• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.23 no.4
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• pp.181-187
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• 2012

Objectives:The objective of this study was to examine the perinatal and developmental risk factors of attention-deficit hyperactivity disorder (ADHD) diagnosed with a structured interview among Korean children. Methods:The current study included 924 children (6-15 years) recruited from schools in five Korean cities or a child psychiatry outpatient clinic of Seoul National University Children's Hospital. The parents of the children completed the structured diagnostic interview for attention-deficit hyperactivity disorder, as well as questionnaires on perinatal and developmental risk factors. Results:Preterm delivery, severe maternal stress during pregnancy, change in primary care taker during the first three years, postpartum depression, and delayed first sentence showed a significant association with ADHD diagnosis. Conclusion:These findings suggest that perinatal and developmental factors contribute to development of ADHD in Korean children. Conduct of future research using a prospective design is needed in order to identify the causal relationship between observed risk factors and development of ADHD.

• Science of Emotion and Sensibility
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• v.13 no.1
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• pp.225-234
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• 2010

To investigate the role of positive emotion in education, we have reviewed the previous studies on positive emotion, learning and motivation. In the present study, we examined the definition of positive emotion, and influences of positive emotion on cognition, creativity, social relationship, psychological resource such as life satisfaction, and interactive relationship among positive emotion, motivation and learning. To investigate the role of positive emotion on motivation and learning more scientifically, we examined the recent results of neuroscience. In other words, we have reviewed diverse research on positive emotion, learning and motivation based on brain-based learning. We also examined the research of autonomy-supportive environment as the specific example of improving positive emotion. As one of the most effective methods for emotional education, we discussed brain-based learning, the new research field. As the future prospects, we discussed the implications, possibilities and limitations of brain-based learning.

• Journal of Oriental Neuropsychiatry
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• v.20 no.1
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• pp.235-247
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• 2009

Objectives : Ginseng Radix Rubra water extract(RGE) has been used in vivo test for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with APP-related dementias and Alzheimer's disease (AD). APP derived from proteolytic processing of the ${\beta}$-amyloid precursor protein (APP), including the amyloid-${\beta}$ peptide (A${\beta}$), plays a critical role in the pathogenesis of Alzheimer's dementia. Methods : We determined that RGE inhibits formation of APP, which are the behavior, and possibly causative, feature of AD. Results and Conclusions : In the cells, RGE significantly activated antiapoptosis and decreased the activity of APP-grim, a key enzyme in the apoptosis cell-signaling cascade. These results suggest that neuronal damage in AD might be due to two factors: a direct APP toxicity and multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of APP, underlie the neuroprotective effects of RGE.

• Journal of Oriental Neuropsychiatry
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• v.20 no.1
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• pp.215-233
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• 2009

Objectives : The aim of this study was to help treatment of Anxiety disorder patients through the study on Keongke(驚悸) and Cheongchung(怔忡) in "Donguibogam" Methods : Author searched the contents of Keongke(驚悸) and Cheongchung(怔忡) in "Donguibogam" and classfied them by concept, pathogenesis and treatment. Results : 1. Concepts of Keongke(驚悸) and Cheongchung(怔忡) are to leap up, be nervous and fear something. Keongke(驚悸) and Cheongchung(怔忡) are same kinds of disease but they are only distinguished as their seriousness. 2. There are four main causes of Keongke(驚悸) and Cheongchung(怔忡) such as phlegm and fluid retention(痰飮), insufficiency of the heart(心虛), being blocked of qi(氣鬱) and Hwa(火). Additionally the diseases are caused by astonishment(驚) excessive thought(思慮過度), insufficiency of the liver(肝虛), excessive perspiration and dirarrhea (汗,下過多) insufficiency of qi(氣鬱) 3. the number of herbal medicines which treat Keongke(驚悸) and Cheongchung(怔忡) are 68. In result of analyzing them, the number of herbal medicines to treat phlegm(痰) are 22 and the number of herbal medicines to treat deficiency of the heart blood(血心虛) are 18. 4. The number of herbs which treat Keongke(驚悸) and Cheongchung(怔忡) are 25. They stabilize Hon-Baek(魂魄), spirit(精神) and mind(心神), supplement the heart blood, and treat Damhwa(淡火) and Hwa(火). Poria(茯神) take a rule of leading to the causes of Keongke(驚悸) and Cheongchung(怔忡).

• Toxicological Research
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• v.22 no.1
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• pp.9-13
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• 2006

Diesel exhausted particles (DEP), a kind of fine particles with aerodynamic diameters less than $2.5{\mu}m$ (PM2.5), is of great concern to human health because they remain in atmosphere for long periods, invade an indoor air environment, and can be breathed most deeply into lung and reached the alveoli because of their small size ($0.1{\sim}0.4\;{\mu}m$ in diameter). Epidemiological and experimental studies suggested that DEP may play an active role in the increased respiratory mortality and morbidity. In addition to their physical characteristics, the chemical components including polyaromatic hydrocarbon (PAH) are regarded as a carcinogen causing pulmonary tumors. PLD plays an important role in cell proliferation with various physiological phenomena and affects other enzymes by activating signal transduction pathway. We investigated the cytotoxic mechanism of DEP on RAW 264.7 cells focusing on the role in activation of PLD. Our results suggested DEP induced PLD activity through a specific signaling pathway involving phospholipase $A_2$, PLC, PKC and $Ca^{2+}$ mobilization.

• Biomolecules & Therapeutics
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• v.18 no.1
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• pp.48-55
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• 2010

Neural progenitor cells (NPCs) differentiate into astrocytes, neurons and oligodendrocytes, which is controlled by various factors in brain. Recent evidences suggest that small molecules modulating the proliferation and differentiation of NPCs may have therapeutic value as well as the potential use as chemical probes. Phylligenin is a lignan with anti-inflammatory activity that is isolated from the fruits of Forsythia koreana. We investigated effects of phylligenin on proliferation and differentiation of NPCs. Treatment of phylligenin decreased the number of proliferating NPCs in culture without effects on the differentiation and survival of neural cells such as neurons and astrocytes. To examine the mechanism of the decreased NPCs number, we performed cell cycle analysis. Proliferation of NPCs was decreased via G1-S transition block by phylligenin treatment, and it was mediated by the increase of p21 level. However, phylligenin did not induce apoptosis of NPCs as determined by TUNEL assay and PARP cleavage. We also found that viability of glioma cell lines such as C6 and U87MG glioma cells, but not that of primary neuron and astrocyte, was inhibited by phylligenin. These results suggest that phylligenin selectively inhibits proliferation of rapidly growing cells such as neural stem cells and glioma cells. Given that the possible role of brain tumor stem cells in the pathology of brain cancers, the inhibitory effects of phylligenin might be useful in the development of new therapeutic agents against brain cancers.

• Journal of Science and Technology Studies
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• v.13 no.1
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• pp.1-39
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• 2013

How would technoscientists collaborate in their technoscientific practices? Based on the ethnographic research done at NRI(Neuroscience Research Institute), this research shows how collaboration occurs in/outside the interdisciplinary laboratory. As previous studies show, collaboration makes researches possible that otherwise would have been impossible. Korean technoscientists who are situated in the scientific periphery, practice contextualized collaboration in their labs. These collaborations are invisible before opening the black box of the lab. But it acquires visibility after certain incidents such as collaborations, debates and discussions, malfunctioning of the instruments, and networking with other actors occur. These networks again become invisible after the certain incidents end. However these blackboxing and whiteboxing (opening the blackbox) processes occur simultaneously in various levels, it is almost impossible to identify them separately. In real technoscientific practices, blackboxing and whiteboxing do not occur distinctively. They almost always occur at the same time on multi-layered levels, hence forming the 'grey box' of technoscientific practices. Lastly, collaborations inside laboratory have in/visible features, because laboratories function as Foucauldian heterotopias.

• The Journal of Korean Academy of Sensory Integration
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• v.5 no.1
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• pp.31-40
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• 2007

Objective: The purpose of this study was to get the cognitive reaction time according to the intensity of auditory stimuli in older people and to differentiate the cognitive reaction time between older people and adults. Method: 49 subjects consisted of 32 older people and 17 adults. Cognitive reaction time was assessed with Simple Auditory Reaction of Foundation I in PSS CogReHab. Analysis of the data was done by using independent t-test. Results: The results were as follows: 1. There was a significant difference of the mean of cognitive reaction time to the intensity of auditory stimuli. 2. There was no significant difference from older people regardless of sexual distinction in mean of cognitive reaction time. However, there was a significant difference of the mean of cognitive reaction time in adults. 3. There was a significant difference between older people who got a job or not in 90 dB of auditory stimuli. 4. The mean of cognitive reaction time to the intensity of auditory stimuli in older people was slower than adults. There was a significant difference of the mean of cognitive reaction time between older people and adults in 70 dB of auditory stimuli. 5. The mean of cognitive reaction time to the intensity of auditory stimuli in older people did not have the significant difference in scholastic ability. Conclusions: The results of the study showed slowing of the cognitive reaction time in auditory stimuli to aging in older people. Therefore, applying silver industry and development of equipment for older people may maintain independent life.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.6
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• pp.739-744
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• 2012

Cirsium japonicum (Gyonggido (GG), Gangwondo (GW), Jeollanamdo (JN) and Jejudo (JJ)) were investigated for their antioxidative components (total polyphenol and flavonoid contents) and their antioxidant activities (2,2-diphenyl-1-picrylhydrazyl) (DPPH), 2,2'-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP) and reducing power). Analysis of antioxidative components and activities showed significant (p<0.05) differences across samples from various regions (GG, GW, JN, JJ). Amounts of total polyphenol and flavonoid contents were in the order of GG${\geq}$GW>JJ>JN (p<0.05). The results of the antioxidative activity test of Cirsium japonicum showed that GG and GW had higher activities compared to others (p<0.05). Therefore, the results of the antioxidative activity test (DPPH, ABTS, FRAP and reducing power) were correlated with total polyphenol and flavonoid contents values.

• The Journal of the Korea Contents Association
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• v.16 no.4
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• pp.36-44
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• 2016

This article serves as a guideline to the policy on Korea brain science program. Given limited resources within Korea, setting priorities in brain science topics is important in science policy. In this study, we determined the priorities of important brain science topics based on the frontier properties, innovativeness, and prospective outcome. Firstly, the significant topics were chosen after the interview with the top nationwide brain scientists, which were neuroglia, brain precision medicine, neuromorphic engineering, neuroepigenetics, and brain oscillation. Secondly, the analytic hierarchy process (AHP) survey were conducted to prioritize and assign the important weight for not only the criteria but also the research topics in pair choice evaluation. In regards to the importance among the criteria, prospects of the topic was determined to be the top criterion to ranked criterion to consider in the government investment. The priority of the research topics was determined by the order for the project to be considered in national science policy in a comparative way.