• 센서학회지
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• 제4권3호
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• pp.51-59
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• 1995

실리콘기판 위에 스트레스균형이 이루어진 150 nm-$Si_{3}N_{4}$/300 nm-$SiO_{2}$/150 nm-$Si_{3}N_{4}$ 구조의 평탄한 유전체 멤브레인을 제작하였다. 이 멤브레인의 스트레스 특성평가를 위하여 stress-deflection, stress-temperature 및 스트레인 진단용 시험패턴의 특성을 측정분석하였고, 중간에 있는 $SiO_{2}$층을 PECVD, LPCVD 및 APCVD방법으로 각각 증착하여 $SiO_{2}$층의 증착방법에 따른 적층 유전체박막의 스트레스특성에 대해서도 논의하였다. 대부분의 경우 적층 유전체 멤브레인에 인장스트레스가 존재하였으나, $SiO_{2}$층의 증착방법과 거의 무관하게 $1,150^{\circ}C$의 후습식산화로 실리콘기판에 의해 멤브레인에 나타나는 인장스트레스의 균형을 얻을 수 있었다. 온도변화에 따른 멤브레인에서의 스트레스 변화특성으로 부터 후산화처리를 하지 않는 경우에는 중간의 $SiO_{2}$ 층으로 APCVD방법에 의해 증착된 LTO가 더 적합한 것으로 나타났다.

• 한국가스학회지
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• 제7권3호
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• pp.13-17
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• 2003

LNG 저장탱크의 주요 구조인 멤브레인은 LNG 누설을 방지하기 위하여 설계되었다. 멤브레인 유닛은 $-162^{\circ}C$의 액화시킨 LNG의 접촉에 따라 발생하는 가스압, 액압, 그리고 열하중을 지지하도록 설계되므로 멤브레인 구조의 강도를 실험적 방법을 이용하여 측정하는 것이 매우 중요하다. 본 논문에서는 상용 전기저항식 스트레인 게이지와 자체적으로 제작한 기계적 열 변형 측정 장치를 이용한 변형 측정 시스템을 제안하였다.

• 한국공간구조학회논문집
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• 제16권1호
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• pp.35-42
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• 2016

Until recently, almost all ETFE film structures that have been erected is the cushion type because there are problems at lower allowable strength under elastic range and viscosity behaviour such as creep and relaxation of ETFE films under long-term stresses. But the number of tension type structures is currently increasing. This paper proposes the stretch fabrication of ETFE film to verify the applicability of ETFE films to tensile membrane structures. First of all, to investigate the possibility of application on tensile membrane structures, the stretch fabrication test is carried out, and it is verified that it is possible to increase the yield strength of the film membrane structures. After simulating the experiment also carries out an analytical investigation, and the effectiveness of the elasto-plastic analysis considering the viscous behavior of the film is investigated. Finally, post-aging tension measurement is conducted at the experimental facilities, and the viscosity behavior resulting from relaxation is investigated with respect to tensile membrane structures.

• Transactions on Electrical and Electronic Materials
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• 제16권4호
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• pp.173-178
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• 2015

In lieu of the excellent radio frequency (RF) performance of microelectromechanical system ( MEMS) switches, these micro switches need higher actuation voltage for their operation. This requirement is secondary to concerns over the swtiches’ reliability. This paper reports high reliability operation of RF MEMS switches with low voltage requirements. The proposed switch is optimised to perform in the Q-band, which results in actuation voltage of just 16.4 V. The mechanical stress gradient in the thin micro membrane is computed by simulating von Mises stress in a multi-physics environment that results in 90.4 MPa stress. The computed spring constant for the membrane is 3.02 N/m. The switch results in excellent RF performance with simulated isolation of above 38 dB, insertion loss of less than 0.35 dB and return loss of above 30 dB in the Q-band.

• Natural Product Sciences
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• 제29권2호
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• pp.67-73
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• 2023

Oxidative stress brings about apoptosis through various mechanisms. In particular, oxidative stress in neuronal cells can causes a variety of brain diseases. This study was conducted to investigate the effect of Bidens tripartita on oxidative stress in neuronal cells. B. tripartita has traditionally been used in Russia as a medicine for diseases such as rhinitis, angina and colitis. Over-production of glutamate induces oxidative stress. When the oxidative stress occurs in the cells, reactive oxygen species (ROS) and Ca²⁺ increase. In addition, the abrupt decline of mitochondrial membrane potential and the decrease of glutathione related enzymes such as glutathione reductase (GR) and glutathione peroxidase (GPx) are also observed. The samples used in the experiment showed cytoprotective effect in the MTT assay. It also lowered the ROS and Ca²⁺ level, and increased degree of mitochondrial membrane potential, GR and GPx. As a result, B. tripartita had a positive effect against oxidative stress. Thus, it is expected to have potential for treatment and prevention of degenerative brain diseases such as Alzheimer's disease.

• Fisheries and Aquatic Sciences
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• 제5권4호
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• pp.263-270
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• 2002

The Pacific oysters, Crassostrea gigas, were stressed with different concentrations of benzo(a) pyrene and depurated to determine the hemocyte lysosomal membrane stability and hydrolytic enzymatic activity as a biomarker candidate to the chemical, using NRR (neutral red retention) and API ZYM System, respectively. The membrane damage measured as NRR decrease was significant with the increase of chemical concentration and exposure time (P<0.05), providing a possible tool for biomarker. Interestingly, the control showed intrinsic stress probably due to captive life in the laboratory, and a recovering trend was also found during the depuration. The benzo(a)pyrene-exposed oysters showed increased enzyme activities in alkaline phosphatase, esterase (C4), acid phosphatase, naphthol-AS-BI-phospho­hydrolase, $\beta$-galactosidase, $\beta$-glucuronidase, and N-acetyl- $\beta$-glucosaminidase. Of them, only two enzymes, acid phosphatase and alkaline phosphatase, showed some potential available for the generation of enzymatic biomarker in the oyster. The results are suggestive of the potential availability of the cellular and enzymatic properties as a biomarker. However, considering that a robust biomarker should be insensitive to natural stress coming from normal physiological variation, but sensitive to pollutants, a concept of intrinsic stress the animal possesses should be taken into consideration. This reflects the necessity of further research on the intrinsic stress affecting the cellular and enzymatic properties of the chemical­stressed oysters prior to using the data as a biomarker.

• 공업화학
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• 제25권4호
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• pp.401-408
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• 2014

분리막 생물반응기에서 산기량 제어는 반응기 내 유체흐름과 특히 막표면 근방에서의 전단응력을 변화시켜 막오염 감소 및 에너지 절약을 구현하는 중요 독립변수 중 하나이다. 본 연구에서는 원통형 생물 반응기 중심에 침지형 평막을 장착하고 하부에서 공기가 공급되는 3차원적 시스템에 대하여 "COMSOL"프로그램을 사용하여 수치해석하였다. 용액의 점도, 온도는 일정하다고 가정했으며 투과액 부피와 산기량의 비인 $SAD_p$를 변수로 사용하였다. 유속센서, 동영상 이미지분석으로 측정한 유속과 수치해석 결과는 11% 이내에서 일치함을 확인하였다. 반응기 내 유체의 흐름은 산기관과 막모듈 구간에서 급격하게 증가하였으나 막모듈을 지나면서 감소하였으며 반응조 벽에서 중심축 방향으로 갈수록 유속이 증가하는 경향을 보였다. 막 표면에서 계산된 전단응력은 하단 중앙부가 가장 크게 나타났으며 산기량이 증가할수록 전단응력이 증가하였다. 특히 산기량을 0.15에서 0.25 L/min로 증가할 경우 크게 증가함을 확인할 수 있었다.

• 생명과학회지
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• 제9권4호
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• pp.473-480
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• 1999

This study was designed to investigate the effects of pine (Pinus densiflora Sieb et Zucc) needle extract (PNE) on membrane fluidity and oxidative stress in liver membranes of Sprague-Dawley (SD) rats as a study on investigation of anti-aging effect and determination of chemical structures of PNE through the animal experiments. Male SD rats were fed basic diets (control group) and experimental diets (0.5% and 1.0%-PNE group) for 6 weeks. Administrations of 0.5% and 1.0%-PNE resulted in a marked decreases (15∼25% and 23∼26%, respectively) in cholesterol accumulations of liver mitochondria and microsomes compared with control group. Membrane fluidities were significantly increased (15∼25%) in liver microsomes of 0.5% and 1.0%-PNE groups compared with control group. Formations of basal and induced oxygen radicals (BOR and IOR) in liver mitochondria were significantly inhibited (11∼12% and 10∼15%, respectively) by administrations of 0.5% and 1.0%-PNE compared with control group. Lipid peroxide (LPO) levels were remarkbly decreased about 20% in liver mitochondria and microsomes of 0.5% and 1.0%-PNE groups compared with control group. Oxidized protein levels calculated with carbonyl group were significantly decreased about 15% in liver mitochondria of 1.0%-PNE group compared with control group. These results suggest that PNE may play a effective role in a attenuating a oxidative stress and increasing a membrane fluidity.

• 한국전산구조공학회논문집
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• 제12권3호
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• pp.457-464
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• 1999

본 논문의 목적은 막구조물의 형상해석, 응력-변형 해석, 재단도 해석을 수행하는 것이고, 재료는 선형탄성, 응력은 평면응력의 상태로 가정한다. 케이블 및 막구조물은 외력에 대한 변형이 매우 큰 구조물이기 때문에 기하비선형을 고려한 비선형해석을 하여야 한다 해석은 일반적인 구조물과는 달리 다음의 3단계로 구성된다. 첫 번째 단계는 초기 평형형상을 결정하기 위한 형상해석이고, 두 번째 단계는 다양한 외력이 가해졌을 때 구조물의 거동을 파악하는 응력-변형 해석이다. 이렇게 하여 일단 만족된 형상이 얻어지면 형상해석에서 얻은 결과를 기초로 하여 시공적 관점의 재단도 해석이 수행된다. 본 논문에서는 서귀포 월드컵 축구 경기장 지붕 구조물의 예를 들어 형상해석, 응력-변형 해석, 재단도 해석을 수행하고, 카테노이드(Catenoid) 구조물을 이용하여 최적재단도에 관한 해석기법을 제시한다.

• International Journal of Industrial Entomology and Biomaterials
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• 제10권2호
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• pp.125-129
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• 2005

Ribosome-associated membrane protein 4 (RAMP4) is a membrane protein that exposes its N-terminal hydrophilic portion on the cytoplasmic side and spans the membrane close to the C-terminal end. RAMP4 has previously been reported to belong to the set of proteins that remains associated with membrane-bound ribosomes, and controls the glycosylation of major histocompatbility complex class II-associated invariant chain. RAMP4 also may be relative to the stabilization of membrane proteins in response to stress, with other components of translocon, and molecular chaperons in ER. Application of 5'-RACE technique with specially designed primer, we cloned a 715 bp cDNA fragment which contains a 195 bp ORF, termed RAMP4. The deduced protein has 64 amino acid residues and contains a putative transmembrane-spanning domain at the COOH terminus.