• Journal of Gastric Cancer
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• v.13 no.4
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• pp.232-241
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• 2013

Purpose: Gastrokine 1 plays an important role in gastric mucosal defense. Additionally, the Gastrokine 1-miR-185-DNMT1 axis has been shown to suppress gastric carcinogenesis through regulation of epigenetic alteration. Here, we investigated the effects of Gastrokine 1 on DNA methylation and gastritis. Materials and Methods: Expression of Gastrokine 1, DNMT1, EZH2, and c-Myc proteins, and the presence of Helicobacter pylori CagA protein were determined in 55 non-neoplastic gastric mucosal tissue samples by western blot analysis. The CpG island methylation phenotype was also examined using six markers (p16, hMLH1, CDH1, MINT1, MINT2 and MINT31) by methylation-specific polymerase chain reaction. Histological gastritis was assessed according to the updated Sydney classification system. Results: Reduced Gastrokine 1 expression was found in 20 of the 55 (36.4%) gastric mucosal tissue samples and was closely associated with miR-185 expression. The Gastrokine 1 expression level was inversely correlated with that of DNMT1, EZH2, and c-Myc, and closely associated with the degree of gastritis. The H. pylori CagA protein was detected in 26 of the 55 (47.3%) gastric mucosal tissues and was positively associated with the expression of DNMT1, EZH2, and c-Myc. In addition, 30 (54.5%) and 23 (41.9%) of the gastric mucosal tissues could be classified as CpG island methylation phenotype-low and CpG island methylation phenotype-high, respectively. Reduced expression of Gastrokine 1 and miR-185, and increased expression of DNMT1, EZH2, and c-Myc were detected in the CpG island methylation phenotype-high gastric mucosa. Conclusions: Gastrokine 1 has a crucial role in gastric inflammation and DNA methylation in gastric mucosa.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.10
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• pp.5078-5090
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• 2013

This study was to identify the relationship among small-medium sized hospitals nurse's career plateau, self-efficacy, job embeddedness and turnover intention. The study was conducted through a survey on 217 nurses in five small-medium sized hospitals in J city. The data were collected from August 5, 2013 to August 20, 2013. The data were analyzed by SPSS/WIN 18.0 program. The mean score of turnover intention was 3.07. The positive correlations between career plateau and turnover intention were found, but the negative correlation between self-efficacy, job embeddedness and turnover intention were found. The significant factors influencing turnover intention were job embeddedness, present clinical career, career plateau and work unit. To decrease turnover intention, therefore, nursing managers need to develop the nurse retention program for increasing job embeddedness and apply to nursing field.

• Asian Oncology Nursing
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• v.3 no.1
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• pp.75-84
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• 2003

Purpose: this study was to identify influencing factors of burnout on oncology nurses. Method: the data was collected using a questionnaire from October 18, 2002 to November 20, 2002 in five general hospitals at Seoul. Participants of this study were the nurses who worked in the wards occupied by more than 50 percent of cancer patients. The collected data were analyzed by using the SPSS10.0 program. Result: 1. The burnout of the subjects show a mean score of 2.72 using the 5 point Likert scale. There were statistically significant difference in burnout between the general characteristics; age, marital status, educational background, job experience, position, nursing service period, and attitudes on nursing job. 2 The self-esteem of the subjects show a mean score of 3.72 using the 5 point Likert scale. The spiritual well-being of the subjects show a mean score of 3.83 using the 6 point Likert scale. The social support of the subjects show a mean score of 3.74 using the 5 point Likert scale. The job stress of the subjects show a mean score of 2.16 using the 4 point Likert scale. 3. The result of correlation between burnout and other variable was that relationship between the burnout and job stress(r=-.206, p<.05), self-esteem(r=-.417, p<.01), spiritual well-being(r=-.403, p<.01), social support(r=-.386, p<.01) were significant variables. 4. The result of the Stepwise Multiple Regression was that self-esteem (17.4%), spiritual well-being(7.9%), social support(3.4%) and job stress(2.3%) explained 31% of burn out.

• Communications for Statistical Applications and Methods
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• v.23 no.1
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• pp.1-20
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• 2016

Causal inference methodologies have been developed for the past decade to estimate the unconfounded effect of an exposure under several key assumptions. These assumptions include, but are not limited to, the stable unit treatment value assumption, the strong ignorability of treatment assignment assumption, and the assumption that propensity scores be bounded away from zero and one (the positivity assumption). Of these assumptions, the first two have received much attention in the literature. Yet the positivity assumption has been recently discussed in only a few papers. Propensity scores of zero or one are indicative of deterministic exposure so that causal effects cannot be defined for these subjects. Therefore, these subjects need to be removed because no comparable comparison groups can be found for such subjects. In this paper, using currently available causal inference methods, we evaluate the effect of arbitrary cutoffs in the distribution of propensity scores and the impact of those decisions on bias and efficiency. We propose a tree-based method that performs well in terms of bias reduction when the definition of positivity is based on a single confounder. This tree-based method can be easily implemented using the statistical software program, R. R code for the studies is available online.

• Fisheries and Aquatic Sciences
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• v.24 no.8
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• pp.277-283
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• 2021

Kudoa septempunctata has been reported as a new parasite in aquacultured olive flounder Paralichthys olivaceus, and also as a causative agent of food poisoning in humans. This paper investigated the infection of K. septempunctata in 216 sashimi and 20 sushi made of olive flounders in Busan, Korea. Among 236 samples, K. septempunctata was detected in eleven sashimi with 6-7 polar capsules by the microscopy. Among eleven sashimi, five sashimi were positive in Polymerase Chain Reaction (PCR) assay with the targets of 18S rDNA and 28S rDNA. The genotype of all the five PCR results is identified as the genotype ST3 which is common in Korea. K. septempunctata was found in olive flounders sashimi from Samcheonpo and Wando outside of Jeju Island. These findings would contribute to establish the standard of K. septempunctata for preventing food-borne outbreaks in advance and providing further preventive management for the seafood safety.

• Journal of Marine Life Science
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• v.2 no.1
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• pp.20-26
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• 2017

In this study, we evaluated the toxic effects of heavy metals (As, Cr and Pb) on the population growth rate (r) of the marine diatom, Skeletonema costatum. The r of the species was determined after 96 h (4 days) exposure to As (0, 0.31, 0.63, 1.25, 2.50 and 5.00 mg L^-1), Cr (0, 0.16, 0.31, 0.63, 1.25 and 2.50 mg L^-1) and Pb (0, 1.25, 2.50, 5.00, 10.00 and 20.00 mg L^-1). It was observed that r in the control (absence of As, Cr and Pb) were greater than 0.04, however suddenly decreased with increased heavy metal concentrations. As, Cr and Pb reduced r in a dose-dependent manner and a significant reduction were occurred at concentration of greater than 0.31, 0.31 and 5.00 mg L^-1, respectively. Based on the toxicity, the heavy metal were ranked as Cr>As>Pb, with EC₅₀ (50% effective concentration) values of 0.80, 2.57 and 13.88 mg L^-1, respectively. The lowest-observed-effective-concentration (LOEC) of r in exposed to As, Cr and Pb were 0.63, 0.63 and 10.00 mg L^-1, respectively. Precisely, a concentration of greater than 0.63 mg L^-1 of As, 0.63 mg L^-1 of Cr and 10.00 mg L^-1 of Pb in marine ecosystems induced toxic effect on the r of S. costatum. Based on our results, we suggested that the r of S. costatum might be a useful bio-indicator for the toxicity assessment of heavy metals on the producer in marine ecosystems.

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.2
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• pp.251-258
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• 2017

The objective of this study was to analyze patient satisfaction and perception of nutritional counseling services quality. A patient satisfaction and perception survey was conducted for 1,095 patients from 43 tertiary hospitals and 20 general hospitals. The number of returned questionnaires was 656 (response rate: 60.0%). Data from 633 questionnaires were analyzed after the questionnaires with unanswered items were excluded. Five domains were identified from the result of the factor analysis using the maximum likelihood and oblique rotation. The five domains were named empathy, responsiveness, tangibles, reliability, and skill and specialty. Patient perception mean score of nutritional counseling was 4.54/5.00. Patient satisfaction scores were significantly higher in empathy (P<0.001), responsiveness, and skill and specialty (P<0.01) with a college or graduate school education than in patients with a middle school education. There was no statistically significant difference between satisfaction scores in tertiary hospitals and those in general hospitals, but patients in capital hospitals reported significantly higher scores than their local counterparts in empathy, responsiveness, reliability, skill and specialty (P<0.001), and tangibles (P<0.05). In responsiveness, significantly higher (P<0.01) scores were observed in patients who received nutritional counseling only once compared to patients who received counseling two times. Patients perception of nutritional counseling services was significantly correlated with their satisfaction of five domains, reliability (r=0.721), responsiveness (r=0.697), empathy (r=0.690), skill and specialty (r=0.678), and tangibles (r=0.622).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.555-565
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• 2018

This study was conducted to investigate factors influencing career maturity in nursing students. A convenience sample of 230 nursing student was selected from S city, between 20 October and 10 November 2017. Data were collected using a structured questionnaire and analyzed using descriptive statistics, t-test, one-way ANOVA, Pearson's correlation, and multiple regression analysis with the SPSS/WIN 21.0 program. Factors that influenced career maturity included gender(t=2.117, p=.035), age(t=-2.572, p=.011), grade(F=4.716, p=.010), education at the time of admission(t=-2.695, p=.008) and perceived academic achievement(F=11.127, p<.001). Career maturity showed a positive correlation with career decision-making self-efficacy(r=.585, p<.001) and problem solving ability(r=.407, p <.001), but a negative correlation with job-seeking stress(r=-.424, p<.001). Regression analysis revealed that significant factors influencing career maturity were career decision-making self-efficacy, problem solving ability and job-seeking stress. This regression model explained 42.8% of the variance in the career maturity. Based on these findings, it is necessary to develop and test programs to ensure an improvement in career decision-making self-efficacy, problem solving ability and job-seeking stress among nursing students to increase their career maturity.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.332-341
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• 2019

This study is a descriptive survey study to investigate the quality of sleep and to compare the factors relating quality of sleep in the young-old people and the old-old people. The subjects of the study were 200 elderly people who live in the G-region applying convenient expression method. Using a structured questionnaire, sociodemographic characteristics, lifestyle and health-related characteristics, depression, and quality of sleep were examined. We analyzed ${\chi}^2-test$, t-test, ANOVA(scheffe's test), Pearson's correlation coefficient and multiple regression using IBM SPSS WIN/21.0. The results of the study were as follows. The quality of sleep was significantly worse in the old-old people than in the young-old people. In young-old people, only depression (r=-.22, p=.038) showed a significant negative correlation with sleep quality. Old-old people was a significant negative correlation between sleep quality and depression (r=-.19, p=.045) and subjective health status (r=-.29, p=.002). In the young-old people, job, chronic illness, and economic level were significant influencing factors in the quality of sleep. In the old-old people, chronic disease, subjective health status, and smoking were significant influencing factors. The results of this study can be used as basic data for establishing tailored strategy for ages that can improve health of the elderly.

• Journal of the Korean Society of Costume
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• v.58 no.6
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• pp.54-68
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• 2008

The purpose of this study is to investigate the effect of dot pattern size(0.8, 1.8, 2.5, 5, 8), color combination(BG/R, Y/B), area-ratio on image formation. Sets of stimulus and response scales(7 point semantic) were used as experimental materials. The stimuli were 20 color pictures manipulated with the combination of dot pattern size, color combination, and area-ratio using computer simulation. The subjects were 240 female undergraduates living in Gyeongnam-do. Image factor of the stimulus was composed of 5 different components, visibility, attractiveness, cuteness, stability and high class image. In the cuteness, color combination, dot pattern size showed independent effect. In the stability, area-ratio, dot pattern size showed independent effect. Interaction effects of color and area-ratio combination was significant on cuteness. For visibility image 8cm yellow dot/blue background, for attractiveness image BG/R coloration, for cuteness image Y/B coloration and for stability image 0.8cm yellow dot/blue background were effective. According to the variation of dot pattern size, color combination and area-ratio, it was investigated that the images for a dress wearer were expressed diversely, were shown differently in image dimensions, and could be produced to different images.