• Journal of Pharmaceutical Investigation
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• v.37 no.4
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• pp.223-227
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• 2007

A rapid, simple and sensitive LC/MS/MS method for the determination of lercanidipine in human serum was validated and applied to the pharmacokinetic study of lercanidipine. Lercanidipine and internal standard, amlodipine, were extracted from human serum by liquid-liquid extraction with hexan-isoamyl alcohol (100: 1, v/v) and analyzed on a $Symmetry^{(R)}$ MS $C_{18}$ column with the mobile phase of acetonitrile-0.2% aqueous formic acid (70: 30, v/v). Using MS/MS with multiple reaction monitoring (MRM) mode, lercanidipine and amlodipine were detected without severe interferences from human serum matrix. Lercanidipine produced a protonated precursor ion ($[M+H]^+$) at m/z 612.3 and a corresponding product ion at m/z 280.0. Internal standard produced a protonated precursor ion ($[M+H]^+$]) at m/z 409.0 and a corresponding product ion at m/z 238.0. The ruggedness of this method was investigated using quality control (QC) samples. This method showed linear response over the concentration range of 0.05-20 ng/mL with correlation coefficient greater than 0.999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ng/mL, which was sensitive enough for pharmacokinetic studies. The overall accuracy of the developed method ranged from 85.51 to 112.2% for lercanidipine with overall precision (% C.V.) being 3.56-13.1%. This method showed good ruggedness (within 15% C.V.) and was successfully applied for the analysis of lercanidipine in human serum samples for the pharmacokinetic studies, demonstrating the suitability of the method.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.232-241
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• 2017

This paper presents an automated cow-feeding system based on an AGV and screw conveyor for domestic livestock farms, which are becoming larger and more commercialized. The system includes a hopper module for loading pellet-type mixed feed at the top of the system, a transfer module mounted with a screw conveyor to transfer feed from the hopper module to the outlet module, an outlet module composed of belt conveyors, and an electromagnetic guided driving-type AGV. The weight of the loaded feed is measured by a load cell located under the transfer module. The system reads the feed discharge information stored in RFID tags installed in each cowshed cell, and a predetermined amount of feed is discharged while the AGV is moving. A cow-feed test system was constructed to determine the design parameters of the screw conveyor in the transfer module that determine the feeding capacity. These parameters include the screw's outer diameter, the screw shaft outer diameter, and screw pitch. The parameters were applied to the finalized cow-feed system construction. A DSP-based main controller and cow-feeding algorithm for different scenarios were also developed to control the system. Experimental results confirmed that the system could supply a total of 21 kg of feed uniformly at 420 g/s for a cowshed cell which has 7 cows. The driving distance was 5 m and the speed was 0.1 m/s. Thus, the proposed system could be applied to standardized domestic livestock farms.

• Journal of Digital Contents Society
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• v.15 no.4
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• pp.481-489
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• 2014

In this paper, the automatic standby power blocking socket outlet to reduce standby power by blocking power threshold is implemented. Where, the standby power means a flowing power when a disused power electronic is plugged into the socket outlet. The proposed socket outlet can cut off the standby power by establishing a proper block power threshold electronic device according to each electronic device because it can monitor the amount of power through the smart machines such as the real-time PC or mobile phone and directly control the blocking power threshold. The software is implemented by using Visual Studio software, code vision and SN8 C studio, and the hardware is embodied in ATmega128, SN8F27E93S, USB to UART, and relay etc. Through the simulation, we find that the standby power of the proposed method is similar to that of the conventional method in case of the cellular phone but the standby power of the proposed method is much less than that of the conventional method in case of the computer, air conditioning, and set-top box. Therefore, it is proved that the proposed socket outlet has a superior performance in terms of the standby power.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.89-92
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• 2015

In this paper, we propose a method to reduce the fire suppression time. Our suggestions can secure a safe area according to the diffusion path and speed of the fire, forest fire prediction minimize casualties and property damage forests. The existing path prediction method wildfire spread predict the wildfire spread model and speed through topography, weather, fuel factor and the image information. In this case, however, occur to control a large mountain huge costs. Also Focus on the diffusion model predictions and the path identified by the problem arises that insufficient efforts to ensure the safe area. In this paper, we estimate the moving direction and speed of fire at a lower cost, and proposes an algorithm to ensure the safety zone for fire suppression. The proposed algorithm is a technique to analyze the attribute information that temperature, wind, smoke measured over time. According to our algorithm forecast wildfire moving direction and ensure the safety zone. By analyzing the moving speed and the moving direction of the simulated fire in a given environment is expected to be able to quickly reduce the damage to the forest fire fighters.

• Journal of the Korea Convergence Society
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• v.11 no.1
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• pp.1-7
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• 2020

Recently 5G technology is one of the technologies that has been receiving much positive responses from users as it is integrated with virtual technology. However, 5G's security issues have not been fully resolved and more security is soon required. In this paper, an approach technique is proposed as a probability-based hierarchy to provide personal privacy for 5G-based IoT users more safely. The proposed technique is aimed at not exposing the privacy of IoT users to third parties by using two random keys created personally by IoT users. In order to satisfy both safety and efficiency, the proposed technology divides the privacy of IoT users into two layers. In the first stage, IoT users will control access to intermediate media using anonymous keys generated by IoT users, and in the second stage, information of IoT users registered with servers will be darkened and replicated. The proposed technique has improved the accuracy of the privacy protection of IoT users as they assign weights to layered information after layering users' privacy information on a probabilistic basis.

• Journal of IKEEE
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• v.2 no.1 s.2
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• pp.1-14
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• 1998

In this paper, Antenna, LNA, Mixer, VCO, and Modulation/Demodulation in Baseband processor which are the RF main components in Wireless LAN system for ultra high-speed communications network are studied. Antenna bandwidth and selective fading due to multipath can be major obstacles in high speed digital communications. To solve this problem, wide band MSA which has loop-structure magnetic antenna characteristics is designed. Distributed mixer using dual-gate GaAs MESFET can achieve over 10dB LO/RF isolation without hybrid, and minimize circuit size. As linear mixing signal is produced, distortions can be decreased at baseband signals. Conversion gain is achieved by mixing and amplification simultaneously. Mixer is designed to have wide band characteristics using distributed amplifier. In VCO design, Oscillator design method by large signal analysis is used to produce stable signal. Modulation/Demodulation system in baseband processor, DS/SS technique which is robust against noise and interference is used to eliminate the effect of multipath propagation. DQPSK modulation technique with M-sequences for wideband PN spreading signals is adopted because of BER characteristic and high speed digital signal transmission.

• Journal of Periodontal and Implant Science
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• v.24 no.3
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• pp.661-670
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• 1994

It is well known that the application of dressings after periodontal surgery have benefits to provide the comforts to patient and to promote the healing process with action of bleeding control and temporary stabilization for the operated mobile teeth. But until recently the relationship between periodontal dressings and cells which are composed of periodontium has not been clear. The purpose of this study was to evaluate the cytotoxic effect of soluble extracts from the four different kinds of periodontal dressings, two of them were eugenol type (K.H.pack, Wondrpak) and the others were non-eugenol type (Coe-pak, Periocare), on the human gingival fibroblasts in vitro. Human gingival fibroblasts were primarily cultured from gingiva around third molar during the extraction for preventive purposes. Extracts solution were prepared with culture medium by means of imersing the consistent size of periodontal dressing made from plastic mold. Cell were inoculated into the 24 well plate with $3\;{\times}\;10^4\;cells/well$ of medium at $37\;^{\circ}C$, 100% of humidity, 5% of $CO_2$, incubator for 24 hours. After discard of the supernatant of medium, those cells were cultured with original, 1/2, 1/5, 1/10 diluted soluble extract for 24, 48 and 72 hours, and counted the number of cells using the hemocytometer at each designed time and concentration. Also, the cytotoxic effect of soluble extract was measured by Wataha's MTT assay method. In briefly, cells were inoculated and cultured into 96 well culture plate with $2\;{\times}\;10^4\;cells/well$ for 24 hours. Soluble extracts were applied to cultured cells and incubated for 48 hours at same condition. $50\;{\mu}l$ of MTT solution and DMSO were added into each well for the detection of absorbance with ELISA reader. The measured data were calculated by value of colorimetric assay for survival rate. The results were as follows ; In the case of eugenol type of dressing, original, 1/2 and 1/5 diluted extracts of K.H.pack showed very low survival rate. And original extract of Wondrpak showed strong cytotoxic effect and 1/2 diluted extract showed moderate cytotoxic effect. In the case of Non-eugenol type of dressings, only original extract of Coe-pak revealed strong cytotoxic effect and Periocare had little cytotoxic effect. It is concluded that eugenol type of dressings showed more cytotoxic effect than non-eugenol types. This study suggest that use of non-eugenol dressings after periodontal surgery is recommended.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.47 no.7
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• pp.52-60
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• 2010

In this paper, we propose a dynamic power management framework for multi-core systems. We reduced the power consumption of multi-core processors such as Intel Centrino Duo and ARM11 MPCore, which have been used at the consumer electronics and personal computer market. Each processor uses a different technique to save its power usage, but there is no embedded multi-core processor which has a precise power control mechanism such as dynamic voltage scaling technique. The proposed dynamic power management framework is suitable for smart phones which have an operating system to provide multi-processing capability. Basically, our framework follows an intuitive idea that reducing the power consumption of idle cores is the most effective way to save the overall power consumption of a multi-core processor. We could minimize the energy consumption used by idle cores with application-targeted policies that reflect the characteristics of active workloads. We defined some properties of an application to analyze the performance requirement in real time and automated the management process to verify the result quickly. We tested the proposed framework with popular processors such as Intel Centrino Duo and ARM11 MPCore, and were able to find that our framework dynamically reduced the power consumption of multi-core processors and satisfied the performance requirement of each program.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.1
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• pp.24-36
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• 2003

The digital mobile communication will be developed till getting multimedia service in anyone, any where, any time. Theses requiring items are going to be come true via IMT-2000 system. Transmitting signal bandwidth of IMT-2000 system is 3 times as large as IS-95 system. That is mean peak to average of signal is higher than IS-95A system. So we have to design it carefully not to effect in adjacent channel. HPA(High Power Amplifier) located in the end point of system is operated in 1-㏈ compression point(Pl㏈), then it generates 3rd and 5th inter modulation signals. Theses signals affect at adjacent channel and RF signal is distorted by compressed signal which is operated near by Pl㏈ point. Then the most important design factor is how we make HPA having high linearity. Feedback, Pre-distorter and Feed-forward methods are presented to solve theses problems. Feed-forward of these methods is having excellent improving capacity, but composed with complex structure. Generally, Linearity and Efficiency in power amplifier operate in the contrary, then it is difficult for us to find optimal operating point. In this paper we applied algorithm which searches optimal point of linear characteristics, which is key in Power Amplifier, using minimum current point of error amplifier in 1st loop. And we made 2nd loop compose with new structure. We confirmed fabricated LPA is operated by having high linearity and minimum current condition with ACPR of -26 ㏈m max. @ 30㎑ BW in 3.515㎒ and ACLR of 48 ㏈c max@${\pm}$㎒ from 1W to 40W.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2002.11a
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• pp.363-369
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• 2002

가정 내에서의 초고속망 이용이 활성화되면서 가정 내에서의 활동은 매우 다양하고 복잡하며 그에 따른 서비스도 여러 가지 형태가 존재한다. 외부 인터넷망과 연동되는 홈 네트워크의 개념이 생기기 전부터 흠 오토메이션, 홈시큐리티 등의 서비스를 제공하기 위한 고립적인 형태의 망과 서비스 제공 시스템이 있었다. 월드 와이드 웹 서비스를 기본으로 한 인터넷의 폭발적인 활성화와 고속 인터넷망의 확산에 따라 가정 내에서 제공되는 서비스를 인터넷과 연계시키려는 시도가 보편화되었고 가정 내에서 사용되는 독립적인 기기들을 인터넷에 연결하여, 외부의 정보를 이용해서 활용하거나, 가전내의 기기들을 외부에서 액세스할 수 있게 되었다. 이렇게 하여 보다 풍부한 서비스를 제공하고, 사용상의 시간적인 제약을 완화할 수 있다. 예들 들어 인터넷상에서 조리법을 전송받아 전자레인지를 작동할 수 있으며, 외부에서 잘못 켜둔 가스밸브를 잠글 수도 있다. 가정 내에서 wrhd되던 이러한 서비스들은 서로 다른 하드웨어와 통신방법을 사용하고 있어, 이러한 서비스를 통합하여 운영, 관리할 수 있도록 하는 흠 서버의 개념이 대두되었다. 외부 인터넷 망과 연계된 흠 오토메이션, 홈 시큐리티등을 제공할 수 있는 기반이 마련되었고, 가정 내에서 독립적으로 제공되던 서비스들을 단일 홈 서버를 통해서 관리하려는 시도가 진행되었다. 그러나 홈 서버는 개발하는 업체의 보유기술에 따라 중심기능은 약간씩 차이를 보이고 있다. 홈 서버 응용 영역은 전문 지식을 소유한 인력과의 연계가 필요하고, 다양한 서비스 영역 행위가 아주 복잡하기 때문에 이들을 연결해 주는 자치 시스템을 필요로 한다. 또한 홈 서버 서비스 영역에서 정보는 각 영역 전문가가 가진 지식의 전달을 필요로 하기 때문에, 지식을 주고받는 멀티 에이전트의 시스템의 활용 영역으로 적당하다. 멀티 에이전트 시스템은 분산된 환경에서 에이전트간에 에이전트 통신 언어를 사용해서 대화를 하기도 하고, 상호 협력하는 에이전트들로 구성된 시스템을 뜻하며 흠 서버처럼 동적이고 고도의 자치성을 요구하는 영역에 적당하다. 멀티 에이전트 플랫폼으로는 FIPA(Foundation for Intelligent Physical Agents)가 제시한 에이전트 표준 플랫폼이 1997년부터 2000년에 이르기까지, 계속적으로 변화, 발전하고 있다. 본 연구는 FIPA에서 제시하는 플랫폼을 기반으로 홈 서버에 정보가전을 제어하는 에이전트를 두고 외부에서 다른 에이전트가 홈 서버에 위치하는 에이전트와의 통신을 통하기 정보가전을 지능적으로 제어하도록 하였다. 정보가전 에이전트는 가정 내 가전제품을 외부에서 제어하기 위한 에이전트이다. 단순한 관리가 아닌 에이전트로 하여금 지능적으로 가전제품 관리를 하게 한다. 정보가전 에이전트는 홈 서버에서 작동하는 에이전트와 PDA에서 작동하는 에이전트로 구성된다. 정보가전 에이전트는 전력량, 수도 사용량 제어와 가전제품 제어 기능과 보안 관련 서비스를 제공한다. 두 에이전트는 FIPA에서 정의된 규격에 맞게 만들어지기 때문에 FIPA명세서를 따르는 다른 에이전트와 자유로운 통신이 가능하다.