Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Taebong-eum on Learning and Memory Function in the Cholinergic Cell Damaged Rat

태봉음이 콜린성 신경세포손상 백서의 학습 및 기억에 미치는 영향

  • Park Jong Soo (Department of Oriental Medicine, Biomedical Research Center of Oriental Medicine, Dongeui University) ;
  • Chi Gyoo Yong (Department of Oriental Medicine, Biomedical Research Center of Oriental Medicine, Dongeui University) ;
  • Eom Hyun Sup (Department of Oriental Medicine, Biomedical Research Center of Oriental Medicine, Dongeui University)
  • 박종수 (동의대학교 한의과대학, 한방바이오연구센터) ;
  • 지규용 (동의대학교 한의과대학, 한방바이오연구센터) ;
  • 엄현섭 (동의대학교 한의과대학, 한방바이오연구센터)
  • Published : 2003.02.01
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Abstract

This research was done to make the effective prescription and cope with various senile dementia. So Sprague-Dawley rats were injected with ibotenate to make a damage on learning and memory functions. At first acquisition test and retention rest were done in the Morris water maze. And to evaluate the effects of the sample drug(TBM) on choline acetyltranferase and acetylcholine esterase, immunoreactive measurement and enzymatic activity measuring were carried out. The ibotenic acid were injected to hippocampus CA1 and CA3 area. The results were as following. TBM improved the learning ability in the acquisition test and memory function in the retention test significantly. And TBM increased the level of ChAT which is synthesizing acetylcholine in CA3 area, and at the same time it increased the level of AChE which is resolving acetylcholine. These results show that T8M improved the cholinergic catabolism and anabolism, and the increment of metabolic activity of cholinergic system. In other words, it contributes to the recovery of damaged learning and memory function by ibotenic acid. So it can be concluded that TBM will be helpful to cholinergic brain damage induced by primary or senile reduction of acetylcholine secretive activity.

Keywords

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