• BMB Reports
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• 제50권1호
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• pp.12-19
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• 2017

Traditionally, biologists have devoted their careers to studying individual biological entities of their own interest, partly due to lack of available data regarding that entity. Large, high-throughput data, too complex for conventional processing methods (i.e., "big data"), has accumulated in cancer biology, which is freely available in public data repositories. Such challenges urge biologists to inspect their biological entities of interest using novel approaches, firstly including repository data retrieval. Essentially, these revolutionary changes demand new interpretations of huge datasets at a systems-level, by so called "systems biology". One of the representative applications of systems biology is to generate a biological network from high-throughput big data, providing a global map of molecular events associated with specific phenotype changes. In this review, we introduce the repositories of cancer big data and cutting-edge systems biology tools for network generation, and improved identification of therapeutic targets.

• Annals of Clinical Neurophysiology
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• 제22권1호
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• pp.29-32
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• 2020

Sarcoglycanopathies are a rare group of autosomal recessive limb-girdle muscular dystrophies (LGMDs) caused by genetic variants in α-, β-, γ-, or δ-sarcoglycan that maintain membrane integrity and contribute to molecular signal processing. High-throughput nucleotide sequencing was performed in patients with slowly progressive proximal muscle weakness from early childhood with respiratory involvement, which detected a novel homozygous nonsense variant (c.601C>T;p.Gln201Ter) in SGCB. This report informs about the clinical characteristics of LGMD2E (type-2E LGMD) in Korea and provides genetic confirmation of the disease.

• 공학논문집
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• 제2권1호
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• pp.39-47
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• 1997

실시간 2차원 디지털 IIR 필터링 알고리즘의 구현을 가능하게 하는 디지털 신호처리시스템의 효율적인 구조를 제안하였다. 제안된 구조는 시스템 레벨과 프로세서 레벨에서의 병렬처리를 통하여 높은 시스템 성능을 가능하게 하였다. 프로세서간의 데이터 통신의 양을 크게 줄였으며 시스템이 초기화된 이후에는 다른 오버헤드 없이 계산을 수행할 수 있도록 설계하여 전체 시스템의 효율을 극대화하였다. 기능 레벨의 시뮬레이션을 수행하였으며, 그 결과 1 사이클당 1개의 데이터를 처리할 수 있음을 확인하였다. 이는 단지 10MHz의 시스템 클럭을 사용하는 경우 2차원 4차 IIR필터를 실시간 비디오데이터에 적용할 수 있음을 의미하며, 시스템 클럭의 주파수를 올릴 경우 고선명 TV (HDTV) 등의 전후 처리 필터로 사용가능 할 것이다.

• Journal of Biosystems Engineering
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• 제41권2호
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• pp.116-125
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• 2016

Background: Microfluidics is of considerable importance in food and agricultural industries. Microfluidics processes low volumes of fluids in channels with extremely small dimensions of tens of micrometers. It enables the miniaturization of analytical devices and reductions in cost and turnaround times. This allows automation, high-throughput analysis, and processing in food and agricultural applications. Purpose: This review aims to provide information on the applications of microfluidics in the agro-food sector to overcome limitations posed by conventional technologies. Results: Microfluidics contributes to medical diagnosis, biological analysis, drug discovery, chemical synthesis, biotechnology, gene sequencing, and ecology. Recently, the applications of microfluidics in food and agricultural industries have increased. A few examples of these applications include food safety analysis, food processing, and animal production. This study examines the fundamentals of microfluidics including fabrication, control, applications, and future trends of microfluidics in the agro-food sector. Conclusions: Future research efforts should focus on developing a small portable platform with modules for fluid handling, sample preparation, and signal detection electronics.

• IEIE Transactions on Smart Processing and Computing
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• 제5권1호
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• pp.29-34
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• 2016

A controller area network (CAN) controller is an integral part of an electronic control unit, particularly in an advanced driver assistance system application, and its characteristics should always be advantageous in all aspects of functionality especially in real time application. The cost should be low, while maintaining the functionality and reliability of the technology. However, a CAN protocol implementing serial operation results in slow throughput, especially in a cyclical redundancy checking (CRC) unit. In this paper, digital signal processing (DSP) algorithms are implemented, namely pipelining, unfolding, and retiming the CAN controller in the CRC unit, particularly for the encoder and decoder sections. It must attain a feasible iteration bound, a critical path that is appropriate for a CAN system, and must obtain a superior design of a high-speed parallel circuit for the CRC unit in order to have a faster transmission rate. The source code for the encoder and decoder was formulated in the Verilog hardware description language.

• ETRI Journal
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• 제30권3호
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• pp.451-460
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• 2008

Recently, the power consumption of integrated circuits has been attracting increasing attention. Many techniques have been studied to improve the power efficiency of digital signal processing units such as fast Fourier transform (FFT) processors, which are popularly employed in both traditional research fields, such as satellite communications, and thriving consumer electronics, such as wireless communications. This paper presents solutions based on parallel architectures for high throughput and power efficient FFT cores. Different combinations of hybrid low-power techniques are exploited to reduce power consumption, such as multiplierless units which replace the complex multipliers in FFTs, low-power commutators based on an advanced interconnection, and parallel-pipelined architectures. A number of FFT cores are implemented and evaluated for their power/area performance. The results show that up to 38% and 55% power savings can be achieved by the proposed pipelined FFTs and parallel-pipelined FFTs respectively, compared to the conventional pipelined FFT processor architectures.

• ETRI Journal
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• 제26권5호
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• pp.375-383
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• 2004

This paper proposes a common interleaving method associated with independent channel-encoding among transmitter antenna branches in orthogonal frequency and code division multiplexing based on multiple-input multiple-output (MIMO) multiplexing to achieve an extremely high throughput such as 1 Gbps using a 100 MHz bandwidth. This paper also investigates the average packet error rate performance as a function of the average received signal energy per bit-to-background noise power spectrum density ratio $(E_b/N_0)$. We found that the loss in the required average received $E_b/N_0$ of the proposed method is only within approximately 0.3 dB in up to a 12-path Rayleigh fading channel, using 16QAM and Turbo coding with a coding rate of 5/6. We also clarify that even for a large fading correlation among antenna branches, 1 Gbps is still possible by increasing the transmission power. Therefore, the proposed method reduces the processing rate to 1/4 in the turbo decoder with only a slight loss in the required average received $E_b/N_0$.

• 한국위성정보통신학회논문지
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• 제11권3호
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• pp.119-122
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• 2016

특징 검출 기법은 원하는 신호에 대한 부분적인 정보가 수신단에 알려진 상황에서 정확도 높은 검출이 가능한 기법으로 알려져 있다. 이러한 방식의 검출 기법은 잡음이 강한 환경을 위해 제안되었다. 사이클로스테이셔너리 검출은 인지 무선 시스템에서 스펙트럼 검출 기법의 하나의 예이다. 그러나 이 기법은 원하는 신호에 대한 많은 양의 정보와 처리 시간을 요구한다. 반면, 에너지 검출 기반의 스펙트럼 검출은 단순한 기법으로 널리 알려져 있다. 그러나 에너지 검출은 잡음의 영향을 많이 받으며 이로 인한 검출 오류가 많이 발생하게 된다. 본 논문에서는 에너지와 사이클로스테이셔너리 기반의 기법을 결합하여 검출의 정확도를 높이는 한편 계산량과 처리 시간을 감소시키는 기법을 제안한다. 2단계의 문턱값을 이용하여 사이클로스테이셔너리 기법의 복잡도와 처리시간을 단축하여 시스템의 전송 효율을 증가시킨다. 시뮬레이션 결과 에너지 기반 사이클로스테이셔너리 검출 기법은 신호 검출에 소요되는 시간을 상당히 감소시키는 반면 시스템의 성능을 향상시킴을 보여준다.

• 전자공학회논문지A
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• 제33A권7호
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• pp.55-63
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• 1996

In this paper, a multiple-access algorithm for PCN is proposed. The proposed algorithm provides th integrated service of information soruces and can be operated stably in high load state. Given bandwidth is efficiently used for it in the microcell environment. And system performance can be improved through the statistical-multiplexing technque. In order to process the speech signal usually requiring real-tiem processing, we adopt a random access of AlOHA type for th ebasic protocol sturcture and assume the form of ALOHA-reservation. We have analyzed the performance of the proposed algorithm through system throughput and packet delay in the microcell environment.

• 전자공학회논문지A
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• 제31A권4호
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• pp.11-20
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• 1994

The error rate equation of DS-CDMA/DQPSK skgnal adopting ARQ scheme has been derived in indoor radio channel which is characterized by AWGN, multi-user interference (MUI) and Rician fading, Using the derived equation the error performance has been evaluated and shown in figures as a function of direct to diffuse signal power ratio(KS1rT), the number of active users (K), PN code sequence length (N), the number of parity bit of linear code (b), forward channel BER, and ES1bT/NS1OT. From the results it is known that in severe fading environments (KS1rT=6) the performance of DS-CDMA/DQPSK system is not reliable so it is needed to adopt techniques for improvement. When an ARQ scheme is adopted, as a method for improving error performance, the performance improves compared with that of non-ARQ scheme and the degree of improvement is proportional to the number of parity bits of linear code. As increasing the number of parity bits, system performance is improved vut system throughput efficiency must be considered. In severe fading channel Hybrid ARQ scheme is more effective than ARQ scheme. As a result, ARQ scheme is appropriate for the high-reliability data communication systems over the radio channel in which the real time processing is not required.