• Magazine of the Korean Society of Agricultural Engineers
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• v.45 no.3
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• pp.116-126
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• 2003

In this study, we research about the relationships of human longevity and environments, inducted the significant factors of longevity from the statistical analysis, and represented spatial distribution of longevity using geographic information system. The factors confining human longevity can be categorized by geography/geology, climate/weather, economy, and social welfare. After analyzing statistical data, dependent variable which means the longevity index is defined by the ratio of population more than 85 years old among population more than 65 years old. The results of analysis show that longevity are related with waterworks ratio, temperature, local tax ratio, and latitude. In this study we discussed about the spatial characteristics which are represented by variance of the longevity index and described a spatial relationship between the longevity index and significant factors which are chosen by statistical analysis. In the further study, in order to sustain the longevity of a region, it is necessary for the effective rural planning to propagate a longevity of rural areas.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.1035-1044
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• 2021

Corporate longevity is an interesting issue from a theoretical point of view. In today's uncertain economic climate, the first priority for a company is survival. The longevity of an organization is basically one of the areas that can classify the sustainability of a company. Known as the cultural heritage of Indonesia, the traditional herbal medicine industry faces challenges of longevity. The word Jamu is a generic expression for traditional herbal medicine in Indonesia. The Jamu industry as Indonesia's cultural heritage must be preserved with good support from a technical, regulatory, and commercial perspective so that Jamu companies do not go into the decline stage. Operational resilience is usually defined as the ability of an organization to adapt rapidly to changing environments. This study aims to identify the effect of operational resilience and human capital on corporate sustainable longevity through innovation performance. The questions are addressed through empirical research of 108 small companies that produce Jamu, traditional herbal medicine in Java, Indonesia. This study was conducted during July-September 2020. Data analysis is carried out with SEM-PLS using SmartPLS software version 3.0 to evaluate the data collected. The results indicated that operational resilience influences corporate sustainable longevity directly and indirectly through innovation performance. However, human capital could not play the antecedent role to corporate sustainable longevity directly or even indirectly through innovation performance. Human capital indicators require deeper exposure in the context of small industries.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.3
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• pp.466-470
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• 2011

The purpose of this study was to investigate the anti-cancer effects of Carthami Flos in some kinds of human gastric cancer cells. We used two kinds of human gastric cancer cell lines, such as AGS cells and MKN45 cells. We examined cell death by MTT assay and observed the morphological changes with Carthami Flos. Also, we showed that the combination of sub-optimal doses of Carthami Flos and cisplatin noticeably suppresses in AGS cells and doxorubicin in MKN45 cells. Furthermore, we studied the caspase 3 activity to identify the apoptosis. Therefore, our findings provide insight into unraveling the effects of Carthami Flos in human gastric cancer cells and developing therapeutic agents against gastric cancer.

• Korean Journal of Oriental Medicine
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• v.17 no.2
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• pp.129-134
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• 2011

Objective : The purpose of this study was to investigate the anti-cancer effects of Carthami Flos in some kinds of human colorectal adenocarcinoma cells. Method : We used two kinds of human colorectal adenocarcinoma cell lines, such as HT-29 and WiDr cells. We examined cell death by MTT assay and observed the morphological changes with Carthami Flos. Result : We showed that the combination of sub-optimal doses of Carthami Flos and cisplatin noticeably suppresses in HT-29 cells and doxorubicin in WiDr cells. Furthermore, we studied the caspase 3 activity to identify the apoptosis. Conclusion : Our findings provide insight into unraveling the effects of Carthami Flos in human colorectal adenocarcinoma cells and developing therapeutic agents against colorectal cancer.

• Journal of Korean Society of Rural Planning
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• v.9 no.3 s.20
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• pp.35-39
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• 2003

In this study, the longevity index was suggested for researches about social and environmental effects to human immorality and criteria for defining longevity area were developed using statistical analysis. Candidates indexes based on researches about the tend of human death ratio were investigated. As a result statistical analysis, ratio of population over 85 yearn old and over 65 years was selected as a longevity index. Statistical analysis on the longevity distribution at each district showed that 'eup' and 'myun' are appropriate spatial unit to study social and geographical characteristics of longevity. The spatial analysis using the $ArcView^{TM}$ with the suggested index shows the time dependent variances of degree of immorality and spatial relationship between degree of immorality and human migration.

• Journal of Digital Convergence
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• v.18 no.11
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• pp.87-97
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• 2020

This study summarized longevity factors of enterprises and presented longevity mechanism. By analogy of human aging and corporate longevity, the company's decline and longevity phenomenon were analyzed to derive corporate longevity mechanism, presented domestic and foreign longevity enterprises' cases study using above mechanism. The longevity mechanism first, as the human body restricts free radicals by dietary restrictions, companies also need continuous input efficiency. Second, as cognitive reserve by high thinking activities helps heath lifespan, companies can strengthen their profitability by continuous R&D. Third, as humans improve antioxidant functions by exercise, companies should develop risk management capabilities for environmental changes. This study can contribute to sustainable strategies for corporate managers, ultimately plan to suggest model of evaluation or diagnosis of corporate longevity.

• Korean Journal of Oriental Medicine
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• v.18 no.1
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• pp.75-84
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• 2012

Objective : The purpose of this study was to investigate the anti-cancer effects of Sophorae Radix and the effects of Doxorubicin (DOX) in human breast adenocarcinoma cells (MCF-7). Method : We used human breast adenocarcinoma cell line, MCF-7 cells. We examined cell death by MTT assay and caspase 3 assay with Sophorae Radix. To examine the inhibitory effects of Sophorae Radix, cell cycle analysis was done the MCF-7 cells after three days with Sophorae Radix. The reversibility of Sophorae Radix was examined on one day to five days treatment with 100 ${\mu}g/ml$ Sophorae Radix. Result : Sophorae Radix inhibited the growth of MCF-7 cells in a dose-dependent fashion. Also we showed that Sophorae Radix induced apoptosis in MCF-7 cells by MTT assay, caspase 3 assay and sub-G1 analysis. Sophorae Radix combined with DOX markedly inhibited the growth of MCF-7 cells compared to Sophorae Radix or DOX alone. After 3 days treatment of MCF-7 cells with Sophorae Radix, the fraction of cells in sub-G1 phase was much higher than that of the control group. Conclusion : Our findings provide insight into unraveling the effects of Sophorae Radix in human breast adenocarcinoma cells and developing therapeutic agents against breast cancer.

• BMB Reports
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• v.56 no.10
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• pp.537-544
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• 2023

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DR-induced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human.

• Journal of Pharmacopuncture
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• v.15 no.2
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• pp.15-19
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• 2012

The purpose of this study was to investigate the anti-cancer effects of Sophorae Radix (SR) and doxorubicin (DOX) in human gastric and colorectal adenocarcinoma cells. We used the human gastric and colorectal adenocarcinoma cell lines (MKN-45 and WIDR cells, respectively). We examined cell death by using the MTT(3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay and the caspase 3 assay with SR. To examine the inhibitory effects of SR, we performed a cell cycle (sub G1) analysis for the MKN-45 and WIDR cells after three days with SR. The reversibility of SR was examined for one-day to five-day treatments with SR. SR inhibited the growth of MKN-45 and WIDR cells in a dosedependent manner. Also, we showed that SR induced apoptosis in MKN-45 and WIDR cells by using the MTT assay, the caspase 3 assay and the sub-G1 analysis. SR combined with DOX markedly inhibited the growth of MKN-45 and WIDR cells compared to SR or DOX alone. After 3 days of treating MKN-45 and WIDR cells with SR, the fraction of cells in the sub-G1 phase was much higher than that of the control group. Our findings provide insights into unraveling the effects of SR on human gastric and colorectal adenocarcinoma cells and into developing therapeutic agents for use against gastric and colorectal adenocarcinomas.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.29 no.5
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• pp.479-485
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• 2011

A number of case studies that find distribution of longevity population and influencing factors through the spatial data fusion using GIS techniques are growing. The majority cases of these studies are adopt census administrative boundary data for the spatial analysis. However, these methods cannot fully explain the phenomenon of longevity because there are a variety of spatial characteristics within the census administrative boundaries. Therefore, studies of spatial unit are required that realistically reflect the phenomenon of human longevity. The dasymetric mapping method enables to product of spatial unit more realistic than census administrative boundary map and statistic estimates of small area utilizing diversity spatial information. In this study, elderly population of small area has been estimated within statistically significant level that applied the vector based dasymetric mapping method. Also, the cluster analysis confirmed that the variation of local spatial relationship within census administrative boundary. The result of this study implied that the need for local-level studies of the human longevity and the validity of the dashmetric mapping techniques.