• 제목/요약/키워드: isolated trachea

검색결과 65건 처리시간 0.021초

윤폐제수음(潤肺除嗽飮)이 GUINEA PIG의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響) (Effects of Yunpaejaesueum extract on the contraction of isolated guinea pig trachea smooth muscle)

  • 윤호석
    • 대한한방내과학회지
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    • 제13권1호
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    • pp.99-109
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    • 1992
  • In order to study the effects of Yunpaejaesueum known clinically for their effects of treatment for cough and asthma, the study was carried out to investigate the effect of Yunpaejaesueum extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism. The results were obtained as follows: 1. The isolated trachea smooth muscle of guinea pig was suspended in the organ bath with oxygenated Kreb's Henseleite bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recorded with isometric transducer(Nacro F-60). The resting tension was approximately 0.5g. 2. The isolated trachea smooth muscle of guinea pig was remakably relaxed by the administration of Yunpaejaesueum. 3. Yunpaejaesueum is significantly inhibited the contractile response of histimine 10-4 M in isolated guinea pig trachea smooth muscle. 4. Yunpaejaesueum is significantly inhibited the contractile response of acetylcholine 10-4 M in isolated guinea pig trachea smooth muscle. 5. Yunpaejaesueum is significantly inhibited the contractile response of 5-hydroxytryptamine 10-4 M in isolated guinea pig trachea smooth muscle. 6. Yunpaejaesueum is significantly inhibited the contractile response of prostaglandin F2a 10-7 M in isolated guinea pig trachea smooth muscle.

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이모산(二母散)이 Guinea Pig의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響) (Effect of Yeemosan(二母散) extract on the contraction of isolated Guinea Pig Trachea Smooth Muscle)

  • 이춘재
    • 대한한방내과학회지
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    • 제13권1호
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    • pp.70-79
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    • 1992
  • This study was carried out to investigate the effect of Yeemosan extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism. The results were obtained as follows: 1. The contractile response of the trachea smooth muscle of isolated guinea pig to acetylcholine was significantly inhibited by Yeemosan. 2. The contractile response of the trachea smooth muscle of isolated guinea pig pretreated propranolol was significantly inhibited by Yeemosan. 3. Effects of Yeemosan extract on the contractile response of the isolated guineapig trachea smooth muscle pretreated methylene blue was not significant. 4. The contractile response of the trachea smooth muscle of isolated guinea pig to prostaglandin $F2{\alpha)$ was significantly inhibited by Yeemosan. 5. Effects of prostaglandin $F2{\alpha)$ on the contractile response of the isolated guinea pig trachea smooth muscle pretreated Yeemosan was not significant. According to the above results. it was suggested that the contractile response mechanism of the guinea pig trachea smooth muscle to Yeemosan was related to sympathetic nervous system receptor and other mechanism should have further study.

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시호지길탕(柴胡枳桔湯)이 GUINEA PIG의 기관지평활근(氣管支平滑筋)에 미치는 영향(影響) (Effects of Shihogigiltang(柴胡枳桔湯) extracts on the contraction of isolated guinea pig trachea smooth muscle)

  • 이민섭
    • 대한한방내과학회지
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    • 제13권1호
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    • pp.34-45
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    • 1992
  • This study was carried out to investigate the effect of Shihogigiltang extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism. The results were obtained as follows: 1. The isolated trachea smooth muscle was suspended in the organ bath with oxygenated Kreb's Henseleit bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recorded with isometric transducer(Nacro F-60). The resting tension was approximately 0.5g. 2. The trachea smooth muscle of the isoiated guinea pig was significantly relaxed by the administration of Shihogigiltang extract. 3. ShihogigiItang significantly inhibited the contractile response of histamine 10-4 M is isolated guinea pig trachea smooth muscle. 4. The contractile response of the trachea smooth muscle of the isolated guinea pig by acetylcholine 10-4 M was significantly inhibited by Shihogigiltang extract. 5. The contractile response of the trachea smooth muscle of the isolated guinea pig by 5-hydorxytryptamine 10-4 M was significantly inhibited by Shihngigiltang extract. 6. The contractile response of the trachea smooth muscle of the isolated guinea pig by prostaglandin $F2\;{\alpha}$ 10-7 M was significantly inhibited by Shihngigiltang extract.

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삼요탕(三拗湯) 및 신출산(神朮散)이 GUINEA PIG의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響) (Effects of Samyootang and Shinchulsan Extract on the Contraction of Isolated Guinea pig's Trachea Smooth Muscle)

  • 오영욱
    • 대한한방내과학회지
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    • 제13권2호
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    • pp.84-94
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    • 1992
  • This study was carried out to investigate the effect of samyootang and shinchulsan extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate it's mechanism The isolated were obtained as follows ; 1. The isolated trachea smooth muscle was suspended in the organ bath with oxygenated kreb's Henseleit bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recored with Isometric transducer (nacro F-60) The resting tension was approximately 0.5g 2. The contractile response of the trachea smooth muscle of the isolated guinea pig to histamine $10^{-4}M$ was significantly inhibited by samyootang and shinchulsan extract. 3. The contractile response of the trachea smooth muscle of the isolated guinea pig to acetylcholine $10^{-4}M$ was considerably inhibited by samyootang and shinchulsan extract. 4. The contractile response of the trachea smooth muscle of the isolated guinea pig to histamine $10^{-4}M$ was significantly inhibited by samyootang and shinchulsan extract. 5. The contractile response of the trachea smooth muscle of the isolated guinea pig to acetylcholine $10^{-4}M$ was significantly inhibited by samyootang and shinchulsan extract.

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마황산(麻黃散) 및 그 구성약물(構成藥物)이 GUINEAPIG의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響) (Effects of Mahwangsan(麻黃散) Extract and Its Constituent Drug on the Contraction of Isolated Guinea pig Trachea Smooth Muscle)

  • 홍재의;신조영
    • 대한한방내과학회지
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    • 제12권2호
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    • pp.30-43
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    • 1991
  • Mahwangsan is used in the treatment of asthma due to wind and cold(風寒喘). This study was carried out to investigate the effect of Mahwangsan extract and each drug composing it on the contractile force of the isolated guinea pig trachea muscle and elucidate its mechanism. The results were obtained as follows; 1. The isolated trachea smooth muscle of guinea pig was signifi-cantly relaxed by the administration of Mahwangsan extract. 2. The contractile response of the isolated trachea smooth muscle of guinea pig to histamine was significantly inhibited by the administration of Mahwangsan extract. 3. The contractile response of the isolated trachea smooth muscle of guinea pig to histamine was significantly inhibited by the administraction of Herba Ephedrae, Cortex Cinnamoni, Flos Farfarae, Fructus Chebulae and Semen Armeniacae extract. 4. The contractile response of the isolated trachea smooth muscle of guinea pig to acetylcholine was significantly inhibited by the administration of Mahwangsan extract. 5. The contractile response of the isolated trachea smooth muscle of guinea pig to acetylcholine was significantly inhibited by the administration of Herba Ephedrae, Flos Farfarae, Fructus Chebulae and Semen Armeniacae extract. 6. The contractile response of the isolated trachea smooth muscle of guinea pig to 5-hydroxytryptamine was significantly inhibited by the administration of Mahwangsan extract. 7. The contractile response of the isolated trachea smooth muscle of guinea pig to 5-hydroxytryptamine was significantly inhibited by the administration of Herba Ephedrae, Flos Farfarae, Fructus Chebulae and Semen Armeniacae extract.

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자소음자(紫蘇飮子)가 GUINEA PIG의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響) (Effects of Jasoeumja Extract On the Contraction of Isolated Guinea pig Trachea Smooth Muscle)

  • 송진오;한상환
    • 대한한방내과학회지
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    • 제11권1호
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    • pp.77-91
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    • 1990
  • This study was carried out to investigate the effect of Jasoeumja extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism. The results were obtained as follows: 1. The isolated trachea smooth muscle was suspended in the Organ bath with oxygenated Kreb's Henseleit bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recorded with Isometric transducer (Nacro F-60). The resting tension was approximately 0.5g. 2. The trachea smooth muscle of the isolated guinea pig was significantly relaxed by the administration of Jasoeumja extract. 3. The contractile response of the trachea smooth muscle of the isolated guinea pig to histamine $10^{-4}M$ was significantly inhibited by Jasoeumja extract. 4. The contractile response of the trachea smooth muscle of the isolated guinea pig to acetylcholine $10^{-4}M$ was considerably inhibited by Jasoeumja extract. 5. The contractile response of the trachea smooth muscle of the isolated guinea pig to 5-hydroxytryptamine $10^{-4}M$ was considerably inhibited by Jasoeumja extract.

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해표양진탕(解表兩陳湯) 및 해표이진탕(解表二陳湯)이 Guinea Pig의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響) (Effects of Haepyoyangjintang and Haepyoejintang Extract On the Contraction of Isolated guinea pig trachea smooth muscle)

  • 박천수;한상환
    • 대한한방내과학회지
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    • 제11권2호
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    • pp.68-79
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    • 1990
  • This study was carried out to investigate the effect of Heapyoyangjintang and Haepyoejintang extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism. The results were obtained as follows : 1. The isolated trachea smooth muscle was suspended in the organ bath with oxygenated kreb's Henseleit bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recorded with Isometric transducer(nacro F-60). The resting tension was approximately 0.5g. 2. The trachea smooth muscle of the isolated guinea pig was significantly relaxed by the administration of Haepyoyangjintang and Haepyoejintang extract. 3. The contractile response of the trachea smooth muscle of the isolated guinea pig to histamine$10^4M$ Was significantly inhibited by Heapyoyangjintang and Haepyoejintang extract. 4. The contractile response of the trachea smooth muscle of the isolated guinea pig to acetylcholine$10^4M$ was considerably inhibited by Haepyoyangjintang and Haepyoejintang extract. 5. The contractile response of the trachea smooth muscle of the isolated guinea pig to 5-hydorxytrtrypptamine $10^4M$ was considerably inhibited by Haepyoyangjintang and haepyoejintang extract.

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오요탕(五拗湯) 및 신출산(神朮散)이 GUINEA PIG의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響) (Effects of Oyootang and shinchulsan Extract on the Contraction of Isolated Guinea pig's Trachea Smooth Muscle)

  • 이시형
    • 대한한방내과학회지
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    • 제14권1호
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    • pp.1-16
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    • 1993
  • This study was carried out to investigate the effect of Oyootang and Shinchulsan extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism The result were obtained as follow: 1. The isolated trachea smooth muscle was suspended in the organ bath with oxygenated kerb's Henseleit bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recorded with isometric tranducer(Nacro F-60). The resting tension was approximately 0.5g 2. The contractile response of the trachea smooth muscle of the isolated guinea pig by histamine $10^{-4}M$ was significantly inhibited by Oyootang and Shinchulsan extract. 3. The contractile response of the trachea smooth muscle of the isolated guinea pig by acetylcholine $10^{-4}M$ was considerably inhibited by Oyootang and Shinchulsan extract. 4. The contractile response of the trachea smooth muscle of the isolated guinea pig by histamine $10^{-4}M$ was significantly inhibited by Oyootanghabshinchulsan extract. 5. The contractile response of the trachea smooth muscle of the isolated guinea pig by acetylcholine $10^{-4}M$ was significantly inhibited by Oyootanghabshinchulsan extract. 6. The contractile response of the trachea smooth muscle of the iso-lated guinea pig by histamine $10^{-4}M$ was significantly inhibited by Oyootang, Shinchulsan and its constituent herbs extract. 7. The contractile response of the trachea smooth muscle of the iso-lated guinea pig by acetylcholine $10^{-4}M$ was significantly inhibited by Oyootang, Shinchulsan and its constituent herbs extract.

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행인반하탕(杏仁半夏湯)이 GUINEA PIG의 기관지평활근(氣管支平滑筋)에 미치는 영향(影響) (Effects of Haenginbanhatang Extract on the Contraction of Isolated Guinea Pig Trachea Smooth Muscle)

  • 이영자
    • 대한한방내과학회지
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    • 제13권1호
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    • pp.124-134
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    • 1992
  • Effects of Haenginbanhatang Extract on the Contraction of Isolated Guinea Pig Trachea Smooth Muscle. This study was carried out to investigate the effect of Haenginbanhatang extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism. The results were obtained as follows: 1. The contratile response of the trachea smooth muscle of the guinea pig to histamine was significantly inhibited by Haenginbanhatang. 2. Effects of Haenginbanhatang extract on the contractile response of the isolated guinea pig smooth muscle pretreated propranolol was not significant. 3. The contractile response of isolated guinea pig smooth muscle pretreated methylene blue was significantly inhibited by Haenginbanhatang, 4. The contractile response of the trachea smooth muscle of the guinea pig to prostaglandin F2a was significantly inhibited by Haenginbanhatang. 5. Effect of prostaglandin F2a on the contractile response of guinea pig smooth muscle pretreated Haenginbanhatang was not significant. According to the above results, it was suggested that the contractile response mechanism of the guinea pig smooth muscle to Haenginbanhatang was related to cyclic GMP.

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반하온폐탕(半夏溫肺湯) 및 그 구성약물(構成藥物)이 실험(實驗) 동물(動物)에 미치는 영향(影響) (Effects of Banhaonpaetang(半夏溫肺湯) extract and its Constituent herbs on the Contraction of Isolated Guinea Pig Trachea Smooth Muscle)

  • 송진오;한상환
    • 대한한방내과학회지
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    • 제13권2호
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    • pp.1-15
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    • 1992
  • This study has been carried out to investigate the effects of Banhaonpaetang extract and its constituent herbs on the contractile force of Isolated Guinea pig trachea smooth muscle and to elucidate its mechanism. The results were as follows; 1. Banhaonpaetang significanly inhibitd the contractile force of isolated guinea pig trachea smooth muscle pretreated by histamine. 2. Banhaonpaetang significantly inhibited the contractile force of isolated guinea pig trachea smooth muscle pretreated by acetylcholine. 3. Radix Asari(細辛), Flos Inulae(旋覆花), Pericarpium Citri Nobilis(陳皮) and Radix Ginseng(人蔘) extract significantly inhibited the contractile force of isolated guinea pig trachea smooth muscle pretreated by histamine. 4. Radix Asari(細辛), Cortex Cinnamomi(桂心), Flos Inulae(旋覆花), Pericarpium Citri Nobilis(陳皮) and Radix Ginseng(人蔘) extract significantly inhibited the contractile force of isolated guinea pig trachea smooth muscle pretreated by acetylcholine. 5. The effects of Banhaonpaetang extract on the changes of plasma ACTH in rats were shown to be insignificant. 6. The effects of Banhaonpaetang extract on the changes of serum electrolytes were shown to be significant in $K^+$ and $Ca^{2+}$.

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