• 대한본초학회지
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• 제38권6호
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• pp.73-91
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• 2023

Objectives : This study used a network pharmacology approach to elucidate the efficacy and molecular mechanisms of Daehwangmokdanpitang (DHMDPT) on Psoriasis. Methods : Using OASIS databases and PubChem database, compounds of DHMDPT and their target genes were collected. The putative target genes of DHMDPT and known target genes of psoriasis were compared and found the correlation. Then, the network was constructed using Cytoscape 3.10.1. The key target genes were screened by Analyzer network and their functional enrichment analysis was conducted based on the Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms. Results : The result showed that total 30 compounds and 439 related genes were gathered from DHMDPT. 264 genes were interacted with psoriasis gene set, suggesting that the effects of DHMDPT are closely related to psoriasis. Based on GO enrichment analysis and KEGG pathways, 'Binding', 'Cytokine Activity', 'Receptor Ligand Activity' 'HIF-1 signaling pathway', 'IL-17 signaling pathway', 'Toll-like receptor signaling pathway', and 'TNF signaling pathway' were predicted as functional pathways of 16 key target genes of DHMDPT on psoriasis. Among the target genes, IL6, IL1B, TNF, AKT1 showed high correlation with the results of KEGG pathways. Additionally, Emodin, Acetovanillone, Gallic acid, and Ferulic acid showed a high relevance with key genes and their mechanisms. Conclusion : Through a network pharmacological method, DHMDPT was predicted to have high relevance with psoriasis. This study could be used as a basis for studying therapeutic effects of DHMDPT on psoriasis.

• 한국지역지리학회지
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• 제21권1호
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• pp.1-20
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• 2015

이 논문은 네트워크도시 이론의 정책적 함의와 분석적 유용성을 고찰하면서 그 한계를 보완하고, 이를 영남권 지역에 적용하여 지역 발전을 위한 전망을 제시하고자 한다. 네트워크도시는 상대적 자립성을 가진 중소도시들이 네트워크를 구축하여 상호보완성과 시너지를 확보함으로써 개별 도시와 권역의 발전을 동시에 추구한다는 점에서, 지구 지방화 과정에 대한 도시 및 지역의 적극적인 대응방안이 될 수 있다. 그러나 네트워크도시 이론과 이를 응용한 경험적 연구가 가지는 한계와 문제를 해소하기 위하여, 네트워크도시의 연계성을 경험적으로 고찰하기 위한 분석기법의 체계화, 연계성 지표의 확장, 네트워크도시에 내재된 규범성의 재확인, 네트워크도시를 위한 협력적 거버넌스 구축, 네트워크도시와 연계된 도시 내부 공동체의 발전 방안의 모색 등이 요구된다. 이 이론을 활용한 영남권 도시지역에 관한 예비적 분석에서 이 지역은 네트워크도시에 근접하고 있지만, 명확히 네트워크도시라고 판단하기는 어렵다. 그러나 규범적, 정책적 측면에서 영남권 도시지역이 네트워크도시를 지향하기 위하여, 권역 내 도시 및 지역들 간 교통통신 인프라의 확충, 경제적 상호연계성의 강화, 협력적 거버넌스의 구축, 권역 차원의 기능적 연계성의 국지적 착근화가 필요하다는 점이 제시된다.

• Journal of Dairy Science and Biotechnology
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• 제25권2호
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• pp.29-32
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• 2007

An understanding functional properties and molecular interactions of milk proteins was critical to improve qualities of fermented dairy products including yogurts and cheeses. Extensive rearrangements of casein particles were important factors to enhance whey separation in yogurt gel network. The use of high hydrostatic pressure treated whey protein as an ingredient of low fat processed cheese food resulted in the production of low fat processed cheese food with acceptable firmness and enhanced meltabilities. Milk protein-based nano particles produced by self-association of proteins could be better nutrient delivery vehicle than micro particle since particle size reduction in nano particles could lead to increased residence time and surface area available in GI tract.

• 한국정보시스템학회지:정보시스템연구
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• 제14권3호
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• pp.97-104
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• 2005

The paper proposes an implementation architecture of DiffServ-over-MPLS traffic engineering (TE) on Intel IXP2400 network processor using Intel IXA SDK 4.0 Framework. Program architecture and functions are described. Also fast and scalable range-match classification scheme is proposed for DiffServ-over-MPLS TE that has been integrated with functional blocks from Intel Microblocks library. Performance test shows that application can process packets at approximate data rate of 3.5 Gbps. The proposed implementation architecture of DiffServ-over-MPLS TE on Network processor can provide guaranteed QoS on high-speed next generation Internet, while being flexible and easily modifiable.

• Journal of Acupuncture Research
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• 제37권2호
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• pp.128-135
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• 2020

Background: Classical acupuncture is being used in the treatment of rheumatoid arthritis (RA). To explore the biological response to acupuncture, a network-based analysis was performed on gene expression data collected from an animal model of RA treated with acupuncture. Methods: Gene expression data were obtained from published microarray studies on blood samples from rats with collagen induced arthritis (CIA) and non-CIA rats, both treated with manual acupuncture. The weighted gene co-expression network analysis was performed to identify gene clusters expressed in association with acupuncture treatment time and RA status. Gene ontology and pathway analyses were applied for functional annotation and network visualization. Results: A cluster of 347 genes were identified that differentially downregulated expression in association with acupuncture treatment over time; specifically in rats with CIA with module-RA correlation at 1 hour after acupuncture (-0.27; p < 0.001) and at 34 days after acupuncture (-0.33; p < 0.001). Functional annotation showed highly significant enrichment of porphyrin-containing compound biosynthetic processes (p < 0.001). The network-based analysis also identified a module of 140 genes differentially expressed between CIA and non-CIA in rats (p < 0.001). This cluster of genes was enriched for antigen processing and presentation of exogenous peptide antigen (p < 0.001). Other functional gene clusters previously reported in earlier studies were also observed. Conclusion: The identified gene expression networks and their hub-genes could help with the understanding of mechanisms involved in the pathogenesis of RA, as well understanding the effects of acupuncture treatment of RA.

• 한국콘텐츠학회논문지
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• 제14권12호
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• pp.753-763
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• 2014

은퇴 후 사회적 관계망은 삶의 만족도에 중요한 영향을 끼친다. 사회적 관계망은 개인을 중심으로 여러 사람들과 관계를 맺는 것으로 구조적/기능적 특성으로 구분될 수 있다. 본 연구에서는 이러한 두 가지 특징에 의해 체계적으로 은퇴 후 사회적 관계망의 변화와 변화에 영향을 주는 요인을 검증하였다. 본 연구에는 "고령화연구패널조사" 2008년도, 2010년도, 2012년도 자료를 활용하여, 45세 이상의 은퇴자 1,569명을 최종분석대상으로 추출하였다. STATA 12.0을 이용하여 빈도분석, 기술통계분석을 실시하였으며, 은퇴자의 개인적 특성과 은퇴여부가 사회적관계망의 변화에 미치는 영향을 보기 위해 Panel logit model과 fixed effects regression model방식을 이용하였다. 마지막으로 은퇴 여부와 사회적 관계망의 관계에 영향을 미치는 요인을 파악하기 위해 Multiple panel logit model과 fixed effects model의 within추정 방식을 통해 분석하였다. 분석 결과 구조적 특성에서는 친한 사람 접촉빈도와 사회활동 참여 정도가 더 줄어들었다. 기능적 특성인 자녀로부터의 지원 유무는 은퇴자가 비은퇴자에 비해 지원이 더 적었다. 이에 본 연구는 은퇴 이후 사회적 관계망을 변화를 확인 하였으며 은퇴 후 노년기의 삶의 시작과 맞물린 현실에서 사회적 관계망이 축소되는 은퇴자들을 위한 제도적 지원 필요성을 시사한다.

• 대한본초학회지
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• 제39권3호
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• pp.37-47
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• 2024

Objectives : Because predicting the potential efficacy and mechanisms of Korean medicines is challenging due to their high complexity, employing an approach based on network pharmacology could be effective. In this study, network pharmacological analysis was utilized to anticipate the effects of YunPye-Hwan (YPH) in treating Chronic obstructive pulmonary disease (COPD). Methods : Compounds and their related target genes of YPH were gathered from the TCMSP and PubChem databases. These target genes of YPH were subsequently compared with gene sets associated with COPD to assess correlation. Next, core genes were identified through a two-step screening process, and finally, functional enrichment analysis of these core genes was conducted using both Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways. Results : A total of 15 compounds and 437 target genes were gathered, resulting in a network comprising 473 nodes and 14,137 edges. Among them, 276 genes overlapped with gene sets associated with COPD, indicating a significant correlation between YPH and COPD. Functional enrichment analysis of the 18 core genes revealed biological processes and pathways such as "miRNA Transcription," "Nucleic Acid-Templated Transcription," "DNA-binding Transcription Factor Activity," "MAPK signaling pathway," and "TNF signaling pathway" were implicated. Conclusion : YPH exhibited significant relevance to COPD by modulating cell proliferation, differentiation, inflammation, and cell death pathways. This study could serve as a foundational framework for further research investigating the potential use of YPH in the treatment of COPD.

• 가정과삶의질연구
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• 제20권4호
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• pp.149-164
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• 2002

The purpose of this study was to identify the types of social networks of urban housewives according to different network composition patterns and to analyze the structural and functional characteristics of identified types. The data used in this study were collected from 589 full-time housewives residing in Taejeon city. The major findings are as follows: 1) The social networks of housewives in urban nuclear families were classified into eight types: the kin network, the non-kin network, the kin-centered network, the friend-centered network, the neighbor-centered network, the associate-centered network, the parallel network, and the decentralized network. 2) The structual characteristics (size, density, homogeneity, duration, proximity, frequency, closeness, direction) varied according to the type. The kin network type and the non-kin network type showed extreme degrees in network characteristics. The parallel network type and the decentralized network type showed an average level of network characteristics. The kin-, friend-, neighbor-, and the associate-centered types showed network characteristics of an intermediate level between the single-category types and the decentralized type. 3) The average levels of function of social network types were different in only two(service support, interference) of the six function areas(emotional support, service support, material support, information support, social companionship support, interference). The average level of service support by the non-kin network type was higher than other types. The average level of interference by the kin-centered network type was higher than other types, and that of the neighbor-centered network type was lower than other types. On the other hand, the total amount of function performance of social network types was different in all function areas. The total amount of social support given by the decentralized network type was greater than the other types. The total amount of interference given by the non-kin network type was smaller than the other types.

• 지역연구
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• 제31권1호
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• pp.3-20
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• 2015

본 연구는 도시의 특정 기능이 도시규모에 의존하는지 혹은 도시 네트워크도에 의존하는지를 파악함으로서 네트워크 도시이론의 적용가능성을 검토하고자 하는데 주된 목적을 가지고 있다. 이를 위하여 본 연구에서는 2005년 및 2010년 전국 163개 시 군을 대상으로 실증분석을 수행하였다. 분석의 결과를 종합하면 다음과 같다. 규모기반은 제조업에 큰 영향을 미치는 것으로 나타났으며, 네트워크 기반은 주로 서비스업에 영향을 미치는 것으로 나타났다. 또한 시기의 흐름에 따라, 규모기반이 미치는 영향은 과거에 비해 점차 감소하는 반면, 네트워크기반이 미치는 영향은 서비스업을 중심으로 점차 증대되는 경향이 있음을 확인할 수 있었다. 본 연구에서는 새로운 시대의 담론으로서의 네트워크 도시이론의 적용 가능성을 실증적으로 분석하였다는 측면에서 그 의의를 갖는다고 할 수 있겠다.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2005년도 추계학술대회 논문집
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• pp.185-188
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• 2005

With the development of digital technology and the advent of the concept of well-being, kitchen will be worked as the center of housing and turn into multi-functional space. So a research is requested to consider the users' needs for kitchen based on their life characteristics. The purpose of this study is to find out housing lifestyles, and to search and analyze users' needs for kitchen planning according to their lifestyles. And then plans for kitchen design are suggested. The findings are as follows. (1) Housing lifestyles of users living in apartment are categorized into the type of network and trial & development, pursing the new environment and technology, the type of high quality and convenience, seeking the way to make housework easy and comfortable, the type of housework oriented and the type of unspecification. (2) The type of network and trial & development requests home automation, confrontation layout of counter-top, the type of high quality and convenience requests enlargement of kitchen space, the newest appliance and kitchen island, the type of housework oriented requests the efficiency of space utilization with a counter-top style table, and the type of unspecification asks space for study and office work. All of the types have needs for water use space, larger storing space and a Kimchi refrigerator.