Browse > Article

Antibacterial Activity of (2S)-7,4'-dihydroxy-5-methoxy-8-(${\gamma}$, ${\gamma}$-dimethylally)-flavanone against Methicillin-Resistant Staphylococcus aureus  

Kim, Eun-Sook (Vestibulocochlear Research Center & Department of Microbiology, School of Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.3, 2009 , pp. 704-709 More about this Journal
Abstract
The emergence of methicillin-resistant of Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) has led to an urgent need for the discovery and development of new antibacterial agents. As part of an ongoing investigation into the antibacterial properties of the natural products, (2S)-7,4'-dihydroxy-5-methoxy-8-(${\gamma}$, ${\gamma}$-dimethylally)-f1avanone (2S-DMDF), isolated from the roots of Sophora flavescens, was found to be antibacterial active MRSA and VRE. Sophora flavescens has been used as antibacterial, antiviral, antiprotozoal, anti-inflammatory. Therefore, this study investigated the antibacterial activity of 2S-DMDF against all the bacterial strains tested. In this result, at the end point of an optically clear well, the minimum inhibitory concentrations (MICs) ranged from 0.97 to 15.6 mg/ml for 2S-DMDF, from 125 to 256 mg/ml for ampicillin, and from 64 to 512 mg/ml for gentamicin with MRSA, also, 7.8 to 15.6 mg/ml for 2S-DMDF, from 125 to 256 mg/ml for ampicillin, and from 512 to 1024< mg/ml for vacomicin with VRE. These findings indicated that the application of the tested 2S-DMDF alone might prove useful in the control and treatment of MRSA and VRE infections.
Keywords
Sophora flavescens; enterotoxin gene; (2S)-7,4'-dihydroxy-5-methoxy-8-(${\gamma}$, ${\gamma}$-dimethylally)-flavanone; MRSA; VRE;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 da Cunha Mde, L., Calsolari, R.A., Júnior, J.P. Detection of enterotoxin and toxic shock syndrome toxin 1 genes in Staphylococcus, with emphasis on coagulase-negative staphylococci. Microbiol Immunol. 51: 381-390, 2007   DOI   PUBMED   ScienceOn
2 Schlievert, P.M., Shands, K.N., Dan, B.B., Schmid, G.P., Nishimura, R.D. Identification and characterization of an exotoxin from Staphylococcus aureus associated with toxic-shock syndrome. J Infect Dis. 143: 509-516, 1981   DOI   PUBMED   ScienceOn
3 Linton, A.H., Hedges, A.J., Bennett, P.M. Monitoring for the development of antimicrobial resistance during the use of olaquindox as a feed additive on commercial pig farms. J Appl Bacteriol. 64: 311-327, 1988   DOI
4 Botta, B., Vitali, A., Menendez, P., Misiti, D., Delle Monache, G. Prenylated flavonoids: pharmacology and biotechnology. Curr Med Chem. 12: 717-739, 2005   PUBMED
5 Ryffel, C., Tesch, W., Birch-Machin, I., Reynolds, P.E., Barberis-Maino, L., Kayser, F.H., Berger-B$\ddot{a}$chi, B. Sequence comparison of mecA genes isolated from methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. Gene. 28: 137-138, 1990
6 Tsiodras, S., Gold, H.S., Sakoulas, G., Eliopoulos, G.M., Wennersten, C., Venkataraman, L., Moellering, R.C., Ferraro, M.J. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet. 358: 207-208, 2001   DOI   ScienceOn
7 Toh, S.M., Xiong, L., Arias, C.A., Villegas, M.V., Lolans, K., Quinn, J., Mankin, A.S. Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol. 64: 1506-1514, 2007   DOI   ScienceOn
8 Syu, W.J., Shen, C.C., Lu, J.J., Lee, G.H., Sun, C.M. Antimicrobial and cytotoxic activities of neolignans from Magnolia officinalis. Chem Biodivers. 1: 530-537, 2004   DOI   ScienceOn
9 Xiang, Q., Tan, M.Q., Huang, Y.H. Anti-leukemia effect of sophora flavescens combined with the low molecular weight natural tumor suppressor of the human fetal liver and its mechanism. Hunan Yi. Ke Da Xue Xue Bao. 27: 108-110, 2002   PUBMED
10 Son, J.K., Park, J.S., Kim, J.A., Kim, Y., Chung, S.R., Lee, S.H. Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med. 69: 559-561, 2003   DOI   ScienceOn
11 Kim, S.J., Son, K.H., Chang, H.W., Kang, S.S., Kim, H.P. Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens. Biol Pharm Bull. 26: 1348-1350, 2003   DOI   ScienceOn
12 Kang, S.S., Kim, J.S., Son, K.H., Chang, H.W., Kim, H.P. A new prenylated flavanone from the roots of Sophora flavescens. Fitoterapia, 71: 511-515, 2000   DOI   ScienceOn
13 Jung, H.J., Kang, S.S., Woo, J.J., Choi, J.S. A new lavandulylated flavonoid with free radical and ONOO- scavenging activities from Sophora flavescens. Arch Pharm Res. 28: 1333-1336, 2005   과학기술학회마을   DOI   ScienceOn
14 Kang, T.H., Jeong, S.J., Ko, W.G., Kim, N.Y., Lee, B.H., Inagaki, M., Miyamoto, T., Higuchi, R., Kim, Y.C. Cytotoxic lavandulyl flavanones from Sophora flavescens. J Nat Prod. 63: 680-681, 2000   DOI   ScienceOn
15 Becker, K., Roth, R., Peters, G. Rapid and specific detection of toxigenic Staphylococcus aureus: use of two multiplex PCR enzyme immunoassays for amplification and hybridization of staphylococcal enterotoxin genes, exfoliative toxin genes, and toxic shock syndrome toxin 1 gene. J Clin Microbiol. 36: 2548-2553, 1998   PUBMED
16 Piao, X.L., Piao, X.S., Kim, S.W., Park, J.H., Kim, H.Y., Cai, S.Q. Identification and characterization of antioxidants from Sophora flavescens. Biol Pharm Bull. 29: 1911-1915, 2006   DOI   ScienceOn
17 Dai, S., Chan, M.Y., Lee, S.S., Ogle, C.W. The antiarrhythmic effects of Sophora flavescens Ait. in rats and mice. Am J Chin Med. 14: 119-123, 1986   DOI   ScienceOn
18 Hatano, T., Shintani, Y., Aga, Y., Shiota, S., Tsuchiya, T., Yoshida, T. Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull (Tokyo). 48: 1286-1292, 2000   DOI   PUBMED   ScienceOn
19 Kang, T.H., Jeong, S.J., Ko, W.G., Kim, N.Y., Lee, B.H., Inagaki, M., Miyamoto, T., Higuchi, R., Kim, Y.C. Cytotoxic lavandulyl flavanones from Sophora flavescens. J Nat Prod. 63: 680-681, 2000   DOI   ScienceOn
20 Kim, J.H., Ryu, Y.B., Kang, N.S., Lee, B.W., Heo, J.S., Jeong, I.Y., Park, K.H. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 29: 302-305 2006   PUBMED
21 Fukai, T., Oku, Y., Hou, A.J., Yonekawa, M., Terada, S. Antimicrobial activity of hydrophobic xanthones from Cudrania cochinchinensis against Bacillus subtilis and methicillin-resistant Staphylococcus aureus. Chem Biodivers. 1:1385-1390, 2004   DOI   ScienceOn
22 Chi, Y.S., Jong, H.G., Son, K.H., Chang, H.W., Kang, S.S., Kim, H.P. Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases. Biochem Pharmacol. 62: 1185-1191, 2001   DOI   ScienceOn
23 Brewer, J.D., Hundley, M.D., Meves, A., Hargreaves, J., McEvoy, M.T., Pittelkow, M.R. Staphylococcal scalded skin syndrome and toxic shock syndrome after tooth extraction. J Am Acad Dermatol. 59: 342-346, 2008   DOI   ScienceOn
24 Clinical and Laboratory Standards Institute. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: Approved standard 9th ed. Document M100-S19. Clinical and Laboratory Standards Institute, Villanova, Pa, USA, 2009
25 Shahverdi, A.R., Fakhimi, A., Zarrini, G., Dehghan, G., Iranshahi, M. Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus. Biol Pharm Bull. 30: 1805-1807, 2007   DOI   ScienceOn
26 Fujita, N. Vancomycin-resistant Enterococci (VRE)--for VRE endemics in apan. Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi. 16: 1-16, 2005   PUBMED
27 Heslop, A., Ovesen, T. Severe acute middle ear infections: microbiology and treatment. Int J Pediatr Otorhinolaryngol. 70: 1811-1816, 2006   DOI   ScienceOn
28 Coque, T.M., Tomayko, J.F., Ricke, S.C., Okhyusen, P.C., Murray, B.E. Vancomycin-resistant enterococci from nosocomial, community, and animal sources in the United States. Antimicrob Agents Chemother. 40: 2605-2609, 1996   PUBMED
29 Fukai, T., Marumo, A., Kaitou, K., Kanda, T., Terada, S., Nomura, T. Antimicrobial activity of licorice flavonoids against methicillin-resistant Staphylococcus aureus. Fitoterapia. 73: 536-539, 2002   DOI   ScienceOn
30 Aucken, H.M., Ganner, M., Murchan, S., Cookson, B.D., Johnson, A.P. A new UK strain of epidemic methicillin-resistant Staphylococcus aureus (EMRSA-17) resistant to multiple antibiotics. J Antimicrob Chemother. 50: 171-175, 2002   DOI   ScienceOn
31 Sun, M., Han, J., Duan, J., Cui, Y., Wang, T., Zhang, W., Liu, W., Hong, J., Yao, M., Xiong, S., Yan, X. Novel antitumor activities of Kushen flavonoids in vitro and in vivo. Phytother Res. 21: 269-277, 2007   DOI   ScienceOn
32 Rosec, J.P., Guiraud, J.P., Dalet, C., Richard, N. Enterotoxin production by staphylococci isolated from foods in France. Int J Food Microbiol. 35: 213-221, 1997   DOI   ScienceOn
33 Kim, D.W., Chi, Y.S., Son, K.H., Chang, H.W., Kim, J.S., Kang, S.S., Kim, H.P. Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response. Arch Pharm Res. 25: 329-335, 2002   DOI   ScienceOn
34 Hwang, J.S., Lee, S.A., Hong, S.S., Lee, K.S., Lee, M.K., Hwang, B.Y., Ro, J.S. Monoamine oxidase inhibitory components from the roots of Sophora flavescens. Arch Pharm Res. 28: 190-194, 2005   DOI   ScienceOn
35 Rice, L.B. Antimicrobial resistance in gram-positive bacteria. Am J Infect Control. 34: S11-S9, 2006   DOI   PUBMED   ScienceOn
36 Pajor, A., Durko, M., Jankowski, A., Stańczyk, A. Bartoszko-Tyczkowska, Bacteriological evaluation in chronic otitis media. Otolaryngol Pol. 60: 757-763, 2006   PUBMED
37 Sato, M., Tanaka, H., Tani, N., Nagayama, M., Yamaguchi, R. Different antibacterial actions of isoflavones isolated from Erythrina poeppigiana against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. 43: 243-248, 2006   DOI   ScienceOn
38 Zhang, L., Xu, L., Xiao, S.S., Liao, Q.F., Li, Q., Liang, J., Chen, X.H., Bi, K.S. Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry. J Pharm Biomed Anal. 44: 1019-1028, 2007   DOI   ScienceOn
39 De Naeyer, A., Vanden Berghe, W., Pocock, V., Milligan, S., Haegeman, G., De Keukeleire, D. Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. J Nat Prod. 67: 1829-1832, 2004   DOI   ScienceOn