• The Korean Journal of Physiology and Pharmacology
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• v.24 no.1
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• pp.1-10
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• 2020

Autophagy is a highly conserved intracellular degradation and energy-recycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy innate immune cells. In this review, we describe the current state of knowledge regarding the role of autophagy in neutrophil biology and a picture of molecular mechanism underlying autophagy in neutrophils. Neutrophils are professional phagocytes that comprise the first line of defense against pathogen. Autophagy machineries are highly conserved in neutrophils. Autophagy is not only involved in generalized function of neutrophils such as differentiation in bone marrow but also plays crucial role effector functions of neutrophils such as granule formation, degranulation, neutrophil extracellular traps release, cytokine production, bactericidal activity and controlling inflammation. This review outlines the current understanding of autophagy in neutrophils and provides insight towards identification of novel therapeutics targeting autophagy in neutrophils.

• Asian Journal of Innovation and Policy
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• v.3 no.2
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• pp.245-261
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• 2014

Knowledge, technology and information have special characteristics different from the ones of normal consumer products and services. Especially the value of such information varies according to external elements such as the provided environment, their method of utilization, and the level and purpose, etc. of the user. In this study, the indicators of information customer value are developed and measured to enhance customer-based values with efforts for making new customers and maintaining existing customers. The result is as follows: 14 customer value indicators were developed. Among the indicators, value gained versus effort, reduced time for research idea investigation and savings in time searching for equipment, and tools and materials got the highest score, which means that time-saving effects were the most important. The field study of this paper was conducted from information users in the field of national R&D, and thus future studies could be conducted in various industries in many countries to attain generalized results.

• Journal of Korean Society for Quality Management
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• v.32 no.4
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• pp.274-285
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• 2004

This study, in particular, studied the consortium-participating companies on their plans of Quality Management as to how they carry them out in order to advance to the first-class business enterprises. These companies' present status and activities under implementation identified and interpreted by this study, therefore, are insufficient to be generalized into knowledge applicable to most of the companies in Gangwon-do. For more precise and detailed results, it is suggested to make further studies that cover not only those consortium companies but also non-consortium manufacturing companies if Gangwon-do.

• Industrial Engineering and Management Systems
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• v.13 no.4
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• pp.442-448
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• 2014

Portfolio optimization in the presence of estimation error can be stabilized by incorporating norm-constraints; this result was shown by DeMiguel et al. (A generalized approach to portfolio optimization: improving performance by constraining portfolio norms, Management Science, 5, 798-812, 2009), who reported empirical performance better than numerous competing approaches. We extend the idea of norm-constraints by introducing a powerful enhancement, grouped selection for portfolio optimization. Here, instead of merely penalizing norms of the assets being selected, we penalize groups, where within a group assets are treated alike, but across groups, the penalization may differ. The idea of groupwise selection is grounded in statistics, but to our knowledge, it is novel in the context of portfolio optimization. Novelty aside, the real benefits of groupwise selection are substantiated by experiments; our results show that groupwise asset selection leads to strategies with lower variance, higher Sharpe ratios, and even higher expected returns than the ordinary norm-constrained formulations.

• STI Policy Review
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• v.4 no.2
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• pp.136-158
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• 2013

This study identifies the structural determinants of the social acceptance of genetically modified (GM) foods across European countries. Toward this end, we suggest an integrated theoretical model to explain the social acceptance of GM foods by including both perception factors (perceived benefit, perceived risk, feelings, trust, and knowledge) and value factors (ethical concerns, science optimism, religiosity, and ideology). This model is then tested by analyzing survey data collected from 18,634 Europeans in 32 countries. The results indicate that first, not only perception factors but also value factors significantly contribute to explaining the acceptance of GM foods. Second, perceived benefits, perceived risk, feelings, and ethical concerns tend to be the four biggest determinants for acceptance. Third, this two-factor model could be generalized even with variation across countries. Finally, ethical concerns and scientific optimism play a moderating role between predictors and outcomes in the acceptance of GM foods.

• Journal of the Korean School Mathematics Society
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• v.5 no.2
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• pp.23-31
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• 2002

The purpose of this study is to analyze thinking process in problem solving and to get some teaching materials to improve students' problem solving abilities. For this study, 14 girl and boy students in highschool were tested with 7 testing questions. The whole process of students' problem solving was observed by using 'Thinking aloud', recorded by Audio Tape and finally drawn up to Protocol. On the basis of that Protocol, coding system was set up and characteristics of thinking process in each stage were analyzed. -In the stage of planning, successful problem solvers tried to check the properties of words included in problems(Pr) and made it clear that they were seeking(O) -In the stage of planning, students used abstraction strategy(Ab, making equation(E) or using variable(V)) appropriately could solve more difficult problems. Successful problem solvers turned used unsystematical trial into systematical method and were good at using partial objects, assistant factors. - In the stage of carring out the plan, successful problem solvers to reduce the error, check the purpose, used formula, knowledge and calculation. -In the looking back stage, successful problem solvers generalized the answer and checked the total process.

• The Journal of Korean Physical Therapy
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• v.5 no.1
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• pp.71-77
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• 1993

The baby makes very great strides in the first year of his life. The developmental principles may be summarised as follows : first, the continuous process from conception to maturity, second, the physical manifestation of neural maturation, third, the cephalocaudal direction, from proximal to distal, fourth generalized mass activity to specific individual responses, fifth, reflex dominance to integration. The stages of normal movement development an head control, rolling creeping(on belly), sitting crawling(on hands and on knees), standing and walking. The knowledge of normal movement development needs for the assessment treatment and management of C.N.S. injuried infant.

• Journal of the Optical Society of Korea
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• v.9 no.2
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• pp.68-73
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• 2005

When aligning catoptric or catadioptric telescopes for space cameras, it is difficult to align precisely if the field of view is large or there are several reflective surfaces. The quantitative knowledge of mirror misalignments greatly helps align a misaligned telescope precisely, and also reduce the alignment time. This paper describes a generalized reverse-optimization alignment solution algorithm using Zernike sensitivity, and proposes the minimum number of fields to take interferograms. This method was successfully applied on a Cassegrain telescope design for Earth observation from space with arbitrary misalignments and a model including some primary mirror deformation.

• Proceedings of the IEEK Conference
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• 2000.07a
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• pp.482-485
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• 2000

A modified watershed transform is proposed which is context-free marker-controlled and minima imposition-free to reduce the over-segmentation and to speedup the transform. In contrast to the conventional methods in which a priori knowledge, such as flat zones, zones of homogeneous texture, and morphological distance, is required for marker extraction, context-free marker extraction is proposed by using the attention operator based on the GST (generalized symmetry transform). By using the context-free marker, the proposed watershed transform exploit marker-constrained labeling to speedup the computation and to reduce the over-segmentation by eliminating the unnecessary geodesic reconstruction such as the minima imposition and thereby eliminating the necessity of the post-processing of region merging. The simulation results show that the proposed method can extract context-free markers inside the objects from the complex background that includes multiple objects and efficiently reduces over-segmentation and computation time.

• 전기의세계
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• v.29 no.6
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• pp.393-400
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• 1980

It is shown in this paper that it is possible to derive generalized state equations for computation of electrical circults constanining SCR and diode elements. Revankar's binary logic variable method is used for formulation of the state equation of chopper circuit. Advantage of this method is that the state equations can be set up without the exact knowledge of the circuit operaton. The different modes of operation of the circuit are identified by the computer itself. By applying this method, the steady state performances of separately excited chopper-fed dc motor considering the counter electromotive force of the motor are investigated and the results of the computer simulation are presented. There is a satisfactory agreement between the theoretical and experimental results.