• Journal of Ginseng Research
• /
• v.36 no.4
• /
• pp.403-410
• /
• 2012

The current inquiry was conducted to assess the change in sleep architecture after long periods of administration to determine whether ginseng can be used in the therapy of sleeplessness. Following post-surgical recovery, red ginseng extract (RGE, 200 mg/kg) was orally administrated to rats for 9 d. Data were gathered on the 1st, 5th, and 9th day, and an electroencephalogram was recorded 24 h after RGE administration. Polygraphic signs of unobstructed sleep-wake activities were simultaneously recorded with sleep-wake recording electrodes from 11:00 a.m. to 5:00 p.m. for 6 h. Rodents were generally tamed to freely moving polygraphic recording conditions. Although the 1st and 5th day of RGE treatment showed no effect on power densities in nonrapid eye movement (NREM) and rapid eye movement (REM) sleep, the 9th day of RGE administration showed augmented ${\alpha}$-wave (8.0 to 13.0 Hz) power densities in NREM and REM sleep. RGE increased total sleep and NREM sleep. The total percentage of wakefulness was only decreased on the 9th day, and the number of sleep-wake cycles was reduced after the repeated administration of RGE. Thus, the repeated administration of RGE increased NREM sleep in rats. The ${\alpha}$-wave activities in the cortical electroencephalograms were increased in sleep architecture by RGE. Moreover, the levels of both ${\alpha}$- and ${\beta}$-subunits of the ${\gamma}$-aminobutyric acid $(GABA)_A$ receptor were reduced in the hypothalamus of the RGE-treated groups. The level of glutamic acid decarboxylase was over-expressed in the hypothalamus. These results demonstrate that RGE increases NREM sleep via $GABA_A$ergic systems.

• Journal of Korea Society of Industrial Information Systems
• /
• v.22 no.1
• /
• pp.41-51
• /
• 2017

This Paper Describes a Method for the Evaluation of Sleep Apnea, Namely, the Peak Signal-to-noise ratio (PSNR) of Wavelet Transformed Electroencephalography (EEG) Data. The Purpose of this Study was to Investigate EEG Properties with Regard to Differences between Sleep Spindles and K-complexes and to Characterize Obstructive Sleep Apnea According to Sleep Stage. We Examined Non-REM and REM Sleep in 20 Patients with OSA and Established a New Approach for Detecting Sleep Apnea Base on EEG Frequency Changes According to Sleep Stage During Sleep Apnea Events. For Frequency Bands Corresponding to A3 Decomposition with a Sampling Applied to the KC and the Sleep Spindle Signal. In this Paper, the KC and Sleep Spindle are Ccalculated using MSE and PSNR for 4 Types of Mother Wavelets. Wavelet Transform Coefficients Were Obtained Around Sleep Spindles in Order to Identify the Frequency Information that Changed During Obstructive Sleep Apnea. We also Investigated Whether Quantification Analysis of EEG During Sleep Apnea is Valuable for Analyzing Sleep Spindles and The K-complexes in Patients. First, Decomposition of the EEG Signal from Feature Data was Carried out using 4 Different Types of Wavelets, Namely, Daubechies 3, Symlet 4, Biorthogonal 2.8, and Coiflet 3. We Compared the PSNR Accuracy for Each Wavelet Function and Found that Mother Wavelets Daubechies 3 and Biorthogonal 2.8 Surpassed the other Wavelet Functions in Performance. We have Attempted to Improve the Computing Efficiency as it Selects the most Suitable Wavelet Function that can be used for Sleep Spindle, K-complex Signal Processing Efficiently and Accurate Decision with Lesser Computational Time.

• Journal of the Korean Society of Industry Convergence
• /
• v.23 no.3
• /
• pp.433-444
• /
• 2020

This study proposes a method to improve the sleep stage and efficiency estimation of sleep apnea patients using a UWB (Ultra-Wideband) radar. Motion and respiration extracted from the radar signal were used. Respiratory signal disturbances by motion artifacts and irregular respiration patterns of sleep apnea patients are compensated for in the preprocessing stage. Preprocessing calculates the standard deviation of the respiration signal for a shift window of 15 seconds to estimate thresholds for compensation and applies it to the breathing signal. The method for estimating the sleep stage is based on the difference in amplitude of two kinds of smoothed respirations signals. In smoothing, the window size is set to 10 seconds and 34 seconds, respectively. The estimated feature was processed by the k-nearest neighbor classifier and the feature filtering model to discriminate between the sleep periods of the rapid eye movement (REM) and non-rapid eye movement (NREM). The feature filtering model reflects the characteristics of the REM sleep that occur continuously and the characteristics that mainly occur in the latter part of this stage. The sleep efficiency is estimated by using the sleep onset time and motion events. Sleep onset time uses estimated features from the gradient changes of the breathing signal. A motion event was applied based on the estimated energy change in the UWB signal. Sleep efficiency and sleep stage accuracy were assessed with polysomnography. The average sleep efficiency and sleep stage accuracy were estimated respectively to be about 96.3% and 88.8% in 18 sleep apnea subjects.

• Journal of Ginseng Research
• /
• v.34 no.4
• /
• pp.304-313
• /
• 2010

This study was undertaken to discover the effects and possible mechanisms of the effect of red ginseng extract (RGE) on spontaneous sleep. The effects of a low dose (10 mg/kg) and a high dose (200 mg/kg) of RGE were compared in rats. After recovery from a surgical operation enabling electroencephalograms recordings, rats were administered RGE orally. RGE was administered orally for 1 day or once per day for 5 days in either 10 or 200 mg/kg doses. Polygraphic signs were recorded for 12 h after oral administration of RGE. Both treatment with a large dose (200 mg/kg) of RGE for one day and treatment with either a large or a small dose for 5 days reduced the number of sleep.wake cycles. Daily treatment with RGE (either 10 or 200 mg/kg) for 5 days augmented NREM and total sleep, but reduced wakefulness. Delta wave activity recorded during non-REM (NREM) sleep and REM sleep was increased after one treatment with RGE (either 10 or 200 mg/kg). Delta wave activity during NREM was enhanced after daily treatment with RGE (either 10 or 200 mg/kg) for 5 days. Both alpha and beta subunits of the $\gamma$-aminobutyric acid $(GABA)_A$ receptor were significantly over-expressed in the hypothalamus of the RGE-treated groups. Moreover, the expression of glutamic acid decarboxylase was also increased in the hypothalamus. These results demonstrate that RGE may regulate spontaneous sleep via $GABA_A$ergic systems.

• Sleep Medicine and Psychophysiology
• /
• v.6 no.1
• /
• pp.19-25
• /
• 1999

Sleep alters both breathing pattern and the ventilatory responses to external stimuli. These changes during sleep permit the development or aggravation of sleep-related hypoxemia in patients with respiratory disease and contribute to the pathogenesis of apneas in patients with the sleep apnea syndrome. Fundamental effects of sleep on the ventilatory control system are 1) removal of wakefulness input to the upper airway leading to the increase in upper airway resistance, 2) loss of wakefulness drive to the respiratory pump, 3) compromise of protective respiratory reflexes, and 4) additional sleep-induced compromise of ventilatory control initiated by reduced functional residual capacity on supine position assumed in sleep, decreased $CO_2$ production during sleep, and increased cerebral blood flow in especially rapid eye movement(REM) sleep. These effects resulted in periodic breathing during unsteady non-rapid eye movement(NREM) sleep even in normal subjects, regular but low ventilation during steady NREM sleep, and irregular breathing during REM sleep. Sleep-induced breathing instabilities are divided due primarily to transient increase in upper airway resistance and those that involve overshoots and undershoots in neural feedback mechanisms regulating the timing and/or amplitude of respiratory output. Following ventilatory overshoots, breathing stability will be maintained if excitatory short-term potentiation is the prevailing influence. On the other hand, apnea and hypopnea will occur if inhibitory mechanisms dominate following the ventilatory overshoot. These inhibitory mechanisms include 1) hypocapnia, 2) inhibitory effect from lung stretch, 3) baroreceptor stimulation, 4) upper airway mechanoreceptor reflexes, 5) central depression by hypoxia, and 6) central system inertia. While the respiratory control system functions well during wakefulness, the control of breathing is commonly disrupted during sleep. These changes in respiratory control resulting in breathing instability during sleep are related with the pathophysiologic mechanisms of obstructive and/or central apnea, and have the therapeutic implications for nocturnal hypoventilation in patients with chronic obstructive pulmonary disease or alveolar hypoventilation syndrome.

• Biomolecules & Therapeutics
• /
• v.18 no.2
• /
• pp.219-225
• /
• 2010

We tested whether ginsenosides $Rg_3$-standardized ginseng extract (RGE) has anti-stress effects in restraint-stressed animals. RGE increased time spent in the open arms and open arm entries in the elevated plus-maze test. In addition, RGE blocked the reduction of center zone distance and stereotypes behaviors in the open-field test. RGE also increased head dips in stressed mice, indicating anxiolytic-like effects. Stress decreased movement distance and duration, burrowing, and rearing frequency but increased face washing and grooming. RGE significantly reversed burrowing and rearing activity in stressed mice. In addition, we measured sleep architecture in restraint stressed rats using EEG recorder. Stress increased rapid eye movement (REM) sleep, but total sleep and non-rapid eye movement (NREM) sleep were not changed. RGE did not affect sleep architecture in stressed rats. These behavioral experiments suggest that RGE has anti-stress effects in restraint-stressed animal models.

• Korean Institute of Interior Design Journal
• /
• v.13 no.2
• /
• pp.29-37
• /
• 2004

This study analyze the architectural space in the aspect of the 'Raumplan' and 'Plan Libre'. These concepts based on the 'Raumplan versus Plan Libre' exhibition in Delft University, Netherlands. It is generally agreed that the concept of 'Plan Libre' in connection with Le Corbusie architecture and 'Raumplan' related to Adolf Loos's works. that exhibition contents was focused an extent of modem architecture. But, These concepts continually influence contemporary architecture and offer diverse vision in architecture. Therefore, this study focused on the analysis that look for common element in the space through the case study and space element connection in change of the values, technical growth. This Paper reveals that Adolf Loos's Raumplan is similar to Louis I. Kahn's 'Room' concept and Ando Tadao's centrifugal space composition method In the dwelling architecture. And the concept 'Plan Libre': non-definitive formal system and the elements : column, free form screening wall is revived as formal application of 3 dimension composition in architecture. and transfer lots, void, and linear space in Rem Koolhaas's urban design projects. These aspects is so called topology. This topological concept is an attempt in view of the space connection state rather than formative viewpoint.

• Journal of the Korean Applied Science and Technology
• /
• v.36 no.4
• /
• pp.1050-1059
• /
• 2019

The self diffusion, hole volume, and flow thermodynamic parameters of polyamide fibers were calculated from rheological parameters and crystallite size in order to study of flow segments in amorphous region. The stress relaxation of polyamide filament fibers were carried out in air and various solvents at various temperatures using the tensile tester with the solvent chamber. The rheological parameters were obtained by applying the experimental stress relaxation curves to the theoretical equation of the Ree-Eyring and Maxwell non-Newtonian model. It was observed that the rheological parameters of these polyamide filament fibers are directly related to the relaxation spectra, self diffusion, viscosities, and activation energies of flow segments.

• Natural Product Sciences
• /
• v.18 no.2
• /
• pp.67-75
• /
• 2012

Zizyphi Spinosi Semen (ZSS) have been widely used for the treatment of insomnia in Asia. This experiment was performed to investigate whether methanol extract of ZSS (MEZSS) has hypnotic effects through the ${\gamma}$-amino butyric acid (GABA)ergic systems. MEZSS inhibited the locomotor activity. MEZSS enhanced pentobarbital-induced sleep behaviors. However, MEZSS itself did not induce sleep at higher dose, similar to muscimol. On the other hand, both pentobarbital and MEZSS increased the non rapid eye move (NREM) sleep, especially reducing the -wave electroencephalogram (EEG) activity in REM sleep. MEZSS showed similar effects with muscimol on potentiating chloride influx induced by pentobarbital. MEZSS significantly increased GABAA receptors ${\gamma}$-subunit expression and slightly decreased ${\beta}$-subunit expression in hypothalamus and thalamus, showing that subunit-expression was similar to diazepam. In addition, MEZSS enhanced the expression of glutamic acid decarboxylase (GAD). In conclusion, it is suggested that MEZSS might augment pentobarbital-induced sleep behaviors through the modification of GABAergic systems.

• The Journal of Asian Finance, Economics and Business
• /
• v.8 no.5
• /
• pp.785-793
• /
• 2021

The purpose of the research is to assess the factors affecting the liquidity of the commercial banks that are conducting mergers and acquisitions activities in Vietnam during the 2008-2018 period. This study employs samples based on 2-component data sets with cross-section and time-series data collected from the annual report of the State Bank and the audited acquisitions financial statements of nine commercial banks engaged in mergers and acquisitions activities. To carry out the research objectives, the authors conducted quantitative analysis through the Pooled OLS, REM, FEM and GMM models. The results shown that: (i) bank liquidity is positively affected by liquidity lagged, the return on equity (ROE) and economic growth; negatively affected by bank size, non-performing loan, short-run loan to deposit ratio; (ii) there is not enough evidence to conclude about the relationship between net profit margin, equity-to-assets ratio and inflation rate to bank liquidity; (iii) notably, we found evidence that, after the mergers and acquisitions, the liquidity of Vietnamese commercial banks decreased. The findings of this study suggest that bank managers take a more comprehensive view of the results of mergers and acquisitions and implications for banks to improve liquidity in the post-merger and acquisitions conditions.