• Journal of Acupuncture Research
• /
• v.24 no.3
• /
• pp.145-161
• /
• 2007

Objectives : The purpose of this study is to investigate the effect of electroacupuncture at Joksanmi($ST_{36}$) on Rat's aging by experimental methods. Methods : The author performed several experimental procedures to observe the effects of the EC-HAS at the arthritis. First, I measured the cell survival rate of the mice lung fibroblasts. Second, the incidence rate of arthritis and arthritis index of CIA were analyzed. Third, the levels of IL-6, $INF-{\gamma}$ , $INF-{\alpha}$ , $IL-1{\beta}$, IgG, IgM and anti-collagen II were measured in serum and the level of $INF-{\gamma}$, $INF-{\gamma}$/IL-4 ratio in the CIA mouse spleen cell culture. Fourth, histological analysis of the mice joint was performed. Fifth, the expression ratio of $CD3e^+$ cells to $CD19^+$ cells, $CD4^+$ cells to $CD8^+$ cells, $CD11a^+CD19^+$ cells, $CD4^+CD25^+$ cells, $CD3^+CD69^+$ cells, and $CD11b^+Gr-1^+$ cells were checked. Results: 1. The hematocrit was meaningfully (p<0.01, p<0.05) decreased in $ST_{36}$ group in comparison with the control and sham group. 2. The glucose, ALP were meaningfully (p<0.05, p<0.05) decreased in $ST_{36}$ group in comparison with the control group. 3. In the activation of hepatic antioxidase, the catalase was meaningfully (p<0.01) increased in $ST_{36}$ group in comparison with the control group. 4. In the liver, the NO formation was meaningfully (p<0.001) decreased in $ST_{36}$ group in comparison with the nomal, control and sham group. 5. In the activation of splenetic antioxidase, the GSH was meaningfully (p<0.01) increased in $ST_{36}$ group in comparison with the sham group, and the catalase was meaningfully (p<0.001) increased in $ST_{36}$ group in comparison with the control group. 6. In the spleen, the MDA formation was meaningfully (p<0.01, p<0.05) decreased in $ST_{36}$ group in comparison with the control and sham group. 7. In the spleen cell culture, the levels of IL-6 was meaningfully (p<0.05) decreased in comparison with the sham group, $INF-{\gamma}$( was meaningfully (p<0.05) increased in comparison with the control group. Conclusions: According to the results, it is considered that electroacupuncture at Joksamni($ST_{36}$) is effective in increasing the activities of antioxidative enzyme and inhibiting lipid peroxides, and has an immunomodulatory reaction. In conclusion, it han an significant anti-aging effect and need more experimental study.

• 제어로봇시스템학회:학술대회논문집
• /
• 1990.10b
• /
• pp.847-851
• /
• 1990

In this paper we present a method of reducing controller design problem from LQG/LTR approach to H.inf. optimization. The condition of the existance of the optimal solution is derived. In order to derive the controller equation for NMP plant we reduce the H.inf. LTR problem to Nehari's extension problem and derive the optimal controller equation which is best approximation for this problem. Furthermore, we show that the controller obtained by presented method guarantee the asymptotic LTR condition and stability of closed loop system.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.23 no.8
• /
• pp.936-942
• /
• 2019

Autonomous driving of drone indoor must move along a narrow path and overcome other factors such as lighting, topographic characteristics, obstacles. In addition, it is difficult to operate the drone in the hallway because of insufficient texture and the lack of its diversity comparing with the complicated environment. In this paper, we study an autonomous drone navigation using Convolution Neural Network(CNN) in indoor environment. The proposed method receives an image from the front camera of the drone and then steers the drone by predicting the next path based on the image. As a result of a total of 38 autonomous drone navigation tests, it was confirmed that a drone was successfully navigating in the indoor environment by the proposed method without hitting the walls or doors in the hallway.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.19 no.1
• /
• pp.106-113
• /
• 2005

Asthma is an inflammatory disease of airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. In this study we wanted to investigate the effect of SCT and BJT on eosinophilla and cytokines of BALF in a mouse model established airway inflammmation. Asthma was induced to male c57/bl6 mice. Allergen-specific antibody responses, cytokine$(IL-4,\;IL-5,\;INF-{\gamma})$, and eosinophil inflammation of the airways were investigated on the BALF and splenocyte. SCT and BJT effectively induced $INF-{\gamma}$ and inhibited IL-4, IL-5 as well as eosinophilic inflammation when SCT and BJT were administered. Total Ig E level in the BALF decreased. SCT was more effectiveness than BJT. It is considered that SCT and BJT have faborable effect on the asthma because the asthma specific series of abnormalities in respiratory system were decreased.

• The Journal of Internal Korean Medicine
• /
• v.30 no.1
• /
• pp.64-73
• /
• 2009

Objectives : Consumption of fermented foods has been known to alleviate some of the symptoms of atopy and may limit allergy development, while there are also many medicinal herbs proved to be effective for immunologically-mediated diseases. In this study, we introduced modern zymology to ferment some herbs to see if fermentation has the possibility of increasing the anti-inflammatory effects of medicinal herbs. Interleukin-4 (IL-4) and interferon-gamma $(INF-\gamma)$ have been demonstrated to be the main factors in the pathology of allergic diseases. Methods : We measured the levels of IL-4 and $INF-\gamma$ on concanavalin A-induced BALB/c mice spleen cells, which were subsequently treated with fermented and unfermented herbs. We then compared the fermented groups with unfermented groups to see if the anti-inflammatory effects of the herbs were influenced by fermentation. Results and Conclusions : Our results showed that fermentation had the potential to increase the anti-inflammatory effects of some medicinal herbs, and Astragalus membranaceus and Salvia miltiorrhiza would be the most suitable medicinal herbs for fermentation among the herbs in this study.

• Journal of the Korean Mathematical Society
• /
• v.8 no.1
• /
• pp.5-7
• /
• 1971

• Bulletin of the Korean Mathematical Society
• /
• v.22 no.2
• /
• pp.95-98
• /
• 1985

In [1], E.B. Lee and L. Markus described a sufficient condition for which the domain of null-controllability of a linear autonomous system is all of R$^{n}$ . The purpose of this note is to extend the result to a certain linear nonautonomous system. Thus we consider a linear control system dx/dt = A(t)x+B(t)u in the Eculidean n-space R$^{n}$ where A(t) and B(t) are n*n and n*m matrices, respectively, which are continuous on 0.leq.t<.inf. and A(t) is a periodic matrix of period .omega.. Admissible controls are bounded measurable functions defined on some finite subintervals of [0, .inf.) having values in a certain convex set .ohm. in R$^{m}$ with the origin in its interior. And we present a sufficient condition for which the domain of null-controllability is all of R$^{n}$ .

• Journal of the Korean Institute of Telematics and Electronics B
• /
• v.33B no.4
• /
• pp.17-26
• /
• 1996

A submerged vehicle which is a nonlinear multivariable system must be designed to be roubst against inner-outer perturbations and hydrodynamic disturbances induces maneuvering operation. But a practical design of motion controller is limited by both mathematical modeling error and linearization errors. Performance of a motion controller based on traditional design method is very poor when the vehicle motion is under wave force distrubacnes near sea surface. Therefore, this ppaer proposes a design method of $^{\infty}$ controller under model uncertainty and sea wave disturbances. performance of the controllers by both computer simulation and HILS (hardwave in the loop simulation) shows that $H^{\infty}$ controller is more robust than PID controller under model uncertainty and high sea state...

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.16 no.2
• /
• pp.233-238
• /
• 2002

Moxibustion is one of major healing technique in oriental medicine. It has been widely used in many diseases such as rheumatoid arthritis, Hashimoto disease, breech presentation, etc. However, till now, effects of moxibustion on NK cell activity and relations between sympathetic nerve system(SNS) and the immune alteration induced by moxibustion were not well studied. This study was designed to evaluate effects of moxibustion on NK cell activity and the intervention of SNS in the alteration of NK cell activity induced by moxibustion. Splenic NK cytotoxity was measured in a standard 4-h 51Cr release assay. We measured the NK cytotoxity at after moxibustion stimulation for 1,3,5, and 7 days, and also measured the NK cell cytotoxity after 3 and 7 days burn stimulation with similar temperature. IL-2, IL-4, INF-γ in serum were measured by rat IL-2, IL-4, INF-γ ELISA TEST KIT. To evaluate the effects of sympathectomy on alteration of NK cell cytotoxity, 6-hydroxydopamine(6-OHDA : 5Omg/kg) was used. We showed that NK cell activity of moxibustion stimulation group increased at the 3rd day, and declined at 7th day in comparison with that of contol group. In moxibustion stimulation group, NK cell activity of 3 day stimulation group was significantly higher than sham group. On the contrary, in burn stimulation group, NK cell activity was significantly higher than that of sham groups at 3rd, 7th days. Patterns between moxibustion and burns were different. INF- γ level of 3 days moxibustion stimulation group significantly higher than sham group. IL 2 level among groups were not different. IL-4 was not detected in serum with this method. Sympathectomy abolished the NK cell activity alteration induced by moxibustion. The results suggest that moxibustion induces the alteration of NK cell activity, along with INF-γ and SNS is related to these effects.

• Journal of Life Science
• /
• v.15 no.4 s.71
• /
• pp.652-656
• /
• 2005

Tuberculosis is the leading infectious disease in the world. It is urgent to develop new vaccine and treating drugs. Besides vaccines, we want to know the effects of regular swim training on TB infection in the mouse model. This study was designed to examine the effects of regular swim training on lung and spleen TB counts and $INF-\gamma$ activity in the trained mice at different temperature. The trained mice underwent a 10-wk endurance swim training (5 times/wk) in water at $29\~33^{\circ}C$ (WWG) and $21\~23^{\circ}C$(CWG) for 60 min. And they were divided into 3 groups according to the regular swim training (CG; control, WWG; warm water group, and CWG; cold water group). Mice were challenged by aerosol infection with M. tuberculosis H37Rv using an inhalation device (Glas-Col, Terre Haute, Ind.) calibrated to deliver bacteria into lungs. Three weeks after immunization, the mice were challenged. Four weeks after challenge, the mice were sacrificed and the numbers of viable bacteria in lung and spleen were determined by plating serial dilution of whole organ homogenates on nutrient Middlebrook 7H11 agar (Difco, Detroit, MI). Colonies were counted after four weeks incubation at $37^{\circ}C$. All data were expressed as mean, standard deviation by using SPSS package program (win 10.0). The result through the statistical analysis of this data were summarized as follows; In the weight changes, there were significant differences among CG, WWG, and CWG following the swim training at different temperature, and CWG was the lowest. In the change of $INF-\gamma$ following the swim training, there were significant differences (p<.05) among CG, WWG, and CWG after stimulated with media and CFP. In MTB counts, there were significant differences (p<.05) between CG and WWG in the lung. And also there were significant differences (p<.05) among CG, WWG, and CWG. These results suggest that regular swim training suppress Th1 immune response caused by decreased $INF-\gamma$ level in the WWG, Also For the WWG, highly increased level of TB counts appear in the lung and spleen compare to CG.