• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2011년도 추계학술대회
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• pp.619-620
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• 2011

최근 다양한 형태와 함께 온라인 쇼핑들 간의 치열한 경쟁이 심화되고 있다. 이에 따라 온 오프라인에서 차별화된 특징이 경쟁력을 도모할 수 있게 되었으며, 젊은 계층인 연인들을 마케팅 대상으로 하는 커플 이벤트 기획이 필요하게 되었다. 본 연구에서는 커플 및 젊은 구매계층들을 마케팅 대상으로 하며, 매출 향상을 목적으로 기획 및 구현된 사이트 개발을 목표로 하고 있다. 이를 위해서 기존 상업 사이트에 대한 이벤트 기획들에 대한 분석을 기반으로, 커플 생일을 마케팅 전략 및 다양한 기념 이벤트 및 고객들이 사이트를 방문하였을 때 이벤트가 한층 돋보이도록 마케팅 기획과 정보 배치를 중심으로 사이트를 구축하였다. 이를 통해 일부 고객층 대상으로 이벤트 효과 증대를 통한 매출 증대를 도모할 수 있을 것으로 기대된다.

• 한국정보통신학회논문지
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• 제25권12호
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• pp.1942-1948
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• 2021

우리나라 토지공부는 일제 시대의 낙후된 기술로 정립되어 현재 국내 토지의 15%가 지적도와 맞지 않는다. 이에 정부는 '지적재조사 사업'이라는 이름 아래 우리나라 토지공부를 정립하고 측량 원점을 세계측지계로 변경 중에 있다. 지적재조사 사업이 끝난 후 우리나라 디지털 정보 서비스가 구축되어 디지털 지적정보가 제공될 때, 그 정보를 이용하여 손쉽게 측량할 수 있는 드론 경계 복원 측량 방법을 제안한다. Mobile GCS는 모바일 어플로 드론을 제어하고 토지공부에 기록된 경계점 좌표를 획득하여 드론이 자동 비행하여 경계점을 표시하도록 한다. 개발한 프로토타입 드론으로 6개 경계점을 2분 내로 순회하였다.

• 한국임상약학회지
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• 제9권1호
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• pp.49-54
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• 1999

This study was carried out to compare the bioavailability of Hanmi clarithromycin (250 mg/tablet) with that of $Klaricid^{(R)}$ The bioavailability was examined on 20 volunteers who received a single dose (500 mg) of each drug in the fasting state in a randomized balanced 2-way crossover design. After dosing, blood samples were collected for a period of 12 hours. Plasma samples were analyzed for clarithromycin and roxithromycin(internal standard) by HPLC/Coulometric BCD. The pharmaco-kinetic parameters ($AUC_{0-l2hr}$, Cmax, Tmax, $AUC_{inf}$, Ka, Kel, $t_{1/2}$, Vd/F and Cl/F) were calculated from the plasma clarithromycin concentration-time data of each volunteer. The computer program 'WinNonlin' was used for compartmental analysis. One compartment model with first-order input, from order output with lag time, weighting factor $l/y^2$ was chosen as the appropriate pharmacokinetic model. The major pharmacokinetic parameters ($AUC_{0-l2hr},\;AUC_{inf}$, Cmax and Tmax) of Hanmi clarithromycin were $10.7\pm0.5\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;12.7\pm0.7\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;1.7\pm0.1\;{\mu}g/ml\;and\;2.0\pm0.2\;hr$, respectively, and those of $Klaricid^{(R)}\;were\;9.8\pm0.5\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;11.7\pm0.6\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;1.6\pm0.1\;{\mu}g/ml\;and\;2.1\pm0.1\;hr$, respectively. The differences in mean values of $AUC_{0-l2hr},\;AUC_{inf}$ and Cmax between two products were $9.88\%,\;8.94%\;and\;6.59\%$, respectively. The least significant differences at $\alpha=0.05$ for $AUC_{0-l2hr},\;AUC_{inf}$ and Cmax were $16.08\%,\;17.81\%\;and\;18.94\%$, respectively. Though the plasma clarithromycin concentrations of Hanmi clarithromycin were higher than those of $Klaricid^{(R)}$ at all observed times, the bioavailability of Hanmi clarithromycin appeared to be bioequivalent with that of $Klaricid^{(R)}$. The Ka, Kel, $t_{1/2}$, Vd/F and Cl/F of the Hanmi clarithromycin were $2.69\pm0.53\;hr^{-1},\;0.18\pm0.01 hr^{-1},\;3.9\;hr,\;248.8\pm11.4\;L\;and\;43.7\pm2.6\;L/hr$, respectively, and those of $Klaricid^{(R)} were 2.19\pm0.51\;hr^{-1},\;0.18\pm0.02\;hr^{-1},\;3.7\;hr,\;266.7\pm22.4\;L\;and\;45.3\pm2.8L/hr$, respectively. There were no statistically significant differences between two drugs in all pharmacokinetic parameters.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1991년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 22-24 Oct. 1991
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• pp.243-247
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• 1991

A roll eccentricity controller for a tandem cold rolling process is designed to attenuate the outlet thickness deviation due to roll eccentricity. In order to design the controller, the excess stability margin is maximized by solving a standard H.inf. optimization problem under the requirement that ensure disturbance rejection for a class of disturbance. Robust performance of the proposed controller is checked by a computer simulation.

• 대한수학회보
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• 제45권2호
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• pp.273-275
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• 2008

We will give a short and elementary proof of the existence of infinitely many primes p such that a given positive integer a congruent 3 modulo 4 is a quadratic non-residue modulo p.

• Journal of Pharmaceutical Investigation
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• 제36권4호
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• pp.277-282
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• 2006

Lisinopril is one of the angiotensin-converting enzyme inhibitors, which have been used for treatment of hypertension and heart failure. The aim of this study was to evaluate the bioequivalence of two lisinopril tablet, $Lisihexal^{\circledR}$ and $Zestril^{\circledR}$ as a test and reference, respectively. The study was came out on 28 healthy male Korean volunteers in $2{\times}2$ crossover design. An analytical method with LC-MS-MS was developed for the quantification of lisinopril and enalapril(IS) using SPE method. The condition was selective, sensitive and precise in human plasma, that was enough for the pharmacokinetic study of lisinopril. The pharmacokinetic parameters such as $AUC_t,\;AUC_{inf},\;C_{max},\;T_{max}\;and\;t_{1/2}$ were calculated and ANOVA test was used for the statistical analysis of the parameters using log transformed $AUC_t,\;AUC_{inf}\;and\;C_{max}$. $t_{1/2}$ of test and reference drugs were calculated $11.4{\pm}5.1\;and\;16.1{\pm}9.9\;hr$, respectively. The 90% confidence intervals of $AUC_t,\;AUC_{inf}\;and\;C_{max}$ were log 0.9245$\sim$log 1.0603, log 0.9270$\sim$log 1.0601 and log 0.9548$\sim$log 1.1009, within the acceptable range of log 0.8 to log 1.25 by KFDA bioequivalence criteria. Two medications of lisinopril were evaluated bioequivalent and thus may be prescribed interchangeably.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.1444-1447
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• 1997

In this paper, the problen of dseigning a H.inf. controller is considered, where the controller is realized through digital equipment. We show that the existing discrete-time controller design method can be improved by usign the inveres bilinear transformation. The usefulness of the given method is confirmed by simulation.

• 대한수학회보
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• 제22권2호
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• pp.83-85
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• 1985

Let K be a real function field over a real closed field F. Then there exists an F-place .phi.:K.rarw.F.cup.{.inf.}. This is Lang's Existence of Rational Place Theorem (6). There is an equivalent version of Lang's Theorem in (4). That is, if K is a function field over a field F, then, for any ordering P$_{0}$ on F which extends to K, there exists an F-place .phi.: K.rarw.F'.cup.{.inf.} where F' is a real closure of (F, P$_{0}$). In [2], Knebusch pointed out the converse of the version of Lang's Theorem is also true. By a valuation theoretic approach to Lang's Theorem, we have found out the following generalization of Lang and Knebusch's Theorem. Let K be an arbitrary extension field of a field F. then an ordering P$_{0}$ on F can be extended to an ordering P on K if there exists an F-place of K into some real closed field R containing F. Of course R$^{2}$.cap.F=P$_{0}$. The restriction K being a function field of F is vanished, though the codomain of the F-place is slightly varied. Therefore our theorem is a generalization of Lang and Knebusch's theorem.

• 약학회지
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• 제49권6호
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• pp.484-489
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• 2005

Streptococcus pmeumoniae is the leading cause of pneumonia and bacterial meningitis. The current polysaccharide vaccine has been reported ineffective in elderly adults and children less than 2 years of age. Thus, in recent many researchers have been focused on a different approach, DNA vaccine. In our laboratory we developed a Streptococcus pneumoniae DNA (SPDNA) vaccine. This SPDNA vaccine was formulated by inserting the region encoding part of the capsule in the S. pneumoniae into the LAMP-1. In present work, with use of the SPDNA vaccine we attempted to establish a certain methodology useful for evaluation of effectiveness and immunoresponse of a DNA vaccine. Results showed that the subcutaneous route was the most effective for production of antisera specific for S. pneumoniae in mice. By isotyping analyses, IgM, IgGl, IgG2a, and IgG2b were determined. In addition, INF-$\gamma$ and IL-4 were predominantly detected. Combination of those data resulted in a pattern of IgGl < IgG2a=IgG2b and INF$\gamma\>$ >IL-4, which indicates the inmmunity towards the Thl response predominantly; furthermore, the SPDNA vaccination induced resistance of the CD4+T lymphocyte-depleted mice against disseminated pneumococcal infection. These data appear to be possibly due to activation of CDS8+T cell-activation. Taken together, this methodology can be applied for evaluating efficacy and mode of action of a DNA vaccine as minimum critera.

• 대한수학회보
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• 제59권1호
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• pp.241-263
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• 2022

We consider a nonlinear Schrödinger equation with critical frequency, (P_𝜀) : 𝜀²∆v(x) - V(x)v(x) + |v(x)|^p-1v(x) = 0, x ∈ ℝ^N, and v(x) → 0 as |x| → +∞, for the infinite case as described by Byeon and Wang. Critical means that 0 ≤ V ∈ C(ℝ^N) verifies Ƶ = {V = 0} ≠ ∅. Infinite means that Ƶ = {x₀} and that, grossly speaking, the potential V decays at an exponential rate as x → x₀. For the semiclassical limit, 𝜀 → 0, the infinite case has a characteristic limit problem, (P_inf) : ∆u(x)-P(x)u(x) + |u(x)|^p-1u(x) = 0, x ∈ Ω, with u(x) = 0 as x ∈ Ω, where Ω ⊆ ℝ^N is a smooth bounded strictly star-shaped region related to the potential V. We prove the existence of an infinite number of solutions for both the original and the limit problem via a Ljusternik-Schnirelman scheme for even functionals. Fixed a topological level k we show that v_k,𝜀, a solution of (P_𝜀), subconverges, up to a scaling, to a corresponding solution of (P_inf ), and that v_k,𝜀 exponentially decays out of Ω. Finally, uniform estimates on ∂Ω for scaled solutions of (P_𝜀) are obtained.