• Biomolecules & Therapeutics
• /
• v.23 no.3
• /
• pp.251-260
• /
• 2015

Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment in spatial learning and memory from repeated neonatal propofol administration in animals. Yet, none of those studies has explored the sex-specific long-term physical changes and behavioral alterations such as social (sociability and social preference), emotional (anxiety), and other cognitive functions (spatial working, recognition, and avoidance memory) after neonatal propofol treatment. Seven-day-old Wistar-Kyoto (WKY) rats underwent repeated daily intraperitoneal injections of propofol or normal saline for 7 days. Starting fourth week of age and onwards, rats were subjected to behavior tests including open-field, elevated-plus-maze, Y-maze, 3-chamber social interaction, novel-object-recognition, passive-avoidance, and rotarod. Rats were sacrificed at 9 weeks and hippocampal protein expressions were analyzed by Western blot. Results revealed long-term body weight gain alterations in the growing rats and sex-specific impairments in spatial (female) and recognition (male) learning and memory paradigms. A markedly decreased expression of hippocampal NMDA receptor GluN1 subunit in female- and increased expression of AMPA GluR1 subunit protein expression in male rats were also found. Other aspects of behaviors such as locomotor activity and coordination, anxiety, sociability, social preference and avoidance learning and memory were not generally affected. These results suggest that neonatal repeated propofol administration disrupts normal growth and some aspects of neurodevelopment in rats in a sex-specific manner.

• Journal of the Korean housing association
• /
• v.12 no.4
• /
• pp.227-230
• /
• 2001

The Sri Autobindo Learning Center(SALC) is sponsoring the development of a passive solar village in Creston, Colorado, Situated near the Sangre de Cristo mountains, Savitri Village will be one of several religious communities in the area. This village will incorporate 12 permanent residences and teaching and guest facilities for fifty to one hundred people. The purpose of this study is to evaluate the passive solar elements and performance of guest house at the Sri Autobindo Learning Center(SALC). To do this evaluation, the following tasks needed to be addressed. 1. the guest house design 2. the location of weather data 3. The determination of the building heating load As part of the evaluation process, guest house design will be modified and the building load and solar saving recalculated. This process will be completed until the building performance is deemed satisfactory. The conclusion is as follows; The high solar savings fraction predicted by SUNCODE should taken as an indication that further design changes would probably not be cost effective. But adding removal overhangs or other low costs measures to increase comfort in the summer appear to be appropriate.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2018.07a
• /
• pp.364-366
• /
• 2018

본 논문에서는 Digital Twin 기반 건설기계 지능화를 위한 실시간 건설기계 데이터 처리 및 이상 유무 예측 시스템을 제안한다. 이 시스템은 빅 데이터 분산처리 기반으로 실시간 스트리밍 처리가 가능하며, CEP(Complex Event Processing)의 Sliding Window Operator를 활용한 Rule 적용을 통해 건설기계 데이터 처리 및 분석한다. 분석된 결과로 건설기계의 실시간 이상 유무를 판단할 수 있으며, 결과를 기반으로 Deep Learning 기술을 적용하고 학습된 모델을 통해 건설기계의 이상 유무를 예측하여 원활한 부품관리를 할 수 있다.

• Journal of Korean Academy of Nursing
• /
• v.36 no.6
• /
• pp.942-949
• /
• 2006

Purpose: This study was to investigate the knowledge and learning needs of chemotherapy in gynecological cancer patients. Method: The subjects consisted of 103 gynecological cancer patients receiving chemotherapy from April 2005 to August 2005. Data was collected using a questionnaire about knowledge and learning needs of chemotherapy. The data was analyzed by t-test, ANOVA, Scheffe test, and Pearson's correlation coefficient using SAS. Result: Average scores of knowledge and learning needs of general treatment and care were 2.74, and 3.30 respectively. Average score of knowledge and learning needs of chemotherapy were 2.54 and 3.23 respectively. Learning needs of general treatment and care and of chemotherapy were significantly different in relation to marital status, educational level, family support, the operation, and the amount of chemotherapy received. Items with the highest level of learning needs were the symptoms of recurring illness of general treatment, and minimizing side effects of chemotherapy. There were a negative correlation between knowledge and learning needs on general treatment and a positive correlation between knowledge and learning needs on chemothearpy but there were not significant statistically. Conclusion: The level of learning needs related to cancer treatment was high, whereas, that of knowledge was low. Therefore, when designing an educational program for gynecological cancer patients, understanding of learning needs is necessary. Also, consideration of a patient's characteristics, and a systematic and detailed educational program should be provided.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
• /
• v.18 no.2
• /
• pp.31-39
• /
• 2012

Background: The purpose of this study was to develop a problem-based learning model for orthopedic manual physical therapy. A problem-based learning (PBL) model for orthopedic manual physical therapy developed from PBL module of Jeju C university (Halla-Newcastle PBL Center). A summary of this study is as follows: 1) PBL model is comprised of a class of 30 students, operated small group as of 4~5 students. 2) PBL is suggested a scenario of clinical case, induced variety reaction through group discussion and presentation. 3) PBL is occurred wide variety learning through group work activity and self-directed learning. 4) The tutor as a facilitator is played a guide for group discussion, work activity and team learning. 5) The evaluation for PBL is performed such as student self-evaluation, group activity evaluation, individual presentation, and practice. This model is considered wide variety learning through team learning and self-directed learning by clinical reasoning and problem solving for musculoskeletal clinical case. We suggest problem based learning for the education of orthopedic manual physical therapy in which the learners are very interested in and has the effective outcome.

• Journal of the Korean Institute of Educational Facilities
• /
• v.27 no.5
• /
• pp.13-23
• /
• 2020

From the perspective of smart learning space, this study aims to take a look at the learning space of college students who do online remote learning in the COVID-19 era, and analyze their demands on what smart learning space they want. Furthermore, this study intends to provide valuable implications for the technology-enhanced learning environments by deriving design elements that make up the university's smart learning space. To achieve these goals, we conducted a review of prior studies, interviews with experts, and case analysis on smart learning spaces of major Korean and foreign universities, which are considered as innovative cases. Additionally, in order to confirm the difference between the importance level recognized by the college students and the current performance level for nine components of technology and for ten components of spaces and facilities, a paired t-test and an Importance-Performance Analysis (IPA) were carried out. According to the result of IPA analysis, Internet of Things from the technological aspects, a desk that can supply power and a flexible learning space from the aspects of spaces and facilities were found to have much lower performance than the importance. This result is meaningful in suggesting key design components for smart campus development in the post-COVID-19 world.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.22 no.5
• /
• pp.515-528
• /
• 2020

Underground concrete structures are usually designed to be used for decades, but in recent years, many of them are nearing their original life expectancy. As a result, it is necessary to promptly inspect and repair the structure, since it can cause lost of fundamental functions and bring unexpected problems. Therefore, personnel-based inspections and repairs have been underway for maintenance of underground structures, but nowadays, objective inspection technologies have been actively developed through the fusion of deep learning and image process. In particular, various researches have been conducted on developing a concrete crack detection algorithm based on supervised learning. Most of these studies requires a large amount of image data, especially, label images. In order to secure those images, it takes a lot of time and labor in reality. To resolve this problem, we introduce a method to increase the accuracy of crack area detection, improved by 0.25% on average by applying adversarial learning in this paper. The adversarial learning consists of a segmentation neural network and a discriminator neural network, and it is an algorithm that improves recognition performance by generating a virtual label image in a competitive structure. In this study, an efficient deep neural network learning method was proposed using this method, and it is expected to be used for accurate crack detection in the future.

• 대학교육
• /
• s.135
• /
• pp.112-114
• /
• 2005

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.17 no.1
• /
• pp.50-56
• /
• 2003

This research was done to make the effective prescription and cope with various senile dementia. So Sprague-Dawley rats were injected with ibotenate to make a damage on learning and memory functions. At first acquisition test and retention rest were done in the Morris water maze. And to evaluate the effects of the sample drug(TBM) on choline acetyltranferase and acetylcholine esterase, immunoreactive measurement and enzymatic activity measuring were carried out. The ibotenic acid were injected to hippocampus CA1 and CA3 area. The results were as following. TBM improved the learning ability in the acquisition test and memory function in the retention test significantly. And TBM increased the level of ChAT which is synthesizing acetylcholine in CA3 area, and at the same time it increased the level of AChE which is resolving acetylcholine. These results show that T8M improved the cholinergic catabolism and anabolism, and the increment of metabolic activity of cholinergic system. In other words, it contributes to the recovery of damaged learning and memory function by ibotenic acid. So it can be concluded that TBM will be helpful to cholinergic brain damage induced by primary or senile reduction of acetylcholine secretive activity.

• The Korean Journal of Pain
• /
• v.30 no.4
• /
• pp.258-264
• /
• 2017

Background: Pulpal pain is one of the most common and severe orofacial pain conditions with considerable adverse effects on physiological processes including learning and memory. Regular exercise is known to be effective on cognitive function as well as pain processing in the central nervous system. Here, the possible effects of regular exercise on pulpal pain response as well as pain-induced changes in learning and memory efficiency in rats were investigated. Methods: Twenty-four male Wistar rats were randomly assigned to the control, capsaicin, exercise, and exercise plus capsaicin groups. Rats in exercise groups were forced to run on a treadmill with a moderate exercise protocol for 4 weeks. Capsaicin was used to induce dental pulp pain. Passive avoidance learning and memory performance was assessed by using a shuttle box apparatus. Results: According to the results, regular exercise could decrease the time course of capsaicin-induced pulpal pain (P < 0.001). Moreover, in capsaicin-treated rats, passive avoidance acquisition was impaired as compared to the control (P < 0.05) and exercise (P < 0.001) groups. Additionally, regular exercise before capsaicin injection could attenuate capsaicin-induced memory impairments (P < 0.05). Conclusions: Taken together, the present data showed that regular exercise has inhibitory effects on capsaicin-induced pulpal pain as well as pain-induced cognitive dysfunction in rats.