The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Network Pharmacology-based Prediction of Efficacy and Mechanism of Yunpye-hwan Acting on COPD

네트워크 약리학을 이용한 윤폐환(潤肺丸)의 COPD 치료 효능 및 작용기전 연구

  • Minju Kim (School of Korean Medicine, Wonkwang University) ;
  • Aram Yang (School of Korean Medicine, Wonkwang University) ;
  • Bitna Kweon (School of Korean Medicine, Wonkwang University) ;
  • Dong-Uk Kim (School of Korean Medicine, Wonkwang University) ;
  • Gi-Sang Bae (School of Korean Medicine, Wonkwang University)
  • 김민주 (원광대학교 한의과대학) ;
  • 양아람 (원광대학교 한의과대학) ;
  • 권빛나 (원광대학교 한의과대학) ;
  • 김동욱 (원광대학교 한의과대학) ;
  • 배기상 (원광대학교 한의과대학)
  • Received : 2024.04.11
  • Accepted : 2024.05.25
  • Published : 2024.05.30
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Abstract

Objectives : Because predicting the potential efficacy and mechanisms of Korean medicines is challenging due to their high complexity, employing an approach based on network pharmacology could be effective. In this study, network pharmacological analysis was utilized to anticipate the effects of YunPye-Hwan (YPH) in treating Chronic obstructive pulmonary disease (COPD). Methods : Compounds and their related target genes of YPH were gathered from the TCMSP and PubChem databases. These target genes of YPH were subsequently compared with gene sets associated with COPD to assess correlation. Next, core genes were identified through a two-step screening process, and finally, functional enrichment analysis of these core genes was conducted using both Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways. Results : A total of 15 compounds and 437 target genes were gathered, resulting in a network comprising 473 nodes and 14,137 edges. Among them, 276 genes overlapped with gene sets associated with COPD, indicating a significant correlation between YPH and COPD. Functional enrichment analysis of the 18 core genes revealed biological processes and pathways such as "miRNA Transcription," "Nucleic Acid-Templated Transcription," "DNA-binding Transcription Factor Activity," "MAPK signaling pathway," and "TNF signaling pathway" were implicated. Conclusion : YPH exhibited significant relevance to COPD by modulating cell proliferation, differentiation, inflammation, and cell death pathways. This study could serve as a foundational framework for further research investigating the potential use of YPH in the treatment of COPD.

Keywords

Acknowledgement

본 연구는 2024년도 원광대학교 교비지원에 의해 수행되었습니다

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