• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.192-202
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• 2003

The wrinkles correspond to the most obvious expression of skin ageing and are manifested by changes on the organization and dermal structure. In the extracellular matrix, decreased quantities of collagens and glycosaminoglycans as well as a deterioration of the fibrillary network is noted, result in a reduction of dermal thickness. In addition, the activity of the collagenases increases in contrast to the synthesis of collagen fibers. Nor are cells spared during the aging process. We thus studied and compared the contractile capacity as well as the synthesis capacity of normal human fibroblasts and human fibroblasts obtained from biopsies of forehead wrinkles. The capacity of the fibroblasts to be adhered to the collagen network and to maintain a three-dimensional structure of dermis was studied on a model of equivalent dermis. The metabolic activity was studied by evaluating the capacities of synthesis of collagen I, main component of dermis. Human fibroblasts resulting from the forehead wrinkle contract less the gel of collagen than the normal human fibroblasts and present an activity of biosynthesis of collagen I less important than normal human fibroblasts. These results show that fibroblasts with aging present a deceleration of their metabolic activity and lose their capacity of adhesion to collagen fibers thus limiting the possibility of organizing the dermal tissue. We investigated the potential of an active ingredient able to compensate for the reduction of the metabolic activity and to restore the contractile capacity of fibroblasts obtained from forehead wrinkles. This effect was compared with a reference molecule: the vitamin C.

• Imaging Science in Dentistry
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• v.31 no.2
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• pp.73-84
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• 2001

Purpose: The purpose of this study was to find the relationship among the joint status, pain and effusion in patients with temporomandibular joint disorders. Materials and Methods: Materials included 406 patients (812 joints) with clinical records and bilateral TMJ MRIs in TMJ clinic, Yongdong Severance Hospital. All joints were classified in 4 groups in MR images according to the disc status of joint; normal disc position, disc displacement with reduction (DDcR), early and late stage of disc displacement without reduction (DDsR), and also 2 groups according to the bony status of joint; normal bony structure and osteoarthrosis. MR evidence of joint effusion was categorized in 4 groups according to its amount. To determine the relationship between joint pain and joint effusion, 289 patients with unilateral TMJ symptoms were selected from total materials. Result: Joint effusion was found 8.0% in normal disc position, 32.6% in DDcR, and 59.2% in DDsR (83.1 % in early state and 23.1 % in late stage). Joint effusion was found 39.7% in osteoarthrosis and 35.0% in normal bony structure. Joint effusion was more found in the painful joints (49.8%) than in the painless joints (22.4% )(p<0.001). Joint effusion in the early stage of DDsR only was more found significantly in painful joints (91.9%) than in painless joints (62.1 %) (p<0.001). Conclusion : MR evidence of joint effusion might be related to disc displacement regardless of the presence of osteoarthrosis, and the early stage of DDsR was found more frequently combined with joint effusion and joint pain.

• Journal of the Korea Convergence Society
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• v.12 no.6
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• pp.151-160
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• 2021

This study decided that it was necessary to present a strategy for survival in the new normal era and securing competitive advantage, and tried to suggest a management strategic alternative. To this end, this study derives the new normal caused by Corona 19 and the business environment change trend and response strategy type caused by this through literature research and intensive interviews of 10 corporate CEOs. This study limited the scope of the study to the digital-based management and business-level strategic alternatives among strategic alternatives that can be deployed in various fields and areas. Business structure redesign strategy, resilience reinforcement strategy, ESG management strategy, and digital transformation strategy were suggested as alternatives to corporate-level digital-based strategies. As an alternative to business-level digital-based strategies, a digital strategy for industrial structure leading, a competitive strategy for digital innovation, an open innovation platform strategy, and a customer value-oriented strategy were suggested. It contributed in that it was an attempt to systematize a digital-based strategy more and it contributed in that it can support companies who have to deal with difficult situations wisely to implement strategic responses more systematically.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2008.04a
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• pp.380-385
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• 2008

3 DOFs model for the collision analysis of a bridge super-structure and a super-structure of the navigating vessels were proposed and analyzed. The collision event between the super-structure of vessel and the super-structure of bridge are different from the normal collision event that collided at sub-structure of bridge. Because of its moment arm, the stability force of vessel could affect to the collision behaviors. To consider this effect, 3 DOFs model including two translation DOFs and one rotational DOF were introduced. The restoration forces of the collision system were considered as nonlinear springs. The equations of motion were derived if form of differential equations and numerically solved by 4th order Runge-Kutta method. The accuracy and the feasibility of this model were verified by the numerical example with parameter of moment arm length.

• East Asian mathematical journal
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• v.36 no.3
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• pp.389-415
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• 2020

Let M be a semi-invariant submanifold of codimension 3 with almost contact metric structure (𝜙, ξ, η, g) in a complex space form M_n+1(c), c ≠ 0. We denote by R_ξ and R'_X be the structure Jacobi operator with respect to the structure vector ξ and be R'_X = (∇_XR)(·, X)X for any unit vector field X on M, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a scalar 𝜃(≠ 2c) and any vector fields X and Y on M. In this paper, we prove that if it satisfies R_ξ𝜙 = 𝜙R_ξ and at the same time R'_ξ = 0, then M is a Hopf real hypersurfaces of type (A), provided that the scalar curvature ${\bar{r}}$ of M holds ${\bar{r}}-2(n-1)c{\leq}0$.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.41-49
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• 1994

The most common conventional method of discovering a drug involves a massive screening of a large number of compounds in chemical libraries or in the extracts from natural sources such as plants or microbial broths followed by chemical modification of one or more active compounds to improve their properties as a drug. When the three-dimensional structure of the target molecule for which the drug is searched is known the drug discovery process can be significantly simplified, This is especially true when the three-dimensional structure of a complex between the target and a lead compound is known. In this lecture our experience on the structure-based drug design for human CDK2(cyclin-dependent protein kinase 2) will be discussed with special emphasis on the strength and weakness of this approach of drug discovery. The regulation of the activity of CDK2 plays an important role in the cell proliferation of normal and cancer cells.

• Nuclear Engineering and Technology
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• v.53 no.7
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• pp.2268-2276
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• 2021

Spent nuclear fuel, which can degrade during long-term storage, must be transported intact in normal transport conditions. In this regard, many studies, including those involving Multi-Modal Transportation Test (MMTT) campaigns, have been conducted. In order to transport the spent fuel safely, a tie-down structure for supporting and transporting a cask containing the spent fuel is essential. To ensure its structural integrity, a method for finding an optimum conceptual design for the tie-down structure is presented. An optimized transportation test model of a tie-down structure for the KORAD-21 metal cask is derived based on the proposed optimization approach, and the transportation test model is manufactured by redesigning the optimized model to enable its producibility. The topology optimization approach presented in this paper can be used to obtain optimum conceptual designs of tie-down structures developed in the future.

• East Asian mathematical journal
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• v.38 no.5
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• pp.549-581
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• 2022

Let M be a semi-invariant submanifold with almost contact metric structure (𝜙, 𝜉, 𝜂, g) of codimension 3 in a complex space form M_n+1(c), c≠ 0. We denote by S and R_𝜉 be the Ricci tensor of M and the structure Jacobi operator in the direction of the structure vector 𝜉, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a certain scalar 𝜃(≠ 2c) and any vector fields X and Y on M. In this paper, we prove that M satisfies R_𝜉S = SR_𝜉 and at the same time R_𝜉𝜙 = 𝜙R_𝜉, then M is a Hopf hypersurface of type (A) provided that the scalar curvature s of M holds s - 2(n - 1)c ≤ 0.

• Kyungpook Mathematical Journal
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• v.62 no.1
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• pp.133-166
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• 2022

Let M be a semi-invariant submanifold with almost contact metric structure (𝜙, 𝜉, 𝜂, g) of codimension 3 in a complex space form M_n+1(c) for c ≠ 0. We denote by S and R_𝜉 be the Ricci tensor of M and the structure Jacobi operator in the direction of the structure vector 𝜉, respectively. Suppose that the third fundamental form t satisfies dt(X, Y) = 2𝜃g(𝜙X, Y) for a certain scalar 𝜃 ≠ 2c and any vector fields X and Y on M. In this paper, we prove that if it satisfies R_𝜉𝜙 = 𝜙R_𝜉 and at the same time S𝜉 = g(S𝜉, 𝜉)𝜉, then M is a real hypersurface in M_n(c) (⊂ M_n+1(c)) provided that $\bar{r}-2(n-1)c{\leq}0$, where $\bar{r}$ denotes the scalar curvature of M.

• Stress
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• v.26 no.4
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• pp.277-289
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• 2018

Background: The purpose of this study is to develop a short form of the normal depression scale for individual use in the school, health, industry, organization, and counseling settings, based on the original normal depression scale (17 items). Methods: To achieve this purpose, we selected five items from the original test and analyzed data using Mplus 7.4 and SPSS 21.0. Results: The normal depression scale-short form consists of 5 items. The reliability of the short form (test-retest reliability) was good. The content validity and internal structure validity (1 factor model) were verified. The cut score between normal and dysfunctional depression was determined to be 18. Conclusions: The normal depression scale-short form for individual screening is verified to have good reliability and validity, so it is expected to be useful to perform quick screening of normal depression in the practical settings.