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Antibacterial Activity of (2S)-7,4'-dihydroxy-5-methoxy-8-(${\gamma}$, ${\gamma}$-dimethylally)-flavanone against Methicillin-Resistant Staphylococcus aureus

  • Kim, Eun-Sook
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.3
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    • pp.704-709
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    • 2009
  • The emergence of methicillin-resistant of Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) has led to an urgent need for the discovery and development of new antibacterial agents. As part of an ongoing investigation into the antibacterial properties of the natural products, (2S)-7,4'-dihydroxy-5-methoxy-8-(${\gamma}$, ${\gamma}$-dimethylally)-f1avanone (2S-DMDF), isolated from the roots of Sophora flavescens, was found to be antibacterial active MRSA and VRE. Sophora flavescens has been used as antibacterial, antiviral, antiprotozoal, anti-inflammatory. Therefore, this study investigated the antibacterial activity of 2S-DMDF against all the bacterial strains tested. In this result, at the end point of an optically clear well, the minimum inhibitory concentrations (MICs) ranged from 0.97 to 15.6 mg/ml for 2S-DMDF, from 125 to 256 mg/ml for ampicillin, and from 64 to 512 mg/ml for gentamicin with MRSA, also, 7.8 to 15.6 mg/ml for 2S-DMDF, from 125 to 256 mg/ml for ampicillin, and from 512 to 1024< mg/ml for vacomicin with VRE. These findings indicated that the application of the tested 2S-DMDF alone might prove useful in the control and treatment of MRSA and VRE infections.

Study on the Annual Building Load Predicting Method using a Polynomial Function (다항함수를 이용한 건물의 연간부하 예측 방법에 관한 연구)

  • Yun, Hi-won;Choi, Seung-Hyuck;Ryu, Hyung-Kyou
    • Journal of the Korean Society for Geothermal and Hydrothermal Energy
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    • v.13 no.1
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    • pp.7-13
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    • 2017
  • In order to use and manage the building energy efficiently, it is necessary to minimize building energy consumptions, and establish operation plans of various equipment. The maximum heating and cooling load calculation is an essential way in various equipment selections, and the annual building load calculation is used in forecasting & evaluating the LCC required for operation plan. In this study, noting that the annual building load changes depending on outside temperature around year, we propose a predicting method of annual building load. By using the $4^{th}$ polynomial function that have two double radix and a feature the $f(x)=a^4$ in x = 0 condition, we can calculate annual building load very easily only with the two result (maximum heating and cooling load) and a minimum parameters.

Wideband VHF and UHF RF Front-End Receiver for DVB-H Application

  • Park, Joon-Hong;Kim, Sun-Youl;Ho, Min-Hye;Baek, Dong-Hyun
    • Journal of Electrical Engineering and Technology
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    • v.7 no.1
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    • pp.81-85
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    • 2012
  • This paper presents a wideband and low-noise direct conversion front-end receiver supporting VHF and UHFbands simultaneously. The receiver iscomposed of a low-noise amplifier (LNA), a down conversion quadrature mixer, and a frequency divider by 2. The cascode configuration with the resistor feedback is exploited in the LNA to achieve a wide operating bandwidth. Four gainstep modesare employed using a switched resistor bank and a capacitor bank in the signal path to cope with wide dynamic input power range. The verticalbipolar junction transistors are used as the switching elements in the mixer to reduce 1/f noise corner frequency. The proposed front-end receiver fabricated in 0.18 ${\mu}m$ CMOS technology shows very low minimum noise figureof 1.8 dB and third order input intercept pointof -12dBm inthe high-gain mode of 26.5 dBmeasured at 500 MHz.The proposed receiverconsumeslow current of 20 mA from a 1.8 V power supply.

Mirrors and Optomechanical Structures Design and Analysis for Linear Astigma-tism Free Three Mirror System (LAF-TMS)

  • Park, Woojin;Hammar, Arvid;Lee, Sunwoo;Chang, Seunghyuk;Kim, Sanghyuk;Jeong, Byeongjoon;Kim, Geon Hee;Kim, Daewook;Pak, Soojong
    • The Bulletin of The Korean Astronomical Society
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    • v.43 no.2
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    • pp.55.4-56
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    • 2018
  • Linear Astigmatism Free - Three Mirror System (LAF-TMS) is the linear astigmatism free off-axis wide field telescope with D = 150 mm, F/3.3, and $FOV=5.51^{\circ}{\times}4.13^{\circ}$. We report the design and analysis results of its mirrors and optomechanical structures. Tolerance allowance has been analyzed to the minimum mechanical tolerance of ${\pm}0.05mm$ that is reasonable tolerance for fabrication and optical alignment. The aluminum mirrors are designed with mounting flexure features for the strain-free mounting. From Finite Element Analysis (FEA) results of mounting torque and self-weight, we expect 33 - 80 nm RMS mirror surface deformations. Shims and the L-bracket are mounted between mirrors and the mirror mount for optical alignment. The mirror mount is designed with four light-weighted mechanical parts. It can stably and accurately fix mirrors, and it also suppresses some of stray light.

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Strength Properties of Permeable Block Using Basalt Waste Rock (현무암 폐석을 활용한 투수블록의 강도 특성)

  • Jeon, Eun-Yeong;Lee, Sang-Soo
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2023.05a
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    • pp.189-190
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    • 2023
  • Environmental pollution problems are occurring in Jeju Island due to negative treatment of basalt waste. Measures for various approaches and utilization measures are needed to solve the problem of waste stones that occur during basalt processing. In this study, the Properties of permeable blocks with basalt were identified and the applicability and functionality as building materials were reviewed. This experiment is basic data for evaluating the functionality of the permeable block by manufacturing permeable blocks using basalt waste stones and analyzing flexural strength and compressive strength. The higher the basalt waste stone replacement rate, the lower the flexural strength and compressive strength, but it was judged that 20% of basalt waste stone replacement rate that satisfies the minimum flexural strength (4.0MPa) stipulated in KS F 4419 was appropriate. In addition, additional permeability coefficient and absorption rate experiments tended to increase as the basalt lung stone replacement rate increased. Therefore, it is judged that the permeable block using basalt waste stone is superior to the existing permeable block.

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A clinical study of allergic rhinitis (알레르기 비염에 관한 임상적 연구)

  • 채병윤
    • The Journal of Korean Medicine
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    • v.21 no.3
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    • pp.149-165
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    • 2000
  • As recent developments of Immunology and Nuclear medicine, serum IgE and IgG values are helpful in the diagnosis and evaluation of the therapeutic effects of nasal allergies. But in Korea, air pollution and the increased use of food additives have become leading factors in nasal allergies, It seems to be induced by environmental change, especially industrialization and urbanization, so allergic rhinitis in our environment has changed in accordance with the changes made in the living environment. Therefore this study is attempted in order to observe a clinical analysis which places more importance on allergic rhinitis. We studied 200 patients who had visited Kyunghee Oriental Medical Center with allergic rhinitis from January 1, 1999 to December 31, 1999 The results were as follows: 1. The sex distribution was 114 males(57%) and 86 females(43%). In age distribution, the average age was 25. In males, ages ranged from 3 to 66 years old and the average was 23.81. In females, ages ranged from 4 to 67 years old and the average was 28.57. The peak age was 30~39 years old(24%); under 9 years old and 10~19 years old were each 18%; 20~29 years old was 22%; 40~49 years old was 11 %; over 50 years old 6.5%. The gulf between males and females showed a statistically significant difference(P<0.025). 2. In the age of onset, male' s maximum was 62.5, minimum was 0.25; female s maximum was 59.5, minimum was 0.2. Under 9 years old was the most with 34%(male 24%, female 10%), 10~19 years old was 18%, 20~29 years old was 22.5%, 30~39 years old was 13.50%, over 40 years old was 12%, The gulf between males and females were showed statistically significant difference.(p<0.014) 3. The average duration of the disease was 5.67 years. In male and female, the maximum was 30, the minimum was 0.05; under 5 years old was the most with 62%(male 34.50%, female 27.50%); 6~10 years old was 23%. So, under 10 years old was 85%. There was no statistically significant difference in the duration of disease. 4. Regarding type of residence, 47.50% of patients with allergic rhinitis lived in apartments, 52.50% lived in houses. In males, 29.50% lived in apartments, 27.50% lived in houses. In females, 18% lived in apartments, 25% lived in houses. There was no statistically significant difference in the residence by T-test and chi-test. 5. In the distribution of season, spring is the most with 29.5% of patients, winter 28%, fall 25.5%, and summer 17%. But there was no statistically significant difference. 6. After observing 200 patients with allergic rhinitis, classifying main symptoms into 5 types, sneezing was the main symptom in 177cases(88.50%), nasal obstruction in 176cases(88%), rhinorrhea in 169cases(84.5%), post nasal discharge in 87cases(43.50%), and itching in I04cases(52%). The Cumulus ration is 98.50% and symptoms overlapped with an average 3.57±0.1 times but in an analysis of variance of these symptoms, the gulf between males and females was not recognized as statistically significant by T-test and ANOVA. 7. Patients whose families have allergic diseases account for 90 cases(45%) : 49cases(24.50%) male and 41cases(20.50%) female. There were 4 cases (71.11 %) whose families have allergic rhinitis, 9cases(10%) of asthma, and 7.78% with allergic dermatitis. There were 61 (67.80%) cases of patients whose parents have allergic diseases; cases wherein the patient s child had allergic diseases numbered 13 (14.45%); and cases with a sibling with allergic diseases totalled 16cases (17.80%). There was no statistically significant difference in allergic disease regarding sex, parents, or siblings by chi-test. 8. Blood type: For males, type A is the most common, with 37cases(18.5%), followed by type B with 32cases(16%), type O 28cases(l4%) and type AB 13cases(6.5%). For females, type B is the most common, with 30cases(15%), followed by type O with 23cases(l1.5%), type A with 18cases(9%) and type AB with 13cases(6.5%). There was no statistically significant difference in blood type by chi-test. 9. In the selection of prefered food, most patients prefer cool food, with 98 such cases(49%), tepid food in 54cases(27%) and warm food in 48cases(24%). These showed a statistically significant difference in the selection of prefered food between males and females by chi-test(p<0.009). 10. The state of Past History was classified into II types. chronic hypertrophic rhinitis is the most common with 11cases (18.64%), tonsil and adenoid hypertrophy is 8cases(l3.56%), sinusitis is 6cases(10.17%), nasal septum deviation is 4cases, nasal polyp is 2cases, others are 10cases(l6.95%). No statistically significant difference in past history between males and females was shown, but a statistically significant difference was shown when males and females were compared with total cases by T-test(p<0.002, P<0.0008). 11. Regarding complications, 37 patients (28.91%) had sinusitis: 22cases(17.19%) in male, 15cases(11.72%) in female. Chronic hypertrophic rhinitis was found in 15cases(11.72%). Others are under 10%. There was no statistically significant difference in the type of complications between males and females, but a statistically significant difference was shown when males and females were compared with total cases by T-test(P<0.00l, P<0.007). 12. In the treatment, medication was used 1691 times, an average of 2.58 times. No.34 was used 370 times for 124 cases, an average of 2.98 times. No. 152 was used 318 times for 106 cases, an average of 3.00 times. No.151 was used 307 times for 97cases, an average of 3.16 times. No. 31 was used 117 times for 33 cases, an average of 3.55 times. No 25 was used 116 times for 33 cases, an average of 3.52 times. 13. In the duration of treatment, the most frequent is 1 week(69cases, 34.50%), the maximum is 20weeks, and the minimum is 1week. A treatment period of 2~3 weeks accounted for 32% of cases, a period of 4~5weeks accounted for 13.5%. The gulf between males and females showed a statistically significant difference in the duration of treatment.(p<0.01). There was a statistical significance when the males were compared with total cases by ANOVA(P<0.03). 14. A comparison between before-treatment and after-treatment showed a statistically significant difference in treatment by T-test (p<0.01) and F-test (p<0.0058).

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Study on Low Temperature Tolerant Methane-Producing Bacteria for the Treatment of Agricultural and Livestock Wastes (농축산(農畜産) 폐기물(廢棄物) 처리(處理)를 위(爲)한 저온내성(低溫耐性) 메탄 생성균(生成菌)의 특성(特性)에 관(關)한 연구(硏究) II. 저온내성(低溫耐性) Clostridia 의 분리(分離))

  • Jung, Kwang-Yong;Kim, Jai-Joung;Daniels, Lacy
    • Korean Journal of Environmental Agriculture
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    • v.13 no.3
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    • pp.311-320
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    • 1994
  • This study was conducted to investigate the biochemical properties of isolated bacteria, low temperature tolerant methane-producing clostridia which were selected for using them as inoculum to anaerobic fermentation of agricultural and livestock wastes at low temperature. The results were; 1. Low temperature tolerant methane-producing clostridia were isolated from the samples which showed the high methanogenesis rate by enrichment culture at low temperature in cellulose medium. These clostridia, Clostridium botulinum SRC-64, Clostridium scatologens SRC-91 and Clostridium tyrobutyricum SRC-100, were isolated from swampy sediment at latitude $56.9^{\circ}N$, lake sediment IV at latitude $55.0^{\circ}N$, and tidal land soil II at latitude $37.0^{\circ}N$, respectively. The optimum growth temperature for these isolates was $37^{\circ}C$ and the minimum, around $10^{\circ}C$. They all had detectable amount of $F_{420}$, specific coenzyme of methanogens. 2. As anaerobic fermentation products of glucose SRC-64 produced $H_2$, acetic, isovaleric and caproic acid, SRC-91 produced $H_2$, propionic, butyric, valeric, and caproic acid, and SRC-100 produced only acetic and propionic acid. The isolates were produced $CH_4$ ranged from 2.6 to 8.68 n moles/ml for 2 days at $13^{\circ}C$.

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High-performance 94 GHz Single Balanced Mixer Based On 70 nm MHEMT And DAML Technology (70 nm MHEMT와 DAML 기술을 이용한 우수한 성능의 94 GHz 단일 평형 혼합기)

  • Kim Sung-Chan;An Dan;Lim Byeong-Ok;Beak Tae-Jong;Shin Dong-Hoon;Rhee Jin-Koo
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.43 no.4 s.346
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    • pp.8-15
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    • 2006
  • In this paper, the 94 GHz, low conversion loss, and high isolation single balanced mixer is designed and fabricated using GaAs-based metamorphic high electron mobility transistors (MHEMTs) with 70 nm gate length and the hybrid ring coupler with the micromachined transmission lines, dielectric-supported air-gapped microstrip lines (DAMLs). The 70 nm MHEMT devices exhibit DC characteristics with a drain current density of 607 mA/mm an extrinsic transconductance of 1015 mS/mm. The current gain cutoff frequency ($f_T$) and maximum oscillation frequency ($f_{max}$) are 320 GHz and 430 GHz, respectively. The fabricated hybrid ring coupler shows wideband characteristics of the coupling loss of $3.57{\pm}0.22dB$ and the transmission loss of $3.80{\pm}0.08dB$ in the measured frequency range of 85 GHz to 105 GHz. This mixer shows that the conversion loss and isolation characteristics are $2.5dB{\sim}>2.8dB$ and under -30 dB, respectively, in the range of $93.65GHz{\sim}94.25GHz$. At the center frequency of 94 GHz, this mixer shows the minimum conversion loss of 2.5 dB at a LO power of 6 dBm To our knowledge, these results are the best performances demonstrated from 94 GHz single balanced mixer utilizing GaAs-based HEMTs in terms of conversion loss as well as isolation characteristics.

Preparation and Characterization of Anti-reflective and Anti-static Double Layered Films by Sol-Gel Spin-Coating Method (졸-겔 스핀코팅법에 의한 반사방지 및 정전기방지 복층막의 제조 및 특성)

  • 이준종;최세영
    • Journal of the Korean Ceramic Society
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    • v.34 no.1
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    • pp.79-87
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    • 1997
  • Anti-reflective and anti-static double layered films were prepared on the VDT panel by sol-gel spin-coating method. Their electrical, opticla, and mechanical properties were investigated. The outer SiO2 film with low re-fractive index was coated over the inner ATO(Antimony-doped Tin Oxide)-SiO2 film which was prepared by mixing ATO sol with SiO2 at molar ratio of 68:32 to satisfy the interference condition of double layers. The heat treatment was conducted at 45$0^{\circ}C$ for 30 min where residual organics were completely removed. The sheet resistance of ATO single layer showed the minimum value of 6$\times$107$\Omega$/$\square$ at 3 mol% addition of Sb and that of SiO2/ATO-SiO2 increased slightly with increasing SiO2 mol% up to 30 mol%, and then increased steeply to the value of 3$\times$108$\Omega$/$\square$ at 32 mol%. The reflectance of double layered films was about 0.64% at the wavelength of 550nm and the transmittance increased about 3.20%. The hardness of double layered films was almost the same as that of uncoated VDT panel, 471.4kg.f/mm2.

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Thermal Characteristics of Waste Organic Sludges Discharged from an Chemical Product Manufacturing Industry (화학제품제조업에서 배출되는 폐 유기성슬러지의 열적 특성)

  • Kim, Min-Choul;Lee, Gang-Woo;Lee, Man-Sig;Shon, Byung-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.9 no.6
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    • pp.1745-1753
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    • 2008
  • We analyzed the physical and chemical properties such as proximate analysis, ultimate analysis, heating values, thermogravimetric analysis, and combustion test for the organic sludge discharged from chemical and petrochemical product manufacturing industries in the industrial complex. The average combustible and ash content of organic sludges from chemical and petrochemical product manufacturing industries were 17.42%, 7.45%, and 18.25%, 4.22%, respectively. The C, H, O, N, and S compositions for chemical and petrochemical product manufacturing industries were 33.06, 4.34, 24.81, 5.18, and 0.72%. And those compositions for petrochemical product manufacturing industries were 36.58, 4.74, 26.79, 5.09, and 0.49%, respectively. From the TGA test, the minimum temperature for combustion of the sludge discharged from B company was $700^{\circ}C$ for direct use for energy and 2 sludges(F and N companies) were about $600^{\circ}C$. According to the basic combustion test, high concentration of CO was formed because oxidation and pyrolysis reaction take place in the batch type reactor at the same time. From this phenomena we could obtain the significant data for the overheating and breakage of furnace.