• Korean Journal of Oriental Medicine
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• v.9 no.2
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• pp.17-27
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• 2003

Eumyang-ohaeng[陰陽五行-Eumyang and five phases], as a standing rule that establishes the theory of Oriental medicine and origin of the oriental philosophy, it provides the perspective of the oriental medicine's outlook of the world. Without knowing the Eumyang-ohaeng, we cannot discuss Oriental medicine, nor can we understand the oriental way of thinking. Time and Space is what the human being created in order to explain the existence and change of matters. There is a common denominator between this universal concept of time and space and the theory of Eumyang-ohaeng. Consequently this paper investigates how characteristics of Eumyang-ohaeng and that of time and space matches Eumyang represents all matter and its characteristic, by comparison with each other space, and Ohaeng shows the change of matter with time gradually and sequancely. But this separation is only a separation by words, they really melt into one like two sides of a coin is actually just one coin. After all the theory of Eumyang-ohaeng is a theory that leads us to realize time and space, matter and power are all just one. So consequently, despite the difference in mass or size or longevity of matters, Eumyang-ohaeng pulls all matter into one body. It's why Eumyang-ohaeng is defined as the unified theory of time and space.

• Journal of Menopausal Medicine
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• v.24 no.3
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• pp.143-149
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• 2018

Lack of adequate sleep has become increasingly common in our 24/7 modern society. Reduced sleep has significant health consequences including metabolic and cardiovascular disorders, and mental problems including depression. In addition, although the increase in life expectancy has provided a dream of longevity to humans, the occurrence of osteoporosis is a big obstacle to this dream for both male and female. It is known that insomnia and bone health problems, which are very critical conditions in human life, interestingly, share a lot of pathogenesis in recent decades. Nevertheless, due to another side effects of the synthetic drugs being taken for the treatment of insomnia and osteoporosis, patients have substantial anxiety for the safety of drugs with therapeutic expectation. This review examines the pathogenesis shared by sleep and osteoporosis together and herbal medicine, which has recently been shown to be safe and efficacious in the treatment of both diseases other than synthetic drugs. We suggestions for how to treat osteoporosis. These efforts will be the first step toward enabling patients to have comfortable and safe prescriptions through a wide selection of therapeutic agents in the future.

• Animal cells and systems
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• v.15 no.2
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• pp.123-130
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• 2011

Transient receptor potential melastatin 7 (TRPM7) channels are novel $Ca^{2+}$-permeable non-selective cation channels that are ubiquitously expressed. Activation of TRPM7 channels has been shown to be involved in the survival of gastric cancer cells. Here we show evidence suggesting that TRPM7 channels play an important role in $Zn^{2+}$- mediated cellular injury. Using a combination of electrophysiology, pharmacological analysis, small interfering RNA (siRNA) methods and cell death assays, we showed that activation of TRPM7 channels augmented $Zn^{2+}$-induced apoptosis of AGS cells, the most common human gastric adenocarcinoma cell line. The $Zn^{2+}$-mediated cytotoxicity was inhibited by the non-specific TRPM7 blockers $Gd^{3+}$ or 2 aminoethoxydiphenyl borate (2-APB) and TRPM7 specific siRNA. In addition, we showed that overexpression of TRPM7 channels in HEK293 cells increased $Zn^{2+}$- induced cell injury. Thus, TRPM7 channels may represent a novel target for physiological disorders where $Zn^{2+}$ toxicity plays an important role.

• Integrative Medicine Research
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• v.3 no.1
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• pp.4-10
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• 2014

Green tea and coffee consumption have been widely popular worldwide. These beverages contain caffeine to activate the central nervous system by adenosine receptor blockade, and due to the caffeine, addiction or tolerance may occur. In addition to this caffeine effect, green tea and coffee consumption have always been at the center of discussions about human health, disease, and longevity. In particular, green tea catechins are involved in many biological activities such as antioxidation and modulation of various cellular lipid and proteins. Thus, they are beneficial against degenerative diseases, including obesity, cancer, cardiovascular diseases, and various inflammatory diseases. Some reports also suggest that daily consumption of tea catechins may help in controlling type 2 diabetes. However, other studies have reported that chronic consumption of green tea may result in hepatic failure, neuronal damage, and exacerbation of diabetes, suggesting that interindividual variations in the green tea effect are large. This review will focus on the effect of green tea catechins extracted from the Camellia sinensis plant on type 2 diabetes and obesity, and the possible mechanistic explanation for the experimental results mainly from our laboratory. It is hoped that green tea can be consumed in a suitable manner as a supplement to prevent the development of type 2 diabetes and obesity.

• Food Science and Industry
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• v.50 no.1
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• pp.16-25
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• 2017

There is no doubt that accumulation of big data using multi-omics technologies will be useful to solve human's long-standing problems such as development of personalized diet and medicine, overcoming diseases, and longevity. However, in the food industry, big data based on omics is scarcely accumulated. In particular, comprehensive analysis of molecular lipid metabolites directly associated with food quality, such as taste, flavor, and texture has been very limited. Moreover, most of food lipidomics studies are applied to analyze lipid components and discriminate authenticity and freshness of limited foods including vegetable and fish oil. However, if lipid big data through food lipidomics research of various foods and materials can be accumulated, lipidomics can be used in the optimization of food processing, production, delivery system, food safety, and storage as well as functional food.

• Food Science and Industry
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• v.51 no.1
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• pp.72-80
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• 2018

Yogurt, which has long been consumed as a longevity food, is characterized by a large number of lactic acid bacteria. The sales of yogurt market have increased for the past three years due to research findings that the intestinal microbial environment is closely associated with many human diseases and the well-being trend of recent consumers. The recent trends in the yogurt market have focused to low sugar content, functionalities such as enhanced immunity, and yogurt for freezing. In addition, recent yogurt products tend to be labeled for certain lactic acid bacteria having functionality in their products. Many yogurts have names of specific lactic acid bacteria on their products, such as 'Activia' and 'Bifidus'. We monitored the 'Bifidus' products in the market for reflecting its regulated counting in their products required to contain more than 10 million Bifidobacteria according to the revised lactic acid bacteria-counting test of Food Code 2015.

• Tribology and Lubricants
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• v.36 no.6
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• pp.297-306
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• 2020

This paper reviews studies on the types and functions of oil sensors used for machine condition monitoring. Machine condition monitoring is essential for maintaining the reliability of machines and can help avoid catastrophic failures while ensuring the safety and longevity of operation. Machine condition monitoring involves several components, such as compliance monitoring, structural monitoring, thermography, non-destructive testing, and noise and vibration monitoring. Real-time monitoring with oil analysis is also utilized in various industries, such as manufacturing, aerospace, and power plants. The three main methods of oil analysis are off-line, in-line, and on-line techniques. The on-line method is the most popular among these three because it reduces human error during oil sampling, prevents incipient machine failure, reduces the total maintenance cost, and does not need complicated setup or skilled analysts. This method has two advantages over the other two monitoring methods. First, fault conditions can be noticed at the early stages via detection of wear particles using wear particle sensors; therefore, it provides early warning in the failure process. Second, it is convenient and effective for diagnosing data regardless of the measurement time. Real-time condition monitoring with oil analysis uses various oil sensors to diagnose the machine and oil statuses; further, integrated oil sensors can be used to measure several properties simultaneously.

• International Journal of Industrial Entomology and Biomaterials
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• v.48 no.2
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• pp.59-66
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• 2024

The mature Bombyx mori silkworm is recognized as a rich source of several nutrients. A unique steaming process has been developed to enhance the palatability of Bombyx mori silkworm and make it more convenient to consume. Additionally, it has also been freeze-dried into a powder form, which is recognized as a nutritional supplement with many health benefits. Steamed and Freeze-dried Mature Silkworm Powder (SMSP) is said to offer a wide range of benefits, including longevity, improved athletic performance, prevention of alcohol-induced liver fibrosis or tumors, amelioration of fatty liver, prevention of peptic ulcers, regulation of melanin production, and mitigation of Parkinson's and Alzheimer's diseases by improving cognitive function. The nutritional composition of SMSP is particularly high in glycine, alanine and serine. This review aims to summarize the molecular mechanisms underlying the diverse effects induced by these key components of SMSP. Such elucidation will enhance the credibility of future studies on SMSP, which will require more comprehensive analyses. It appears that SMSP represents a natural health supplement that could have a positive impact on global human health while increasing income.

• Molecules and Cells
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• v.39 no.5
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• pp.418-425
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• 2016

Resveratrol (RES) plays a critical role in the fate of cells and longevity of animals via activation of the sirtuins1 (SIRT1) gene. In the present study, we intend to investigate whether RES could promote the self-renewal and neural-lineage differentiation in human umbilical cord derived MSCs (hUC-MSCs) in vitro at concentrations ranging from 0.1 to $10{\mu}M$, and whether it exerts the effects by modulating the SIRT1 signaling. Herein, we demonstrated that RES at the concentrations of 0.1, 1 and $2.5{\mu}M$ could promote cell viability and proliferation, mitigate senescence and induce expression of SIRT1 and Proliferating Cell Nuclear Antigen (PCNA) while inhibit the expression of p53 and p16. However, the effects were reversed by 5 and $10{\mu}M$ of RES. Furthermore, RES could promote neural differentiation in a dose-dependent manner as evidenced by morphological changes and expression of neural markers (Nestin, ${\beta}III-tubulin$ and NSE), as well as pro-neural transcription factors Neurogenin (Ngn)1, Ngn2 and Mash1. Taken together, RES exerts a dosage-dependent effect on the self-renewal and neural differentiation of hUC-MSCs via SIRT1 signaling. The current study provides a new strategy to regulate the fate of hUC-MSCs and suggests a more favorable in vitro cell culture conditions for hUCMSCs-based therapies for some intractable neurological disorders.

• The Research Journal of the Costume Culture
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• v.25 no.2
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• pp.130-144
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• 2017

The purpose of this study is to apply iconology to discover the symbolic system of imaginary animals focused on four representative auspicious animals in Korean folk paintings. Study methods included literature review of folk paintings, iconological analytics books, and articles. A total of 16 folk paintings of four auspicious animals in the Joseon Dynasty were analyzed using Panofsky's iconology. The four auspicious animals were Yong(dragon), Bonghwang(the eastern version of the phoenix), Shingoo (divine turtle), and Kirin(one-horned combination of a dragon and horse). According to iconological analysis, Yong is a typical symbol of royal authority, a deity of water as an object of respect with a remarkable talent of transformation, and in iconographical interpretation, represents reverence for transcendent power. Bonhwang is the symbol of a king, sun worship, the emblem of nobility and integrity, and in iconographical interpretation, the psychic bing in the sky. Shingoo is fortune prophecy, longevity and immortality, an envoy of deity, and according to iconographical interpretation, the organic view of the world. Kirin is a divine benign creature, a symbol of talent and honor, mediator between sky and earth, and in iconographical interpretation, an expression of Confucian ideology. This study produced three results. First, the four auspicious animals projected the human hope to overcome human limitations through divine creatures with mythical abilities. Second, they reflected everyday common hopes and values of pursuing fortunes and happiness. Third, the four auspicious animals' iconology was not independent of each other; it seemed to be common to and combined with each other.