• Korean Chemical Engineering Research
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• v.55 no.2
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• pp.180-189
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• 2017

Pharmaceutical co-crystals primarily to improve the solubility as well as stability of insoluble drug are to be investigated more intensively for IMDs as US FDA has reclassified co-crystal as a special case of solvates in August this year. In this study, we proposed a mechanism of indomethacin-saccharin co-crystal formation and the creation of transient indomethacin meta-stable form using in-line monitoring tools with the addition rate of anti-solvent as a critical process parameter. Among various instruments, we combined PVM (particle vision measurement) and FBRM (focused beam reflectance measurement) for the in-line monitoring of anti-solvent co-crystallization process. The off-line characterization of resulting powders was carried out employing the PXRD (powder x-ray diffraction) and DSC (differential scanning calorimeter). It was observed that the pathway to the final IMC-SAC co-crystal was significantly dependent upon the anti-solvent addition rate. The process conditions to obtain high quality co-crystal powder effectively were established. Consequently, we concluded that in-line monitoring combing the PVM and FBRM should be useful for the in-line monitoring of pharmaceutical co-crystallization processes.

• KIPS Transactions on Software and Data Engineering
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• v.2 no.8
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• pp.507-516
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• 2013

Mobile devices have limited computing power and resources. Since mobile devices are equipped with rich network connectivity, an approach to subscribe cloud services can effectively remedy the problem, which is called Mobile Cloud Computing (MCC). Most works on MCC depend on a method to offload functional components at runtime. However, these works only consider the limited verion of offloading to a pre-defined, designated node. Moveover, there is the limitation of managing services subscribed by applications. To provide a comprehensive and practical solution for MCC, in this paper, we propose a self-stabilizing process and its management-related methods. The proposed process is based on an autonomic computing paradigm and works with diverse quality remedy actions such as migration or replicating services. And, we devise a pratical offloading mechanism which is still in an initial stage of the study. The proposed offloading mechanism is based on our proposed MCC meta-model. By adopting the self-stabilization process for MCC, many of the technical issues are effectively resolved, and mobile cloud environments can maintain consistent levels of quality in autonomous manner.

• Journal of the Ergonomics Society of Korea
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• v.33 no.1
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• pp.69-76
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• 2014

Objective: This study aims to present literature providing researchers with insights on specific fields of research and highlighting the major issues in the research topics. A systematic review is suggested using content analysis on literatures regarding "visual search", "eye movement", and "eye track". Background: Literature review can be classified as "narrative" or "systematic" depending on its approach in structuring the content of the research. Narrative review is a traditional approach that describes the current state of a study field and discusses relevant topics. However, since literatures on specific area cover a broad range, reviewers inherently give subjective weight on specific issues. On the contrary, systematic review applies explicit structured methodology to observe the study trends quantitatively. Method: We collected meta-data of journal papers using three search keywords: visual search, eye movement, and eye track. The collected information contains an unstructured data set including many natural languages which compose titles and abstracts, while the keyword of the journal paper is the only structured one. Based on the collected terms, seven categories were evaluated by inductive categorization and quantitative analysis from the chronological trend of the research area. Results: Unstructured information contains heavier content on "stimuli" and "condition" categories as compared with structured information. Studies on visual search cover a wide range of cognitive area whereas studies on eye movement and eye track are closely related to the physiological aspect. In addition, experimental studies show an increasing trend as opposed to the theoretical studies. Conclusion: By systematic review, we could quantitatively identify the characteristic of the research keyword which presented specific research topics. We also found out that the structured information was more suitable to observe the aim of the research. Chronological analysis on the structured keyword data showed that studies on "physical eye movement" and "cognitive process" were jointly studied in increasing fashion. Application: While conventional narrative literature reviews were largely dependent on authors' instinct, quantitative approach enabled more objective and macroscopic views. Moreover, the characteristics of information type were specified by comparing unstructured and structured information. Systematic literature review also could be used to support the authors' instinct in narrative literature reviews.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.11
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• pp.1123-1129
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• 2015

A pair of two-way valves typically is used in automotive washing machines, where the water flow direction is frequently reversed and highly pressurized clean water is sprayed to remove the oil and dirt remaining on machined engine and transmission blocks. Although this valve system has been widely used because of its competitive price, its application is sometimes restricted by surging effects, such as pressure ripples occurring in rapid changes in water flow caused by inaccurate valve control. As an alternative, one three-way reversing valve can replace the valve system because it provides rapid and accurate changes to the water flow direction without any precise control device. However, a cavitation effect occurs because of the complicated bottom plug shape of the valve. In this study, the cavitation index and percent of cavitation (POC) were introduced to numerically evaluate fluid flows via computational fluid dynamics (CFD) analysis. To reduce the cavitation effect generated by the bottom plug, the optimal shape design was carried out through a parametric study, in which a simple computer-aided engineering (CAE) model was applied to avoid time-consuming CFD analysis and difficulties in achieving convergence. The optimal shape design process using full factorial design of experiments (DOEs) and an artificial neural network meta-model yielded the optimal waist and tail length of the bottom plug with a POC value of less than 30%, which meets the requirement of no cavitation occurrence. The optimal waist length, tail length and POC value were found to 6.42 mm, 6.96 mm and 27%, respectively.

• The Journal of the Petrological Society of Korea
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• v.26 no.4
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• pp.327-339
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• 2017

The Cretaceous Myeongseongsan Granite in the northwestern Gyeonggi Massif consists of a major pale pink-colored biotite monzogranite and a minor white-colored biotite alkaligranite. Low Sr and high Ba concentrations, negative Eu-anomalies in REE plot, negative Sr anomalies in spider diagram, a negative correlation between Sr and Rb, and positive correlations between Sr and Ba and $Eu/Eu^*$ indicate that a fractional crystallization of both plagioclase and K-feldspar played a significant role during magma evolution. The Myeongseongsan Granite is plotted in I-& S-type granites on I, S, A-type granite classification scheme. While the biotite monzogranite is plotted in unfractionated I-& S-type granite, the biotite alkaligranite is plotted in fractionated I-& S-type granite, which indicates that the biotite alkaligranite is a more differentiated product. In order to elucidate the nature of the protoliths of the peraluminous Myeongseongsan magma, we plotted in $Al_2O_3/TiO_2$ vs. $CaO/Na_2O$ and Rb/Sr vs. Rb/Ba diagrams, and they suggest that the Myeongseongsan Granite was derived from clay-poor metagreywackes and meta-psammites or their igneous counterparts. Whole-rock zircon saturation temperature indicates that the Myeongseongsan magma was melted at $740-799^{\circ}C$.

• 전자공학회논문지 IE
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• v.47 no.1
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• pp.22-33
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• 2010

The main purpose of this study was to develope a reflective journal and examine its effects on student's academic achievement and self-regulated learning strategies. For this study, 'a structured reflective journal' was designed through the steps of systems approach with the purpose of enhancing student's academic achievement and self-regulated learning strategies, especially meta-cognition and critical thinking. The reflective journal used in this study contained the constructive elements of (1) self-evaluation with 5 likert scale, (2) learning essay, (3) dialogue with peers, and (4) dialogue with professor. A total of 94 freshmen enrolled in one of two sections of the engineering courses(theory-based class and experiment and practice-based class) participated in the study for 8 weeks. A pre-test-post-test design was used to examine the effects of the application of reflective journal on student's achievement and self-regulated learning strategies. For the result, analysis of covariance was conducted to determine whether there were any academic achievement differences and self-regulated learning strategy differences. The results suggested that students were taking advantages of the reflective journal, and there were statistically significant differences in academic achievement in the experiment and practice-based class and self-regulated learning strategies in both classes.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.13 no.4
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• pp.199-204
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• 2003

Microstructure and chemical analysis of sintered bricks containing recycled wastes were investigated by SEM and EDS. The recycled wastes for which substitute ceramic raw materials were EAF (electric arc furnace) dust, fly ash and stone ash. Yellowish and brownish regions on the surface and brownish and blackish regions in the inside of bricks were observed. Main component of yellowish region on the surface turned out to be Zn. No chemical difference between the black-core region and brownish matrix. Mullite crystallites of 1 fm size were distributed in the inside of bricks and enclosed by glass phases. It seems that alumine-silicate mixtures of kaolin and fly ash were transformed to mullite crystallites during the sintering. Relatively large pores ot several ten fm size were observed in the black-core region in the inside of bricks. The main components of the inside of brick were Al and Si. The minor components were C, Na, Mg, K, Ca, and Fe. Particularly, the precipitates of Fe-rich crystallites were observed in the amorphous matrix. These precipitates were formed due to the local reduction atmosphere in the inside of bricks. Zn-rich covers were found on the surface of bricks because Zn diffused from the inside of bricks to the surface under the reduction atmosphere.

• Journal of the Korean Chemical Society
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• v.64 no.5
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• pp.277-290
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• 2020

In this study, four gifted students in the second year of middle school at Gifted Education Center of the National University in Jeollanam-do were surveyed students' perceptions of the effectiveness of science class using science writing heuristic in terms of metacognition and the goals of the 2015 revised science curriculum. Through questionnaires and interviews with gifted science students, science gifted students recognized that the science class using science writing heuristic had a positive effect on the four subdomains (planning, monitoring, control, and evaluation) of metacognition. For this reason, the science gifted students presented self-directed experience in designing experiments, continually checking the collected experimental data, feedback process, and reflecting experience in preparing conclusions. Science gifted students recognized that science class using science writing heuristic had a positive effect on the goals of the 2015 revised science curriculum(attitudes, inquiry, knowledge, Science·Technology·Society(STS), and the enjoyment and usefulness of science learning) that correspond to through inquiry science writing lessons. For this reason, the science gifted students presented self-directed inquiry experiences, continual inquiry experiences on the same subject, thinking process at each stage of inquiry, learning experiences through inquiry, experience of the whole inquiry process, and inquiry of phenomena closely related to real life. Therefore, for the effective science class, it is necessary to apply the characteristics of science class using science writing heuristic which is responded by science gifted students to general science class as well as science gifted class later.

• Journal of Periodontal and Implant Science
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• v.37 no.4
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• pp.719-732
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• 2007

Purpose: Various bone graft materials are being used for periodontal tissue regeneration. Th materials are being developed continuously for ideal clinical effects. Therefore, it is necessary to identify the clinical characteristics of each bone graft material through comparing the various bone graft materials statistically and in doing so, proposing a more efficient bone graft material. In this study, the following results were attained through comparing the clinical effects among the bone graft materials, using the statistical method based on the clinical studies published at the department of periodontology of Yonsei hospital. Materials and Method: 6 selected studies of department of Periodontology at Yonsei University Hospital were based on clinical study of bone grafting in intrabony defects. It was compared the clinical parameters among the 6 clinical studies, using the statistical META analysis. Result: When comparing the probing depth reduction, there was a relatively great amount of decease when using the xenograft, Anorganic Bovine Derived Hydroxapatite Bone Matrix/Cell Binding Peptide(ABM/P-15: PepGen $P-15^{(R)}$) and the autogenous bone and absorbable membrane, d, 1-alctide/glycolide copolymer(GC: $Biomesh^{(R)}$). The allogfrafts showed a relatively low decrease in the probing depth and clinical attachment change. It also showed a slight decrease in the bone probing depth. The allografts showed various results according to different bone graft materials. When comparing the ABM/P-15 and bovine bone $powder(BBP^{(R)})$, ABM/P-15 showed a relatively high clinical attachment level and the bovine bone powder showed a relatively high clinical attachment level. The probing depth change and gingival recession change showed a lower value than the mean value between the two bone graft materials. The synthetic bone showed a relatively high decrease in clinical attachment level and periodontal probing depth change. There was a relatively larger amount of gingival recession when using Bioactive Glass(BG) but a relatively low bone regeneration effect was seen. Conclusion: Good restorative results of the periodontal tissue can be attained by applying the various bone graft materials being used today after identifying the accurate clinical effects.

• Water for future
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• v.14 no.4
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• pp.73-81
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• 1981

More than 650 numbers of water well ranging in depth from 100M to 200M were installed in South Korean Penninsula during the last decade for the purpose of industrial use and municipal water supply. Those data were compiled and synthesized by writer to determine their hydrogeologic occurences in accordance with their geologic and areal characteristics. Rocks yielding the deep seated ground water beared in the geologic primary and secondary porosities are classified into 6 groups according to their geologic, hydrogeologic, and topographic characteristics, that are: volcanic, sedimentary, meta-sediment and/or schist, andesitic, gneissic, and granitic rocks. The order of ground water productivity of the groups is as written above. Even granitic rocks including porphyries, granite, and intermediate and basic plutonic rocks is considered to be the most poorest ground water yielding group among 6, it's average yield form a single well with average drilling depth of 116M is about 225 cubic meters per day if it's drilling site is properly located. Generally speaking, seizable geologic structures such as fractured, sheared, and faulted zone at the flat surface and valley center yield almost 310% more of deep seated bet rock ground water in comparision with minor structures of joints, bedding planes, and so on that are occured at high land. 50 numbers of water well drilled at crystalline rocks were specially checked and measured it's ground water yie 1ds at each drilled depth to determine each interval's productivity while hammer drilling was going on. The results indicate that the specific capacity and yield of each water well at a depth below 70M to 80M was almost neglegible. It means that optimum well depth of crystalline rocks, except the area having seizable geologic structures, shall be not deeper than 80M.