Repeated Administration of Korea Red Ginseng Extract Increases Non-Rapid Eye Movement Sleep via GABAAergic Systems
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Lee, Chung-Il
(College of Pharmacy, Chungbuk National University)
Kim, Chung-Soo (College of Pharmacy, Chungbuk National University) Han, Jin-Yi (Institute of Veterinary Medicine, Chungbuk National University) Oh, Eun-Hye (College of Medicine, Chungbuk National University) Oh, Ki-Wan (College of Pharmacy, Chungbuk National University) Eun, Jae-Soon (College of Pharmacy, Woosuk University) |
1 | Henny P, Jones BE. Vesicular glutamate (VGlut), GABA (VGAT), and acetylcholine (VACht) transporters in basal forebrain axon terminals innervating the lateral hypothalamus. J Comp Neurol 2006;496:453-467. DOI ScienceOn |
2 | Nitz D, Siegel JM. GABA release in posterior hypothalamus across sleep-wake cycle. Am J Physiol 1996;271(6 Pt 2):R1707- R1712. |
3 | Gottesmann C. GABA mechanisms and sleep. Neuroscience 2002;111:231-239. DOI ScienceOn |
4 |
Sugiyama K, Muteki T, Kano T. The Japanese herbal medicine 'saiko-keishi-to' activates |
5 | Nguyen TT, Matsumoto K, Yamasaki K, Watanabe H. Majonoside-R2 reverses social isolation stress-induced decrease in pentobarbital sleep in mice: possible involvement of neuroactive steroids. Life Sci 1997;61:395-402. DOI ScienceOn |
6 |
Kimura T, Saunders PA, Kim HS, Rheu HM, Oh KW, Ho IK. Interactions of ginsenosides with ligand-bindings of GABAA and |
7 | Lee SH, Yang SC, Park JK, Jung MW, Lee CJ. Reduction of electrically evoked neural activity by ginseng saponin in rat hippocampal slices. Biol Pharm Bull 2000;23:411-414. DOI ScienceOn |
8 | Lee DY, Cho JG, Lee MK, Lee JW, Lee YH, Yang DC, Baek NI. Discrimination of Panax ginseng roots cultivated in different areas in Korea using HPLC-ELSD and principal component analysis. J Ginseng Res 2011;35:31-38. 과학기술학회마을 DOI ScienceOn |
9 | Kim MH, Lee YC, Choi SY, Cho CW, Rho J, Lee KW. The changes of ginsenoside patterns in red ginseng processed by organic acid impregnation pretreatment. J Ginseng Res 2011;35:497-503. 과학기술학회마을 DOI ScienceOn |
10 | Samira MM, Attia MA, Allam M, Elwan O. Effect of the standardized ginseng extract G115 on the metabolism and electrical activity of the rabbit's brain. J Int Med Res 1985;13:342-348. DOI |
11 | Kennedy DO, Scholey AB, Drewery L, Marsh VR, Moore B, Ashton H. Electroencephalograph effects of single doses of Ginkgo biloba and Panax ginseng in healthy young volunteers. Pharmacol Biochem Behav 2003;75:701-709. DOI ScienceOn |
12 | Kaku T, Miyata T, Uruno T, Sako I, Kinoshita A. Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part. Arzneimittelforschung 1975;25:539-547. |
13 | Winsky-Sommerer R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur J Neurosci 2009;29:1779-1794. DOI ScienceOn |
14 | Roth C, Achermann P, Borbely AA. Alpha activity in the human REM sleep EEG: topography and effect of REM sleep deprivation. Clin Neurophysiol 1999;110:632-635. DOI ScienceOn |
15 | Bjorvatn B, Fagerland S, Ursin R. EEG power densities (0.5-20 Hz) in different sleep-wake stages in rats. Physiol Behav 1998;63:413-417. DOI ScienceOn |
16 | Sieghart W. Structure and pharmacology of gammaaminobutyric acidA receptor subtypes. Pharmacol Rev 1995;47:181-234. |
17 | Kim CS, Jo YJ, Park SH, Kim HJ, Han JY, Hong JT, Cheong JH, Oh KW. Anti-stress effects of ginsenoside Rg3-standardized ginseng extract in restraint stressed animals. Biomol Ther 2010;18:219-225. DOI ScienceOn |
18 | Kim CS, Han JY, Kim SH, Hong JT, Oh KW. Herbs for the treatment of insomnia. Biomol Ther 2011;19:274-281. DOI ScienceOn |
19 | Datta S, Maclean RR. Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence. Neurosci Biobehav Rev 2007;31:775-824. DOI ScienceOn |
20 | Datta S, Hobson JA. The rat as an experimental model for sleep neurophysiology. Behav Neurosci 2000;114:1239-1244. DOI ScienceOn |
21 | Lee SP, Honda K, Rhee YH, Inoue S. Chronic intake of Panax ginseng extract stabilizes sleep and wakefulness in food-deprived rats. Neurosci Lett 1990;111:217-221. DOI ScienceOn |
22 | Xiang YZ, Shang HC, Gao XM, Zhang BL. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res 2008;22:851-858. DOI ScienceOn |
23 | Kim SK, Park JH. Trends in ginseng research in 2010. J Ginseng Res 2011;35:389-398. 과학기술학회마을 DOI ScienceOn |
24 | Choi HK, Seong DH, Rha KH. Clinical effi cacy of Korean red ginseng for erectile dysfunction. Int J Impot Res 1995;7:181-186. |
25 | Yang SL, Nam SY, Han JY, Kim JC, Lee K, Jin TH, Oh KW, Eun JS. Alterations of spontaneous sleep architecture and cortical electroencephalogram power spectra by red ginseng extract via GABAAergic systems. J Ginseng Res 2010;34:304-313. DOI ScienceOn |
26 | Sanford LD, Yang L, Liu X, Tang X. Effects of tetrodotoxin (TTX) inactivation of the central nucleus of the amygdala (CNA) on dark period sleep and activity. Brain Res 2006;1084:80-88. DOI ScienceOn |
27 | Rhee YH, Lee SP, Honda K, Inoue S. Panax ginseng extract modulates sleep in unrestrained rats. Psychopharmacology(Berl) 1990;101:486-488. DOI |
28 | Kitaoka K, Uchida K, Okamoto N, Chikahisa S, Miyazaki T, Takeda E, Sei H. Fermented ginseng improves the firstnight effect in humans. Sleep 2009;32:413-421. DOI |
29 | Blanco-Centurion C, Xu M, Murillo-Rodriguez E, Gerashchenko D, Shiromani AM, Salin-Pascual RJ, Hof PR, Shiromani PJ. Adenosine and sleep homeostasis in the basal forebrain. J Neurosci 2006;26:8092-8100. DOI ScienceOn |
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