• BMB Reports
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• v.50 no.1
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• pp.12-19
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• 2017

Traditionally, biologists have devoted their careers to studying individual biological entities of their own interest, partly due to lack of available data regarding that entity. Large, high-throughput data, too complex for conventional processing methods (i.e., "big data"), has accumulated in cancer biology, which is freely available in public data repositories. Such challenges urge biologists to inspect their biological entities of interest using novel approaches, firstly including repository data retrieval. Essentially, these revolutionary changes demand new interpretations of huge datasets at a systems-level, by so called "systems biology". One of the representative applications of systems biology is to generate a biological network from high-throughput big data, providing a global map of molecular events associated with specific phenotype changes. In this review, we introduce the repositories of cancer big data and cutting-edge systems biology tools for network generation, and improved identification of therapeutic targets.

• Annals of Clinical Neurophysiology
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• v.22 no.1
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• pp.29-32
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• 2020

Sarcoglycanopathies are a rare group of autosomal recessive limb-girdle muscular dystrophies (LGMDs) caused by genetic variants in α-, β-, γ-, or δ-sarcoglycan that maintain membrane integrity and contribute to molecular signal processing. High-throughput nucleotide sequencing was performed in patients with slowly progressive proximal muscle weakness from early childhood with respiratory involvement, which detected a novel homozygous nonsense variant (c.601C>T;p.Gln201Ter) in SGCB. This report informs about the clinical characteristics of LGMD2E (type-2E LGMD) in Korea and provides genetic confirmation of the disease.

• The Journal of Engineering Research
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• v.2 no.1
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• pp.39-47
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• 1997

This paper presents a single board digital signal processing system which can perform two-dimensional (2-D) digital infinite impulse response (IIR) filtering in realtime. We have developed an architecture to provide not only the necessary computational power but also a balance of the system input/output and computational requirements. The architecture achieves large system throughput by using highly parallel processing at both the system and processor levels. It reduces system data communication requirements significantly by taking advantage of a custom-designed processor and by providing each processor with its own input and ouput channel. After system initialization, almost 100 percent of the time is used for data processing. Data transfers occur concurrently with data processing. The functional level simulation reveals that the system throughput can reach as high as one pixel per system cycle. With only 10MHz clock frequency system, it can implement up to fourth order 2-D IIR filters for video-rate data ($512\times512$ pixels per frame at 30 frames per second). If we increase the system frequency, the system can be used for the preprocessing and postprocessing of video signal of HDTV.

• Journal of Biosystems Engineering
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• v.41 no.2
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• pp.116-125
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• 2016

Background: Microfluidics is of considerable importance in food and agricultural industries. Microfluidics processes low volumes of fluids in channels with extremely small dimensions of tens of micrometers. It enables the miniaturization of analytical devices and reductions in cost and turnaround times. This allows automation, high-throughput analysis, and processing in food and agricultural applications. Purpose: This review aims to provide information on the applications of microfluidics in the agro-food sector to overcome limitations posed by conventional technologies. Results: Microfluidics contributes to medical diagnosis, biological analysis, drug discovery, chemical synthesis, biotechnology, gene sequencing, and ecology. Recently, the applications of microfluidics in food and agricultural industries have increased. A few examples of these applications include food safety analysis, food processing, and animal production. This study examines the fundamentals of microfluidics including fabrication, control, applications, and future trends of microfluidics in the agro-food sector. Conclusions: Future research efforts should focus on developing a small portable platform with modules for fluid handling, sample preparation, and signal detection electronics.

• IEIE Transactions on Smart Processing and Computing
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• v.5 no.1
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• pp.29-34
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• 2016

A controller area network (CAN) controller is an integral part of an electronic control unit, particularly in an advanced driver assistance system application, and its characteristics should always be advantageous in all aspects of functionality especially in real time application. The cost should be low, while maintaining the functionality and reliability of the technology. However, a CAN protocol implementing serial operation results in slow throughput, especially in a cyclical redundancy checking (CRC) unit. In this paper, digital signal processing (DSP) algorithms are implemented, namely pipelining, unfolding, and retiming the CAN controller in the CRC unit, particularly for the encoder and decoder sections. It must attain a feasible iteration bound, a critical path that is appropriate for a CAN system, and must obtain a superior design of a high-speed parallel circuit for the CRC unit in order to have a faster transmission rate. The source code for the encoder and decoder was formulated in the Verilog hardware description language.

• ETRI Journal
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• v.30 no.3
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• pp.451-460
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• 2008

Recently, the power consumption of integrated circuits has been attracting increasing attention. Many techniques have been studied to improve the power efficiency of digital signal processing units such as fast Fourier transform (FFT) processors, which are popularly employed in both traditional research fields, such as satellite communications, and thriving consumer electronics, such as wireless communications. This paper presents solutions based on parallel architectures for high throughput and power efficient FFT cores. Different combinations of hybrid low-power techniques are exploited to reduce power consumption, such as multiplierless units which replace the complex multipliers in FFTs, low-power commutators based on an advanced interconnection, and parallel-pipelined architectures. A number of FFT cores are implemented and evaluated for their power/area performance. The results show that up to 38% and 55% power savings can be achieved by the proposed pipelined FFTs and parallel-pipelined FFTs respectively, compared to the conventional pipelined FFT processor architectures.

• ETRI Journal
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• v.26 no.5
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• pp.375-383
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• 2004

This paper proposes a common interleaving method associated with independent channel-encoding among transmitter antenna branches in orthogonal frequency and code division multiplexing based on multiple-input multiple-output (MIMO) multiplexing to achieve an extremely high throughput such as 1 Gbps using a 100 MHz bandwidth. This paper also investigates the average packet error rate performance as a function of the average received signal energy per bit-to-background noise power spectrum density ratio $(E_b/N_0)$. We found that the loss in the required average received $E_b/N_0$ of the proposed method is only within approximately 0.3 dB in up to a 12-path Rayleigh fading channel, using 16QAM and Turbo coding with a coding rate of 5/6. We also clarify that even for a large fading correlation among antenna branches, 1 Gbps is still possible by increasing the transmission power. Therefore, the proposed method reduces the processing rate to 1/4 in the turbo decoder with only a slight loss in the required average received $E_b/N_0$.

• Journal of Satellite, Information and Communications
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• v.11 no.3
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• pp.119-122
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• 2016

Feature detection is recognized as an accurate spectrum sensing approach when the information of the desired signal is partly known at the receiver. This type of detection was proposed to overcome large noise environment. Cyclostationary detection is an example of feature detection in spectrum sensing technique in cognitive radio. However, the cyclostationary process calculation requires a lot of processing time and information about the designed signals. On the other hand, energy detection spectrum sensing is widely known as a simple and compact spectrum sensing technique. However, energy detection is highly affected by large noise and lead to high detection error probability. In this paper, the combination of energy detection and cyclostationary is proposed in order to increase the accuracy and decrease the calculation and processing time. The two-layer threshold is utilized in order to reduce the complexity of computation and processing time in cyclostationary which can lead to the improved throughput of the system. The simulation result shows that the implementation of energy-based cyclostationary detector can help to improve the performance of the system while it can considerably reduce the required time for signal detection.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.7
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• pp.55-63
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• 1996

In this paper, a multiple-access algorithm for PCN is proposed. The proposed algorithm provides th integrated service of information soruces and can be operated stably in high load state. Given bandwidth is efficiently used for it in the microcell environment. And system performance can be improved through the statistical-multiplexing technque. In order to process the speech signal usually requiring real-tiem processing, we adopt a random access of AlOHA type for th ebasic protocol sturcture and assume the form of ALOHA-reservation. We have analyzed the performance of the proposed algorithm through system throughput and packet delay in the microcell environment.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.31A no.4
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• pp.11-20
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• 1994

The error rate equation of DS-CDMA/DQPSK skgnal adopting ARQ scheme has been derived in indoor radio channel which is characterized by AWGN, multi-user interference (MUI) and Rician fading, Using the derived equation the error performance has been evaluated and shown in figures as a function of direct to diffuse signal power ratio(KS1rT), the number of active users (K), PN code sequence length (N), the number of parity bit of linear code (b), forward channel BER, and ES1bT/NS1OT. From the results it is known that in severe fading environments (KS1rT=6) the performance of DS-CDMA/DQPSK system is not reliable so it is needed to adopt techniques for improvement. When an ARQ scheme is adopted, as a method for improving error performance, the performance improves compared with that of non-ARQ scheme and the degree of improvement is proportional to the number of parity bits of linear code. As increasing the number of parity bits, system performance is improved vut system throughput efficiency must be considered. In severe fading channel Hybrid ARQ scheme is more effective than ARQ scheme. As a result, ARQ scheme is appropriate for the high-reliability data communication systems over the radio channel in which the real time processing is not required.