of normal human fibroblasts and human fibroblasts obtained from biopsies of forehead wrinkles. The capacity of the fibroblasts to be adhered to the collagen network and to maintain a three-dimensional structure of dermis was studied on a model of equivalent dermis. The metabolic activity was studied by evaluating the capacities of synthesis of collagen I, main component of dermis. Human fibroblasts resulting from the forehead wrinkle contract less the gel of collagen than the normal human fibroblasts and present an activity of biosynthesis of collagen I less important than normal human fibroblasts. These results show that fibroblasts with aging present a deceleration of their metabolic activity and lose their capacity of adhesion to collagen fibers thus limiting the possibility of organizing the dermal tissue. We investigated the potential of an active ingredient able to compensate for the reduction of the metabolic activity and to restore the contractile capacity of fibroblasts obtained from forehead wrinkles. This effect was compared with a reference molecule: the vitamin C.

• Imaging Science in Dentistry
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• 제31권2호
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• pp.73-84
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• 2001

Purpose: The purpose of this study was to find the relationship among the joint status, pain and effusion in patients with temporomandibular joint disorders. Materials and Methods: Materials included 406 patients (812 joints) with clinical records and bilateral TMJ MRIs in TMJ clinic, Yongdong Severance Hospital. All joints were classified in 4 groups in MR images according to the disc status of joint; normal disc position, disc displacement with reduction (DDcR), early and late stage of disc displacement without reduction (DDsR), and also 2 groups according to the bony status of joint; normal bony structure and osteoarthrosis. MR evidence of joint effusion was categorized in 4 groups according to its amount. To determine the relationship between joint pain and joint effusion, 289 patients with unilateral TMJ symptoms were selected from total materials. Result: Joint effusion was found 8.0% in normal disc position, 32.6% in DDcR, and 59.2% in DDsR (83.1 % in early state and 23.1 % in late stage). Joint effusion was found 39.7% in osteoarthrosis and 35.0% in normal bony structure. Joint effusion was more found in the painful joints (49.8%) than in the painless joints (22.4% )(p<0.001). Joint effusion in the early stage of DDsR only was more found significantly in painful joints (91.9%) than in painless joints (62.1 %) (p<0.001). Conclusion : MR evidence of joint effusion might be related to disc displacement regardless of the presence of osteoarthrosis, and the early stage of DDsR was found more frequently combined with joint effusion and joint pain.

• 한국융합학회논문지
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• 제12권6호
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• pp.151-160
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• 2021

본 연구는 뉴노멀 시대에의 경쟁우위 확보 및 생존을 위한 전략 제시가 필요하다고 판단하고 경영 전략적 대안을 제시하고자 하였다. 이를 위해 본 연구는 문헌 조사와 기업 CEO 10인의 집중 인터뷰를 통해 코로나19에 의한 뉴노멀과 이로 인해 야기된 경영환경 변화 트렌드 및 대응 전략 유형을 도출한다. 본 연구는 다양한 영역과 분야에서 전개될 수 있는 전략 대안 가운데 기업의 디지털 기반 경영 및 사업 수준의 전략 대안으로 연구 범위를 한정하였다. 기업 수준의 디지털 기반 전략 대안으로는 사업구조 리디자인 전략, 회복탄력성 강화 전략, ESG 경영전략, 디지털 트랜스포메이션 전략을 제시하였다. 사업 수준의 디지털 기반 전략 대안으로는 산업구조 리딩의 디지털전략, 디지털 혁신의 경쟁전략, 개방형 혁신의 플랫폼 전략, 고객 가치 지향 전략을 제시하였다. 본 연구는 디지털 기반의 전략을 보다 체계화하고자 하는 시도였다는 점과 어려운 상황을 슬기롭게 대처해야 하는 기업들의 전략적 대응을 보다 체계적으로 시행하도록 지원할 수 있다는 점에서 기여를 하였다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2008년도 정기 학술대회
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• pp.380-385
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• 2008

3 DOFs model for the collision analysis of a bridge super-structure and a super-structure of the navigating vessels were proposed and analyzed. The collision event between the super-structure of vessel and the super-structure of bridge are different from the normal collision event that collided at sub-structure of bridge. Because of its moment arm, the stability force of vessel could affect to the collision behaviors. To consider this effect, 3 DOFs model including two translation DOFs and one rotational DOF were introduced. The restoration forces of the collision system were considered as nonlinear springs. The equations of motion were derived if form of differential equations and numerically solved by 4th order Runge-Kutta method. The accuracy and the feasibility of this model were verified by the numerical example with parameter of moment arm length.

• East Asian mathematical journal
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• 제36권3호
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• pp.389-415
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• 2020

Let M be a semi-invariant submanifold of codimension 3 with almost contact metric structure (𝜙, ξ, η, g) in a complex space form M_n+1(c), c ≠ 0. We denote by R_ξ and R'_X be the structure Jacobi operator with respect to the structure vector ξ and be R'_X = (∇_XR)(·, X)X for any unit vector field X on M, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a scalar 𝜃(≠ 2c) and any vector fields X and Y on M. In this paper, we prove that if it satisfies R_ξ𝜙 = 𝜙R_ξ and at the same time R'_ξ = 0, then M is a Hopf real hypersurfaces of type (A), provided that the scalar curvature ${\bar{r}}$ of M holds ${\bar{r}}-2(n-1)c{\leq}0$.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.41-49
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• 1994

The most common conventional method of discovering a drug involves a massive screening of a large number of compounds in chemical libraries or in the extracts from natural sources such as plants or microbial broths followed by chemical modification of one or more active compounds to improve their properties as a drug. When the three-dimensional structure of the target molecule for which the drug is searched is known the drug discovery process can be significantly simplified, This is especially true when the three-dimensional structure of a complex between the target and a lead compound is known. In this lecture our experience on the structure-based drug design for human CDK2(cyclin-dependent protein kinase 2) will be discussed with special emphasis on the strength and weakness of this approach of drug discovery. The regulation of the activity of CDK2 plays an important role in the cell proliferation of normal and cancer cells.

• Nuclear Engineering and Technology
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• 제53권7호
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• pp.2268-2276
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• 2021

Spent nuclear fuel, which can degrade during long-term storage, must be transported intact in normal transport conditions. In this regard, many studies, including those involving Multi-Modal Transportation Test (MMTT) campaigns, have been conducted. In order to transport the spent fuel safely, a tie-down structure for supporting and transporting a cask containing the spent fuel is essential. To ensure its structural integrity, a method for finding an optimum conceptual design for the tie-down structure is presented. An optimized transportation test model of a tie-down structure for the KORAD-21 metal cask is derived based on the proposed optimization approach, and the transportation test model is manufactured by redesigning the optimized model to enable its producibility. The topology optimization approach presented in this paper can be used to obtain optimum conceptual designs of tie-down structures developed in the future.

• East Asian mathematical journal
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• 제38권5호
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• pp.549-581
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• 2022

Let M be a semi-invariant submanifold with almost contact metric structure (𝜙, 𝜉, 𝜂, g) of codimension 3 in a complex space form M_n+1(c), c≠ 0. We denote by S and R_𝜉 be the Ricci tensor of M and the structure Jacobi operator in the direction of the structure vector 𝜉, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a certain scalar 𝜃(≠ 2c) and any vector fields X and Y on M. In this paper, we prove that M satisfies R_𝜉S = SR_𝜉 and at the same time R_𝜉𝜙 = 𝜙R_𝜉, then M is a Hopf hypersurface of type (A) provided that the scalar curvature s of M holds s - 2(n - 1)c ≤ 0.

• Kyungpook Mathematical Journal
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• 제62권1호
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• pp.133-166
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• 2022

Let M be a semi-invariant submanifold with almost contact metric structure (𝜙, 𝜉, 𝜂, g) of codimension 3 in a complex space form M_n+1(c) for c ≠ 0. We denote by S and R_𝜉 be the Ricci tensor of M and the structure Jacobi operator in the direction of the structure vector 𝜉, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a certain scalar 𝜃 ≠ 2c and any vector fields X and Y on M. In this paper, we prove that if it satisfies R_𝜉𝜙 = 𝜙R_𝜉 and at the same time S𝜉 = g(S𝜉, 𝜉)𝜉, then M is a real hypersurface in M_n(c) (⊂ M_n+1(c)) provided that $\bar{r}-2(n-1)c{\leq}0$, where $\bar{r}$ denotes the scalar curvature of M.