• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 1999년도 학술발표회 진행표 및 논문초록
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• pp.61-62
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• 1999

;The mechanisms inducing hypertension are actively investigated and are still challenging topics. Basically hypertension must be caused by the disorder of $Ca^{2+}$ metabolism in vascular smooth muscle, such as the increase of $Ca^{2+}$ influx, the decrease of ci+ efflux, or the change of sensitivity of contractile protein etc. The one of cause of the increase of ci+ influx may be the change of ci+ channel activity. Even though the relationships of ci+ channel activity and hypertension were studied using various hypertension models, still it is not clear how much change of $Ca^{2+}$ channel activity in diabetes mellitus (DM) induced hypertension is occurred. We induced DM hypertension in SD rat and compared the $Ca^{2+}$ channel activity with age-matched normotensive SD rat. For inducing DM hypertension, left kidney was removed with 200 gm rat and, after 1 month, 60 mg/kg of streptozotocin was injected into peritoneal space to induce diabetes mellitus. Usually after 4-6 weeks, hypertension was fully induced. For isolating vascular smooth muscle cells (VSMC), we used mesenteric arteriole (3rd - 4th branch of mesenteric artery) of which diameter is below 150 urn. VSMCs were isolated enzymatically. $Ca^{2+}$ current was measured using whole cell patch clamp technique. All experiments were performed at $37^{\circ}C$. The cell membrane area of VSMC of DM hypertensive rat is larger than that of control VSMC($36.6{\pm}3.64{\;}pF{\;}vs{\;}22.4{\pm}1.29{\;}pF, {\;}mean{\pm}S.E.$) When we compared the current amplitude, the $Ca^{2+}$ current amplitude in VSMC of DM hypertensive rat is much larger than that in VSMC of normotensive age-matched rat. After $Ca^{2+}$ current amplitude was normalized by cell membrane area, the current amplitude in DM hypertension is increased to $249.1{\pm}15.9{\;}%{\;}(mean{\pm}S.E.M)$, which means the ;absolute current amplitude is about 4 times larger in DM hypertension. When we compared the steady state activation and inactivation. there were no noticeable differences. From these results. one of cause of the DM hypertension is due to the increase of $Ca^{2+}$ current amplitude. But it need further study why the $Ca^{2+}$ current is so large in VSMC of DM hypertension and how much $Ca^{2+}$ influx through $Ca^{2+}$ channel contribute to the increase of intracellular $Ca^{2+}$ and eventually contribute to development of hypertension.ypertension.

• 터널과지하공간
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• 제3권2호
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• pp.109-117
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• 1993

The existence and exact location of cavity is very important for the stability of the large underground storage house or building. Numerical method such as finite element method and finite diference methods are widely used because of model's complexity. Preliminary tests such as calculation step test, mesh size test and model size test were tried. Upper shadow zone and lower shadow zone can be calculated from 50% amplitude level of measuring data. From these statistical methods, the calculatied position of cavity coincided nearly with actual position of model testing cavity.

• Journal of Mechanical Science and Technology
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• 제17권4호
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• pp.599-605
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• 2003

For practical calculations, the Reynolds equation is frequently used to analyze the lubricating flow. The full Navier-Stokes Equations are used to find validity limits of Reynolds equation in a lubricating flow regime by result comparison. As the amplitude of wavy upper wall increased at a given average channel height, the difference between Navier-Stokes and lubrication theory decreased slightly : however, as the minimum distance in channel throat increased, the differences in the maximum pressure between Navier-Stokes and lubrication theory became large.

• Tribology and Lubricants
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• 제5권2호
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• pp.48-54
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• 1989

The effects of angular misalignment, coning and the temperature difference between the primary seal ring and the seal seat on the pressure distribution in mechanical face seals are analyzed. The modified Reynolds equation for the temperature dependent viscosity was solved by a finite difference approximation and Gauss-Seidel method. It is shown that the amplitude of pressure is significantly affected by the misalignment of the seals and a large temperature difference between the rotor and the stator.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2012년도 제45회 KOSCO SYMPOSIUM 초록집
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• pp.53-54
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• 2012

In an IGCC plant, one of the most important issues on fuel flexibility in the lean premixed combustor is combustion instabilities. They are characterized by large amplitude pressure oscillations which are caused by unsteady heat release from the flames. The relationship between the unsteady heat release and flow oscillation can be qualitatively and quantitatively explained by flame transfer function. This paper introduces combustion instability modeling methods based on the flame transfer function approach.

• 천문학회지
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• 제29권spc1호
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• pp.387-388
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• 1996

The principles to attain improved accuracy in a new controller for large CCD and mosaics detectors with the application of 16- and 32-bit DSP are presented.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2003년도 The Fifth Asian Computational Fluid Dynamics Conference
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• pp.268-269
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• 2003

The Boltzmann kinetic equation is solved directly by means of the conservative splitting method. Underexpanded supersonic free jet flows with small Knudsen numbers are studied. In this numerical simulation features intrinsic to appropriate experiments are observed. Streamwise vortices in a mixing layer and chaotic downstream temporal-spatial fluctuations of microscopic quantities with large amplitude are obtained.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 추계학술대회논문집B
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• pp.416-421
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• 2000

The performance of gas turbine engines is affected by instabilities, like as rotating stall and/or surge. Rotating Stall is a transient intermediate stage between normal flow and complete flow breakdown leading to engine surge. Rotating Stall is associated with large amplitude nonaxisymmetric flow variations rotating around the compressor annulus. This paper presents the evolutions of stall propagation in a compressor cascade by numerical analysis. The flow phenomena due to stall cells and propagation speed are examined using 2 dimensional Navier - Stokes equations.

• 전산구조공학
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• 제6권1호
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• pp.99-105
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• 1993

A Stepped beam with immovable ends under forced vibrations with large amplitude is investigated by using the finite element method and the Ritz vectors. Unlike the Eigen vectors, the Ritz vectors are generated by a simple recurrence relation. Moreover the Ritz vectors yield much faster convergence with respect to the number of vectors used than the use of Eigen vectors. The computer program is developed for nonlinear analysis using Ritz vectors instead of Eigen vectors and numerical examples are analysed for deflections and natural frequencies of stepped beam under various support conditions. Results show that the proposed method is valid and efficient.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2003년도 춘계학술발표대회 논문집
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• pp.211-214
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• 2003

This paper presents the microscopic observation results from the picture frame test using five-harness satin weave fabric composite. Aligned and misaligned specimens are observed to verify the exact tow deformation pattern such as tow interval and change in tow amplitude. To observe the micro-deformation of the fabric structure, appropriate specimens from picture frame test are sectioned and observed under the microscope. From the observation results, it is found that a picture frame test with a misaligned fibre orientation angle shows large differences in deformation between tensile and compressive tow directions.