• BMB Reports
• /
• 제48권10호
• /
• pp.583-588
• /
• 2015

Microtubule actin crosslinking factor 1 (MACF1), a widely expressed cytoskeletal linker, plays important roles in various cells by regulating cytoskeleton dynamics. However, its role in osteoblastic cells is not well understood. Based on our previous findings that the association of MACF1 with F-actin and microtubules in osteoblast-like cells was altered under magnetic force conditions, here, by adopting a stable MACF1-knockdown MC3T3-E1 osteoblastic cell line, we found that MACF1 knockdown induced large cells with a binuclear/multinuclear structure. Further, immunofluorescence staining showed disorganization of F-actin and microtubules in MACF1-knockdown cells. Cell counting revealed significant decrease of cell proliferation and cell cycle analysis showed an S phase cell cycle arrest in MACF1-knockdown cells. Moreover and interestingly, MACF1 knockdown showed a potential effect on cellular MTT reduction activity and mitochondrial content, suggesting an impact on cellular metabolic activity. These results together indicate an important role of MACF1 in regulating osteoblastic cell morphology and function.

• 한국항해항만학회:학술대회논문집
• /
• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.1
• /
• pp.327-332
• /
• 2006

In airborne gravimetry, there are two data streams. One is the specific force measured by an air/sea gravimeter or accelerometers, the other is kinematic acceleration measured by DGPS. And the difference of them provides the gravity disturbance information. To satisfy the requirement of most applications, an accuracy of 1mGal $(1mCal=10^{-5}m/s^{2})$ with a spatial resolution of 1km is the aim of current airborne gravimetry. There are two different methods to derive the kinematic acceleration. The generally used method is to differentiate the position twice, and the position can be calculated by commercial DGPS software. The main defect of this method is that integer ambiguities need to be fixed to get the precise position solution, but it's not a trivial thing for long base line. And to fix integer ambiguities, the noisier iono-free measurement is used. When differentiation is applied, noise is amplified and will influence the accuracy of acceleration. The other method is to get carrier phase acceleration by differentiate the carrier phase first, and then using the acceleration of GPS satellite to derive the vehicle acceleration. The main advantages include that fixing integer ambiguities is not needed anymore, position can be relaxed to about 10 meters, and smoother acceleration can be got since iono-free measurement is not needed. In some literatures, it's considered that the dynamic performance of the second method is inferior to that of the first. Through analysis, it is found that the performance degradation in dynamic environment results from the simplification of the GPS carrier phase observable model. And an iterative algorithm is presented to compensate the model error. Using a dynamic GPS data from an aeromagnetic survey, the importance of this compensation is showed at last.

• 동의생리병리학회지
• /
• 제17권1호
• /
• pp.37-43
• /
• 2003

Dam-eum(痰飮) is peculiar pathological product which is caused by functional difficulty in human fluid replacement and that principally originated functional difficulty between Lung(肺), Spleen(脾), Kidney(腎) and Sam-Cho(三焦). Dam-eum(痰飮) comes into force to disorder about ascending, decending, in and out of human energy circulation and frequently raises functional difficulty in human fluid replacement. As a result of that, it has much effect on action of Spirit(神志). After literatual study on the effect of Dam-eum(痰飮) on Spirit(神志), the result were obtained as follows : Dam-eum is not affecting to Spirit by itself. When Dam-eum is Positive Symptom(實證), Yang Symptom(陽證), mainly it affects to Spirit with Pung(風), Hwa(火), Kyung(驚), Youl(熱). And when it is Negative Symptom(虛症), it mostly affects with 脾胃虛寒, 心血不足. Dam-eum is a factor of causing disharmony between Heart & Kidney(心腎), Heart & Liver(心肝), Stomach & Gall Bladder Line(胃膽經) by 痰迷心竅, 痰火擾心. So it brings out troubles of fluid replacement. These are the main circumstances of affecting Spirit. To cure Disease of Spirit(神志病), which is caused by Dam-eum, there are not only uses the treatment of 理痰氣, 豁痰開竅. There are two treatments to use together. The first treatment is 淸熱, 定驚, 息風, 淸心 that removes fitted toxin. And the other treatment is that keeps the balance of Internal Organs.

• 한국실내디자인학회논문집
• /
• 제26호
• /
• pp.26-34
• /
• 2001

The problems with the small exhibition buildings such a small gallery and art center recently constructed did not make the characteristics of the place specifying and did not form a big flow in the line of urban connection. Also it was deficient in the image like a cultural space because of the commercial aspects of the individual buildings. According to this view, this study is to evaluate the exteriors of the small exhibition buildings that the public prefers on the psychological side as a design theory and then, it is to present the direction of desirable form constitution hereafter. In the design of the small exhibition buildings exterior that the public must prefers, the principles and techniques of constitution that operate are the most initiative as follows. As for the principles of unity in the constitution of the small exhibition buildings exterior that the public prefers, Eigen Value is 7.573 and the explanatory force takes 21.637% at the top and it plays a leading role. In the comparison of the appearance, it shows that it is a factor with the largest specific gravity. The next factors were grouped in good order: the balance, ornamental technique, change, shipping technique, rhythm, harmony, symbolic technique, area technique and adding technique. As a result, in the design of the small exhibition buildings exterior, the architects have to constitute the principles of balance, change, rhythm and harmony by most of the unity and the symbolic technique and form technique by most of the ornamental techniques harmoniously and have to give Identity like exhibition buildings.

• 한국운동역학회지
• /
• 제22권4호
• /
• pp.429-435
• /
• 2012

The purpose of this study was to determine the biomechanical effect of wearing carbon nanotube-based insole on cushioning and muscle tuning during drop landing. Twenty male university students(age: $21.2{\pm}1.5yrs$, height: $175.4{\pm}4.7cm$, weight: $70.2{\pm}5.8kg$) who have no musculoskeletal disorder were recruited as the subjects. Average axial strain, average shear strain, inversion angle, linear velocity, angular velocity, vertical GRF and loading rate were determined for each trial. For each dependent variable, a one-way analysis of variance(ANOVA) with repeated measures was performed to test if significant difference existed among different three conditions(p<.05). The results showed that Average axial strain of line 4 was significantly less in CNT compared with EVA and PU during IP phase. The average shear strain was less in CNT compared with EVA and PU during other phases. The inversion angle was increased in CNT compared with EVA and PU during all phase. In linear velocity, angular velocity, vertical GRF and loading rate, there were no significant difference between the three groups. This result seems that fine particle of carbon nanotube couldn't make geometric form which can absolve impact force by increasing density through eliminating voids of forms. Thus, searching for methods that keep voids of forms may play a pivotal role in developing of insole. This has led to suggestions of the need for further biomechanical analysis to these factors.

• 산업경영시스템학회지
• /
• 제45권1호
• /
• pp.20-30
• /
• 2022

In this study, in order to confirm the relationship between technical innovation competence and corporate performance, the effect of technical innovation competence of small and medium-sized manufacturing companies on corporate performance was identified, and entrepreneurship, which plays a role as a driving force in triggering technical innovation competence, was analyzed to determine whether there is a mediating effect between them. To conduct the research, first, the research model was established by examining previous studies on technical innovation competence, entrepreneurship, and corporate performance. Second, an on-line and offline survey was conducted for employees in companies after constructing a questionnaire that can verify the hypothesis suitable for the research model. Third, the hypothesis was verified by performing validity and reliability analysis, correlation analysis, and regression analysis using a statistical program. Results of this study, first, it was found that R&D competence and technology innovation system, which are elements of technical innovation competence, had a significant effect on financial performance, and technology innovation system and technology accumulation capacity, had a significant effect on non-financial performance. Second, it was analyzed that entrepreneurship has a mediating effect in both R&D capability, technological innovation system and technology accumulation capability, which are elements of technical innovation capability, and financial and non-financial performance, elements of corporate performance.

• 대한조선학회논문집
• /
• 제60권5호
• /
• pp.320-331
• /
• 2023

In this study, a model test was conducted using the soft-mooring technique to evaluate the added resistance of the ship in waves. The study also examined the specific factors that should be considered during the soft-mooring test. The main purpose of soft-mooring is to prevent drifting caused by waves by providing horizontal restoring forces. However, it can also create undesired restoring forces in the vertical direction. Therefore, we examined the restoring force of the ship's 6-DOF motion based on the arrangement of the soft-mooring and the height of the mooring connection point. We also checked the corresponding resonance period and drift distance. The soft-mooring test was conducted twice, once with self-propulsion and once without self-propulsion, allowing us to review the advantages and disadvantages of each test technique. The main parameters measured in these model tests were 6DOF motion and added resistance on the ship. We compared these measurements obtained from two different techniques (with and without self-propulsion). Additionally, we also compared the measurements based on the types of measuring sensors used (2D load cells on FP, AP, and 1D load cells on each mooring line) as well as the height of the mooring connection point.

• 한국가구학회지
• /
• 제24권1호
• /
• pp.24-32
• /
• 2013

The aim of the present study was to investigate and analyze a tendency of the Philippines furniture which are not well-known in Korean market yet, but have been emerging as an OEM base, through the Manila FAME 2012. The study was conducted by visiting some furniture companies in Philippines for the active understanding regarding the current status of the Philippines furniture, in consideration of the material, functional and structural aspects of the goods which were exhibited on the Manila FAME 2012. The methods of the investigation were to research the related literatures concerned and materials had been collected over the internet, to visit the Manila FAME 2012 at work and finally to visit furniture companies in Philippines. Manila FAME has been based on the DTI (DTI: Department of Trade and Industry) through CITEM (CITEM: The Center for International Trade Mission and Expositions) since 1983. The exhibition whichincludes various sorts from furniture, traditional artifacts, leisure goods, gifts, jewelry and clothes is becoming such a potent force by integrating three exhibitions such as Manila Now, CEBUNEXT and Bijoux Cebu, what all had been held before the world economic downturn. The features of the Philippines furniture shown on the Manila FAME are as follows: First, they are focusing on the maximum of function to the exclusion of the decoration and they were mostly made of various kinds of mahogany like jambilina, acacia, bamboo, wisteria and Manila hemp growing up in the Philippines indeed and finally there were a lot of the simple designs of the curved line which were exactly the material nature of the wisteria and Manila hemp.

• 한국문헌정보학회지
• /
• 제48권3호
• /
• pp.335-351
• /
• 2014

이 연구는 전문도서관의 특성에 맞는 SNS 운영방안을 제시하는 것으로, 해양과학도서관의 사례를 중심으로 SNS 운영조직, 인력, 콘텐츠, 홍보에 관하여 심층적으로 분석하였다. 연구를 통해 도출된 전문도서관의 SNS 운영방안을 요약하면, (1) 운영목적에 적합한 SNS 채널의 선택, (2) SNS 운영에 대한 도서관 업무분장, (3) 연성형 T/F팀 조직 운영과 전담인력 지정, (4) 전문주제별 콘텐츠 특성화, (5) 참여형 이벤트 중심의 온 오프라인 홍보 실시, (6) 정기적인 로그분석을 통한 콘텐츠 개선, (7) SNS 이용을 통한 도서관 홈페이지 이용 유도 등이 있다. 또한 전문도서관 SNS 운영의 발전방향으로 전문도서관 직원 간 업무소통 및 협력강화, 모기관 연구 및 학술성과의 확산, 이용자와의 소통창구로서 역할 강화, 도서관의 소셜 큐레이터 역할 수행을 제안하였다.

• 한국의류학회지
• /
• 제38권6호
• /
• pp.796-809
• /
• 2014

This study identifies formativeness and the Korean consciousness of the vernacular design in a Korean designers' collection in order to discover the internal characteristics of vernacular expression elements. The study is based on a theoretical review and an analysis of cases collected from Korean fashion designers' clothes. Research is limited to international collections of clothes presented by Korean fashion designers since 2,000. The process of Korean vernacular designs in fashion were analyzed for formativeness in form, color, pattern and detail. The research findings identified formativeness and Korean's consciousness of modern fashion designs that reflect vernacular designs as follows. First, they are round, flexible line and shape based on assimilated with nature, rhythmic curve to express life force and asymmetry based on an ecstatic world based on nature. Second, a white color explained the pure mind and racial peculiarities in regards to the five colors that expressed the thinking of traditional rituals such as prayers for comfort of life and ancestor worship. Third, there were patterns around shape of nature, praying, and Korea culture. Finally, there were skills of Korean traditional handcrafts such as embroideries, knit-works, gold foils, and quilts where clothes expressed the hardship of life and strong willpower to overcome. In conclusion, the clothing of Korean vernacular designs contains characteristics such as natural beauty, decorativeness, shamanism, and eclecticism.