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Experiential Understanding of Humans and Reconstructing the Theory of Pathophysiology in the Sasang Constitutional Medical Theory (사상체질의학의 경험적 인간해명과 장부이론의 재구성)

  • Choi, Dae-Woo
    • Journal of Sasang Constitutional Medicine
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    • v.31 no.1
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    • pp.79-93
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    • 2019
  • Objective The purpose of this study was to show that the characteristics of the Sasang Constitutional Medical theory(SCM) are different from the traditional medical theory by comparing their theories of humans and pathophysiology. Methods The establishments and developments of the traditional medical theory were reviewed. Then the hypothesis that the theoretical foundation of SCM is different from that of the traditional medical theory was tested by comparing the traditional medical theory and SCM with respect to the theories of humans and the reconstructed theory of pathophysiology. Results The main findings of this study can be summarized as follows. 1. The theory of SCM reconstructed the traditional medical theory by shifting the paradigm concerning the structure of human existence. 2. The theory for SCM reconstructed the theory of pathophysiology by expanding Confucian moral theory from an experiential perspective. 3. The theory of SCM categorizes humans into four constitution groups according to congenital individuality in emotional expressions and pathophysiological functions. The categorization is based on medical treatment through which it was found that there are congenital individuality in the expression of his moral feelings. 4. The reconstructed pathophysiological theory of the SCM provides the foundation for establishing a verifiable medical theory. Discussion and conclusion The Sasang Constitutional Medical Theory is based on the idea that humans do not follow the changes of Nature but pursue morality and wealth in the Sasang system of the Heavenly qi and human affairs. Therefore, the theory is founded on Confucian moral theory but develops its own view of the theory of pathophysiology by way of experiential interpretation.

Potency and plasma protein binding of drugs in vitro-a potentially misleading pair for predicting in vivo efficacious concentrations in humans

  • Yim, Dong-Seok
    • The Korean Journal of Physiology and Pharmacology
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    • v.23 no.4
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    • pp.231-236
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    • 2019
  • In drug discovery or preclinical stages of development, potency parameters such as $IC_{50}$, $K_i$, or $K_d$ in vitro have been routinely used to predict the parameters of efficacious exposure (AUC, $C_{min}$, etc.) in humans. However, to our knowledge, the fundamental assumption that the potency in vitro is correlated with the efficacious concentration in vivo in humans has not been investigated extensively. Thus, the present review examined this assumption by comparing a wide range of published pharmacokinetic (PK) and potency data. If the drug potency in vitro and its in vivo effectiveness in humans are well correlated, the steady-state average unbound concentrations in humans [$C_{u_-ss.avg}=f_u{\cdot}F{\cdot}Dose/(CL{\cdot}{\tau})=f_u{\cdot}AUCss/{\tau}$] after treatment with approved dosage regimens should be higher than, or at least comparable to, the potency parameters assessed in vitro. We reviewed the ratios of $C_{u_-ss.avg}$/potency in vitro for a total of 54 drug entities (13 major therapeutic classes) using the dosage, PK, and in vitro potency reported in the published literature. For 54 drugs, the $C_{u_-ss.avg}$/in vitro potency ratios were < 1 for 38 (69%) and < 0.1 for 22 (34%) drugs. When the ratios were plotted against $f_u$ (unbound fraction), "ratio < 1" was predominant for drugs with high protein binding (90% of drugs with $f_u{\leq}5%$; i.e., 28 of 31 drugs). Thus, predicting the in vivo efficacious unbound concentrations in humans using only in vitro potency data and $f_u$ should be avoided, especially for molecules with high protein binding.

Digital Human Empathy Index (DHEI) for the Era of Human-AI Symbiosis (AI와 인간 공생의 시대를 위한 디지털휴먼공감지표 개발)

  • Rhee, Hyunjung
    • The Journal of the Korea Contents Association
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    • v.22 no.3
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    • pp.1-16
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    • 2022
  • The current AI technology has been developing rapidly enough to realize or even exceed the level of abilities that only humans had in the past. In the near future, it is predicted that humans and AI will influence each other as members of the metaverse society. Therefore, this study emphasizes the importance of empathy as a core competency for humans to pursue happiness while maintaining the dignity of humans in the era when AI and humans will coexist in the metaverse. In this study, 'Digital Human Empathy Index (DHEI)' is developed that reflects the social nature of computer-mediated communication in the metaverse As a result, DHEI consisted of a total of 7 factors, which are Perspective Taking, Self/Other Awareness, Contextual Understanding of Systemic Barriers, Impact Assessment, Solidarity, Being Peaceful, and Anthropomorphism. This study is expected to contribute to setting the direction of future education by suggesting a new measure of empathy.

The Concept of Divine Beings Coined by Jeungsan Kang Il-Sun (증산 강일순의 신명(神明)사상)

  • Kim, Tak
    • Journal of the Daesoon Academy of Sciences
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    • v.35
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    • pp.109-145
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    • 2020
  • Jeungsan, Kang Il-Sun (hereafter, Jeungsan)'s perspective on divine beings can be characterized by the philosophical notion of divinity, which recognizes a variety of divine entities. Jeungsan insisted that all things embrace divine entities. Furthermore, he claimed that the backgrounds of all incidents were influenced by these gods. Jeungsan thought that the universe consists of the heavenly realm, the earthly realm and the underground realm. He insisted that there were many gods in each realm. And Jeungsan defined his times as the era of divine beings, which meant that the age was a time for divine beings to actively interact with one another and take the lead in world affairs. Divine beings were briskly involved in human affairs and could either reciprocate gratitude or attain revenge. They were also divine beings that could change the acts and perception of humans as well as judge human acts. However, Jeungsan predicted that by the time the paradisiacal land of immortals was established in the Later World, divine beings would instead run errands for humans. In addition, he forecast that divine beings would be entities likely to harbor grievances just like humans, yet they would ultimately become perfected beings in the Later World. Jeungsan further suggested a multitude of various concepts such as the mutual relationship wherein the realm of divine beings and the realm of humanity interrelate with each other, the mutual responses and functions between them, mutual itineration, co-existence, and the homogeneity of divine beings and humans, which described how both have the same innate characteristics. Jeungsan proposed the concept that 'Divinity is an existential state experienced after one's death." In this regard, he is the one who formulated a new perspective of divinity. Moreover, Jeunsan stressed the immortality of humans (continuity or eternality) and the co-existence of divine beings and humans. He emphasized that divinity is intrinsically immanent and the realm of divine beings has a hierarchical system that maintains order and is akin to that of the human realm. Jeungsan recognized a revolutionary change and perspective based on humanity by suggesting a unique view of humanity. In other words, he was a religious figure who introduced an ingenious view of divinity and dramatically transformed this pattern of reasoning. In conclusion, Jeungsan re-interpreted traditional views of divinity in Korea and systemized them into a new concept of divinity in an ingenious way.

Nature and Human Seeing Through I-Ching - Point of view of the Environmental Ethics (『주역(周易)』을 통해 본 자연(自然)과 인간(人間) -환경윤리의 관점을 중심으로 -)

  • Seo, Geun Sik;Chi, Chun-Ho
    • The Journal of Korean Philosophical History
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    • no.28
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    • pp.35-60
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    • 2010
  • In this paper, the researcher investigated the relationships between nature and humans through I-Ching(『周易』) from the perspective of environmental ethics. I-Ching(『周易』) is a literature which has been quoted so frequently as a desirable alternative for environmental issue. The researcher closely reviewed how the relationships between nature and humans had been defined in I-Ching(『周易』) and developed the discussions focusing on what humans could and should do for nature. Nature makes up for the portion of extinction through endless birth. By giving birth for a new life continuously, and complementing the portion of extinction at the same time, nature is being maintained and preserved. In the side of nature, extinction and birth are equal, meanwhile, the sage who wrote I-Ching(『周易』) had held the concept of anxiety worrying that the whole living beings would be extinct, therefore, the sage wrote I-Ching(『周易』) in the aspects of birth. For nature has always been maintained and preserved in its own cause, there is no chance of nature being destroyed by itself. Human is one living being amongst all things created by nature, and at the same time, humans had been endowed with a position which is one among SanCai(三才). Nature had given humans responsibility and duty according to their position, but humans neglect to perform their responsibility and duty indulging in enjoyment of their position. Because humans have only enjoyed their position which is the critical one amongst SanCai (三才), this failure has resulted in destruction of nature. It shall be necessary for humans to enjoy their position to a certain extent, in the meantime, however, they should discharge those responsibilities and duties in order for forming and nourishing powers of Heaven and Earth. Although it is the humans that have destroyed nature, they can also provide nature with help to give birth to a new life. Reason for humans have destroyed nature is that they forgot their responsibility and duty having been concealed by their selfish desires. If humans get rid of their selfish desires, and fulfill their given duties and responsibilities, nature shall become revitalized again.

THERMAL COMFORT FOR HUMANS : FROM OUTDOOR TO INDOOR

  • Son, Cheolsoo
    • Proceeding of Spring/Autumn Annual Conference of KHA
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    • 1994.10a
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    • pp.5-25
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    • 1994
  • The purpose of this paper is to provide the thermal comfort for humans using physiological principles of heat transfer and thermoregulation, heat exchange between the human body and its enclosur, and heat exchange between the inside enclosure and the outside environment.

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Interaction Ritual Interpretation of AI Robot in the TV Show (드라마<굿 플레이스>속 인공지능 로봇의 상호작용 의례적 해석)

  • Chu, Mi-Sun;Ryu, Seoung-Ho
    • The Journal of the Korea Contents Association
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    • v.21 no.5
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    • pp.70-83
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    • 2021
  • The issue of predicting the relationship between humans and AI robots is a 'strong AI' problem. Many experts predict the tragic ending which is a strong AI with superior thinking ability than humans will conquer humans. Due to the expectations of AI robots are projected onto media, the 'morally good AI' that meets human expectations is an important issue. However, the demand for good AI and the realization of perfect technology is not limited to machines. Rather, it appears as a result of putting all responsibility on humans, driving humans into immoral beings and turning them into human and human problems, which is resulting in more alienation and discrimination. As such, the result of technology interacts with the human being used and its properties are determined and developed according to the reaction. This again affects humans. Therefore, AI technology that considers human emotions in consideration of interaction is also important. Therefore, this study will clarify the process that the demand for 'Good AI' in the relationship of AI to humans with Randall Collins' Interaction Ritual Chain. Emotional energy in Interaction Ritual Chain has explained the formation of human bonds. Also, the methodology is a type of thinking experiment and explained through Janet and surrounding characters in the TV show .

A Study on the Interior Design of a Dog-Friendly Hotel Using Deepfake DID for Alleviation of Pet loss Syndrome

  • Hwang, Sungi;Ryu, Gihwan
    • International Journal of Advanced Culture Technology
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    • v.10 no.1
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    • pp.248-252
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    • 2022
  • The environment refers to what is surrounded by something during human life. This environment is related to the way humans live, and presents various problems on how to perceive the surrounding environment and how the behaviors that constitute the environment support the elements necessary for human life. Humans have an interest in the supportability of the environment as the interrelationship increases as humans perceive and understand the environment and accept the factors supported by the environment. In space, human movement starts from one space to the next and exchanges stimuli and reactions with the environment until reaching a target point. These human movements start with subjective judgment and during gait movement, the spatial environment surrounding humans becomes a collection of information necessary for humans and gives stimulation. will do. In this process, in particular, humans move along the movement path through movement in space and go through displacement perception and psychological changes, and recognize a series of spatial continuity. An image of thinking is formed[1]. In this process, spatial experience is perceived through the process of filtering by the senses in the real space, and the result of cognition is added through the process of subjective change accompanied by memory and knowledge, resulting in human movement. As such, the spatial search behavior begins with a series of perceptual and cognitive behaviors that arise in the process of human beings trying to read meaning from objects in the environment. Here, cognition includes the psychological process of sorting out and judging what the information is in the process of reading the meaning of the external environment, conditions, and material composition, and perception is the process of accepting information as the first step. It can be said to be the cognitive ability to read the meaning of the environment given to humans. Therefore, if we can grasp the perception of space while moving and human behavior as a response to perception, it will be possible to predict how to grasp it from a human point of view in a space that does not exist. Modern people have the theme of reminiscing dog-friendly hotels for the healing of petloss syndrome, and this thesis attempts to approach the life of companions.

Models of Sexual Response in Humans (인간의 성 반응에 대한 모델)

  • Choi, In Kwang
    • Korean Journal of Biological Psychiatry
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    • v.20 no.3
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    • pp.66-73
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    • 2013
  • Sexual behavior is crucial in life, yet comparatively little is known about the mechanisms in the sexual response in humans. A lot of theories and models have been developed to explain about the process of the sexual response in humans. The first model of sexual function was described by Masters and Johnson, defined the four-phase model (phases of excitation, plateau, orgasm and resolution). Helen Kaplan proposed a slightly different model of human sexual response by adding the conception of the desire phase. Some years later, a new model of circular sexual response pattern was described by Whipple and Brash-McGreer, who acknowledged the cyclic nature of women's sexual response. Basson presented an alternative model of women's normative sexual function, which featured a responsive form of desire in women's sexual response. Bancroft developed a new theoretical model, the Dual Control Model, which postulates sexual response and arousal is ultimately determined by the balance between the sexual activation or excitation system and the sexual inhibition system. The Sexual Tipping Point is a model created by Perelman, suggesting that a sexual response is determined by a balance between excitatory or inhibitory factors that may be psychological, organic, psychosocial, or cultural. A comprehensive understanding of sexual response and function is of paramount importance for the psychiatrist to study sex, offer counseling to the patient on sex, and practice sex therapy. In this literature, models of sexual response would be reviewed to understand the knowledge of the sexual functioning in humans.

The Communication Aspect of Film and Engineering (영화와 공학의 소통 방식)

  • Ham, Jong-ho
    • Journal of Engineering Education Research
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    • v.18 no.6
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    • pp.88-97
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    • 2015
  • This is paper aims to figure out the way movies and engineering have communicated and the right direction for better communication between them. Engineering no longer should be treated as playing a key role when it comes to film making. Engineering is essential in making films look real. It means that movies gain credibility from utilizing engineering, which all other types of arts also seek after. Films can be resonated better through mutual communication with engineering. The paper takes a close look at emotional aspects to figure out what the new direction of communication between movies and engineering is. People's lives shown in films and the material world that engineering represents are mingled to attain the emotional oneness between the two. This can be easily observed in Japanese movies where robots and humans have a close relationship or recent films whose theme is emotional exchange among humans and robots. This kind of contact leads us to explore newly found humans' position that was brought about in the wake of development in engineering and existential conditions that humans need to have accordingly. Artificial intelligence and neurology sectors that the engineering field is today earnestly working on are in line with it. Therefore, this article seeks to find out the meaning and value of communication between movies and engineering when establishing the fresh mankind model based on emotions and pursuit of diversity.