• Title/Summary/Keyword: interrogation

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BioMEMS-EARLY DISEASE DETECTION (BioMEMS 기반의 조기 질병 진단 기술에 관한 연구)

  • Singh, Kanika;Kim, Kyung-Chun
    • Proceedings of the KSME Conference
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    • 2007.05b
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    • pp.2781-2784
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    • 2007
  • Early detection of a disease is important to tackle treatment issues in a better manner. Several diagnostic techniques are in use, these days; for such purpose and tremendous research is going on to develop newer and newer methods. However, more work is required to be done to develop cheap and reliable early detection techniques. Micro-fluidic chips are also playing key role to deliver new devices for better health care. The present study focuses on a review of recent developments in the interrogation of different techniques and present state-of-the-art of microfluidic sensor for better, quick, easy, rapid, early, inexpensive and portable POCT (Point of Care testing device) device for a particular study, in this case, bone disease called osteoporosis. Some simulations of the microchip are also made to enable feasibility of the development of a blood-chip-based system. The proposed device will assist in early detection of diseases in an effective and successful manner.

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Microbial Biosensors for Environmental and Food industrial Applications (환경오염과 식품공업 측정용 미생물 바이오센서)

  • 김의락
    • KSBB Journal
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    • v.17 no.3
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    • pp.213-227
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    • 2002
  • To date, the majority of biosensor technologies use binding components such as enzymes antibodies, nucleic acids and protein ligands. In contrast, the goal underlying the use of cells and tissues of animals and plants for a sensor system is to obtain systems capable of extracting information based on the biological activity, mechanisms of action and consequences of exposure to a chemical or biological agent of interest. These systems enable the interrogation of more complex biological response and offer the potential to gather higher information content from measuring physiologic and metabolic response. In these articles, same of the recent trends and applications of microbial biosensors in environmental monitoring and for use in food and fermentations have been reviewed. This endeavor presents many technological challenges to fabricate new microbial biosensors for other scientific field.

Characteristics of a Bimetal-Layer Chip of a Surface Plasmon Resonance Sensor in the Intensity Interrogation for Tumor Marker Detection

  • Kim, Hyungjin;Kim, Chang-duk;Sohn, Young-Soo
    • Journal of Sensor Science and Technology
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    • v.25 no.4
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    • pp.243-246
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    • 2016
  • The characteristics of a bimetallic surface plasmon resonance (SPR) chip were investigated to detect a tumor biomarker, carcinoembryonic antigen (CEA). The linewidth and the tangential slope of the reflectance curve of the bimetallic SPR chip was compared with those of the reflectance curve of a conventional gold (Au) SPR chip. The changes in reflectance in response to the variation in CEA in the critical concentration range were analyzed at an angle where the tangential slope of the reflectance curve was maximum. From linear regression analysis, the sensitivity of the bimetallic SPR chip with respect to the CEA in critical concentration was obtained.

PIV Measurements of the Pressure Driven Flow Inside a T-Shaped Microchannel Junction (T헝 마이크로채널 연결부 압력구동 유동의 PIV계측)

  • Choi Jayho;Lee In-Seop
    • Journal of the Korean Society of Visualization
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    • v.1 no.1
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    • pp.75-81
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    • 2003
  • A custom micro-PIV optics assembly has been used to measure the flow fold inside a T-junction of a microchannel. The micro-PIV system consists of microscope objectives of various magnifications, a dichroic cube, and an 8-bit CCD camera. Fluorescent particles of diameters 620 nm have been used with a Nd:YAG laser and color filters. A programmable syringe pump with Teflon tubings were used to inject particle-seeded distilled water into the channel at flow rates of 2.0, 4.0, 6.0 mL/hr. The micro-channels are fabricated with PDMS with a silicon mold, then O$_{2}$ -ion bonded onto a slide glass. Results show differences in flow characteristics and resolution according to fluid injection rates, and magnifications, respectively. The results include PIV data with vector-to-vector distances of 2 $\mu$m with 32 pixel-square interrogation windows at 50$\%$ overlap.

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Remote Impedance-based Loose Bolt Inspection Using a Radio-Frequency Active Sensing Node

  • Park, Seung-Hee;Yun, Chung-Bang;Inman, Daniel J.
    • Journal of the Korean Society for Nondestructive Testing
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    • v.27 no.3
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    • pp.217-223
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    • 2007
  • This paper introduces an active sensing node using radio-frequency (RF) telemetry. This device has brought the traditional impedance-based structural health monitoring (SHM) technique to a new paradigm. The RF active sensing node consists of a miniaturized impedance measuring device (AD5933), a microcontroller (ATmega128L), and a radio frequency (RF) transmitter (XBee). A macro-fiber composite (MFC) patch interrogates a host structure by using a self-sensing technique of the miniaturized impedance measuring device. All the process including structural interrogation, data acquisition, signal processing, and damage diagnostic is being performed at the sensor location by the microcontroller. The RF transmitter is used to communicate the current status of the host structure. The feasibility of the proposed SHM strategy is verified through an experimental study inspecting loose bolts in a bolt-jointed aluminum structure.

Visualization of Vortex Lock-on to Oscillatory Incident Flow in the Cylinder Wake Using Time-Resolved PIV (고속 PIV계측에 의한 실린더 근접후류 공진 유동 가시화)

  • 송치성
    • Journal of Advanced Marine Engineering and Technology
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    • v.25 no.6
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    • pp.1353-1361
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    • 2001
  • Vortex lock-on or resonance behind a circular cylinder is visualized using a time-resolved PW when a single frequency oscillation is superimposed on the mean incident velocity. For vector processing, a cross-correlation algorithm in conjunction with a recursive correlation and interrogation window shifting techniques is used. Measurements are made of the Karmas and streamwise vertices in the wake-transition regime at Reynolds lumber 360. When lock-on occurs, the vortex shedding frequency is found to be half the oscillation frequency as expected from previous experiments. At the lock-on state, the Karman vortices are observed to be more disordered by the increased strength and spanwise wavelength of the streamwiee vortices, which lead? to a strong three-dimensional motion.

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Nanoscale-NMR with Nitrogen Vacancy center spins in diamond

  • Lee, Junghyun
    • Journal of the Korean Magnetic Resonance Society
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    • v.24 no.2
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    • pp.59-65
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    • 2020
  • Nitrogen-Vacancy (NV) center in diamond has been an emerging versatile tool for quantum sensing applications. Amongst various applications, nano-scale nuclear magnetic resonance (NMR) using a single or ensemble NV centers has demonstrated promising results, opening possibility of a single molecule NMR for its chemical structural studies or multi-nuclear spin spectroscopy for quantum information science. However, there is a key challenge, which limited the spectral resolution of NMR detection using NV centers; the interrogation duration for NV-NMR detection technique has been limited by the NV sensor spin lifetime (T1 ~ 3ms), which is orders of magnitude shorter than the coherence times of nuclear spins in bulk liquid samples (T2 ~ 1s) or intrinsic 13C nuclear spins in diamond. Recent studies have shown that quantum memory technique or synchronized readout detection technique can further narrow down the spectral linewidth of NMR signal. In this short review paper, we overview basic concepts of nanoscale NMR using NV centers, and introduce further developments in high spectral resolution NV NMR studies.

Development of the Emergency Generator Equipments Diagnosis System (비상용 발전설비 진단시스템 개발)

  • Lee, Sang-Cheol;Na, Chae-Dong;Lee, Seong-Beom;Yoo, Jae-Moon;Choi, Sik
    • Proceedings of the KIEE Conference
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    • 1999.07f
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    • pp.2590-2593
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    • 1999
  • This paper describes the development of Emergency Generator Equipments Diagnosis System for monitoring generator equipments and battery system. This system is capable of measuring on up to 20 separate sites of generator, engine and periphral equipment's. Battery system also capable of measure the setting time, float and discharge voltage of up to 240 cells in a single installation, and has the memory capacity to store battery's alarm data information on up to 200 separate sites. This system are easy to maintain and attain cost effectively, so that prepared for meeting the customer's service needs immediately. The system is additionally programmed with a each model, that will enable to accurately determine the generator equipments and remain battery capacity in a system following a short discharge test. It is also equipped with remote interrogation and control facilities.

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PIV Measurements of the Pressure Driven Flow Inside a T-Shaped Microchannel (T형 마이크로채널 내부 압력구동 유동의 PIV 계측)

  • Choi Jayho;Lee In-Seop
    • Proceedings of the KSME Conference
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    • 2002.08a
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    • pp.423-426
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    • 2002
  • A custom micro-PIV optics assembly has been used to measure the flow field inside a T-shaped microchannel. The micro-PIV system consists of microscope objectives of various magnifications, a dichroic cube, and an 8-bit CCD camera. Fluorescent particles of diameters 620nm have been used with a Nd:YAG laser and color filters. A programmable syringe pump with Teflon tubings were used to inject particle-seeded distilled water into the channel at flow rates of $420,\;40,\;60{\mu}L/hr$. The microchannels are fabricated with PDMS with a silicon mold, then $O_2-ion$ bonded onto a slide glass. Results show differences in flow characteristics and resolution according to fluid injection rates, and magnifications, respectively. The results show PIV results with vector-to-vector distances of $2{\mu}m$ with 32 pixel-square interrogation windows at $50{\%}$ overlap.

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Laser sensor wavelength interrogation using a long-period fiber grating (장주기 격자를 이용한 광섬유 레이저센서의 파장변화 측정)

  • Song, Min-Ho;Lee, Sang-Bae;Choi, Sang-Sam;Nam, Hui;Lee, Byoung-Ho
    • Journal of the Korean Institute of Telematics and Electronics D
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    • v.34D no.12
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    • pp.83-88
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    • 1997
  • We present a fiber laser sensor that uses a fiber grating as a strain sensor head and an end-reflector of the laser cavity. A passive wavelength. The long-period grating band-rejection filter showed a wide usable filter wavelength range of about 25 nm, and the intensity of transmitted light increased by 16% for 1nm sensor wavelength shift in trhe measurement range.

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