• 제목/요약/키워드: miR-29a

검색결과 226건 처리시간 0.034초

아동병원 간호사의 감염관리조직문화, 감염예방환경이 감염관리 수행에 미치는 영향 (Factors Influencing Infection Control Performance by Children's Hospital Nurses Infection Control Organizational Culture and Infection Prevention Environment)

  • 양현미
    • 한국산업융합학회 논문집
    • /
    • 제27권3호
    • /
    • pp.675-684
    • /
    • 2024
  • The purpose of the study is to determine the relationship between the infection control organizational culture, infection prevention environment, and infection control performance of nurses at a children's hospital and to identify factors affecting infection control performance. The subjects of the study were 160 nurses from five children's hospitals, and data collection was conducted from February 19 to 29, 2024. Data analysis was performed using frequency, percentage, mean, standard deviation, and difference analysis of variables using t-test, ANOVA, Pearson's correlation analysis, and multiple regression analysis. As a result of the study, infection control performance was positively correlated with infection control organizational culture (r= .610, p< .001) and infection prevention environment (r= .586, p< .001), and as a result of multiple regression analysis, infection control organization The influencing factors appeared in the following order: culture (β= .369), infection prevention environment (β= .312), medical institution accreditation evaluation experience (β= .165), and infection control education experience (β= .137), and the overall explanatory power was It was 50.8% (F=41.966, p< .001). Based on the results of this study, to carry out infection control in children's hospitals, integrated management including the will and effort of individual nurses, support and policy from medical institutions and the government is needed, and the development of an infection control education program that takes into account the special characteristics of children's hospital nurses. Application is necessary.

Anterior Lumbar Interbody Fusion with Stand-Alone Interbody Cage in Treatment of Lumbar Intervertebral Foraminal Stenosis : Comparative Study of Two Different Types of Cages

  • Cho, Chul-Bum;Ryu, Kyeong-Sik;Park, Chun-Kun
    • Journal of Korean Neurosurgical Society
    • /
    • 제47권5호
    • /
    • pp.352-357
    • /
    • 2010
  • Objective : This retrospective study was performed to evaluate the clinical and radiological results of anterior lumbar interbody fusion (ALIF) using two different stand-alone cages in the treatment of lumbar intervertebral foraminal stenosis (IFS). Methods : A total of 28 patients who underwent ALIF at L5-S1 using stand-alone cage were studied [Stabilis$^{(R)}$ (Stryker, Kalamazoo, MI, USA); 13, SynFix-LR$^{(R)}$ (Synthes Bettlach, Switzerland); 15]. Mean follow-up period was 27.3 ${\pm}$ 4.9 months. Visual analogue pain scale (VAS) and Oswestry disability index (ODI) were assessed. Radiologically, the change of disc height, intervertebral foraminal (IVF) height and width at the operated segment were measured, and fusion status was defined. Results : Final mean VAS (back and leg) and ODI scores were significantly decreased from preoperative values (5.6 ${\pm}$ 2.3 ${\rightarrow}$ 2.3 ${\pm}$ 2.2, 6.3 ${\pm}$ 3.2 ${\rightarrow}$1.6 ${\pm}$ 1.6, and 53.7 ${\pm}$ 18.6 ${\rightarrow}$ 28.3 ${\pm}$ 13.1, respectively), which were not different between the two devices groups. In Stabilis$^{(R)}$ group, postoperative immediately increased disc and IVF heights (10.09 ${\pm}$ 4.15 mm ${\rightarrow}$ 14.99 ${\pm}$ 1.73 mm, 13.00 ${\pm}$ 2.44 mm ${\rightarrow}$ 16.28 ${\pm}$ 2.23 mm, respectively) were gradually decreased, and finally returned to preoperative value (11.29 ${\pm}$ 1.67 mm, 13.59 ${\pm}$ 2.01 mm, respectively). In SynFix-LR$^{(R)}$ group, immediately increased disc and IVF heights (9.60 ${\pm}$ 2.82 mm ${\rightarrow}$ 15.61 ${\pm}$ 0.62 mm, 14.01 ${\pm}$ 2.53 mm ${\rightarrow}$ 21.27 ${\pm}$ 1.93 mm, respectively) were maintained until the last follow up (13.72 ${\pm}$ 1.21 mm, 17.87 ${\pm}$ 2.02 mm, respectively). The changes of IVF width of each group was minimal pre- and postoperatively. Solid arthrodesis was observed in 11 patients in Stabilis group (11/13, 84.6%) and 13 in SynFix-LR$^{(R)}$ group (13/15, 86.7%). Conclusion : ALIF using stand-alone cage could assure good clinical results in the treatment of symptomatic lumbar IFS in the mid-term follow up. A degree of subsidence at the operated segment was different depending on the device type, which was higher in Stabilis$^{(R)}$ group.

섬망환자의 라이프케어를 위한 간호학생의 섬망간호 수행 영향요인 (Influencing Factors of Nursing Performance for Life Care of Delirium Patients among Nursing Students)

  • 오효숙;장미영
    • 한국엔터테인먼트산업학회논문지
    • /
    • 제13권4호
    • /
    • pp.401-410
    • /
    • 2019
  • 병원 입원환자들이 갈수록 고령화되고 질병의 중증도가 높아져서 섬망 발생율이 증가하고 있다. 본 연구는 간호학생들을 대상으로 섬망지식, 섬망간호 자신감과 섬망간호 수행도를 파악하고, 이들 요인들이 섬망간호 수행도에 미치는 영향을 규명함으로써 섬망간호 교육전략에 기초자료를 제공하고자 시도하였다. 연구 대상자는 G시에 소재한 3개교의 간호학과 4학년 학생 252명이며, 자료수집 방법은 2017년 4월부터 9월까지 구조화된 설문지를 통하여 수집하였다. 섬망지식은 조귀래(2001)가 개발하고 박용숙(2011) 수정한 도구, 섬망간호 자신감은 Akechi 등(1996)이 개발하고 김문자(2014)가 번역하고 수정 보완한 도구, 섬망간호 수행은 서희정과 유양숙(2006)이 개발한 도구를 김미영과 은영(2013)이 수정 보완한 도구를 사용하였다. 수집된 섬망간호 수행에 영향요인에 대한 자료는 단계적 다중 회귀분석으로 분석하였다. 대상자의 섬망 지식은 47점 만점에 29.0점, 섬망간호 자신감은 150점 만점에 71.7점, 섬망간호 수행은 69점 만점에 41.2점으로 나타났다. 대상자의 일반적 특성에 따른 섬망간호 수행은 섬망환자 경험(t=7.719, p<.001), 섬망 간호진단 사용 경험(t=4.850, p=<.001), 섬망간호 교육(t=3.039, p=.003), 임상실습 만족도(t=3.526, p=.001), 섬망환자 경험 부서(t=3.446, p=.001), 중환자실 실습 경험(t=5.349, p<.001)에 따라 유의한 차이를 나타냈다. 섬망간호 수행은 섬망 지식(r=.140, p=.026)과 섬망간호 자신감(r=.341, p<.001) 간에 유의한 순 상관관계가 있었다. 섬망간호 수행에 가장 주요한 예측 요인은 섬망환자 간호 경험(β=.314, p<.001) 섬망간호 자신감(β=.174, p=.003), 중환자실 실습 경험(β=.170, p=.001), 섬망 간호진단 사용경험(β=.129,p=.026), 실습만족도(β=.109, p=.048)의 순으로 나타났다. 모형의 설명력은 28.8%였다(F=22.307, p<.001). 본 연구결과, 간호학생들의 섬망간호 수행을 높이기 위해 섬망환자 간호 경험, 섬망간호 자신감, 중환자실 실습 경험, 섬망관련 간호진단, 실습만족도를 고려한 섬망간호 교육전략의 개발이 필요하다.

제오급와동(第五級窩洞) 수복(修復)에 사용(使用)되는 수종(數種) 충전재(充塡材)의 변연누출(邊緣漏出) 비교(比較) (COMPARISON OF THE MARGINAL LEAKAGE OF SEVERAL FILLING MATERIALS ON CLASS V CAVITIES)

  • 김미옥;조규징
    • Restorative Dentistry and Endodontics
    • /
    • 제14권2호
    • /
    • pp.20-29
    • /
    • 1989
  • 발거된 소구치 80개의 협, 설면에 교합면쪽의 법량질변연과 치은쪽의 상아질변연을 부여한 제 5급와동을 형성한 후, 각 20개씩 4개의 군으로 나누었다. 각 군별로 초미세입자형 광중합 복합레진과 법랑질접착체인 Durafill$^{(R)}$-Durafill bond$^{(R)}$, Bisfil M$^{(R)}$-Resin bond$^{(R)}$, 초미세입자형 복합레진과 상아질 접착제인 Silux$^{(R)}$-Scotchbond$^{(R)}$ 그리고 글라스 아이오노머 시멘트인 Fuji ionomer$^{(R)}$로 충전하였다. 온도변화는 $40^{\circ}C$$60^{\circ}C$의 2% methylene blue 용액에 각각 30초간 침척을 반복시킨 후 $37^{\circ}C$ 동용액에 24시간 경과시켜 법랑질변연부와 상아질변연부에서의 색소침투를 관찰하므로써 변연누출의 정도률 비교한 바 다움과 같은 결과를 얻었다. 1. 법랑질변연부에서 Durafill$^{(R)}$-Durafill bond$^{(R)}$, Bisfil M$^{(R)}$-Resin bond$^{(R)}$ 및 Silux$^{(R)}$-Scotchbond$^{(R)}$군 상호간에는 대차가 없었으나(P>0.05), 3군 공히 Fuji ionomer$^{(R)}$군보다는 변연누출이 적었다(P<0.01). 2. 상아질변연부에서는 Silux$^{(R)}$-Scotchbond$^{(R)}$군과 Fuji ionomer$^{(R)}$군이 각각 Durafill$^{(R)}$-Durafill bond$^{(R)}$군 및 Bisfil M$^{(R)}$-Resin bond$^{(R)}$군에 비해 변연누출이 적었다(P<0.01). 3. 충전한 모든군의 5급 와동에서 법랑질변연부가 상아질변연부보다 변연누출이 적었다(P<0.01).

  • PDF

보육교사의 전염성 질환에 대한 지식 및 전염성 질환 아동 관리 실태 (Knowledge and Management of Children with Infectious Diseases by Daycare Facility Teachers)

  • 박선남;이영란;정영주;김경미
    • 한국보건간호학회지
    • /
    • 제24권1호
    • /
    • pp.115-125
    • /
    • 2010
  • Purpose: This study was conducted to investigate the knowledge of infectious diseases and the management of children with infectious diseases among daycare facility teachers. Methods: This study was based on survey questionnaires completed by 122 day care facility teachers from 36 daycare center sin one district in Seoul. Results: Seventy three (72.8%) of the participating daycare facility teachers had not received infectious disease prevention education. They recognized that they did not have enough knowledge of infectious diseases. The average knowledge level of infectious diseases was scored as 9.30 on a 0-30 scale, with 0 representing no knowledge and 30 expert knowledge, and compliance level of management of children with infectious diseases was scored as 4.29 on a 0-16 scale, with 0 present no compliance and 16 representing total compliance Confidence of management of children with infectious diseases (r=0.24, p=.031) and the compliance level of management (r=0.35, p=.001) were higher with increased knowledge of infectious diseases. Conclusions: Daycare facility teacher scan lack sufficient knowledge about b infectious diseases. The education about infectious diseases and management of children with infectious diseases is indispensable to prevent trans mission of infectious diseases in daycare facilities.

Factors Associated with Attendance in a Nutrition Education Program for Hyperlipidemic Patients

  • Yim, Kyeong-Sook;Kim, Young-Joo;Cho, Young-Yun;Rha, Mi-Yong;Kim, Duk-Kyoung
    • Journal of Community Nutrition
    • /
    • 제3권1호
    • /
    • pp.21-29
    • /
    • 2001
  • This study was conducted to examine factors with attendance in hyperlipidemia nutrition eduction program among 101 hyperlipidemic outpatients (38 males 63 females) at Samsung Medical Center We employed the Health Belief Model (HBM) as the theoretical framework The individual nutrition education and counseling program was scheduled with 4- half hour session sin 2 to 4 weeks intervals. Upon initiation of the program a trained dietitian surveyed HBM constructs and psychosocial factors. The following were included perceived susceptibility to cardiovascular disease(CVD) perceived severity to CVD percieved benefits to diet modification perceived barriers to persistence in maintaining therapy and self efficicacy and social support from family Sociodemographic data health factors stress level nutrition knowledge, and 24-hour dietary recall behavior were also surveyed All these data was analyzed according to the number of nutrition sessions attended The subjects were 55.9$\pm$9.4 year old and 24.6$\pm$kg/㎡ Sociodemographic factors were not associated with the number of nutrition sessions attended HBM constructs and psychosocial factors were significantly associated with the number of nutrition sessions attended. According to Spearman correlation coefficients. From stepwis regression analyses using HBM constructs as independent variables perceive barriers to persistence in maintaining diet therapy (negative) proved to be the strongest predictors for the number of nutrition sessions attended (partial R$^2$= 72.3%) followed by perceived severity to CVD and self efficacy (model R$^2$=76.6% The findings indicate that HBM constructs and psychosocial factors were closely associated with patient attendance It suggests that information and guidance to minimize patients perceived barriers to diet therapy might help to improve patients to scheduled appointments in nutrition education programs.

  • PDF

기관지천식 환자에서 유도객담으로 평가한 기도염증과 기관지 과민성과의 관계 (Relationship Between Airway Inflammation Assessed by Induced Sputum and Airway Hyperresponsiveness in Asthmatic Patient)

  • 정이영;김현진;정경원;강미정;김휘종;정효영;이종덕;황영실
    • Tuberculosis and Respiratory Diseases
    • /
    • 제47권4호
    • /
    • pp.517-524
    • /
    • 1999
  • 배 경: 기관지천식은 만성적인 기도염증질환으로서 기도염증으로 인해 기도 과민성과 가역적인 기도폐쇄양상을 나타내는 것으로 알려져 있다. 기도염증의 정도를 측정하는데 있어서 유도객담이 내시경을 이용한 방법보다 비침습적이고 안전하며 반복적으로 시행할 수 있는 믿을 만한 검사 방법으로 인정을 받고 있다. 그래서 본 연구에서는 유도객담을 이용하여 기도염증과 기관지 과민성간의 상관관계를 관찰하였다. 방 법 : 기관지천식의 기왕력이 있는 17명의 환자를 대상으로 검사 시작 4주 이내에 호흡기 감염이 있었거나 객담을 배출할 수 없는 환자는 제외시켜 15명이 연구에 참가하였다. 기도염증의 정도를 측정하기 위해 고장성 생리식염수(3%)로 유도객담을 채취한 후 타액과 분리한 객담 1cc를 pippet을 사용하여 15ml conical tube에 옮긴다. 4cc의 dithiothreitol 0.1%용액(Sputalysin 10%, Calbiochem Corp., San Diego, California.)과 이 용액의 완충제인 Dulbecco's phosphate buffered saline 4cc를 사용하여 처리한 다음 염증세포수와 ECP를 측정하였다. 기관지 과민성을 알기 위해 메타콜린 기관지 유발시험을 시행하여 $PC_{20}$을 구하였다. 결 과 : 기저치 폐기능검사상 $FEV_1$은 예측치의 $76.3{\pm}30.3%$였고 유도객담 검사상 대식세포 수, 호중구, 호산구, 림프구는 각각 $39.1{\pm}27.0%$, $29.6{\pm}21.0%$, $28.8{\pm}18.8%$, $1.3{\pm}3.1%$였다. 유도객담 내의 ECP농도는 평균 $1,101{\pm}833\;{\mu}g/L$였고, 기하평균 $PC_{20}$은 0.56 mg/mL로 나왔다. 유도객담 내의 ECP농도는 유도객담 내의 호산구 수와 유의한 양의 상관관계(r=0.81, p<0.05)가 있었고, 가저치 폐기능검사 결과($FEV_1$)와는 유의한 역상관관계(r=-0.62, p<0.05)를 보였다. 유도객담 내 호산구 수와 메타콜린 기관지 유발시험에 의한 $PC_{20}$간에는 유의한 역상관관계(r=-0.78, p<0.05)를 보였으나, 호중구 수와 $PC_{20}$사이에는 유의한 상관관계(r=0.11, p=0.69)를 나타내지 않았다. 결 론 : 유도객담은 천식환자에서 기도염증의 정도를 반영하는 안전하면서도 유용한 검사이며 호산구의 침윤으로 인한 기도염증이 기관지천식 환자에서 기관지 과민성을 유발시키는 주요한 원인인자로서 관여할 것으로 생각된다.

  • PDF

간호대학생의 임상실습 동안 적용한 SBAR 보고교육이 의사소통명 확성, 의사소통만족도, 보고자신감과 의사소통능력에 미치는 효과 (The Effects of SBAR Report Education on Communication Clarity, Communication Satisfaction, Reporting Confidence and Communication competency in Clinical Practice of Nursing Students)

  • 정애화;김지영;문미영
    • 한국응용과학기술학회지
    • /
    • 제38권4호
    • /
    • pp.1129-1142
    • /
    • 2021
  • 본 연구는 간호대학생의 임상실습 동안 적용한 SBAR 보고교육이 의사소통명확성, 의사소통 만족도, 보고자신감, 의사소통능력에 미치는 영향요인을 파악하고자 실시되었다. 자료수집기간은 2019년 12월 1일부터 12월 20일까지이며 2개 대학교에서 임상실습을 6주 이상 완료한 3학년을 편의 추출하였다. 대상자 수는 SBAR 보고교육을 받은 103명과 교육을 받지 않은 113명이다. 자료분석은 SPSS 21.0 프로그램을 이용하여 t-tests, one-way ANOVA, Pearson's correlation coefficient 등으로 분석하였다. 의사소통명확성과 의사소통능력은 양의 상관관계(r=.52, p<.001)가 있었고, 보고자신감은 의사소통만족도와 양의 상관관계(r=.53, p<.001)가 있으며, 의사소통능력은 보고자신감과 양의 상관관계(r=.46, p<.001)가 있었다. 의사소통능력은 의사소통명확성(𝛽=.29, p<.001), 의사소통만족도(𝛽=.43, p<.001), 보고자신감(𝛽=.15, p=.009)이 유의한 영향요인이었으며, 설명력은 49.0%로 나타났다. 결론적으로 간호대학생에게 임상실습 중 실무능력을 파악하여 보고체계를 강화하기 위한 교육적 제도와 교수방법의 프로그램 개발이 필요하다.

가족의 지지와 제왕절개술 산모의 자아개념간의 관계연구 (A Study on the Relationship Between Perceived Family Support & Self Concept of Cesarean Section Mothers)

  • 장명자;이미라
    • 모자간호학회지
    • /
    • 제1권
    • /
    • pp.23-33
    • /
    • 1991
  • Recently, Cesarean Section has been revealed as major events in maternity nursing, because it has influence on tile formatter of the self concept of cesarean section mothers as well as later coping mechanism and mother-child relationship including the mothering role. The study is conducted to clarify the relationships between the perceired family support and the self concept of cesarean section mothers, and to find out other Influencing factors on the formation of the self concept. Measuring instrument used in this study was Lee's scale to measure the self concept and the degree of perceived family support of the cesarean section mothers, The subject were 155 cesarean section mothers who were selected conveniently. Volunteers answered self reporting questionnaires which asked about their self concept. Data was analyzed as follows using SAS. The relationship between scores of the self concept and degree of the perceived family support was analyzed by Pearson's product moment correlation. In order to identify the influencing effects of demographic variables on the formation of self concept & F test were used. Result were summarized as follows : 1. Scores of self concept of cesarean section mothers were significantly correlated with scores of the perceived family support (r=0.3438, p<0.01) These results show that the family support is closely related to the self concept of cesarean mothers and has positive effects on their coping capacity. 2. Scores of self-concept of those who have lower ducation background and are multipara were significantly higher than those who have higher education background and are primipara(M=29.90$\pm$9.37, 27.69$\pm$3.89, t=2.006, df=105.8, p=0.0480: M=27.75$\pm$3.49. 29.46$\pm$8.68, t=-1.7183, 2. p=0.08).

  • PDF

Fucoxanthin derivatives from Sargassum siliquastrum inhibit matrix metalloproteinases by suppressing NF-κB and MAPKs in human fibrosarcoma cells

  • Nguyen, Van-Tinh;Qian, Zhong-Ji;Lee, Bonggi;Heo, Soo-Jin;Kim, Kil-Nam;Jeon, You-Jin;Park, Won Sun;Choi, Il-Whan;Jang, Chul Ho;Ko, Seok-Chun;Park, Sun-Joo;Kim, Yong-Tae;Kim, GeunHyung;Lee, Dae-Sung;Yim, Mi-Jin;Je, Jae-Young;Jung, Won-Kyo
    • ALGAE
    • /
    • 제29권4호
    • /
    • pp.355-366
    • /
    • 2014
  • Fucoxanthin is known to be an effective cell proliferation inhibitor with anti-tumor and anti-angiogenic activities. However, there is a lack of data regarding the biological effects of cis isomers of fucoxanthin. To assess the potential therapeutic properties of 9'-cis-(6'R) fucoxanthin (FcA), and 13-cis and 13'-cis-(6'R) fucoxanthin complex (FcB) isolated from Sarggassum siliquastrum, we investigated their inhibitory effects on matrix metalloproteinases (MMPs) in phorbol 12-myristate 13-acetate (PMA)-induced human fibrosarcoma (HT1080) cells. FcA and FcB reduced MMP-2 and MMP-9 protein and mRNA levels, as well as the migration of these cells, in a dose-dependent manner. Additionally, FcA and FcB increased levels of MMPs inhibition factors such as tissue inhibitor of metalloproteinase-1. FcA and FcB significantly inhibited the transcriptional activity of nuclear factor ${\kappa}B$ (NF-${\kappa}B$) and by inhibiting c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. Our results demonstrate that suppression of the NF-${\kappa}B$, JNK, and p38 signaling pathways may inhibit PMA-induced MMP-2 and MMP-9 activity. Therefore, FcA and FcB may be useful in noninvasive therapeutic strategies against fibrosarcoma metastasis.