• 한국농공학회지
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• 제45권3호
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• pp.116-126
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• 2003

In this study, we research about the relationships of human longevity and environments, inducted the significant factors of longevity from the statistical analysis, and represented spatial distribution of longevity using geographic information system. The factors confining human longevity can be categorized by geography/geology, climate/weather, economy, and social welfare. After analyzing statistical data, dependent variable which means the longevity index is defined by the ratio of population more than 85 years old among population more than 65 years old. The results of analysis show that longevity are related with waterworks ratio, temperature, local tax ratio, and latitude. In this study we discussed about the spatial characteristics which are represented by variance of the longevity index and described a spatial relationship between the longevity index and significant factors which are chosen by statistical analysis. In the further study, in order to sustain the longevity of a region, it is necessary for the effective rural planning to propagate a longevity of rural areas.

• The Journal of Asian Finance, Economics and Business
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• 제8권3호
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• pp.1035-1044
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• 2021

Corporate longevity is an interesting issue from a theoretical point of view. In today's uncertain economic climate, the first priority for a company is survival. The longevity of an organization is basically one of the areas that can classify the sustainability of a company. Known as the cultural heritage of Indonesia, the traditional herbal medicine industry faces challenges of longevity. The word Jamu is a generic expression for traditional herbal medicine in Indonesia. The Jamu industry as Indonesia's cultural heritage must be preserved with good support from a technical, regulatory, and commercial perspective so that Jamu companies do not go into the decline stage. Operational resilience is usually defined as the ability of an organization to adapt rapidly to changing environments. This study aims to identify the effect of operational resilience and human capital on corporate sustainable longevity through innovation performance. The questions are addressed through empirical research of 108 small companies that produce Jamu, traditional herbal medicine in Java, Indonesia. This study was conducted during July-September 2020. Data analysis is carried out with SEM-PLS using SmartPLS software version 3.0 to evaluate the data collected. The results indicated that operational resilience influences corporate sustainable longevity directly and indirectly through innovation performance. However, human capital could not play the antecedent role to corporate sustainable longevity directly or even indirectly through innovation performance. Human capital indicators require deeper exposure in the context of small industries.

• 동의생리병리학회지
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• 제25권3호
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• pp.466-470
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• 2011

The purpose of this study was to investigate the anti-cancer effects of Carthami Flos in some kinds of human gastric cancer cells. We used two kinds of human gastric cancer cell lines, such as AGS cells and MKN45 cells. We examined cell death by MTT assay and observed the morphological changes with Carthami Flos. Also, we showed that the combination of sub-optimal doses of Carthami Flos and cisplatin noticeably suppresses in AGS cells and doxorubicin in MKN45 cells. Furthermore, we studied the caspase 3 activity to identify the apoptosis. Therefore, our findings provide insight into unraveling the effects of Carthami Flos in human gastric cancer cells and developing therapeutic agents against gastric cancer.

• 한국한의학연구원논문집
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• 제17권2호
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• pp.129-134
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• 2011

Objective : The purpose of this study was to investigate the anti-cancer effects of Carthami Flos in some kinds of human colorectal adenocarcinoma cells. Method : We used two kinds of human colorectal adenocarcinoma cell lines, such as HT-29 and WiDr cells. We examined cell death by MTT assay and observed the morphological changes with Carthami Flos. Result : We showed that the combination of sub-optimal doses of Carthami Flos and cisplatin noticeably suppresses in HT-29 cells and doxorubicin in WiDr cells. Furthermore, we studied the caspase 3 activity to identify the apoptosis. Conclusion : Our findings provide insight into unraveling the effects of Carthami Flos in human colorectal adenocarcinoma cells and developing therapeutic agents against colorectal cancer.

• 농촌계획
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• 제9권3호
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• pp.35-39
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• 2003

In this study, the longevity index was suggested for researches about social and environmental effects to human immorality and criteria for defining longevity area were developed using statistical analysis. Candidates indexes based on researches about the tend of human death ratio were investigated. As a result statistical analysis, ratio of population over 85 yearn old and over 65 years was selected as a longevity index. Statistical analysis on the longevity distribution at each district showed that 'eup' and 'myun' are appropriate spatial unit to study social and geographical characteristics of longevity. The spatial analysis using the $ArcView^{TM}$ with the suggested index shows the time dependent variances of degree of immorality and spatial relationship between degree of immorality and human migration.

• 디지털융복합연구
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• 제18권11호
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• pp.87-97
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• 2020

본 연구를 통하여 장수기업의 요인을 종합하고 각 요인 별로 어떻게 선순환을 이루는지 장수기업 메커니즘을 제시하고자 한다. 이를 위해 인간 노화의 특징을 연구하고 이를 기업의 장수 메커니즘에 유비함으로써, 기업의 쇠퇴와 장수 현상을 분석하여 기업의 장수 메커니즘을 도출하였으며, 이를 활용한 국내외 장수기업 사례를 제시하였다. 장수 메커니즘은 첫째, 인체가 식이 제한으로 활성산소를 제한하듯, 기업도 투입 효율의 지속적 관리가 필요하다. 둘째, 고등사고 활동을 통한 인지비축이 건강수명에 도움이 되듯, 기업도 지속적인 R&D를 통해 수익성 강화가 가능하다. 셋째, 인간이 운동을 통해 항산화 기능 향상을 이루듯, 기업도 환경 변화에 대한 위기관리능력을 키워야 한다. 본 연구는 기업 경영자의 지속가능경영 전략 수립에 일조할 것으로 사료되며, 나아가 궁극적으로 기업 장수 평가 또는 진단 모형을 제시하고자 한다.

• 한국한의학연구원논문집
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• 제18권1호
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• pp.75-84
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• 2012

Objective : The purpose of this study was to investigate the anti-cancer effects of Sophorae Radix and the effects of Doxorubicin (DOX) in human breast adenocarcinoma cells (MCF-7). Method : We used human breast adenocarcinoma cell line, MCF-7 cells. We examined cell death by MTT assay and caspase 3 assay with Sophorae Radix. To examine the inhibitory effects of Sophorae Radix, cell cycle analysis was done the MCF-7 cells after three days with Sophorae Radix. The reversibility of Sophorae Radix was examined on one day to five days treatment with 100 ${\mu}g/ml$ Sophorae Radix. Result : Sophorae Radix inhibited the growth of MCF-7 cells in a dose-dependent fashion. Also we showed that Sophorae Radix induced apoptosis in MCF-7 cells by MTT assay, caspase 3 assay and sub-G1 analysis. Sophorae Radix combined with DOX markedly inhibited the growth of MCF-7 cells compared to Sophorae Radix or DOX alone. After 3 days treatment of MCF-7 cells with Sophorae Radix, the fraction of cells in sub-G1 phase was much higher than that of the control group. Conclusion : Our findings provide insight into unraveling the effects of Sophorae Radix in human breast adenocarcinoma cells and developing therapeutic agents against breast cancer.

• BMB Reports
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• 제56권10호
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• pp.537-544
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• 2023

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DR-induced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human.

• 대한약침학회지
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• 제15권2호
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• pp.15-19
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• 2012

The purpose of this study was to investigate the anti-cancer effects of Sophorae Radix (SR) and doxorubicin (DOX) in human gastric and colorectal adenocarcinoma cells. We used the human gastric and colorectal adenocarcinoma cell lines (MKN-45 and WIDR cells, respectively). We examined cell death by using the MTT(3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay and the caspase 3 assay with SR. To examine the inhibitory effects of SR, we performed a cell cycle (sub G1) analysis for the MKN-45 and WIDR cells after three days with SR. The reversibility of SR was examined for one-day to five-day treatments with SR. SR inhibited the growth of MKN-45 and WIDR cells in a dosedependent manner. Also, we showed that SR induced apoptosis in MKN-45 and WIDR cells by using the MTT assay, the caspase 3 assay and the sub-G1 analysis. SR combined with DOX markedly inhibited the growth of MKN-45 and WIDR cells compared to SR or DOX alone. After 3 days of treating MKN-45 and WIDR cells with SR, the fraction of cells in the sub-G1 phase was much higher than that of the control group. Our findings provide insights into unraveling the effects of SR on human gastric and colorectal adenocarcinoma cells and into developing therapeutic agents for use against gastric and colorectal adenocarcinomas.

• 한국측량학회지
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• 제29권5호
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• pp.479-485
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• 2011

GIS기법을 이용하여 공간데이터간의 융합을 통한 지역적 장수인구의 분포와 영향요인을 밝혀내는 연구사례가 증가하고 있다. 일반적으로 이러한 연구들은 분석의 공간단위로써 센서스 행정구역을 채택한다. 그러나 센서스 구역 안에서도 공간적 특징의 다양성이 존재하기 때문에 장수현상을 충분히 설명한다고 할 수 없다. 따라서 장수라는 현상을 현실적으로 반영하는 공간단위에 대한 연구가 필요하다. 대시매트릭 기법은 다양한 공간정보를 이용하여 센서스 행정경계 보다 현실적인 공간단위의 재구성이 가능하게 해준다. 또한 이를 응용하여 소지역의 통계량 추정이 가능하다. 본 연구에서는 벡터기반 건물 데이터를 기반으로 대시매트릭 매핑기법을 응용하여 소지역 노인인구 수를 통계적으로 유의한 수준 안에서 재구성 하였다. 또한 클러스터 분석을 통해 센서스 행정경계안에 존재하는 국지적인 공간 영향관계의 변이를 확인 하였다. 본 연구를 통해 국지적 수준의 장수연구에 대한 필요성과 대시매트릭 기법의 응용이 유효한 방법론임을 제시하였다고 판단된다.