• Korean Journal of Human Ecology
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• v.18 no.5
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• pp.995-1008
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• 2009

This study investigated the causal relationships among the elderly, looking at social participation, depression, self-reported health, and life satisfaction. It was especially focused on the mediating effects of depression and self-reported health on the relationship between social participation and life satisfaction. From the 2006 Korean Longitudinal Study of Aging, data for 4,155 elderly over age 65 was analyzed with structural equations modeling with Amos 7.0 and sobel test. Major findings were as follows. First, social participation of the elderly has a negative influence on depression and a positive influence on self-reported health and life satisfaction. Second, self-reported health has a partial mediating effect on the relationship between social participation and life satisfaction. Third, the direct effect of depression on life satisfaction was not statistically significant, while the direct effect of social participation was significant. Therefore, depression was not proved as a significant mediator. This study tested the effects of social participation on depression, self-reported health, and life satisfaction empirically and confirmed the partial mediating model, in which social participation improves the elderly's self-reported health, which in turn improves the elderly's life satisfaction. These results suggest the importance of an integrated approach for the healthy and successful aging and the diverse types of social participation in an elderly person's quality of life.

• The Journal of the Korea Contents Association
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• v.17 no.1
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• pp.363-377
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• 2017

The purpose of this study is to investigate the impact of leader-member exchange(LMX) on employees' creativity, and task performance focusing on the mediating effect of information sharing and job involvement. Based on the review of related references, we suggested our research model and hypothesis and then tested empirically. From these analyses, we can find some significant findings. First, LMX has a positive impact on information sharing. Second, information sharing has a positive impact on job involvement, creativity, and task performance. Third, information sharing has significant mediating effects on the relationship between LMX and job involvement, creativity, and task performance. Fourth, job involvement also has significant mediating effects on the relationship between information sharing and creativity and task performance. These results showed that information sharing and job involvement played their role as a meaningful mediator.

• Journal of Families and Better Life
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• v.35 no.2
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• pp.17-29
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• 2017

The purposes of this study were to analyze the effect of perceived parent-adolescent communication on SNS addiction tendency among high school students and to investigate the mediating effects of self-control on the relationship between above variables. 567 students who were registered in three high schools located in D city completed a questionnaire on parent-adolescent communication, SNS addiction tendency, and self-control. Structural equation models were conducted to compare the research model (complete mediating effect) and the competing model (partial mediating effect), and bootstrapping was conducted to investigate the mediating effects of self-control with SPSS 23.0 and AMOS 23.0. The results are as follow: First, while the parent-adolescent communication did not directly have an effect the SNS addiction tendency, the self-control had a direct effect on the SNS addiction tendency. Second, the research model was selected as a final model which implied that parent-adolescent communication had an indirect effect on SNS addiction tendency among high school students. Third, self-control had a significant mediating effect on the relationship between parent-adolescent communication and high school students' SNS addiction tendency. Based on the results of this study, it can be concluded that parent-adolescent communication had an indirect effect rather than a direct effect through self-control on high school students' SNS addiction tendency. This result indicates that the SNS addiction tendency rate of high school student can be lowered, by mediating self-control. Finally, this study suggests that the implicit points on counseling methods to remedy self-control of high school students, and shortcomings and limits of this study and advice for follow-up studies all be discussed.

• Journal of Family Resource Management and Policy Review
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• v.18 no.3
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• pp.159-176
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• 2014

This study examined the mediating effects of couple communication on self-differentiation and marital satisfaction among married women. The ANOVA, correlation and the multiple regression analysis were used to figure out the relationships and the mediating effects of those variables. The results revealed that self-differentiation was significantly related to marital satisfaction. Also, couple communication was revealed to be a partial and full mediator between self-differentiation and marital satisfaction. The results were as follows. First, there were differences in couple communication and marital satisfaction. Marital satisfaction showed differences according to socio-economic variables such as educational level, occupation, family income, and the years of married life. Educational level and family income made differences in couple's communication. However, socio-economic variables did not make any difference with regard to self-differentiation. Second, there was a significant correlation among all sub-factors for self-differentiation, whole self-differentiation, married couples' communication, and marital satisfaction. Third, the result shows that the mediating effect of couple communication between self-differentiation and marital satisfaction. Couple communication completely mediated the relationship between cognitive vs. emotional function, family projection, emotional cutoff, and marital satisfaction. It also partially mediated the relationship between family regression and marital satisfaction. In addition, there was a tendency to partially mediate the relationship between general self-differentiation and marital satisfaction. The results suggested that self-differentiation and couples communication should be considered together when explaining marital satisfaction among married women. Also, the results implied the importance of the increased self-differentiation and the better couple communication in women's marital satisfaction. Finally, this research suggested the necessity of counseling services to enhance the self-differentiation as well as couple communication programs for the marital satisfaction of women.

• Molecules and Cells
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• v.40 no.11
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• pp.837-846
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• 2017

As a component of the neurovascular unit, cerebral smooth muscle cells (CSMCs) are an important mediator in the development of cerebral vascular diseases such as stroke. Epoxyeicosatrienoic acids (EETs) are the products of arachidonic acid catalyzed by cytochrome P450 epoxygenase. EETs are shown to exert neuroprotective effects. In this article, the role of EET in the growth and apoptosis of CSMCs and the underlying mechanisms under oxygen glucose deprivation (OGD) conditions were addressed. The viability of CMSCs was decreased significantly in the OGD group, while different subtypes of EETs, especially 14,15-EET, could increase the viability of CSMCs under OGD conditions. RAPA (serine/threonine kinase Mammalian Target of Rapamycin), a specific mTOR inhibitor, could elevate the level of oxygen free radicals in CSMCs as well as the anti-apoptotic effects of 14,15-EET under OGD conditions. However, SP600125, a specific JNK (c-Jun N-terminal protein kinase) pathway inhibitor, could attenuate oxygen free radicals levels in CSMCs as well as the anti-apoptotic effects of 14,15-EET under OGD conditions. These results strongly suggest that EETs exert protective functions during the growth and apoptosis of CSMCs, via the JNK/c-Jun and mTOR signaling pathways in vitro. We are the first to disclose the beneficial roles and underlying mechanism of 14,15-EET in CSMC under OGD conditions.

• Journal of the Korea Safety Management & Science
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• v.16 no.1
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• pp.53-68
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• 2014

The purpose of this study is to verify the relationships among innovative behavior, turnover intention, and job security. An additional purpose was to examine partial mediating effects on psychological ownership. The baseline of analyzing those relationships in this study is that the role of psychological ownership will be a mediator between job security and turnover intention as well as innovative behavior in the organization. To accomplish these purposes, a model was built among job security as predictor variable, the psychological ownership as mediating variable and turnover intention, and innovative behavior as criteria variables based on the studies conducted in the various areas. The 248 questionnaires surveyed from the area of DaeGu and Kyungbuk were used in the statistical analyses. The detail statistical techniques are such as descriptive analysis, reliability analysis, factor analysis, correlation analysis, and multi regression analysis. The results of the study show that job security had positively significant effect on turnover intention and innovative behavior. In addition, only the psychological ownership of organization-level thinking have partial mediating effects between job security and innovative behavior also job security and turnover intention. The results may indicate that the psychological ownership of organization-level thinking be a key factor to alleviate the turnover intention of employees and to encourage the innovative behavior during their works for the small-medium size companies showing the unstable job security.

• The Journal of the Korea Contents Association
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• v.16 no.3
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• pp.376-390
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• 2016

The purpose of present study is to investigate mediating effects of emotional labor in the links between communication ability of small businessmen and customer orientation behavior. In detail, it is demonstrated both impacts of communication ability on customer orientation behavior and emotional labor (surface acting, deep acting), and of emotional labor (surface acting, deep acting) on customer orientation behavior. Furthermore, mediating effects of emotional labor (surface acting, deep acting) will be verified. The data for analysis was collected from 270 employees in small businessmen located in Jeju. The results are as follows. First, the main impacts of communication ability on customer orientation behavior and emotional labor (surface acting, deep acting) were statistically significant, in addition, emotional labor (surface acting) was positively associated with customer orientation behavior. Surface acting as a mediator was partially mediated the relation. The result will help to understand the importance for communication ability in small businessmen, and it suggests the crucial implecation in the communication study of service suppliers.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.3
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• pp.599-607
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• 2009

Prunellae Spica is the spike or whole plant of Prunella vulgaris Linne, which has been used for clearing heat from the liver, brightening the eyes and treating headache in traditional oriental medicines. This study was conducted to evaluate the inhibitory effects of the aqueous extract of Prunellae Spica (PSE; PS extract) on the production of NO and PGE2 in LPS-activated Raw 264.7 cells. Cell viability was determined by MTT assay, and all three doses of PS extract (0.03, 0.1 and 0.3 mg/ml) had no significant cytotoxicity during the entire experimental period. The cells were treated with 1 ${\mu}g/ml$ of LPS 1 h before adding PS extract, and increased NO and PGE2 production were detected in LPS-activated cells compared to control. However, these increases were dose-dependently attenuated by treatment with PS extract. The inhibition of NO by PS extract was due to the suppression of iNOS expression via inhibition of $NF{\kappa}B$ nuclear translocation and proteolytic degradation of $I{\kappa}B{\alpha}$. The decreased level of PGE2 was derived from inhibition of COX-2 activity, but expression of COX-2 protein was not affected by PS extract. Moreover, PS extract reduced the elevated production of IL-${\beta}$ and IL-6 by LPS. These results demonstrate that PS extract has inhibitory effects on the production of NO and PGE2 as a consequence of the reduction of proinflammatory cytokines, especially IL-${\beta}$ and IL-6 in LPS-activated Raw 264.7 cells.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.78-78
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• 1995

Increasing evidence indicates that the production of nitric oxide (NO) by inducible NO synthase (NOS) is tightely regulated. Transforming growth factor-${\beta}$ (TGF-${\beta}$) is a homodimeric protein secreted during macrophage activation, but several lines of evidence suggest that TGF-${\beta}$ is selectively suppressive for macrophage NO production. We therefore reasoned that a strategy employing oligodeoxynucleotides(ODNs) complemently to TGF-${\beta}$ mRNA (antisense ODNs) might increase NO production in IFN-${\gamma}$-treated murine peritoneal macrophages. To evaluate this concept, we tested the effects of antisense ODNs targeted to TGF-${\beta}$ mRNA (25-mer ODNs complemently to TGF-${\beta}$mRNA sequences) by introducing it into the medium of cultured macrophages. Phosphorothiolation of ODNs were employed to retard their degradation. Antisense ODNs had no effect on NO production by itself, whereas IFN-${\gamma}$ alone had modest effect. When antisense ODNs were used in combination with IFN-${\gamma}$, there was a marked cooperative induction of NO production, These effects of antisense ODNs were associated with decreased TGF-${\beta}$ expression in activated macrophages. ODNs with the same nucleotides but a scrambled sequence had no effect. Adding anti-TGF-${\beta}$ antibodies to the IFN-${\gamma}$-treated macrophages mimicked the positive effect of antisense ODNs on NO production. In addition, the effects of either antisense ODNs or anti-TGF-${\beta}$ antibodies were blocked by adding TGF-${\beta}$ in cultured macrophages. These results indicate that the generation of TGF-${\beta}$ by activated macrophages provides a self-regulating mechanism by which the temporal and perhaps spatial production of NO, a reactive and potentially toxic mediator, can be finely regulated.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.8
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• pp.5042-5052
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• 2014

This study examined the mediator or moderator role of job embeddedness in the relationship between the nursing performance and turnover intention. Data was collected from 653 nurses in 3 tertiary hospitals, 2 secondary hospitals, and 3 small-medium sized hospitals in Daegu, and analyzed by descriptive statistics, Pearson's correlations, hierarchical multiple regression using the PASW 18.0 program and structural equation model (SEM) using the AMOS 18.0 program. The job embeddedness showed mediating effects between the nursing performance and turnover intention. On the other hand, job embeddedness did not have moderating effects. This study confirmed that job embeddedness had a mediating effect on the relationship between the nursing performance and turnover intention. Enhancing job embeddedness is required to promote nursing performance and reduce turnover intention.