• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.382.2-382.2
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• 2014

We explain a method to fabricate multi-layered transparent conductive films (TCF) using graphene oxide (GO), copper powder and polyurethane (PU) solution. The flexible graphene nanosheets (GNSs) serve as nanoscale connection between conductive copper nanoparticles (CuNps) and PU nanofibers, resulting in a highly flexible TCF. To fabricate conductive films with high transmittance, polyurethane (PU) nanofibers were used for a conductive network consisting of CuNps and GNSs (CuNps-GNSs). In this experiment, copper powder and graphene oxides were mixed in deionized water with the ultrasonication for 2 h. NaBH4 solution is used as a reduction agents of CuNps and GNSs (CuNps-GNSs) under a nitrogen atmosphere in the oil bath at 100% for 24 h to mixed. The purified and dispersed CuNp-GNS were obtained in deionized water, and diluted to a 10wt.% based on the contents of GNSs. Polyurethane (PU) nanofibers on a PET substrate were formed by electrospinning method. PET slides coated with the PU nanofibers were immersed into CuNp-GNS solution for several second, rinsed briefly in deionized water, and dried to obtain self-assembled CuNp-GNS/PU films. The morphology of the multi-layered films were characterized with a field emission scanning electron microscope (FE-SEM, Hitachi S-4700) and atomic force microscope (AFM, PSIA XE-100). The electrical property was analysed by the I-V measurement system and the optical property was measured by the UV/VIS spectroscopy.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.10
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• pp.1862-1872
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• 2017

To overcome the limitations of the current Central Mobility Management (CMM) protocols, IETF has been discussing about the Distributed Mobility Management (DMM) protocols that the centralized mobility functions of Home Agents (HA) are distributed to network edges closer to mobile users. The DMM protocol has some advantages of low-cost traffic delivery and high scalability. However, it faces several problems such as a high signaling cost and a complex address management. Especially, users moving at a high speed and with long-live sessions can make these problems worse. To reduce the high signaling cost for long-live sessions, we propose a novel hybrid DMM protocol allocating different mobility anchors according to the session durations. In this paper, we analyze the performance of the proposed hybrid DMM protocol and show superior performance with respect to the signaling cost.

• Analytical Science and Technology
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• v.33 no.2
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• pp.98-107
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• 2020

Methamphetamine (MA) is currently the most abused illicit drug in Korea. MA is produced by chemical synthesis, and the final target drug that is produced contains small amounts of the precursor chemicals, intermediates, and by-products. To identify and quantify these trace compounds in MA seizures, a practical and feasible approach for conducting chromatographic fingerprinting with a suite of traditional chemometric methods and recently introduced machine learning approaches was examined. This was achieved using gas chromatography (GC) coupled with a flame ionization detector (FID) and mass spectrometry (MS). Following appropriate examination of all the peaks in 71 samples, 166 impurities were selected as the characteristic components. Unsupervised (principal component analysis (PCA), hierarchical cluster analysis (HCA), and K-means clustering) and supervised (partial least squares-discriminant analysis (PLS-DA), orthogonal partial least squares-discriminant analysis (OPLS-DA), support vector machines (SVM), and deep neural network (DNN) with Keras) chemometric techniques were employed for classifying the 71 MA seizures. The results of the PCA, HCA, K-means clustering, PLS-DA, OPLS-DA, SVM, and DNN methods for quality evaluation were in good agreement. However, the tested MA seizures possessed distinct features, such as chirality, cutting agents, and boiling points. The study indicated that the established qualitative and semi-quantitative methods will be practical and useful analytical tools for characterizing trace compounds in illicit MA seizures. Moreover, they will provide a statistical basis for identifying the synthesis route, sources of supply, trafficking routes, and connections between seizures, which will support drug law enforcement agencies in their effort to eliminate organized MA crime.

• Journal of Internet Computing and Services
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• v.2 no.4
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• pp.41-53
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• 2001

Multi-distributed web cluster model built for high availability E-Business model exposes internal system nodes on its structural characteristics and has a potential that normal job performance is impossible due to the intentional prevention and attack by an illegal third party. Therefore, the security system which protects the structured system nodes and can correspond to the outflow of information from illegal users and unfair service requirements effectively is needed. Therefore the suggested distributed invasion detection system is the technology which detects the illegal requirement or resource access of system node distributed on open network through organic control between SC-Agents based on the shared memory of SC-Server. Distributed invasion detection system performs the examination of job requirement packet using Detection Agent primarily for detecting illegal invasion, observes the job process through monitoring agent when job is progressed and then judges the invasion through close cooperative works with other system nodes when there is access or demand of resource not permitted.

• Journal of Veterinary Clinics
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• v.25 no.5
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• pp.346-354
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• 2008

The combined effects of EDTA-Tris and eighteen antimicrobial agents have been evaluated in eight clinically isolated methicillin-resistant bacteria (Staphylococcus aureus, Escherichia coli, Streptococcus uberis and Streptococcus agalactiae) from bovine mastitis. The antimicrobial activity was evaluated by measuring the minimal bactericidal concentration (MBC) for the antibiotics alone or in combination with EDTA-Tris in Mueller-Hilton broth and milk. Combined use of EDTA-Tris and antibiotics potentiated or antagonized activity of antibiotics against mastitic pathogens. Milk increased the antibiotic potency of erythromycin and spiramycin on S. aureus. Culture in milk changed patterns of EDTA-Tris combinational effects compared with that in standard Mueller-Hilton broth. Combined with EDTA-Tris in milk, synergic effects were observed in colistin, dihydrostreptomycin, kanamycin, erythromycin, gentamycin, oxytetracycline, streptomycin to E. coli, Str. uberis, and Str. agalactiae. However, significant antagonistic effects of milk on antibiotic susceptibility in combination with EDTA-Tris were noted in neomycin, streptomycin, penicillin, roxithromycin, and amoxicillin. This study indicates that combination therapy of EDTA-Tris with antibiotics in bovine mastitis should be used with caution because of the possible antagonistic effects of antibiotic combination with EDTA-Tris on mastitic pathogens. In addition, antibiotic susceptibility test in combination with EDTA-Tris in milk culture condition can be benefit in search of effective treatment regimen for some antibiotic-resistant bacteria of mastitis.

• Journal of the Korean Geographical Society
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• v.44 no.3
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• pp.355-371
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• 2009

The purpose of this study is to investigate the spatial structure of the production of technological knowledge in the Korean photonics industry. Patent data were used as a proxy of knowledge production. The data were gathered by keywords among the registered patents which were applied from 1996 to 2007. The photonics industry patents registered at United States Patent Trademark Office(USPTO) show that Korea and Taiwan, as a latecomer, have rapidly increased. The photonics industry patents registered at Korean Intellectual Property Office(KIPO) were analyzed by type of application: single-applicant and co-applicant patents. The analysis of single-applicant patents shows that technological knowledge in the Korean photonics industry has been produced mainly in Seoul, Suwon, and Daejeon. The degree of spatial bias, however, has been slightly decreased during the study period. Above-mentioned regions are also main centers in the analysis of co-applicant patents, but the forms of inter-regional cluster and network are different over time. It is because agents participating in co-applicant patents are diverse and increased. Furthermore, it seems that policies, such as the improvement of the infrastructure of ICT, the promotion of the photonics industry and the industry-university-institute collaboration, are very influential.

• Convergence Security Journal
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• v.16 no.6_1
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• pp.43-50
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• 2016

As North Korea has a sufficient ability to attack our society's vulnerable computer network, various large-scale cyber attacks are expected to be tried. North Korea's cyber military strength is known a world-class level. The number of its cyber agents is increasing consistently. Recently North Korea's cyber attack has been made regardless of trick and target. But up to now North Korea's cyber attack is more of an exploration than a real attack. Its purpose was to check how fast Korea found a problem and recovered from it. In future, cyber attack that damages substantially is highly probable. In case of an attack against national infrastructure like traffic, financial and energy services, the extent of the damage will be great beyond imagination. In this paper, characteristics of recent North Korea's cyber attack is addressed in depth and countermeasures such as the enactment of cyber terror prevention law, simulation training enforcement, private and public cooperation system construction, cyber security infrastructure expansion, etc. are proposed.

• Journal of Ginseng Research
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• v.44 no.5
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• pp.690-696
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• 2020

Background: As the main metabolites of ginsenosides, 20(S, R)-protopanaxadiol [PPD(S, R)] and 20(S, R)-protopanaxatriol [PPT(S, R)] are the structural basis response to a series of pharmacological effects of their parent components. Although the estrogenicity of several ginsenosides has been confirmed, however, the underlying mechanisms of their estrogenic effects are still largely unclear. In this work, PPD(S, R) and PPT(S, R) were assessed for their ability to bind and activate human estrogen receptor α (hERα) by a combination of in vitro and in silico analysis. Methods: The recombinant hERα ligand-binding domain (hERα-LBD) was expressed in E. coli strain. The direct binding interactions of ginsenosides with hERα-LBD and their ERα agonistic potency were investigated by fluorescence polarization and reporter gene assays, respectively. Then, molecular dynamics simulations were carried out to simulate the binding modes between ginsenosides and hERα-LBD to reveal the structural basis for their agonist activities toward receptor. Results: Fluorescence polarization assay revealed that PPD(S, R) and PPT(S, R) could bind to hERα-LBD with moderate affinities. In the dual luciferase reporter assay using transiently transfected MCF-7 cells, PPD(S, R) and PPT(S, R) acted as agonists of hERα. Molecular docking results showed that these ginsenosides adopted an agonist conformation in the flexible hydrophobic ligand-binding pocket. The stereostructure of C-20 hydroxyl group and the presence of C-6 hydroxyl group exerted significant influence on the hydrogen bond network and steric hindrance, respectively. Conclusion: This work may provide insight into the chemical and pharmacological screening of novel therapeutic agents from ginsenosides.

• IMMUNE NETWORK
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• v.14 no.6
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• pp.296-306
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• 2014

There is growing evidence that crosstalk between mantle cell lymphoma (MCL) cells and stromal microenvironments, such as bone marrow and secondary lymphoid tissues, promotes tumor progression by enhancing survival and growth as well as drug resistance of MCL cells. Recent advances in the understanding of lymphoma microenvironment have led to the identification of crucial factors involved in the crosstalk and subsequent generation of their targeted agents. In the present study, we evaluated the combinatory effect of blocking antibodies (Ab) targeting CXCR4 and VLA-4, both of which were known to play significant roles in the induction of environment-mediated drug resistance (EMDR) in MCL cell line, Jeko-1. Simultaneous treatment with anti-CXCR4 and anti-VLA-4 Ab not only reduced the migration of Jeko-1 cells into the protective stromal cells, but also enhanced sensitivity of Jeko-1 to a chemotherapeutic agent to a greater degree than with either Ab alone. These combinatorial effects were associated with decreased phosphorylation of ERK1/2, AKT and NF-${\kappa}B$. Importantly, drug resistance could not be overcome once the adhesion of Jeko-1 to the stromal occurred despite the combined use of Abs, suggesting that the efforts to mitigate migration of MCLs should be attempted as much as possible. Our results provide a basis for a future development of therapeutic strategies targeting both CXCR4 and VLA-4, such as Ab combinations or bispecific antibodies, to improve treatment outcomes of MCL with grave prognosis.

• The Journal of Society for e-Business Studies
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• v.9 no.4
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• pp.65-83
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• 2004

Keen competence in business environments induces companies to introduce Supply Chain Management (SCM), which is accelerated by emerging information technology. Consequently, supply chain integration requires interacting and information sharing among the companies participating in the supply chain. Web services, platform independent technologies, are recently used for SCM. However, web services themselves do not provide high level supply chain integration. Therefore, the ways to control and manage global processes over supply chain need to be developed. In this paper, we introduce a method of executing and managing supply chain process using Business Process Management (BPM) system. BPM system is a software system to support an efficient execution and management of complex business processes, and it is applied to supply chain processes . The supply chain processes can be regarded network of activities, each of which is served as web service and related to one of the participants. Our approach enables not only efficient managing but also effective monitoring of the process, which can be a good basis for improvement of the processes. For a speedy execution of processes, we provide a method to support decision making in course of executing process by software agents, which are also web services.